Abstract:
:We studied epidemiologic and immunologic factors in infants with bronchiolitis caused by influenza virus. The proportion of these infants who were male and who had an immediate family member with a history of asthma was similar to that of a control group of infants with respiratory syncytial virus (RSV) bronchiolitis. In subjects with influenza virus infection, concentrations of the beta chemokine macrophage inflammatory protein-1alpha (MIP-1alpha), but not other beta chemokines, in nasopharyngeal secretions (NPS) were greater among infants with more severe, hypoxic bronchiolitis than in subjects with mild, nonhypoxic bronchiolitis, or upper respiratory tract infection alone. Quantities of MIP-1alpha were also correlated with lower values of oxygen saturation. These findings point out epidemiologic and immunologic similarities between bronchiolitis caused by influenza and RSV, and suggest that host factors are more important than the nature of the infecting virus in the development of severe forms of bronchiolitis caused by influenza and RSV.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Garofalo RP,Hintz KH,Hill V,Patti J,Ogra PL,Welliver RC Srdoi
10.1002/jmv.20268keywords:
subject
Has Abstractpub_date
2005-02-01 00:00:00pages
282-9issue
2eissn
0146-6615issn
1096-9071journal_volume
75pub_type
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