Homotypic immune response to primary infection with rotavirus serotype G1.

Abstract:

:Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. In this study, all the infecting virus strains were characterized as G type and some also as P type. Primary natural infection induces a significantly greater homotypic neutralization response than heterotypic response. In addition, there was no significant difference in the number of homotypic or heterotypic responses following reinfection. Transplacentally acquired homotypic antibodies were associated with protection against dehydration during rotavirus gastroenteritis.

journal_name

J Med Virol

authors

Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

doi

10.1002/jmv.1890470418

subject

Has Abstract

pub_date

1995-12-01 00:00:00

pages

404-9

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

47

pub_type

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