Abstract:
:Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were measured in HAM/TSP patients, HTLV-1 asymptomatic carriers (ACs), and healthy controls. The PVL, CCR6, and CXCR3 mRNA expression, and CXCL9 and CXCL10 protein levels were measured in all subjects. The PVL of HAM/TSP patients was higher than that of ACs (P = 0.02). CCR6 expression was higher in HAM/TSP patients and in ACs compared to the healthy controls (P = 0.005 and P = 0.04, respectively). A significant difference was observed in CCR6 expression when a combination of HAM/TSP patients and ACs were compared to the healthy individuals (P = 0.005). Furthermore, there was a significantly lower CXCR3 expression between HAM/TSP and control groups (P = 0.001), and between the ACs and healthy controls (P = 0.001). However, the increased CXCR3 expression in ACs compared to HAM/TSP patients was not significant. Furthermore, the CXCL10 protein levels in HAM/TSP patients was higher than in controls (P = 0.012), and CXCL9 protein levels was also higher in the HAM/TSP and ACs groups than in the controls (P = 0.001 and P = 0.004, respectively). In conclusion, it seems that decreased expression of CXCR3 and higher expression of CCR6 were associated with HTLV-1 infection, what indicate that these alterations may favor virus dissemination but not disease manifestation.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Rafatpanah H,Felegari M,Azarpazhooh MR,Vakili R,Rajaei T,Hampson I,Hassanshahi G,Valizadeh N,Gerayli S,Hamid F,Zamanian S,MollaHosseini F,Rezaee SAdoi
10.1002/jmv.24779subject
Has Abstractpub_date
2017-08-01 00:00:00pages
1461-1468issue
8eissn
0146-6615issn
1096-9071journal_volume
89pub_type
杂志文章abstract::The aim of this study was to compare the data obtained using the new LIAISON® XL chemiluminescence system to search for HBsAg, anti-HCV, and anti-HIV1-2/p24 Ag with those obtained using the VITROS system currently adopted by the Microbiology Unit of the Hospital of Legnano. Routine samples of patients who were referre...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24648
更新日期:2017-03-01 00:00:00
abstract::The characteristics and response rate to pegylated interferon and ribavirin (PEG-INF + RBV) of patients with chronic hepatitis C infected with genotype 5 are poorly documented. A meta-analysis of two large phase III/IV prospective randomized clinical trials conducted in Belgium in patients with chronic hepatitis C (n ...
journal_title:Journal of medical virology
pub_type: 杂志文章,meta分析
doi:10.1002/jmv.22049
更新日期:2011-05-01 00:00:00
abstract::Respiratory tract infections are a principal cause of illness and mortality in children worldwide and mostly caused by viruses. In this study, the epidemiology of 11 respiratory RNA viruses was investigated in a cohort of hospitalized children at a tertiary referral center in Riyadh from February 2008 to March 2009 us...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24435
更新日期:2016-06-01 00:00:00
abstract::We studied epidemiologic and immunologic factors in infants with bronchiolitis caused by influenza virus. The proportion of these infants who were male and who had an immediate family member with a history of asthma was similar to that of a control group of infants with respiratory syncytial virus (RSV) bronchiolitis....
