Abstract:
:Hepatitis A infections still represent a major global health concern. During the past years, a transition pattern of the hepatitis A epidemiology was noted in many parts of the world. In Tunisia, there is not a recent survey on age-specific hepatitis A virus seroprevalence. This study aimed to investigate the seroprevalence of hepatitis A virus infection in Central-West Tunisia, representative of regions with lowest socioeconomic level in the country, before vaccine implementation. Sera obtained from the blood samples of subjects were screened for the detection of hepatitis A virus. The seroprevalence was evaluated by detection of total antibodies to hepatitis A virus using commercially available immunoassay kits. A total of 1379 subjects, aged 5-75 years (mean age: 29.0 ± 17.3 years) were studied. The global anti-hepatitis A virus seroplevalence was 84.7% (95% confidence interval: [82.6-86.5]). A higher hepatitis A virus seroprevalence was showed in subjects aged 10-14 years compared to those aged less than 10 years (50.0% vs. 31.0%). In subjects aged 20-29 years, a rapid increase in the hepatitis A virus prevalence was noted; it reached 97.0%. The seroprevalence of anti-hepatitis A virus differed by zone of residence (81.1% in rural area vs. 72.4% in urban area, p = .005) and increased significantly with lower level of education (p = .019). There was no statistical significant seroprevalence difference between male and female: 84.2% versus 85.2%, respectively. Our study confirm the transition pattern of the hepatitis A virus endemicity in Tunisia from high to intermediate and provide an evaluation of the hepatitis A virus epidemiological situation before vaccine implementation.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Ayouni K,Kharroubi G,Mallekh R,Hammami W,Marouani R,Mhamdi M,Ben Salah A,Triki H,Bettaieb Jdoi
10.1002/jmv.26563subject
Has Abstractpub_date
2020-09-28 00:00:00eissn
0146-6615issn
1096-9071pub_type
杂志文章abstract::Cervical cancer development has been mainly associated with persistent human papillomavirus (HPV) infections. However, HPV infection is unlikely to be sufficient to cause cervical cancer, and the contribution of other sexually transmitted infections (STIs) could be the determining factor for cervical lesion-progressio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24278
更新日期:2015-12-01 00:00:00
abstract::Human metapneumovirus (hMPV) is a pathogen of the respiratory tract with a worldwide distribution. The purpose of this study was to identify hMPV as the cause of acute respiratory diseases in children admitted at Spedali Civili, a public hospital in Brescia, Italy. Eight hundred forty-six nasopharyngeal aspirate sampl...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23213
更新日期:2012-03-01 00:00:00
abstract::Hepatitis A virus infections have been reported recently among hemophilic patients in Italy and Germany, leading to speculation that infectious hepatitis A virus (HAV) might have been present in some factor VIII concentrates. In both cases, the implicated factor concentrates had been treated by a solvent/detergent met...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410113
更新日期:1993-09-01 00:00:00
abstract::Hepatitis C virus (HCV) core protein has been reported to alter the cell cycle in vitro, but the data remain inconclusive, and in vitro experiments do not represent precisely events that occur in vivo, which may involve hepatic inflammation or regeneration. A group of double-transgenic mice carrying tetracycline trans...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21403
更新日期:2009-03-01 00:00:00
abstract::The relative frequency and distribution of the VP4 (P) genotypes of 227 human rotavirus field strains were investigated in South Africa. The stool samples were collected between 1984-1993 from infants and young children with diarrhea at Ga-Rankuwa Hospital, Pretoria, South Africa. The RNA was extracted from stools, he...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470102
更新日期:1995-09-01 00:00:00
abstract::Hepatitis A incidence has been decreasing in Brazil since child vaccination was implemented in 2014. This trend was interrupted by an outbreak among adult male in São Paulo in 2017. This study was outlined to estimate whether the increase of hepatitis A cases among adult men in Brazil was restricted to São Paulo. Case...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25694
更新日期:2020-08-01 00:00:00
