The estimation of prevalence and risk factors of hepatitis B virus infection among blood donors in Chengdu, China.

Abstract:

:The reported positive rates of hepatitis B virus surface antigen (HBsAg) among Chinese blood donors generally do not include data from pre-donation rapid tests. The aim of this study was to estimate the prevalence of serologic markers for HBsAg and risk factors among blood donors from Chengdu, China. From April 2010 to March 2011, a total of 16,875 blood donors were enrolled. Data from HBsAg tests before and after donations were collected to estimate the prevalence of HBsAg. A case-control study was conducted in 265 unique HBsAg-positive blood donors and 530 seronegative donors between January 2011 and October 2012. The odds ratio (OR) and 95% confidence interval (CI) were calculated using conditional logistic regression. The population attributable risk (PAR) was estimated. The prevalence of HBsAg was 3.17% (95%CI, 2.91-3.43%). The following risk factors were associated with HBV infection: non-vaccination for HBV (OR = 4.236; 95%CI, 2.72-6.60%), razor sharing (OR = 2.370; 95%CI, 1.46-3.84%), dental treatment (OR = 1.714; 95%CI, 1.21-2.43%), acupuncture (OR = 1.983; 95%CI, 1.20-3.28%), a family history of HBV infection (OR = 2.257; 95%CI, 1.32-3.86%), and endoscopy (OR = 2.17; 95%CI, 1.04-4.51%). The PAR values of the risk factors were 42.77%, 31.78%, 13.68%, 6.18%, 6.09%, and 2.85%, respectively, and the total PAR was 68.78%. The prevalence of HBsAg among Chinese blood donors is still high. HBV vaccinations can provide protection. Blood contact from sharing instruments is still a high risk route of transmission for HBV. Immunization programs and behavioral interventions should be used to prevent blood donation infections and improve blood safety.

journal_name

J Med Virol

authors

Zhong L,Xi G,Zhang L,Liu S,Wan L,Yu L,Zhou M,Zhang J,He Y

doi

10.1002/jmv.24339

subject

Has Abstract

pub_date

2016-02-01 00:00:00

pages

260-7

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

88

pub_type

杂志文章
  • Detection and phylogenetic analysis of human pegivirus (GBV-C) among blood donors and patients infected with hepatitis B virus (HBV) in Qatar.

    abstract::Human Pegivirus (HPgV), formerly GB virus-C/Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is widely spread and has been reported to be associated with non-A-E hepatitis. To our knowledge, no previous study was conducted about HPgV in Qatar. Thus, the objectives of this study were as follows: (i) to deter...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24289

    authors: AbuOdeh RO,Al-Absi E,Ali NH,Khalili M,Al-Mawlawi N,Hadwan TA,Althani AA,Nasrallah GK

    更新日期:2015-12-01 00:00:00

  • New variations of Epstein-Barr virus-encoded small RNA genes in nasopharyngeal carcinomas, gastric carcinomas, and healthy donors in northern China.

    abstract::It has been generally believed that the Epstein-Barr virus (EBV)-encoded small RNA 1 and 2 (EBER1 and EBER2) genes are conserved as two families that correlated with type 1 (B95-8) and type 2 (AG876 or P3HR-1) EBV strains. EBER polymorphism and its association with EBV-associated disease have not received much attenti...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21714

    authors: Wang Y,Zhang X,Chao Y,Jia Y,Xing X,Luo B

    更新日期:2010-05-01 00:00:00

  • Flow cytometric analysis of cytomegalovirus-specific cell-mediated immunity in the congenital infection.

    abstract::Flow cytometric analysis of CD4(+) and CD8(+) T cells specific to human cytomegalovirus (CMV) was undertaken in seven patients with congenital CMV infection, six healthy infants who had acquired infection, and six CMV-seropositive adults. Intracellular cytokine assays showed that 0.03-2.23% of CD4(+) T cells in the he...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10477

    authors: Hayashi N,Kimura H,Morishima T,Tanaka N,Tsurumi T,Kuzushima K

    更新日期:2003-10-01 00:00:00

  • Replication of enhancer-deficient amphotropic murine leukemia virus in human fibrosarcoma but not in primary human fibroblasts.

