Abstract:
:Guinea pig infection with a highly passaged XJ prototype strain of Junín virus by the intramuscular route (IM) was carried out in order to study viral tropism modification in this host. The neurotropism of this strain was demonstrated by viral isolation, meningitis, and by the presence of Junín antigens as shown by immunofluorescence. These events, not previously observed with the same lower-passaged strain, revealed the appearance of neurotropism after multiple passages in guinea pigs.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Oubiña JR,Carballal Gdoi
10.1002/jmv.1890150208subject
Has Abstractpub_date
1985-02-01 00:00:00pages
157-61issue
2eissn
0146-6615issn
1096-9071journal_volume
15pub_type
杂志文章abstract::Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children's H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25214
更新日期:2018-09-01 00:00:00
abstract::Human parechoviruses (HPeV) are associated with central nervous system (CNS) infections and sepsis-like illnesses. However, data from China are not available. The aim of this study was to determine the prevalence, age, and seasonal distributions and genotypes of HPeV infections in children with CNS related disease in ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23449
更新日期:2013-02-01 00:00:00
abstract::The prognostic value of early hepatitis C virus (HCV)-RNA load was evaluated among nonresponder patients to previous interferon (IFN) therapy treated with daily IFN and ribavirin. One hundred-six nonresponders (83 men), mean age 44.8 +/- 11 years, were treated with IFN-alpha 2b 3 MU/day for 24 weeks, followed by 3 MU ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10528
更新日期:2004-01-01 00:00:00
abstract::Healthcare-associated infections with hepatitis C virus (HCV) hitherto have been observed mainly in hemodialysis settings as well as in hematology and oncology wards. In this communication, molecular and epidemiologic investigations to elucidate an HCV outbreak in an orthopedic ward are reported. One hundred and thirt...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21394
更新日期:2009-02-01 00:00:00
abstract::Hepatitis C virus (HCV) load is one of the most important predictive factors of response to interferon treatment. However, little is known about the mode and determinants of viremia. The mode of viremia was investigated in 78 patients with chronic HCV genotype 1b infection during 1-2 years follow up. Virus load, deter...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199907)58:3<247::aid-jmv10
更新日期:1999-07-01 00:00:00
abstract::In this meta-analysis, we evaluated the diagnostic role of Epstein-Barr virus deoxyribonucleic acid detection and quantitation in the serum of pediatric and young adult patients with infectious mononucleosis. The primary outcome of this meta-analysis was the sensitivity and specificity of Epstein-Barr virus (EBV) deox...
journal_title:Journal of medical virology
pub_type: 杂志文章,meta分析,评审
doi:10.1002/jmv.24402
更新日期:2016-05-01 00:00:00
abstract::Enterovirus infections are usually mild but can also cause severe illnesses and play a role in chronic diseases, such as cardiomyopathies and type 1 diabetes. Host response to the invading virus can markedly modulate the course of the infection, and this response varies between individuals due to the polymorphism of i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23903
更新日期:2014-08-01 00:00:00
abstract::Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24322
更新日期:2016-02-01 00:00:00
abstract::Glycoprotein B (gB) and glycoprotein H (gH) of human herpesvirus 7 (HHV-7) are believed to play an important role in virus entry and as targets for host immune response. This study examined the genetic diversity of these glycoproteins among 90 HHV-7 isolates collected from different individuals in Hong Kong. Overall, ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10496
更新日期:2003-11-01 00:00:00
abstract::This study aimed to investigate the characteristics of female high-risk human papillomavirus (HR-HPV) infection in Shaanxi province of China. A total of 14 111 women were enrolled for HPV genotyping test, and a cytology, and/or cervix biopsy were performed in partial women. Of these women, the HPV infection rate was 3...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24748
更新日期:2017-07-01 00:00:00
abstract::The aims of the present study were to confirm measles outbreaks by detection of measles-specific IgM antibodies, isolation of measles virus, and genetic characterization to document the circulating genotypes in Tamil Nadu. Eight outbreaks were reported from six districts of Tamil Nadu, India during the period Jan-Dec ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20569
更新日期:2006-04-01 00:00:00
abstract::Human flavivirus group-reactive, dengue complex-reactive, and encephalitis virus complex-reactive antibodies were detected using epitope-blocking immunoassays in which the binding of selected mouse monoclonal antibodies to flavivirus antigens was blocked by human serum. When late (greater than 6 months after illness) ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230209
更新日期:1987-10-01 00:00:00
abstract::Hepatitis C Virus (HCV) genotype 4 predominates in Middle East and Central Africa countries. Recently, it has become also prevalent in Southern European countries where it is thought to have been introduced through immigration and the movement of intravenous drug users. In Italy, the prevalence of genotype 4 is partic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23384
更新日期:2012-10-01 00:00:00
abstract::A procedure is described for the detection of hepatitis C virus (HCV) RNA in blood by means of the polymerase chain reaction (PCR) in which the reverse transcription step and two rounds of amplification are carried out in a single tube. This results in fewer manipulations, reduced risk of contamination, and economy of...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380312
更新日期:1992-11-01 00:00:00
abstract::Analysis of the HIV-1 V3 quasispecies present in an individual at the time of seroconversion was carried out. The polymerase chain reaction (PCR) was used to amplify proviral HIV-1 DNA extracted from peripheral blood mononuclear cells from a patient who was viraemic (p24 = 15 pg/ml) and had an equivocal HIV-1 antibody...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410403
更新日期:1993-12-01 00:00:00
abstract::The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509-4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Furthermore, the polymorph...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200009)62:1<60::aid-jmv10>3.0.co
更新日期:2000-09-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between H...