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20268
更新日期:2005-02-01 00:00:00
abstract::The TD97 strain vaccine virus was prepared from the Tanabe strain measles virus by low-temperature passages in primary cell cultures and ultraviolet (UV) mutagenesis. The TD97 strain exhibited the following characteristics: highly temperature sensitive, neither multiplying nor forming any plaques at 40 degrees C in Ve...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890320311
更新日期:1990-11-01 00:00:00
abstract::A sensitive radioimmunoassay technique was used to detect hepatitis B e antigen (HBeAg). A strong correlation was found between HBeAg positivity of the serum of hepatitis B surface antigen (HBsAg) carrier women in Taiwan and the subsequent development of surface antigenemia in their babies. All babies who became chron...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890030310
更新日期:1979-01-01 00:00:00
abstract::A random peptide library of heptamers displayed on the surface of M13 bacteriophage was used to identify specific epitopes of antibodies in pooled sera of swine naturally infected by Nipah virus. The selected heptapeptides were aligned with protein sequences of Nipah virus and several putative epitopes were identified...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20249
更新日期:2005-01-01 00:00:00
abstract::Enzyme immunoassay (EIA) for parainfluenza virus type 1, 2, and 3 antibodies was compared with the complement fixation test (CF) as a diagnostic method in 180 patients with respiratory symptoms. The CF test detected rises in parainfluenza virus antibodies in 30 cases, whereas EIA detected 47 rises. Patients with antib...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890140212
更新日期:1984-01-01 00:00:00
abstract::A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean+/-standard deviation age, 48.4+/-13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20363
更新日期:2005-07-01 00:00:00
abstract::The influence of an acute Epstein-Barr virus (EBV) infection on the serological parameters of persistent varicella-zoster virus (VZV) and herpes simplex virus (HSV) was studied. Sera from 161 patients with infectious mononucleosis caused by EBV and 178 age-matched controls were tested for HSV- and VZV-specific IgA. 98...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440308
更新日期:1994-11-01 00:00:00
abstract::Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890370208
更新日期:1992-06-01 00:00:00
abstract::Transmission of rotavirus infection was studied in a birth cohort of children based in an urban slum in Vellore and their familial contacts. Contemporaneous samples from index patients and their familial contacts were collected for analysis in three different settings. Firstly, samples were collected from familial con...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21263
更新日期:2008-10-01 00:00:00
abstract::Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between H...
journal_title:Journal of medical virology
pub_type: 杂志文章,meta分析
doi:10.1002/jmv.24858
更新日期:2017-12-01 00:00:00
abstract::Herpes simplex virus (HSV) DNA in the cerebrospinal fluid (CSF) of children with herpes simplex encephalitis (HSE) was quantified and typed using the polymerase chain reaction (PCR) assay. During the acute phase, HSV-DNA was detected in the CSF of 13 patients with HSE, including 5 neonates. A restriction profile of th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410214
更新日期:1993-10-01 00:00:00
abstract::One hundred twenty strains of adenovirus types 1, 2, 5, and 6 (subgenus C), isolated at various times and places, were tested by neutralization and hemagglutination inhibition with two antisera of each type. Except for one type 5 strain they reacted largely type-specifically in both tests and neither qualitative nor q...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890180310
更新日期:1986-03-01 00:00:00
abstract::Human parainfluenza virus 3 (HPIV-3) is a leading cause of respiratory disease in children worldwide. Previous sequence analyses of the entire virus genome, among different HPIV-3 strains, demonstrated that HN is the most variable gene. There is a dearth of data on HPIV-3 strains circulating in Saudi Arabia. In this r...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23326
更新日期:2012-08-01 00:00:00
abstract::GII.b norovirus is an obligatory recombinant with an open reading frame (ORF) 1 comprising the GII.b genotype and the ORF 2 region corresponding to one of a number of other norovirus genotypes. GII.b is the second most common genotype after GII.4 associated with gastroenteritis outbreaks in Victoria, Australia. The st...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23633
更新日期:2013-08-01 00:00:00
abstract::In October 1977 an outbreak of acute infectious diarrhea occurred in an infant home in the city of Sapporo, Japan. Of 34 residents aged two to 20 months, 26 (77%) suffered from diarrhea. In ten of these patients the diarrhea was accompanied by vomiting. Electron microscopic examinations revealed typical calicivirus pa...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890040402
