A two dose combined hepatitis A and B vaccine in Chinese youngsters.

Abstract:

:This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two-dose schedule with the profile of the corresponding monovalent vaccines, while the concomitant vaccine was administered also on a two-dose schedule but simultaneously in opposite arms. All vaccinees had antibodies against hepatitis A (anti-HAV) after the 2-dose administration, whereas all but four in the first and two in the second group had protective titres against hepatitis B (anti-HBs). At month 7, the geometric mean titres for both antibodies were more than double for the group of subjects receiving the combined vaccine: 3,701 vs. 1,705 mIU/ml for the anti-HAV, and 1,524 vs. 720 mIU/ ml for the anti-HBs response. Injection site pain was the most commonly reported local symptom and headache was the most reported general symptom. It is concluded that this combined vaccine against hepatitis A and B, administered according to a two-dose schedule, is well-tolerated and highly immunogenic.

journal_name

J Med Virol

authors

Lee SD,Chan CY,Yu MI,Wang YJ,Chang FY,Lo KJ,Safary A

keywords:

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

1-4

issue

1

eissn

0146-6615

issn

1096-9071

pii

10.1002/(SICI)1096-9071(199909)59:1<1::AID-JMV1>3.

journal_volume

59

pub_type

临床试验,杂志文章,随机对照试验
  • Measles immunity and response to revaccination of a young adult population in Israel.

    abstract::In order to evaluate the true immune status and the effect of revaccination on a young adult population, we collected serum samples from 289 military recruits who were vaccinated during an outbreak in 1991. Most vaccinees, age 18-25 years, had apparently been immunized once before as infants. Sera collected just prior...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199611)50:3<249::AID-JMV7>

    authors: Mendelson E,Duvdevani P,Varsano N,Lerman Y,Slepon R,Dagan R,Cohen D,Danon Y,Shohat T

    更新日期:1996-11-01 00:00:00

  • Infection of a human retinal pigment epithelial cell line with human herpesvirus 6 variant A.

    abstract::A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucle...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Arao Y,Soushi S,Sato Y,Moriishi E,Ando Y,Yamada M,Padilla J,Uno F,Nii S,Kurata T

    更新日期:1997-10-01 00:00:00

  • Hepatitis C infection, Cognition, and inflammation in an Egyptian sample.

    abstract::Chronic hepatitis C (HCV) infection is associated with cognitive impairments which might be mediated through a secondary inflammatory cascade. Egypt has an unusually high prevalence of HCV monoinfections and is an ideal site for the study of the isolated effects of HCV infection. Therefore, in a hospital-based cross-s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21879

    authors: Farag NH,Rashed HA,Hassan M,Darweesh A,Shehata M,Hassanein T,Mills PJ

    更新日期:2011-02-01 00:00:00

  • Increased prevalence of human herpesvirus type 8 (HHV-8) genome among blood donors from North-Western Argentina.

    abstract::The prevalence of HHV-8 infection varies widely in South American populations, displaying geographical variations in its distribution. The heterogeneous genetic contributions provided by the transatlantic parental populations that modified the Native American genomes may explain this epidemiological observation. Aimin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24656

    authors: Hulaniuk ML,Torres O,Bartoli S,Fortuny L,Burgos Pratx L,Nuñez F,Salamone H,Corach D,Trinks J,Caputo M

    更新日期:2017-03-01 00:00:00

  • Persistent hyperendemicity of hepatitis C virus infection in Taiwan: the important role of iatrogenic risk factors.

    abstract::The purpose of this study was to investigate determinants of endemic hepatitis C virus (HCV) infection within communities in Taiwan. A two-phase study, including a seroprevalence survey and a prevalent case-control study at the first phase, which has been published previously, and a follow-up seroconversion determinat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Sun CA,Chen HC,Lu SN,Chen CJ,Lu CF,You SL,Lin SH

    更新日期:2001-09-01 00:00:00

  • Epstein-Barr and cytomegalovirus DNA salivary shedding correlate with long-term plasma HIV RNA detection in HIV-infected men who have sex with men.

    abstract::The aim of the study was to evaluate cytomegalovirus (CMV) and Epstein-Barr virus (EBV) DNA salivary shedding in HIV-positive men who have sex with men (MSM) and to determine whether viro-immunological parameters and long-term (24 months) plasma HIV RNA (pHIV) detection may predict herpesviruses replication. A total o...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24441

    authors: Scaggiante R,Andreis S,Basso M,Franchin E,Franzetti M,Del Vecchio C,Torti C,Mengoli C,Cruciani M,Sarmati L,Palù G,Parisi SG