abstract::Kaposi's sarcoma-associated herpesvirus (KSHV), the etiologic agent of Kaposi's sarcoma, causes malignancies frequently in patients with acquired immunodeficiency syndrome. In the United States and Europe, KSHV infection is common among men who have sex with men. However, the seroprevalence of KSHV among men who have ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23558
更新日期:2013-06-01 00:00:00
abstract::Human papillomavirus (HPV) detection is used for screening of cervical cancer and genotype-specific persistence has shown to be mandatory for dysplasia development. Aim of this study was to evaluate the clinical performance of HPV DNA Array for cervical intraepithelial neoplasia 2+ (CIN2+) lesion detection. HPV DNA A...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25583
更新日期:2020-01-01 00:00:00
abstract::Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with genital warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in genital warts acro...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.23646
更新日期:2013-10-01 00:00:00
abstract:PROBLEM:Objective studies that use validated questionnaires are needed to evaluate the changes in the sexual functions of women diagnosed with human papillomavirus (HPV) infection. METHOD OF STUDY:The study comprised 80 sexually active women diagnosed with a high-risk HPV infection. These patients were divided into fo...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25623
更新日期:2020-08-01 00:00:00
abstract::A novel coronavirus associated with acute respiratory disease (named SARS-CoV-2) is recently identified in Wuhan city, China, spread rapidly worldwide. Early identification of this novel coronavirus by molecular tools is critical for surveillance and control of the epidemic outbreak. We aimed to establish a simple met...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26171
更新日期:2020-11-01 00:00:00
abstract::In order to demonstrate the viral specificity of IgM-containing immune complexes (IgM-CIC) detected by a C1q assay in renal allograft recipients developing a CMV infection, a technique is described allowing: 1) the dissociation of IgM-CIC by action of an acid buffer, and 2) the characterization of the viral specificit...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890330312
更新日期:1991-03-01 00:00:00
abstract::Human parainfluenza viruses (HPIVs) are an important cause of acute lower respiratory tract infections (ALRTIs). HPIV-4, a newly identified virus, has been associated with severe ALRTIs recently. A total of 771 nasopharyngeal aspirate samples were collected from hospitalized children between March 2010 and February 20...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24580
更新日期:2016-12-01 00:00:00
abstract::Little is known on the association between clinical factors and coronavirus disease 2019 (COVID-19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26601
更新日期:2020-10-15 00:00:00
abstract::Enterovirus 68 (EV-D68) was associated with mild to severe respiratory infections. In the last 4 years, circulation of different EV-D68 strains has been documented worldwide. In this study, the phylogenetic characterization of nine EV-D68 strains identified in patients in the 2010-2012 period and 12 additional EV-D68 ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23821
更新日期:2014-09-01 00:00:00
abstract::Seasonal fluctuations in hepatitis A have been observed in the Netherlands related to Turkish and Moroccan children after visiting their home countries. This study determined the prevalence and associated factors of hepatitis A virus (HAV) antibodies in Turkish and Moroccan children in Rotterdam. A random sample was t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10576
更新日期:2004-02-01 00:00:00
abstract::Human papillomavirus (HPV) is a carcinogenic agent responsible for tumor development in many sexually involved tissues. We present a survey on the prevalence of HPV infection in a risk population for sexually transmitted infections (STIs). The studied population was formed by 125 STI clinic attendees, who took part in...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24746
更新日期:2017-06-01 00:00:00
abstract::The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21304
更新日期:2008-12-01 00:00:00
abstract::The presence of HPV 16 E6*I/E6*II spliced transcripts, in cervical lesions of different grade, was analyzed to characterize the transcription pattern. The presence and amount of spliced transcripts were correlated with DNA viral markers such as E2/E6 ratio and physical state. The detection of HPV 16 E6*I/E6*II mRNAs w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21496
