Mix-breeding with HEV-infected swine induced inapparent HEV infection in SPF rabbits.

Abstract:

:Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, the pigs with HEV infection were farmed along with SPF rabbits in the same enclosed space. Five of 10 rabbits had seroconversion for anti-HEV antibody from the third week after mix-breeding. However, HEV RNA remained undetectable in feces, serum, liver and bile of the ten rabbits; and no obvious elevation of ALT was observed. The results possibly suggested that sHEV might lead to an inapparent infection of SPF rabbits by fecal-oral route.

journal_name

J Med Virol

authors

Liu L,Wang L,Xia J,Zhang Y,Zeng H,Liu P,Zou Q,Wang L,Zhuang H

doi

10.1002/jmv.24374

subject

Has Abstract

pub_date

2016-04-01 00:00:00

pages

681-5

issue

4

eissn

0146-6615

issn

1096-9071

journal_volume

88

pub_type

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