Receptor for pre-S1(21-47) component of hepatitis B virus on the liver cell: role in virus cell interaction.


:Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with pre-S1 peptides was dose dependent, and demonstrated it as the dominant binding site. In view of the suggested sequence homology between the peptide and IgA, cross-competition studies were carried out. The results indicate no direct role of IgA receptor in HBV binding. The receptor for the pre-S1 peptide was identified as a single major peptide of molecular weight 31 kD using in-situ ligand receptor crosslinking.


J Med Virol


Dash S,Rao KV,Panda SK





Has Abstract


1992-06-01 00:00:00












  • Coinfection of individual leukocytes with human cytomegalovirus and human immunodeficiency virus is a rare event in vivo.

    abstract::Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Bertram S,Hufert FT,van Lunzen J,von Laer D

    更新日期:1996-08-01 00:00:00

  • Improved detection of cytomegalovirus viremia in AIDS patients using shell vial and indirect immunoperoxidase methodologies.

    abstract::One hundred twelve peripheral blood specimens were tested for the presence of cytomegalovirus (CMV) by the tube culture indirect immunoperoxidase (TC-IPA) procedure, the shell vial assay [shell vials were pre- and postinoculation treated with medium containing 2 of 10% fetal bovine serum (FBS) or 100 micrograms% corti...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Lipson SM,Kaplan MH,Simon JK,Ciamician Z,Tseng LF

    更新日期:1992-09-01 00:00:00

  • Impact of COVID-19 preventative measures on dengue infections in Taiwan.

    abstract::We read with great interest the recent issue,1 which raised the concern about the co-circulation of dengue during the COVID-19 pandemic. This article is protected by copyright. All rights reserved. ...

    journal_title:Journal of medical virology

    pub_type: 信件


    authors: Lin SF,Lai CC,Chao CM,Tang HJ

    更新日期:2020-11-03 00:00:00

  • Measles virus RNA is not detected in inflammatory bowel disease using hybrid capture and reverse transcription followed by the polymerase chain reaction.

    abstract::Recent epidemiological and immunohistochemical studies have indicated a possible link between measles virus and inflammatory bowel disease (IBD). The aim of this study was to use a sensitive and robust method for the detection of measles virus RNA in IBD and control clinical samples. Peripheral blood mononuclear cells...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Chadwick N,Bruce IJ,Schepelmann S,Pounder RE,Wakefield AJ

    更新日期:1998-08-01 00:00:00

  • Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

    abstract::The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

    更新日期:2009-01-01 00:00:00

  • Unconventional pathogens causing spongiform encephalopathies absent in blood products.

    abstract::To determine whether unconventional pathogens causing subacute spongiform encephalopathy may be present in blood products, a newly developed hepatitis B vaccine and a widely used blood product were injected into mice and rats. As only a few aged mice in the test and the control groups showed spongiform encephalopathic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Tateishi J,Tsuji S

    更新日期:1985-05-01 00:00:00

  • Seroprevalence against Norwalk-like human caliciviruses in beijing, China.

    abstract::Serum specimens from 1,109 individuals at different ages in Beijing, China, were collected between April 1996 and March 1997 and tested for IgG antibodies against human caliciviruses using enzyme immune assays (EIAs). Baculovirus-expressed recombinant Norwalk virus (rNV) and Mexican virus (rMxV) capsid proteins were u...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Jing Y,Qian Y,Huo Y,Wang LP,Jiang X

    更新日期:2000-01-01 00:00:00

  • Evaluation of a reduced dose of hepatitis B vaccine administered intradermally.

    abstract::Intradermal inoculation of hepatitis B vaccine (HBsAg subtype adw) caused no side effects, but the vaccine was less immunogenic than following intramuscular administration. Intradermal inoculation does not, therefore, offer a major advantage to the generally used intramuscular immunization. A single multisite intrader...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Zoulek G,Lorbeer B,Jilg W,Deinhardt F

    更新日期:1984-01-01 00:00:00

  • Development of a hepatitis delta virus antibody assay for study of the prevalence of HDV among individuals infected with hepatitis B virus in China.

