High rate of missed HIV infections in individuals with indeterminate or negative HIV western blots based on current HIV testing algorithm in China.

Abstract:

:It remains unclear if China's current HIV antibody testing algorithm misses a substantial number of HIV infected individuals. Of 196 specimens with indeterminate or negative results on HIV western blot (WB) retrospectively examined by HIV-1 nucleic acid test (NAT), 67.57% (75/111) of indeterminate WB samples, and 16.47% (14/85) of negative WB samples were identified as NAT positive. HIV-1 loads in negative WB samples were significantly higher than those in indeterminate WB samples. Notably, 86.67% (13/15) of samples with negative WB and double positive immunoassay results were NAT positive. The rate of HIV-1 infections missed by China's current HIV testing algorithm is unacceptably high. Thus, China should consider using NAT or integrating fourth generation ELISA into current only antibodies-based HIV confirmation. J. Med. Virol. 88:1462-1466, 2016. © 2016 Wiley Periodicals, Inc.

journal_name

J Med Virol

authors

Liu MQ,Zhu ZR,Kong WH,Tang L,Peng JS,Wang X,Xu J,Schilling RF,Cai T,Zhou W

doi

10.1002/jmv.24490

subject

Has Abstract

pub_date

2016-08-01 00:00:00

pages

1462-6

issue

8

eissn

0146-6615

issn

1096-9071

journal_volume

88

pub_type

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