Receptor for pre-S1(21-47) component of hepatitis B virus on the liver cell: role in virus cell interaction.

Abstract:

:Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with pre-S1 peptides was dose dependent, and demonstrated it as the dominant binding site. In view of the suggested sequence homology between the peptide and IgA, cross-competition studies were carried out. The results indicate no direct role of IgA receptor in HBV binding. The receptor for the pre-S1 peptide was identified as a single major peptide of molecular weight 31 kD using in-situ ligand receptor crosslinking.

journal_name

J Med Virol

authors

Dash S,Rao KV,Panda SK

doi

10.1002/jmv.1890370208

keywords:

subject

Has Abstract

pub_date

1992-06-01 00:00:00

pages

116-21

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

37

pub_type

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