    abstract::Co-infection with hepatitis delta virus (HDV) and hepatitis B virus (HBV) has been shown to be associated with a more severe form of acute and chronic hepatitis. Cloning and expression of recombinant HDV antigen (rHDAg) in Escherichiacoli are described. Using purified rHDAg, a cost-effective indirect anti-HDV enzyme-l...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Shen L,Gu Y,Sun L,Yang Y,Wang F,Li Y,Bi S

    更新日期:2012-03-01 00:00:00

  • Prevalence of delta agent among Chinese in Taiwan and Los Angeles.

    abstract::The prevalence of delta agent among 120 Chinese patients with HBsAg-positive chronic active and hepatocellular carcinoma from Taiwan and Los Angeles were studied by serological assay for antibody to delta antigen and immunoperoxidase staining for delta antigen in the liver biopsies. Of 120 patients, only four with chr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Govindarajan S,Lee SD,Tong MJ,Tsai YT,Lo KJ

    更新日期:1984-01-01 00:00:00

  • Depletion of mitochondrial DNA in HIV-1-infected patients and its amelioration by antiretroviral therapy.

    abstract::Mitochondrial DNA (mtDNA) of peripheral blood mononuclear cells (PBMCs) collected from Human immunodeficiency virus 1 (HIV-1)-infected patients and healthy controls were measured longitudinally using real-time polymerase chain reaction to evaluate the effects of antiretroviral agents on mtDNA synthesis in vivo and to ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Miura T,Goto M,Hosoya N,Odawara T,Kitamura Y,Nakamura T,Iwamoto A

    更新日期:2003-08-01 00:00:00

  • Use of recombinant glycoprotein antigens gB and gH for diagnosis of primary human cytomegalovirus infection during pregnancy.

    abstract::The major risk factor for intrauterine transmission of human cytomegalovirus (HCMV) is a primary infection during pregnancy. The neutralizing antibody response appeared after an average of 13 weeks after seroconversion and therefore the absence of neutralizing titers in HCMV IgG positive pregnant women is a reliable m...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Eggers M,Radsak K,Enders G,Reschke M

    更新日期:2001-02-01 00:00:00

  • Weathering the pandemic: How the Caribbean Basin can use viral and environmental patterns to predict, prepare, and respond to COVID-19.

    abstract::The 2020 coronavirus pandemic is developing at different paces throughout the world. Some areas, like the Caribbean Basin, have yet to see the virus strike at full force. When it does, there is reasonable evidence to suggest the consequent COVID-19 outbreaks will overwhelm healthcare systems and economies. This is par...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审


    authors: de Ángel Solá DE,Wang L,Vázquez M,Méndez-Lázaro PA

    更新日期:2020-09-01 00:00:00

  • Reactivation of human herpesvirus 6 by infection of human herpesvirus 7.

    abstract::We have attempted to reactivate human herpesvirus 6 (HHV-6) by infection with HHV-7 using childhood exanthem subitum patients in vitro. Peripheral blood mononuclear cells (PBMCs) were collected from children who had a history of exanthem subitum(ES) by HHV-6 and were infected by human herpesvirus 7 (HHV-7) in vitro. T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Tanaka-Taya K,Kondo T,Nakagawa N,Inagi R,Miyoshi H,Sunagawa T,Okada S,Yamanishi K

    更新日期:2000-03-01 00:00:00

  • Diversity of hepatitis B and C viruses in Chile.

    abstract::Although there is a low prevalence rate (around 1% of the population) of infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) in Chile, little is known about the diversity and molecular characteristics of the circulating viruses. In the present study, 40 HBV and 57 HCV samples from Santiago City, Chile, ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Di Lello FA,Piñeiro Y Leone FG,Muñoz G,Campos RH

    更新日期:2009-11-01 00:00:00

  • Influence of amino-acid polymorphism in the core protein on progression of liver disease in patients infected with hepatitis C virus genotype 1b.

