Abstract：
:Fifty-six renal allograft recipients were studied prospectively for 3 months or longer after transplant. The polymerase chain reaction (PCR) was used to screen peripheral blood leucocyte (PBL) specimens for CMV, human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) DNA (DNAemia) in 67 healthy controls and in serial (fortnightly) PBL specimens from the 56 allograft recipients. None of the healthy controls had detectable CMV DNAemia, although HHV6 and HHV7 DNAemia was found in 7% and 9% of individuals respectively. In contrast, DNAemia due to CMV, HHV6 and HHV7 was found in 50%, 36% and 39% of patients respectively, at some time during the post-transplant period. Of the 28 patients who had CMV DNAemia, eight developed "CMV disease". The risk of progression to "CMV disease" was increased in patients with concurrent DNAemia to all three viruses (relative risk 3.7; 95% CI 1.3-10.5). The relative risk of "CMV disease" for patients with concurrent CMV and HHV7 was also increased (RR = 3.5; 95% CI = 1.1-11.6), while the association between CMV and HHV6 was inconclusive (RR = v2.1; 95% CI = 0.7-6.6). The first 26 patients recruited to the study also had serial serum samples tested for antibody responses to the three viruses. "CMV disease" was associated with rising antibody titres to HHV7 (Fisher's exact test, P = 0.02), and weakly so with HHV6 (P = 0.07). It is concluded that in patients with CMV DNAemia, concurrent infection/reactivation HHV7 (and possibly HHV6) is associated with an increased risk of progression to "CMV disease".
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Osman HK,Peiris JS,Taylor CE,Warwicker P,Jarrett RF,Madeley CRdoi
10.1002/(SICI)1096-9071(199604)48:4<295::AID-JMV1>subject
Has Abstractpub_date
1996-04-01 00:00:00pages
295-301issue
4eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(199604)48:4<295::AID-JMV1>journal_volume
48pub_type
杂志文章abstract：:An "in-house" recombinant virus protease inhibitor susceptibility assay was carried out (median of 3 per patient) retrospectively in 26 patients failing HIV protease inhibitor based therapy at regular intervals to the initiation of the first protease inhibitor. Patients were treated with either indinavir (N = 6), rito...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.10076
更新日期：2002-07-01 00:00:00
abstract：:Human peripheral blood mononuclear cell (PBMC) proliferative responses to live respiratory syncytial (RS) virus, formalin-inactivated RS (Fl-RS) virus, RS virus F (fusion) protein, and RS virus G (attachment) protein were assessed. All donors responded to challenge with whole RS virus antigens and F and G proteins. F ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9071(199607)49:3<161::AID-JMV2>
更新日期：1996-07-01 00:00:00
abstract：:Mixed cryoglobulinemia is a lymphoproliferative disorder associated with hepatitis C virus (HCV). In patients chronically affected by HCV the prevalence of mixed cryoglobulinemia is variable ranging from 0% to 56%. To verify whether polyomaviruses (PyV) play a role in this disorder a total of 222 blood samples from 63...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.23867
更新日期：2014-04-01 00:00:00
abstract：:Acute hepatitis B virus (HBV) infection was diagnosed in 57 adults admitted to Toranomon Hospital in Tokyo, Japan. Genotypes of HBV were determined by a serological method and compared to those in 1,077 patients with chronic hepatitis B. The distribution of genotypes were: genotype A (acute, 22.8% vs. chronic, 1.9%; P...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.10239
更新日期：2002-12-01 00:00:00
abstract：:Eastern equine encephalitis (EEE) is rare, but the most severe of the mosquito-borne encephalitides in the United States with a high case fatality rate of 30%. Here, we present a patient with EEE. EEE virus causes sporadic human disease in the Eastern parts of the United States, but the case we describe was a Scottish...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21379
更新日期：2009-02-01 00:00:00
abstract：:During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isola...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.10393
更新日期：2003-06-01 00:00:00
abstract：:The natural history of chronic hepatitis B virus (HBV) infection is highly variable, ranging from a benign course to one of shortened life expectancy. Liver histology represents an accurate tool for assessing progressive liver disease, and has been used in five recent Phase III clinical trials of the oral nucleoside a...
journal_title：Journal of medical virology
pub_type： 杂志文章,评审
doi：
更新日期：2000-07-01 00:00:00
abstract：:It is need for development of new means against influenza virus due to the lack of efficacy of available therapeutic strategies. In previous research, 1,8-cineol exert its inhibition of nuclear factor (NF)-κB, the main regulator of cytokine and chemokine production in influenza, and anti-inflammatory activity. These f...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24755
更新日期：2017-07-01 00:00:00
abstract：:Sex differences in the predictors for hepatocellular carcinoma (HCC) development after direct-acting antiviral (DAA) therapy was investigated. DAA therapy was given to 1438 (663 male, 775 female) patients. Sex differences in the HCC development rate and the factors contributing to HCC development after DAA therapy wer...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.25984
更新日期：2020-05-06 00:00:00
abstract：:Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24844
更新日期：2017-10-01 00:00:00
abstract：:We studied epidemiologic and immunologic factors in infants with bronchiolitis caused by influenza virus. The proportion of these infants who were male and who had an immediate family member with a history of asthma was similar to that of a control group of infants with respiratory syncytial virus (RSV) bronchiolitis....
