Abstract：
:To provide background for future hepatitis A vaccine trials, sera were collected from 0- to 4-year-old Liberian infants and their mothers on two occasions an average of 14.75 months apart and tested for antibody to hepatitis A virus (anti-HAV). The prevalence of anti-HAV rose from 2.5% in infants 0-6 months of age to 70% in children 3-4 years of age and did not differ between male and female infants. The annual incidence of new infections was slightly lower in the first year of life (35%) than in the subsequent 3 years, when it averaged 45%. The presence of HBV infection did not affect the incidence of HAV seroconversion. No clinical hepatitis was recognized in the subjects who seroconverted. Dual hepatitis A and B virus infection were observed; these were all clinically inapparent. The extraordinary incidence of HAV infection documented in the present study offers an opportunity for vaccine efficacy trials requiring minimal numbers of subjects.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Prince AM,Brotman B,Richardson L,White T,Pollock N,Riddle Jdoi
10.1002/jmv.1890150411subject
Has Abstractpub_date
1985-04-01 00:00:00pages
421-8issue
4eissn
0146-6615issn
1096-9071journal_volume
15pub_type
杂志文章abstract：:Travel influences the spread of non-B subtypes of HIV in Europe. The aim of this study was to assess whether the spread of non-B subtypes occurred in Croatia, a country with a low level HIV infection. Phylogenetic analysis of the reverse transcriptase and protease genes was undertaken in 145 Croatian patients with the...
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doi：10.1002/jmv.21306
更新日期：2008-11-01 00:00:00
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journal_title：Journal of medical virology
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doi：10.1002/(sici)1096-9071(199803)54:3<204::aid-jmv11
更新日期：1998-03-01 00:00:00
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journal_title：Journal of medical virology
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更新日期：2009-07-01 00:00:00
