Abstract:
:This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two-dose schedule with the profile of the corresponding monovalent vaccines, while the concomitant vaccine was administered also on a two-dose schedule but simultaneously in opposite arms. All vaccinees had antibodies against hepatitis A (anti-HAV) after the 2-dose administration, whereas all but four in the first and two in the second group had protective titres against hepatitis B (anti-HBs). At month 7, the geometric mean titres for both antibodies were more than double for the group of subjects receiving the combined vaccine: 3,701 vs. 1,705 mIU/ml for the anti-HAV, and 1,524 vs. 720 mIU/ ml for the anti-HBs response. Injection site pain was the most commonly reported local symptom and headache was the most reported general symptom. It is concluded that this combined vaccine against hepatitis A and B, administered according to a two-dose schedule, is well-tolerated and highly immunogenic.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Lee SD,Chan CY,Yu MI,Wang YJ,Chang FY,Lo KJ,Safary Akeywords:
subject
Has Abstractpub_date
1999-09-01 00:00:00pages
1-4issue
1eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(199909)59:1<1::AID-JMV1>3.journal_volume
59pub_type
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