Developing a sensitive HBV genotyping assay for HBV DNA suppressed patients using both DNA and RNA sequencing.

abstract：:The expression levels of many genes change after treatment of human immunodeficiency virus (HIV)-infected subjects by antiretroviral drugs. High-throughput analysis of tremendous datasets led to the discovery of genes that are implicated in the treatment pathways. In this study, we performed a gene-enrichment analysis...

journal_title：Journal of medical virology

authors： Mozhgani SH,Zarei Ghobadi M,Behnam Rad M,Farzanehpour M,Behzadian F

更新日期：2019-12-01 00:00:00

abstract：:Intramuscular (IM) influenza vaccines are about 50% effective in preventing clinical illness among the elderly and their effectiveness in eliciting mucosal response may be even lower. The aim of the present study was to evaluate the immunological effect of a novel inactivated intranasal (IN) trivalent whole influenza ...

journal_title：Journal of medical virology

authors： Muszkat M,Yehuda AB,Schein MH,Friedlander Y,Naveh P,Greenbaum E,Schlesinger M,Levy R,Zakay-Rones Z,Friedman G

更新日期：2000-05-01 00:00:00

abstract：:The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509-4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Furthermore, the polymorph...

journal_title：Journal of medical virology

authors： Fukada K,Matumoto K,Takakura F,Yamaki M,Sato H,Okochi K,Maeda Y

更新日期：2000-09-01 00:00:00

abstract：:In order to shorten the time required for the detection of enteroviruses in stool specimens, an 18-h immunoperoxidase test combining low-speed centrifugation and the use of a group specific anti-VP1 monoclonal antibody (5-D8/1, Dako) was developed. This rapid culture assay (RCA) was compared blindly to a conventional ...

journal_title：Journal of medical virology

authors： Bourlet T,Gharbi J,Omar S,Aouni M,Pozzetto B

更新日期：1998-03-01 00:00:00

abstract：:Between 1999 and 2007 1,388 stool specimens from patients with acute flaccid paralysis or aseptic meningitis were submitted to the Austrian reference laboratory for poliomyelitis. Samples (201) yielded non-poliovirus enterovirus in culture. One hundred eighty-one viruses were available for typing and 78 isolates which...

journal_title：Journal of medical virology

authors： Ortner B,Huang CW,Schmid D,Mutz I,Wewalka G,Allerberger F,Yang JY,Huemer HP

更新日期：2009-02-01 00:00:00

abstract：:A thirteen-year-old boy with bilateral orchitis was diagnosed as being infected by Coxsackie A9 virus by isolation of the virus from a throat swab and a fecal specimen. Serologic investigations revealed the development of transitory specific neutralizing IgM antibodies against the isotate and of persistent antibodies ...

journal_title：Journal of medical virology

authors： Willems WR,Hornig C,Bauer H,Klingmüller V

更新日期：1978-01-01 00:00:00

abstract：:The Balkan Peninsula and Bulgaria in particular, is a well-known endemic region for Crimean-Congo hemorrhagic fever (CCHF). This study describes the prevalence of Crimean-Congo hemorrhagic fever virus (CCHFV) among tick populations from areas, previously recognized with emerging cases of CCHF disease in humans. These ...

journal_title：Journal of medical virology

authors： Gergova I,Kunchev M,Kamarinchev B

更新日期：2012-04-01 00:00:00

abstract：:Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belg...

journal_title：Journal of medical virology

authors： Ling J,Verner-Carlsson J,Eriksson P,Plyusnina A,Löhmus M,Järhult JD,van de Goot F,Plyusnin A,Lundkvist Å,Sironen T

更新日期：2019-05-01 00:00:00

abstract：:The efficacy of interferon therapy for hepatitis C virus (HCV) infection improved remarkably. However, virologic relapse occurs in a substantial proportion of patients with virologic response (defined as an HCV RNA level below 50 IU/ml at the end-of-treatment). A highly sensitive RT-nested PCR assay capable of detecti...

journal_title：Journal of medical virology

authors： Kinai E,Hanabusa H,Kato S

更新日期：2007-08-01 00:00:00

abstract：:The ability of hepatitis A virus (HAV) to agglutinate human erythrocytes was used to develop IgM and IgG antibody capture haemadherence tests (MACHAT and GACHAT). Haemadherence was dependent on the pH of the red cell suspension and was best in the pH range 5.4 to 5.8. The tests were applied to serum, urine, and saliva...

journal_title：Journal of medical virology

authors： Perry KR,Parry JV

更新日期：1993-01-01 00:00:00

abstract：:Most cases of hepatocellular carcinoma (HCC) are due to chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection worldwide. The aim of this study was to determine the viral genotypes and frequency of 17 mutations (15 for HBV and 2 for HCV), described previously as able to influence the course of chronic li...

journal_title：Journal of medical virology

authors： Araujo OC,Barros JJ,do Ó KM,Nabuco LC,Luz CA,Perez RM,Niel C,Villela-Nogueira CA,Araujo NM