更新日期:1979-01-01 00:00:00
abstract::To define better the human immune response to individual structural proteins of human cytomegalovirus (HCMV), 55 human sera with different IgG and IgM titres were studied for their reactivity with HCMV structural polypeptides separated by SDS-PAGE and electrotransferred to nitrocellulose paper. The results obtained sh...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890170403
更新日期:1985-12-01 00:00:00
abstract::Nucleotide sequences of the hypervariable region (HVR) of the E2/NS1 gene of hepatitis C virus (HCV), which are now thought to contain epitopes for neutralizing antibodies, were compared between antibody-bound HCV and free HCV in a patient with type II cryoglobulinemia. Antibody-bound HCV was immunoprecipitated with a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460418
更新日期:1995-08-01 00:00:00
abstract::Although many reports have already shown RSV outbreaks among hemato-oncology patients, genomic studies detecting similar RSV strains prior to an outbreak in the hospital are rare. In 2014, the University of the Ryukyus hospital hemato-oncology unit experienced, and successfully managed, a respiratory syncytial virus (...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24800
更新日期:2017-08-01 00:00:00
abstract::In patients infected with the hepatitis C virus (HCV), a heterogeneous population of viruses, so-called quasispecies exists in vivo. The hypervariable regions (HVR) within the second envelope gene (HCV-E2) show particularly highly intratypic variability and are considered to be the target of neutralizing antibodies. T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199711)53:3<245::aid-jmv11
更新日期:1997-11-01 00:00:00
abstract::In April 2004, two patients were admitted to hospital in Berlin, Germany, with clinical signs of acute respiratory infection after returning from a military exercise in their home country of Turkey. They were admitted to a high security infectious disease unit as epidemiological data pointed to an outbreak of unknown ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20441
更新日期:2005-10-01 00:00:00
abstract::A line of hepatitis C virus (HCV) transgenic mice was established previously that was mediated by Cre/loxP system using HCV cDNA, including core, E1, E2 and NS2 genes. Intravenous infection of a recombinant adenovirus that expresses Cre DNA recombinase (AxCANCre) induced HCV structural protein expression in the liver ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200011)62:3<308::aid-jmv2>3.0.co
更新日期:2000-11-01 00:00:00
abstract::As a consequence of the high prevalence of TorqueTeno virus (TTV) in blood donors, thalassemia patients frequently acquire various genotypes of this virus through therapeutic blood transfusions. At present, the clinical consequences of TTV infection remain indeterminate for these patients. Here, several hundred thalas...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21070
更新日期:2008-02-01 00:00:00
abstract::Parainfluenza virus type 3 (Para 3) is an important childhood pathogen causing a significant amount of bronchiolitis and pneumonia in infants. Virus data were analysed over a twelve-year period (1978-1989), and a peak incidence of infection was observed in spring as in Houston, USA, unlike in the United Kingdom where ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890350105
更新日期:1991-09-01 00:00:00
abstract::Exacerbations of chronic hepatitis B have been associated with accumulation of mutations in the HBV core gene, with amino acid (aa) substitutions clustering between aa 50 and 69. This region of the nucleocapsid protein is known as an immunodominant epitope for CD4+ T-lymphocytes, however the impact of these mutations ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20016
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. We aim to characterize the longitudinal test results of SARS-CoV-2 RNA in anal swabs and to explore the association with disease severity. METHODS:We...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26307
更新日期:2021-02-01 00:00:00
abstract::During the period 2007-2008 several epizootics of Yellow fever with dead of monkeys occurred in southeastern Brasil, Paraguay, and northeastern Argentina. In 2008 after a Yellow fever outbreak an exhaustive prevention campaign took place in Argentina using 17D live attenuated Yellow fever vaccine. This vaccine is cons...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22236
更新日期:2011-12-01 00:00:00
abstract:AIMS:Little data have been published so far on the epidemiological aspects of hepatitis D virus (HDV) infection in immigrant populations and even poorer is the information on the virological, phylogenetic, and clinical aspects of this infection in these populations. This review article, aimed primarily at physicians ca...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.25570
更新日期:2019-12-01 00:00:00