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20268
更新日期：2005-02-01 00:00:00
abstract：:The genetic variability of hepatitis B virus (HBV) represents a challenge for the sensitivity of immunologic and molecular based assays. Genotyping studies show that the genetic diversity of HBV is very high even in industrialized countries. The analytical sensitivity of HBsAg and anti-HBs assays may be dependent on H...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20610
更新日期：2006-01-01 00:00:00
abstract：:A solid-phase radioimmunoassay (RIA) for the detection of hepatitis B e antigen (HBeAg) and antibody (anti-HBe) was developed. The RIA was approximately 1,000-fold more sensitive than rheophoresis for HBeAg, and approximately 6,000-fold more sensitive than rheophoresis for anti-HBe. Generally, less than one-fifth of h...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890020202
更新日期：1978-01-01 00:00:00
abstract：:Chronic hepatitis B patients with low pre-treatment HBeAg (and HBV-DNA) levels are more likely to respond to interferon-alpha therapy. In retrospect, this low level of HBeAg may have been reached just before the start of therapy. Pre-treatment changes in HBeAg levels were studied in 121 patients undergoing interferon-...
journal_title：Journal of medical virology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2001-03-01 00:00:00
abstract：:Knowledge of the antigenic diversity of rotaviruses circulating in a region should be acquired before introducing a rotavirus vaccine. In a collection of 151 rotavirus-positive samples from Mendoza, Argentina, strain diversity was evaluated utilizing G-typing monoclonal antibodies (MAbs), reverse-transcriptase-polymer...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：2000-08-01 00:00:00
abstract：:The infectivity titer of a standard stock of the SAR-55 strain of hepatitis E virus (HEV) was determined in cynomolgus macaques (Macaca fascicularis) and the effect of dose on the course of the infection was examined by weekly monitoring of alanine aminotransferase (ALT) and anti-HEV levels. Antibody to HEV (anti-HEV)...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890430207
更新日期：1994-06-01 00:00:00
abstract：:KI is a novel polyomavirus identified in the respiratory secretions of children with acute respiratory symptoms. Whether this reflects a causal role of the virus in the human respiratory disease remains to be established. To investigate the presence of KIV in the respiratory tissue, we examined 20 fresh lung cancer sp...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21417
更新日期：2009-03-01 00:00:00
abstract：:It has been generally believed that the Epstein-Barr virus (EBV)-encoded small RNA 1 and 2 (EBER1 and EBER2) genes are conserved as two families that correlated with type 1 (B95-8) and type 2 (AG876 or P3HR-1) EBV strains. EBER polymorphism and its association with EBV-associated disease have not received much attenti...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21714
更新日期：2010-05-01 00:00:00
abstract：:The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL-6 (NF-IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx transactivated the inter...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9071(199905)58:1<11::aid-jmv2>3
更新日期：1999-05-01 00:00:00
abstract：:A common causative agent for uterine cervical cancer is the human papillomavirus type 18 (HPV-18) which has three phylogenic variants: Asian-Amerindian, European, and African. Each variant shows significant molecular differences in the E6 gene. E6 oncoprotein is a negative regulator of tumor suppressor protein p53, he...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.23568
更新日期：2013-07-01 00:00:00
abstract：:Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs). Five different chromosomal integration sites were found i...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21299
更新日期：2008-11-01 00:00:00
abstract：:Sexually transmitted disease (STD) remains a major public health challenge in developed countries, exacerbated by the advent of the HIV epidemic. The objectives of this study were to assess the prevalence of serological markers of syphilis, HIV-1/2, HTLV-I/II, HBV, and HCV infections among immigrant sex workers in Mad...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20208
更新日期：2004-12-01 00:00:00
abstract：:Enterovirus 68 (EV-D68) was associated with mild to severe respiratory infections. In the last 4 years, circulation of different EV-D68 strains has been documented worldwide. In this study, the phylogenetic characterization of nine EV-D68 strains identified in patients in the 2010-2012 period and 12 additional EV-D68 ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.23821
更新日期：2014-09-01 00:00:00
abstract：:Hepatitis E virus (HEV), a positive-strand RNA agent, has been associated with enterically transmitted non-A, non-B hepatitis in Asia, Africa, and Mexico. To evaluate the role of HEV in an outbreak of hepatitis in Pakistan, we used immune electron microscopy to detect 1) antibody to HEV, for evidence of infection, and...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890360205
更新日期：1992-02-01 00:00:00
abstract：:Previous investigations of fomite transmission have focused on the presence of pathogens on inanimate objects in clinical settings. There has been limited investigation of fomite transmission in non-clinical pediatric settings where there is a high prevalence of respiratory virus infections. Over a 5 week period, this...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24102
更新日期：2015-06-01 00:00:00
abstract：:Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20872
更新日期：2007-09-01 00:00:00
abstract：:The presence of HPV 16 E6*I/E6*II spliced transcripts, in cervical lesions of different grade, was analyzed to characterize the transcription pattern. The presence and amount of spliced transcripts were correlated with DNA viral markers such as E2/E6 ratio and physical state. The detection of HPV 16 E6*I/E6*II mRNAs w...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21496
更新日期：2009-07-01 00:00:00
abstract：:An enzyme-linked immunosorbent assay (ELISA) test using polyvalent antigens and antisera was used to detect Coxsackie B virus-specific IgM responses in 329 patients admitted to the Coronary Care Unit, Wellington Hospital, New Zealand over a 12-month period. The sera of 30 of 153 (19.6%) patients with acute myocardial ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890180211
更新日期：1986-02-01 00:00:00
abstract：:A common receptor for coxsackie B virus and adenovirus has been described recently in cells of human and murine origin. Since the established cell line A-549 is suitable for adenoviruses, the potential use of A-549 cells for the isolation of coxsackie B viruses from clinical samples was investigated. All throat swabs ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:The seroprevalences of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers were evaluated in a random sample of 803 children attending school in Ashanti-Akim North district in Ghana in order to gain a better understanding of transmission patterns of these viruses, particularly horizontal transmission of HBV. T...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9071(199603)48:3<278::AID-JMV11
更新日期：1996-03-01 00:00:00