journal_title:Journal of medical virology
pub_type: 杂志文章,meta分析
doi:10.1002/jmv.24858
更新日期:2017-12-01 00:00:00
abstract::Neutralization of virus is likely to be necessary for development of an effective prophylactic vaccine against genital human papillomavirus (HPV) infection. Two New Zealand white rabbits were immunized with purified HPV type 11 (HPV 11) virions in Freund's adjuvant. An enzyme linked immunoassay (ELISA) was used to det...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199711)53:3<185::aid-jmv1>
更新日期:1997-11-01 00:00:00
abstract::A solid phase enzyme linked immunosorbent assay (ELISA) that detects IgM and IgG to hepatitis E virus (HEV) was used to study seroepidemiology in 40 healthy subjects and 227 consecutive patients with liver diseases in an endemic area. Fifty-two of the liver diseases patients (22.9 percent) had acute hepatitis E. In co...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430316
更新日期:1994-07-01 00:00:00
abstract::Investigation of varicella-zoster virus (VZV) DNA in 20 healthy children with varicella vaccination was carried out by using the polymerase chain reaction (PCR) and nested double PCR. Samples of peripheral blood mononuclear cells (PBMC) and throat swabs were simultaneously collected 3 times (before, 1 week, and 4 week...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420110
更新日期:1994-01-01 00:00:00
abstract::In order to shorten the time required for the detection of enteroviruses in stool specimens, an 18-h immunoperoxidase test combining low-speed centrifugation and the use of a group specific anti-VP1 monoclonal antibody (5-D8/1, Dako) was developed. This rapid culture assay (RCA) was compared blindly to a conventional ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199803)54:3<204::aid-jmv11
更新日期:1998-03-01 00:00:00
abstract::A small percentage of renal patients become infected with the BK polyomavirus (BKV), a pathogenic virus that causes BKV-associated nephropathy (BKVN), after kidney transplantation. This study presents a simple, rapid, high-throughput method for BKV genotyping using high-resolution melt analysis (HRMA). Using this nove...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22239
更新日期:2011-12-01 00:00:00
abstract::Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890130208
更新日期:1984-01-01 00:00:00
abstract::In 2000, we monitored the course and persistence of human papillomavirus (HPV) infection in 54 women who were HPV positive and free of any cytological disease using HPV-DNA genotyping with a linear array assay (baseline). The impact of HPV infection on development of cervical cytological abnormality (dyskaryosis) was ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20062
更新日期:2004-05-01 00:00:00
abstract::It has been reported that a new pattern of mutations, E44D/A and/or V118I, in the reverse transcriptase (RT) gene of HIV-1 confers a moderate level of resistance to lamivudine in the absence of the M184V mutation. The prevalence of this mutational pattern was studied in HIV-1 isolates obtained from 280 patients. These...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2145
更新日期:2002-03-01 00:00:00
abstract::The impact of dynamic respiratory syncytial virus (RSV) load on the clinical severity of hospitalized infants with bronchiolitis has not been clarified. Nasopharyngeal aspirates were obtained from 60 infants who were diagnosed with bronchiolitis within 96 hr of wheezing onset upon admission and on days 3, 5, and 7 in ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24111
更新日期:2015-08-01 00:00:00
abstract::We developed an immunoperoxidase staining test to detect structural antigens of BK virus (BKV) in Vero cell cultures. This test was used to examine the neutralizing activity of human and immunized animal sera. It was shown that sera positive for BKV antibodies measured by hemagglutination inhibition test and enzyme-li...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890190311
更新日期:1986-07-01 00:00:00
abstract::Cytomegalovirus-specific complement-fixing IgM (CMV CF-IgM) antibody was detected in 12/84 (14.3 percent) sera containing CMV-specific IgM. Higher titres were obtained by using a purified antigen preparation containing enveloped virus particles and membrane fragments when compared with a crude extract of infected cell...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890240312
更新日期:1988-03-01 00:00:00
abstract::The occurrence of viral coinfections in childhood pneumonia has received little attention, probably because suitable detection methods have been lacking. Between November 2004 and October 2006, the presence of 14 respiratory viruses in children aged less than 3 years old with community-acquired pneumonia were investig...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21271
更新日期:2008-10-01 00:00:00
abstract::Fifty-six renal allograft recipients were studied prospectively for 3 months or longer after transplant. The polymerase chain reaction (PCR) was used to screen peripheral blood leucocyte (PBL) specimens for CMV, human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) DNA (DNAemia) in 67 healthy controls and in seria...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199604)48:4<295::AID-JMV1>
更新日期:1996-04-01 00:00:00