    更新日期:2016-07-01 00:00:00

  • Genotypic and phenotypic analysis of the env gene from South African HIV-1 subtype B and C isolates.

    abstract::The objective of the study was to assess the genotypic and phenotypic properties of 18 viral strains from human immunodeficiency virus-1 (HIV-1) positive patients and to identify subtype C isolates for vaccine design strategies. All the isolates were non-syncytium-inducing (NSI) in both the primary and MT-2 cell cultu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10199

    authors: Treurnicht FK,Smith TL,Engelbrecht S,Claassen M,Robson BA,Zeier M,van Rensburg EJ

    更新日期:2002-10-01 00:00:00

  • Rapid detection of varicella-zoster virus in clinical specimens using monoclonal antibodies on shell vials and smears.

    abstract::Monoclonal antibodies were used for detecting varicella-zoster virus (VZV) by immunofluorescence (IF) in clinical specimens inoculated on shell vial cultures. Vesicles of 74 patients with varicella or herpes zoster-like eruptions were tested by this method and by conventional cell culture. Further diagnostic tests wer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890280102

    authors: Schirm J,Meulenberg JJ,Pastoor GW,van Voorst Vader PC,Schröder FP

    更新日期:1989-05-01 00:00:00

  • Fraction-specific populations of the hypervariable region of the hepatitis C virus in a patient with cryoglobulinemia.

    abstract::Nucleotide sequences of the hypervariable region (HVR) of the E2/NS1 gene of hepatitis C virus (HCV), which are now thought to contain epitopes for neutralizing antibodies, were compared between antibody-bound HCV and free HCV in a patient with type II cryoglobulinemia. Antibody-bound HCV was immunoprecipitated with a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460418

    authors: Kurosaki M,Enomoto N,Nouchi T,Sakuma I,Marumo F,Sato C

    更新日期:1995-08-01 00:00:00

  • Comparison of the efficacy of ribavirin plus peginterferon alfa-2b for chronic hepatitis C infection in patients with and without coagulation disorders.

    abstract::Many patients with coagulation disorders are infected with hepatitis C virus (HCV) that advances to end stage liver disease, resulting in an increased number of deaths. The efficacy of ribavirin and peginterferon combination therapy for chronic HCV infection in patients with coagulation disorders has not been clarifie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23444

    authors: Honda T,Katano Y,Kuzuya T,Hayashi K,Ishigami M,Itoh A,Hirooka Y,Nakano I,Ishikawa T,Toyoda H,Kumada T,Yamamoto K,Matsushita T,Kojima T,Takamatsu J,Goto H

    更新日期:2013-02-01 00:00:00

  • Prevalence and risk factors of hepatitis C and B virus infections in hemodialysis patients and their spouses: a multicenter study in Beijing, China.

    abstract::Hemodialysis patients are at risk for hepatitis C and B virus infections. This study investigated the prevalences and risk factors of HCV and HBV infection and the distribution of HCV genotypes among hemodialysis patients and their spouses. From August to November 2011, a cross-sectional study was conducted on 20 hemo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.23486

    authors: Su Y,Yan R,Duan Z,Norris JL,Wang L,Jiang Y,Xing W,Chen Y,Xiao Y,Li L,Tao J,Wang N

    更新日期:2013-03-01 00:00:00

  • Synthesis of human rotavirus polypeptides in cell culture.

    abstract::The replication strategy of a human serotype 1 rotavirus, adapted to rapid growth in CV-1 cells, was investigated. A single cycle growth curve revealed eclipse and latent periods of 3 and 4 hours, respectively. Although the extent of reduction of host cell protein synthesis was directly related to the multiplicity of ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890250113

    authors: Heath RL,Birch CJ

    更新日期:1988-05-01 00:00:00

  • Molecular characterization of human respiratory syncytial virus subtype B: a novel genotype of subtype B circulating in China.

    abstract::Human respiratory syncytial virus (HRSV) is major pathogen of lower respiratory tract infections in infants and young children worldwide. There have been many studies regarding HRSV subgroup A (HRSV-A) G protein genetic variability but little information about HRSV subtype B (HRSV-B) G protein genetic diversity and mo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23960

    authors: Ren L,Xiao Q,Zhou L,Xia Q,Liu E

    更新日期:2015-01-01 00:00:00

  • Detection and typing of human papillomavirus in biopsy and cytological specimens by polymerase chain reaction and restriction enzyme analysis: a method suitable for semiautomation.

