Study of influenza C virus infection in France.

Abstract:

:From November 2004 to April 2007, specimens were obtained from 2,281 patients with acute respiratory tract illness in Normandy, France. Eighteen strains of influenza C virus were detected in these samples using a combined tissue culture/RT-PCR diagnostic method. Most patients with influenza C virus infection (13/18) were infants or young children (<2 years of age). The most frequent symptoms were fever and cough, and the clinical presentation of influenza C virus infection was similar to that of other respiratory viruses. Thirteen of the 18 infected patients were hospitalized; 3 presented with a severe lower respiratory infection. The hemagglutinin-esterase (HE) gene of 10 isolates was sequenced to determine the lineages of the circulating influenza C viruses. Phylogenetic analysis revealed that most of the isolated strains had an HE gene belonging to the C/Yamagata/26/81-related lineage. These results show that influenza C virus regularly circulates in Normandy and generally causes a mild upper respiratory infection. Because the differential clinical diagnosis of influenza C virus infection is not always easy, it is important to identify viral strains for both patient management and epidemiological purposes.

journal_name

J Med Virol

authors

Gouarin S,Vabret A,Dina J,Petitjean J,Brouard J,Cuvillon-Nimal D,Freymuth F

doi

10.1002/jmv.21218

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

1441-6

issue

8

eissn

0146-6615

issn

1096-9071

journal_volume

80

pub_type

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