更新日期：2014-02-01 00:00:00

abstract：:Isolated reactivity to hepatitis B virus (HBV) core antigen (anti-HBc) is observed relatively frequently in immunocompromised individuals, intravenous drug abusers (IVDA), and in the presence of HCV infection. The reason for the lack of HBsAg is not clear. The aim of the present study was to investigate which factors ...

journal_title：Journal of medical virology

authors： Weber B,Melchior W,Gehrke R,Doerr HW,Berger A,Rabenau H

更新日期：2001-07-01 00:00:00

abstract：:We have previously reported that concanavalin A-immobilized polystyrene nanospheres (Con A-NS) could efficiently capture HIV-1 particles and that intranasal immunization with inactivated HIV-1-capturing nanospheres (HIV-NS) induced vaginal anti-HIV-1 IgA antibody response in mice. In this study, to evaluate the protec...

journal_title：Journal of medical virology

authors： Miyake A,Akagi T,Enose Y,Ueno M,Kawamura M,Horiuchi R,Hiraishi K,Adachi M,Serizawa T,Narayan O,Akashi M,Baba M,Hayami M

更新日期：2004-07-01 00:00:00

abstract：:Human parechoviruses (HPeV) are associated with central nervous system (CNS) infections and sepsis-like illnesses. However, data from China are not available. The aim of this study was to determine the prevalence, age, and seasonal distributions and genotypes of HPeV infections in children with CNS related disease in ...

journal_title：Journal of medical virology

authors： Zhong H,Lin Y,Su L,Cao L,Xu M,Xu J

更新日期：2013-02-01 00:00:00

abstract：:A total of 402 fecal specimens collected during July 2003-June 2004 from infants and children with acute gastroenteritis, encompassing five localities (Maizuru, Tokyo, Sapporo, Saga, and Osaka) of Japan, were tested for the presence of norovirus by RT-PCR. It was found that 58 (14.4%) fecal specimens were positive for...

journal_title：Journal of medical virology

authors： Phan TG,Kuroiwa T,Kaneshi K,Ueda Y,Nakaya S,Nishimura S,Yamamoto A,Sugita K,Nishimura T,Yagyu F,Okitsu S,Müller WE,Maneekarn N,Ushijima H

更新日期：2006-07-01 00:00:00

abstract：:In end-stage renal disease patients treated by hemodialysis with HBeAg-negative chronic hepatitis B virus (HBV) infection, the evaluation of the presence of viral replication is essential in the assessment for renal transplantation. Data on HBV viral load, prevalence of precore mutations, as well as the influence of H...

journal_title：Journal of medical virology

authors： Moutinho RS,Perez RM,Medina-Pestana JO,Figueiredo MS,Koide S,Alberto FL,Silva AE,Ferraz ML

更新日期：2006-10-01 00:00:00

abstract：:Noroviruses are an important cause of acute gastroenteritis. Increasing data showed that the GII-4 strains are predominant worldwide and new GII-4 variants emerge every 1-2 years causing major epidemics. Surveillance of gastroenteritis in hospitalized children under 5 years of age in China is described. Among 1,110 sp...

journal_title：Journal of medical virology

authors： Jin M,Xie HP,Duan ZJ,Liu N,Zhang Q,Wu BS,Li HY,Cheng WX,Yang SH,Yu JM,Xu ZQ,Cui SX,Zhu L,Tan M,Jiang X,Fang ZY

更新日期：2008-11-01 00:00:00

abstract：:SARS-CoV-2 infection is causing a pandemic disease that is reflected in challenging public health problems worldwide. Human leukocyte antigen (HLA)-based epitope prediction and its association with disease outcomes provide an important base for treatment design. A bioinformatic prediction of T cell epitopes and their ...

journal_title：Journal of medical virology

authors： Romero-López JP,Carnalla-Cortés M,Pacheco-Olvera DL,Ocampo-Godínez JM,Oliva-Ramírez J,Moreno-Manjón J,Bernal-Alferes B,López-Olmedo N,García-Latorre E,Domínguez-López ML,Reyes-Sandoval A,Jiménez-Zamudio L

更新日期：2020-09-28 00:00:00

abstract：:Serum levels of interleukin-6 (IL-6) are elevated in acute and chronic hepatitis B patients. The effect of IL-6 and its transcription factor of NF-IL6 (a nuclear factor for IL-6) on hepatitis B virus (HBV) enhancer 1 (Enh1), which controls HBV X expression, were investigated in HepG2 cells. Twenty ng/ml of IL-6 increa...

journal_title：Journal of medical virology

authors： Ohno H,Kaneko S,Kobayashi K,Murakami S

更新日期：1997-08-01 00:00:00

abstract：:Response to ribavirin therapy (1,000-1,200 mg/day for 6 months) was evaluated in nine patients with chronic hepatitis C virus (HCV) infections who had previously failed to respond to a 6-month course of alpha-interferon. All had chronic active hepatitis with elevated serum aminotransferase activities (mean +/- SD = 13...