    abstract::The substitution of amino acid (aa) 70 of arginine for glutamine and/or that of aa91 of leucine for methionine in the core protein in patients infected with hepatitis C virus (HCV) genotype 1b is associated with a poor response to pegylated interferon and ribavirin. Factors influencing these substitutions were sought ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Kobayashi M,Akuta N,Suzuki F,Hosaka T,Sezaki H,Kobayashi M,Suzuki Y,Arase Y,Ikeda K,Watahiki S,Mineta R,Iwasaki S,Miyakawa Y,Kumada H

    更新日期:2010-01-01 00:00:00

  • Methylation of Epstein-Barr virus Rta promoter in EBV primary infection, reactivation and lymphoproliferation.

    abstract::During Epstein-Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds to three Zta-response elements (ZRE) from the Rta promoter (Rp), two of which (ZRE2 and ZRE3)...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Germi R,Guigue N,Lupo J,Semenova T,Grossi L,Vermeulen O,Epaulard O,de Fraipont F,Morand P

    更新日期:2016-10-01 00:00:00

  • Dysregulation of the immune response affects the outcome of critical COVID-19 patients.

    abstract::Critical cases of coronavirus disease 2019 (COVID-19) are associated with a high risk of mortality. It remains unclear why patients with the same critical condition have different outcomes. We aimed to explore relevant factors that may affect the prognosis of critical COVID-19 patients. Six critical COVID-19 inpatient...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Wei LL,Wang WJ,Chen DX,Xu B

    更新日期:2020-11-01 00:00:00

  • Prevalence of high risk genital papillomaviruses in the Belgian female population determined by fast multiplex polymerase chain reaction.

    abstract::Because in situ/filter hybridisation is not sensitive enough and because classical polymerase chain reaction (PCR) protocols are generally not sufficiently reproducible and specific, there is little accurate information on the prevalence of human papillomaviruses (HPV) 16, 18, and 33 infections in women without dyskar...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Vandenvelde C,Scheen R,Van Pachterbeke C,Loriaux C,Decelle J,Hubert T,Delhaye C,Cattoor JP,Duys M,Van Beers D

    更新日期:1992-04-01 00:00:00

  • Close relationship between immunoglobulin secreting-cells and Epstein-Barr virus reservoir in patients infected with HIV.

    abstract::Individuals infected with HIV have higher circulating Epstein-Barr virus (EBV) DNA load compared to healthy carriers. This study investigated whether level of spontaneous immunoglobulin secreting cells, one of the major hallmarks of HIV infection, is associated with an increase of EBV DNA load in PBMCs and the spontan...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Ouedraogo DE,Tuaillon E,Rubbo PA,Bollore K,Foulongne V,Reynes J,Vendrell JP

    更新日期:2014-01-01 00:00:00

  • Evaluation of LIAISON® XL system for HBsAg, and anti-HCV and anti-HIV/Ag p24.

    abstract::The aim of this study was to compare the data obtained using the new LIAISON® XL chemiluminescence system to search for HBsAg, anti-HCV, and anti-HIV1-2/p24 Ag with those obtained using the VITROS system currently adopted by the Microbiology Unit of the Hospital of Legnano. Routine samples of patients who were referre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: De Paschale M,Manco MT,Belvisi L,Cagnin D,Cerulli T,Paganini A,Arpino O,Cianflone A,Agrappi C,Mirri P,Clerici P

    更新日期:2017-03-01 00:00:00

  • Use of N-acetylethyleneimine [AEI] for the inactivation of Semliki Forest virus in vitro.

    abstract::N-Acetylethyleneimine (AEI) was used to inactivate the avirulent Togavirus Semliki Forest virus (A774 strain) grown in chick embryo, Vero, and brain cell cultures. The purity of the virus preparation affected the kinetics of inactivation. The rate of inactivation increased with a rise in temperature from 5 to 40 degre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Amor S,Webb HE

    更新日期:1986-08-01 00:00:00

  • Neutralizing activity of antibodies against the major herpes simplex virus type 1 glycoproteins.