更新日期:2009-07-01 00:00:00
abstract::Herpesviruses produce assembly proteins (AP) that act as scaffolding proteins for the assembly of the viral capsids. The products of the assemblin gene, which encodes both maturational protease and AP, have been established for herpes simplex virus type 1 (HSV-1) and human cytomegalovirus (CMV). We cloned an inframe O...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-12-01 00:00:00
abstract::Chronic hepatitis C (HCV) infection is associated with cognitive impairments which might be mediated through a secondary inflammatory cascade. Egypt has an unusually high prevalence of HCV monoinfections and is an ideal site for the study of the isolated effects of HCV infection. Therefore, in a hospital-based cross-s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21879
更新日期:2011-02-01 00:00:00
abstract::The effect of antiviral treatment on apoptosis in chronic hepatitis B (CHB) has not been clarified. We evaluated the hepatic immunohistochemical expression of the pro-apoptotic bax and the antiapoptotic bcl-xL protein in HBeAg-negative CHB patients before and after treatment. In our study we included 72 paired biopsie...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21780
更新日期:2011-07-01 00:00:00
abstract::Genotype-specific effects of parvovirus B19 (B19V) infections on left ventricular function in patients with dilated cardiomyopathy (DCM) have not been investigated so far. In this prospective clinical study, the prevalences of B19V genotypes in endomyocardial biopsies from patients presenting with inflammatory heart d...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22187
更新日期:2011-10-01 00:00:00
abstract::Therapy failure due to drug resistance development is a common phenomenon in HIV-infected patients. However, when the drug pressure leads to the earliest selection of drug-resistant HIV-1 populations is still unclear. In this study, the extent to which selection of the HIV-1 reverse transcriptase M184I/V mutations occ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21363
更新日期:2009-01-01 00:00:00
abstract::Capillary blood of febrile children was lysed by using a lysis buffer containing ascorbic acid. MxA quantitation was performed by an immunochemiluminescent assay. The MxA values were significantly higher in capillary blood of infants with viral infections due to adenovirus (n = 5), rotavirus (n = 15), or respiratory s...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1999-12-01 00:00:00
abstract::BK polyomavirus (BKV) is a ubiquitous virus in humans that remains latent in the urogenital tract after a primary infection during childhood. The virus, which is reactivated frequently and excreted in urine, can cause nephropathy in renal transplant recipients. BKV sequences are classified into four subtypes (I-IV). S...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22035
更新日期:2011-04-01 00:00:00
abstract::A rapid technique for the detection of hepatitis C virus (HCV) RNA in liver section using nonisotopic in situ hybridization was described. Only 3 of the 10 patients seropositive for antibody to HCV and HCV RNA had detectable HCV RNA in the hepatocytes (1%, 2%, and 15% of cells positive). No specific signal was detecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420313
更新日期:1994-03-01 00:00:00
abstract::The expression levels of many genes change after treatment of human immunodeficiency virus (HIV)-infected subjects by antiretroviral drugs. High-throughput analysis of tremendous datasets led to the discovery of genes that are implicated in the treatment pathways. In this study, we performed a gene-enrichment analysis...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25549
更新日期:2019-12-01 00:00:00
abstract::Sera of patients from China with hepatocellular carcinoma (HCC) were tested for the presence of HBc/HBe- and HBx antibodies by immunoblotting using recombinant MS2 or beta gal fusion proteins as substrate. Antibodies against HBx were detected in four out of 68 HBsAg positive and in one out of three HBsAg negative sera...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890250310
更新日期:1988-07-01 00:00:00
abstract::A procedure is described for the detection of hepatitis C virus (HCV) RNA in blood by means of the polymerase chain reaction (PCR) in which the reverse transcription step and two rounds of amplification are carried out in a single tube. This results in fewer manipulations, reduced risk of contamination, and economy of...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380312
更新日期:1992-11-01 00:00:00