journal_title：Journal of medical virology

authors： Koskinas J,Tibbs C,Saleh MG,Pereira LM,McFarlane IG,Williams R

更新日期：1995-01-01 00:00:00

abstract：:In 2000, we monitored the course and persistence of human papillomavirus (HPV) infection in 54 women who were HPV positive and free of any cytological disease using HPV-DNA genotyping with a linear array assay (baseline). The impact of HPV infection on development of cervical cytological abnormality (dyskaryosis) was ...

journal_title：Journal of medical virology

authors： Cuschieri KS,Whitley MJ,Cubie HA

更新日期：2004-05-01 00:00:00

abstract：:Acute hepatitis B virus (HBV) infection was diagnosed in 57 adults admitted to Toranomon Hospital in Tokyo, Japan. Genotypes of HBV were determined by a serological method and compared to those in 1,077 patients with chronic hepatitis B. The distribution of genotypes were: genotype A (acute, 22.8% vs. chronic, 1.9%; P...

journal_title：Journal of medical virology

authors： Kobayashi M,Arase Y,Ikeda K,Tsubota A,Suzuki Y,Saitoh S,Kobayashi M,Suzuki F,Akuta N,Someya T,Matsuda M,Sato J,Takagi K,Miyakawa Y,Kumada H

更新日期：2002-12-01 00:00:00

abstract：:Serial serum samples from 20 untreated patients with chronic hepatitis C virus (HCV) infection were tested for HCV RNA by a nested polymerase chain reaction assay using primers from the highly conserved 5' noncoding region to determine the relationship between hepatitis C viremia and the activity of liver disease duri...

journal_title：Journal of medical virology

authors： Cheung RC,Chan RT,Lok AS

更新日期：1993-12-01 00:00:00

abstract：:The plaque reduction neutralization test (PRNT) has been used routinely in serological studies with such arenaviruses as Junin, Machupo, and Parana. However, difficulties have been encountered in using the PRNT for LCM virus, while conflicting views have been expressed about the reliability and efficacy of the test wi...

journal_title：Journal of medical virology

authors： Tomori O,Johnson KM,Kiley MP,Elliott LH

更新日期：1987-05-01 00:00:00

abstract：:Varicella in the immunocompetent adult is an infrequent but potentially serious infection. Previous studies in immunocompetent hosts and normal adults have demonstrated the value of intravenous acyclovir in the treatment of varicella-zoster virus infections. Oral acyclovir has also shown efficacy in both normal adults...

journal_title：Journal of medical virology

authors： Wallace MR,Bowler WA,Oldfield EC 3rd

更新日期：1993-01-01 00:00:00

abstract：:The emergence of drug-resistant variants during antiretroviral therapy is a serious obstacle to sustained suppression of the human immunodeficiency virus type 1 (HIV-1). For that reason, resistance assays are essential to guide clinicians in the selection of optimal treatment regimens. Genotypic assays are less expens...

journal_title：Journal of medical virology

authors： Garcia-Perez J,Sanchez-Palomino S,Perez-Olmeda M,Fernandez B,Alcami J

更新日期：2007-02-01 00:00:00

abstract：:Among 39,656 voluntary blood donors in Okinawa Prefecture, Japan, 115 (0.29%) were repeatedly reactive for antibody to hepatitis C virus (anti-HCV) by second generation (2nd-gen) passive hemagglutination assay (PHA). Positive serum samples were tested for anti-HCV using three different enzyme immunosorbent assays (ELI...

journal_title：Journal of medical virology

authors： Sakugawa H,Nakasone H,Nakayoshi T,Kinjo F,Saito A,Yakabi S,Zukeran H,Miyagi Y,Taira R,Koja K

更新日期：1995-08-01 00:00:00

abstract：:The avalanche of genomic data generated from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus requires the development of tools to detect and monitor its mutations across the world. Here, we present a webtool, coronapp, dedicated to easily processing user-provided SARS-CoV-2 genomic sequences and...

journal_title：Journal of medical virology

authors： Mercatelli D,Triboli L,Fornasari E,Ray F,Giorgi FM

更新日期：2020-11-18 00:00:00

abstract：:Nasopharyngeal carcinoma is closely associated with Epstein-Barr virus (EBV) and the EBV encoded latent membrane protein-1 expression (LMP1) is commonly found in the tumour cells. LMP1 has been shown to be involved in modulation of cell growth in B cells but the biological properties of LMP1 expression in nasopharynge...

journal_title：Journal of medical virology

authors： Liu Y,Wang X,Lo AK,Wong YC,Cheung AL,Tsao SW

更新日期：2002-01-01 00:00:00

abstract：:Human herpesvirus 6 (HHV-6) prototype isolate GS is a newly identified lymphotropic herpesvirus and several subsequent herpes isolates were recognized as HHV-6 by their hybridization to a HHV-6(GS) DNA probe pZVH14. DNA restriction analysis and in vitro tropism studies show that HHV-6 isolates can be divided into two ...

journal_title：Journal of medical virology

authors： Chandran B,Tirawatnapong S,Pfeiffer B,Ablashi DV

更新日期：1992-08-01 00:00:00