    abstract::The specificity and neutralizing activity of antibodies against the major herpes simplex virus type 1 (HSV-1) glycoproteins were tested in serum samples of patients with a history of HSV-1 infection. By preabsorption of sera to preparations of native and denatured HSV-1 proteins, followed by immunoblotting and microne...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Eing BR,Kühn JE,Braun RW

    更新日期:1989-01-01 00:00:00

  • Randomized controlled trial of seroresponses to double dose and booster influenza vaccination in frail elderly subjects.

    abstract::Responses to influenza vaccination are poor in frail elderly subjects who suffer the greatest morbidity and mortality due to infection. Therefore, a randomized clinical trial was performed to determine the effect of a double dose and booster vaccination on antibody responses after influenza vaccination. A total of 815...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Roos-Van Eijndhoven DG,Cools HJ,Westendorp RG,Ten Cate-Hoek AJ,Knook DL,Remarque EJ

    更新日期:2001-04-01 00:00:00

  • The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.

    abstract::Epstein-Barr virus (EBV) is an important DNA tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (NPC). DNA methylation and microRNAs (miRNAs) are the most studied epigenetic mechanisms that can prompt disease susceptibility. This study aimed to detect the effe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Zhao Z,Liu W,Liu J,Wang J,Luo B

    更新日期:2017-10-01 00:00:00

  • Combinations of 1,8-cineol and oseltamivir for the treatment of influenza virus A (H3N2) infection in mice.

    abstract::It is need for development of new means against influenza virus due to the lack of efficacy of available therapeutic strategies. In previous research, 1,8-cineol exert its inhibition of nuclear factor (NF)-κB, the main regulator of cytokine and chemokine production in influenza, and anti-inflammatory activity. These f...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Lai YN,Li Y,Fu LC,Zhao F,Liu N,Zhang FX,Xu PP

    更新日期:2017-07-01 00:00:00

  • Performance of rapid tests for discrimination between HIV-1 and/or HIV-2 infections.

    abstract::Major differences exist between HIV-1 and HIV-2 in terms of epidemiology, pathogenicity, sensitivity to antiretrovirals. Determining the type of HIV infecting a patient is essential for management. The aim of this study was to evaluate the ability of simple/rapid tests to differentiate between HIV-1 and/or HIV-2 infec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Gautheret-Dejean A,Bocobza J,Brunet S,Damond F,Plantier JC,Barin F

    更新日期:2015-12-01 00:00:00

  • Cytomegalovirus excretion after bone marrow transplantation cannot be predicted from the pre-transplant level of IgG antibodies.

    abstract::The relationship of pre-bone-marrow transplant recipient and donor cytomegalovirus (CMV) antibody level to post-transplant recipient CMV excretion was investigated. CMV excretion was found to be related to pre-transplant recipient serological status, but not to level of antibody. This therefore contrasts with herpes s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Pillay D,Webster A,Lee D,Prentice HG,Griffiths PD

    更新日期:1991-04-01 00:00:00

  • Genotypic and phenotypic analysis of the env gene from South African HIV-1 subtype B and C isolates.

    abstract::The objective of the study was to assess the genotypic and phenotypic properties of 18 viral strains from human immunodeficiency virus-1 (HIV-1) positive patients and to identify subtype C isolates for vaccine design strategies. All the isolates were non-syncytium-inducing (NSI) in both the primary and MT-2 cell cultu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Treurnicht FK,Smith TL,Engelbrecht S,Claassen M,Robson BA,Zeier M,van Rensburg EJ

    更新日期:2002-10-01 00:00:00

  • Tampon culture for quantitation of cervicovaginal herpes simplex virus.

    abstract::From 10(1) to 10(6) TCID50 (mean tissue culture infective doses) per ml HSV I and II can be quantitatively recorded from vaginal tampons. Tampons and sterile cotton swabs are equally sensitive in recovering HSV I and II. Direct cotton swab cultures of the cervix and cervicovaginal tampon cultures from the same patient...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Ekwo EE,Myers MG

    更新日期:1978-01-01 00:00:00