    abstract::Screening for high-risk human papillomavirus (HPV) types allows the detection of women at a high risk of cervical squamous carcinomas, thereby defining a subset of patients targeted for more intensive screening and follow-up. Thirty-four cervical biopsy specimens and isolated cells from cervical smears of normal women...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199602)48:2<161::AID-JMV8>

    authors: Adams V,Moll C,Schmid M,Rodrigues C,Moos R,Briner J

    更新日期:1996-02-01 00:00:00

  • Sequence typing of adenovirus from samples from hematological stem cell transplant recipients.

    abstract::Adenovirus infections are usually mild or even asymptomatic, but infections with the virus are being recognized increasingly as a major cause of mortality and morbidity in the immunocompromised, particularly hematological stem cell transplant patients where infections can be life threatening and mortality may reach 60...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22204

    authors: Al Qurashi YM,Guiver M,Cooper RJ

    更新日期:2011-11-01 00:00:00

  • Prevalence of delta infection in the western Pacific region.

    abstract::The prevalence of coinfection and superinfection with the delta agent was studied in 2,645 hepatitis B surface antigen (HBsAg)-positive subjects from six countries and nine islands in the Western Pacific region. The study group comprised 262 patients with acute hepatitis B and 2,383 chronic carriers of HBsAg, of whom ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890180406

    authors: Dimitrakakis M,Crowe S,Gust I

    更新日期:1986-04-01 00:00:00

  • Detection of human herpesvirus-6 DNA in peripheral blood and saliva.

    abstract::Saliva and peripheral blood samples from 20 healthy adults were examined for the presence of human herpesvirus-6 (HHV-6) DNA sequences using the polymerase chain reaction. Eighteen out of 20 whole saliva samples contained detectable HHV-6 genomes. The majority of peripheral blood samples were also positive; however, t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890320113

    authors: Jarrett RF,Clark DA,Josephs SF,Onions DE

    更新日期:1990-09-01 00:00:00

  • Single human cytomegalovirus gB genotype shed in multiple sites at the time of diagnosis in renal transplant recipients.

    abstract::Human cytomegalovirus (HCMV) is a major cause of morbidity and mortality in immunocompromised patients, such as renal transplant recipients. Analysis of the gene encoding the envelope glycoprotein B (gB) showed that clinical isolates adopted one of the sequence configurations, permitting the isolates to be assigned a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10383

    authors: Carraro E,Granato CF

    更新日期:2003-06-01 00:00:00

  • Experimental studies of acute and recurrent herpes simplex virus infections in the murine heart and dorsal root ganglia.

    abstract::The multiplication of HSV-1 and HSV-2 strains in the heart and the corresponding dorsal root ganglia (DRG) was examined in experimentally infected mice. Infectious HSV-1 was recovered from the heart between the second and fourth day after inoculation and 3 days later from the DRG. Both the heart and DRG yielded infect...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890070211

    authors: Grodums EI,Kuling PJ,Zbitnew A

    更新日期:1981-01-01 00:00:00

  • Relative frequency of human rotavirus subgroups 1 and 2 in Japanese children with acute gastroenteritis.

    abstract::Recently developed monoclonal antibodies against the 42,000-dalton major inner capsid protein were used in an enzyme immunoassay to subgroup a total of 156 rotavirus specimens obtained from Japanese infants and young children with acute gastroenteritis during the period between December 1981 and April 1983. Only 2 spe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890170105

    authors: Nakagomi O,Nakagomi T,Oyamada H,Suto T

    更新日期:1985-09-01 00:00:00

  • Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey.

    abstract::In April 2004, two patients were admitted to hospital in Berlin, Germany, with clinical signs of acute respiratory infection after returning from a military exercise in their home country of Turkey. They were admitted to a high security infectious disease unit as epidemiological data pointed to an outbreak of unknown ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20441

    authors: Chmielewicz B,Benzler J,Pauli G,Krause G,Bergmann F,Schweiger B

    更新日期:2005-10-01 00:00:00

  • In vitro neutralization of HSV-2: inhibition by binding of normal IgG and purified Fc to virion Fc receptor (FcR).

