Abstract:
:Patients with acquired immunodeficiency syndrome (AIDS) commonly suffer from opportunistic infections associated with members of the herpes virus family. To investigate whether certain of these other viruses might have an effect on the ability of the human immunodeficiency virus type 1 (HIV-1) to replicate, we coincubated peripheral blood mononuclear cells (PBMC) from nine HIV-1-seropositive donors with live preparations of various herpes viruses. In seven of nine cases, exposure of PBMC to preparations of either HSV-1, HSV-2, or CMV stimulated the cells to become active producers of HIV-1, as determined by reverse transcriptase activity and by the presence of infectious progeny virus. This increased production of HIV-1 particles appeared to be a consequence of mitogenic proliferation and of herpes virus-encoded transacting factors. These results supplement earlier findings on the molecular activation of the HIV-1 genome by both HSV and CMV genetic elements and point to a possible role for these viruses in the pathogenesis and ultimate clinical outcome of HIV-1 infections.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Tremblay M,Gornitsky M,Wainberg MAdoi
10.1002/jmv.1890290207subject
Has Abstractpub_date
1989-10-01 00:00:00pages
109-14issue
2eissn
0146-6615issn
1096-9071journal_volume
29pub_type
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journal_title:Journal of medical virology
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pub_type: 杂志文章
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journal_title:Journal of medical virology
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更新日期:1999-09-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:1985-04-01 00:00:00
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journal_title:Journal of medical virology
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更新日期:2000-03-01 00:00:00
abstract:BACKGROUND AND AIM:The hepatitis B virus (HBV) prevalence study performed in 2003 in Belgium is believed to be underestimating HBV prevalence due to underrepresentation of the non-Belgian population. Therefore, we assessed the prevalence and risk factors of HBV infection in a multi-ethnic region situated in Middle-Limb...
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更新日期:2009-01-01 00:00:00
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