Abstract:
:A retinal pigment epithelial (RPE) cell line (K-1034) was examined for its susceptibility to human herpesvirus 6 variant A (HHV-6A). Exposure of K-1034 cells to HHV-6A induced the formation of multinucleated giant cells, which was suppressed by an inhibitor of viral DNA synthesis. In the giant cells, herpesvirus nucleocapsids were demonstrated by electron microscopy and the viral glycoprotein B was detected by immunofluorescence assay. These results indicate that K-1034 cells are susceptible to HHV-6A and suggest that HHV-6A has an ability to directly destroy epithelial cells.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Arao Y,Soushi S,Sato Y,Moriishi E,Ando Y,Yamada M,Padilla J,Uno F,Nii S,Kurata Tsubject
Has Abstractpub_date
1997-10-01 00:00:00pages
105-10issue
2eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(199710)53:2<105::AID-JMV1>journal_volume
53pub_type
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