Abstract:
:It remains unclear if China's current HIV antibody testing algorithm misses a substantial number of HIV infected individuals. Of 196 specimens with indeterminate or negative results on HIV western blot (WB) retrospectively examined by HIV-1 nucleic acid test (NAT), 67.57% (75/111) of indeterminate WB samples, and 16.47% (14/85) of negative WB samples were identified as NAT positive. HIV-1 loads in negative WB samples were significantly higher than those in indeterminate WB samples. Notably, 86.67% (13/15) of samples with negative WB and double positive immunoassay results were NAT positive. The rate of HIV-1 infections missed by China's current HIV testing algorithm is unacceptably high. Thus, China should consider using NAT or integrating fourth generation ELISA into current only antibodies-based HIV confirmation. J. Med. Virol. 88:1462-1466, 2016. © 2016 Wiley Periodicals, Inc.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Liu MQ,Zhu ZR,Kong WH,Tang L,Peng JS,Wang X,Xu J,Schilling RF,Cai T,Zhou Wdoi
10.1002/jmv.24490subject
Has Abstractpub_date
2016-08-01 00:00:00pages
1462-6issue
8eissn
0146-6615issn
1096-9071journal_volume
88pub_type
杂志文章abstract::Distinct human papillomavirus (HPV) 18 variants are thought to differ in oncogenic potential and geographic distribution. As such, understanding the regional variants of HPV 18 would be of great importance for evolutionary, epidemiological, and biological analysis. In this regard, the sequence variations of E6 gene we...
journal_title:Journal of medical virology
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更新日期:2020-07-09 00:00:00
abstract::Serum levels of interleukin-6 (IL-6) are elevated in acute and chronic hepatitis B patients. The effect of IL-6 and its transcription factor of NF-IL6 (a nuclear factor for IL-6) on hepatitis B virus (HBV) enhancer 1 (Enh1), which controls HBV X expression, were investigated in HepG2 cells. Twenty ng/ml of IL-6 increa...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199708)52:4<413::aid-jmv12
更新日期:1997-08-01 00:00:00
abstract::Hepatitis A infections still represent a major global health concern. During the past years, a transition pattern of the hepatitis A epidemiology was noted in many parts of the world. In Tunisia, there is not a recent survey on age-specific hepatitis A virus seroprevalence. This study aimed to investigate the seroprev...
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pub_type: 杂志文章,多中心研究
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2017-06-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2020-05-06 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199605)49:1<55::AID-JMV9>3
更新日期:1996-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20427
更新日期:2005-09-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
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journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440411
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pub_type: 杂志文章
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更新日期:2021-02-01 00:00:00
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abstract::GB Virus C (GBV-C) is a non-pathogenic flavivirus, commonly found in HIV infected patients. Studies suggest a survival benefit of GBV-C viremia in HIV infection. Impact of GBV-C viremia was evaluated on clinical outcome in multidrug-resistant HIV. The OPTIMA study enrolled advanced multidrug-resistant HIV patients wit...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2014-03-01 00:00:00
abstract::Primary HIV-1 infections (PHI) with non-B subtypes are increasing in developed countries while transmission of HIV-1 harboring antiretroviral resistance-associated mutations (RAMs) remains a concern. This study assessed non-B HIV-1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseil...
journal_title:Journal of medical virology
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更新日期:2018-10-01 00:00:00
abstract::Occult HBV infection is defined as the persistence of HBV DNA in individuals negative for HBV surface antigen (HBsAg), and many different mechanisms have been reported in different countries. However, in China, one of the endemic areas for HBV infection, no reports have been published on occult HBV infection. The pres...
journal_title:Journal of medical virology
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更新日期:2003-11-01 00:00:00
abstract::The reported positive rates of hepatitis B virus surface antigen (HBsAg) among Chinese blood donors generally do not include data from pre-donation rapid tests. The aim of this study was to estimate the prevalence of serologic markers for HBsAg and risk factors among blood donors from Chengdu, China. From April 2010 t...
journal_title:Journal of medical virology
pub_type: 杂志文章
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更新日期:2016-02-01 00:00:00
abstract::Dual infection with hepatitis B and C viruses is often encountered in endemic areas of both viruses. However, understanding of the clinical and virological implications is limited. The aim of this study was to investigate the role of each virus in liver injury and the interaction between the two viruses in dual infect...
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更新日期:1995-07-01 00:00:00