    abstract::We designed experiments to assess the effects of binding of the HSV-2 Fc receptor (FcR) to purified rabbit nonimmune IgG and purified Fc. Purified Fc (75 micrograms) or nonimmune IgG (100 micrograms) when bound to HSV-2 did not reduce infectivity but did protect the virions against thermal inactivation at 37 degrees C...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890130307

    authors: Dowler KW,Veltri RW

    更新日期:1984-01-01 00:00:00

  • Surveillance of measles in the Sudan using filter paper blood samples.

    abstract::Dried blood spots collected on filter paper are considered potential clinical specimens for measles surveillance because of their ease of collection, storage, and transport. The usefulness of these samples for surveillance of measles was evaluated in a field setting. Blood spots were collected by finger-prick from 316...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20136

    authors: El Mubarak HS,Yüksel S,Mustafa OM,Ibrahim SA,Osterhaus AD,de Swart RL

    更新日期:2004-08-01 00:00:00

  • Weak correlation between antibody titers and neutralizing activity in sera from SARS-CoV-2 infected subjects.

    abstract::Plenty of serologic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed so far, thus documenting the importance of evaluating the relevant features of the immune response to this viral agent. The performance of these assays is currently under investigation. Amongst them, LIAISON®...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26605

    authors: Criscuolo E,Diotti RA,Strollo M,Rolla S,Ambrosi A,Locatelli M,Burioni R,Mancini N,Clementi M,Clementi N

    更新日期:2020-10-16 00:00:00

  • Hemagglutinin-neuraminidase sequence and phylogenetic analyses of mumps virus isolates from a vaccinated population in Singapore.

    abstract::During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isola...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10393

    authors: Lim CS,Chan KP,Goh KT,Chow VT

    更新日期:2003-06-01 00:00:00

  • Laboratory diagnosis and surveillance of human respiratory viruses by PCR in Victoria, Australia, 2002-2003.

    abstract::Respiratory viruses were identified by the polymerase chain reaction (PCR) in more than 4,200 specimens collected during 2002 and 2003 in Victoria, Australia from patients admitted to hospitals or participating in an influenza surveillance program. Influenza viruses and picornaviruses were important causes of morbidit...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20246

    authors: Druce J,Tran T,Kelly H,Kaye M,Chibo D,Kostecki R,Amiri A,Catton M,Birch C

    更新日期:2005-01-01 00:00:00

  • A comparative study of strains of Ebola virus isolated from southern Sudan and northern Zaire in 1976.

    abstract::During the 1976 Ebola virus outbreak in Sudan, the investigations team gained the impression that fewer haemorrhagic manifestations and few fatalities occurred during the later stages of the epidemic after the virus had undergone several generations in man. This impression was also noted in guinea pigs experimentally ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890060205

    authors: Bowen ET,Platt GS,Lloyd G,Raymond RT,Simpson DI

    更新日期:1980-01-01 00:00:00

  • Hepatitis C virus genotypes in hemodialysis patients in Angola.

    abstract::To our knowledge, there are no published data on hepatitis C virus (HCV) genotypes in Angola. This study aimed at assessing the distribution of HCV genotypes in seropositive hemodialysis patients in Luanda. Among 51 HCV-positive subjects included, viremia was detected in 27 (53%). HCV genotyping was performed by bidir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25354

    authors: da Costa Marques Borges LF,Zalis MG,Santoro-Lopes G,Varella RB

    更新日期:2019-03-01 00:00:00

  • Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome.

    abstract::Hemorrhagic fever with renal syndrome (HFRS) is a severe acute viral disease with pathological changes of impaired capillary and small vessels and thrombocytopenia. In this study, serum thrombospondin (TSP)-1 concentration in patients with HFRS was determined to explore its possible role in the pathogenesis of HFRS. T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21270

    authors: Liu Z,Zhao Q,Han Q,Gao M,Zhang N

    更新日期:2008-10-01 00:00:00

  • Methylation of Epstein-Barr virus Rta promoter in EBV primary infection, reactivation and lymphoproliferation.

    abstract::During Epstein-Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds to three Zta-response elements (ZRE) from the Rta promoter (Rp), two of which (ZRE2 and ZRE3)...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24524

    authors: Germi R,Guigue N,Lupo J,Semenova T,Grossi L,Vermeulen O,Epaulard O,de Fraipont F,Morand P

    更新日期:2016-10-01 00:00:00