    abstract::Amphotropic murine leukemia virus (MLV) replicates in cells from various mammalian species including humans and is a potential contaminant in MLV vector preparations for human gene transfer studies. In general, MLV replication depends on the expression of viral genes under the control of 75 bp enhancer elements in the...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10202

    authors: Reuss FU,Berdel B,Heber R,Bantel-Schaal U

    更新日期:2002-10-01 00:00:00

  • Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals.

    abstract::The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct genotype. The present study describes the...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25035

    authors: Mourez T,Decroos A,Goria O,Montialoux H,De Oliveira F,Larrat S,Plantier JC,Riachi G

    更新日期:2018-05-01 00:00:00

  • Gastroenterology manifestations and COVID-19 outcomes: A meta-analysis of 25,252 cohorts among the first and second waves.

    abstract:BACKGROUND AND AIM:A meta-analysis was performed to identify COVID-19 patients presenting with gastrointestinal (GI) symptoms during the first and second pandemic waves and investigate their association with the disease outcomes. METHODS:A systematic search in PubMed, Scopus, Web of Science, ScienceDirect, and EMBASE ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26836

    authors: Elshazli RM,Kline A,Elgaml A,Aboutaleb MH,Salim MM,Omar M,Munshi R,Mankowski N,Hussein MH,Attia AS,Toraih EA,Settin A,Killackey M,Fawzy MS,Kandil E

    更新日期:2021-02-02 00:00:00

  • Diagnosis and quantitative evaluation of parvovirus B19 infections by real-time PCR in the clinical laboratory.

    abstract::A real-time PCR assay was developed for quantitative detection of B19 DNA in clinical serum samples. The assay was carried out using a LightCycler instrument and product formation was monitored continuously with the fluorescent double-stranded DNA binding dye SYBR Green I. With an optimized PCR protocol, this system w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2218

    authors: Manaresi E,Gallinella G,Zuffi E,Bonvicini F,Zerbini M,Musiani M

    更新日期:2002-06-01 00:00:00

  • Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system.

    abstract::A line of hepatitis C virus (HCV) transgenic mice was established previously that was mediated by Cre/loxP system using HCV cDNA, including core, E1, E2 and NS2 genes. Intravenous infection of a recombinant adenovirus that expresses Cre DNA recombinase (AxCANCre) induced HCV structural protein expression in the liver ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200011)62:3<308::aid-jmv2>3.0.co

    authors: Wakita T,Katsume A,Kato J,Taya C,Yonekawa H,Kanegae Y,Saito I,Hayashi Y,Koike M,Miyamoto M,Hiasa Y,Kohara M

    更新日期:2000-11-01 00:00:00

  • Baseline NS5A resistance associated substitutions may impair DAA response in real-world hepatitis C patients.

    abstract::Oral DAA have demonstrated high efficacy as treatment of hepatitis C. However, the presence of resistance-associated substitutions (RAS) at baseline has occasionally been associated with impaired treatment response. Herein, we examined the impact of baseline RAS at the HCV NS5A gene region on treatment response in a r...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24971

    authors: Carrasco I,Arias A,Benítez-Gutiérrez L,Lledó G,Requena S,Cuesta M,Cuervas-Mons V,de Mendoza C

    更新日期:2018-03-01 00:00:00

  • Comparison of viral load and duration of virus shedding in symptomatic and asymptomatic neonatal rotavirus infections.

    abstract::A single rotavirus strain causing asymptomatic infections as well as severe gastrointestinal disease has been described in the neonatal nurseries of the Christian Medical College, Vellore. In this study, quantitative real-time RT-PCR was used to determine the association of viral load with the presence of gastrointest...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21872

    authors: Ramani S,Sankaran P,Arumugam R,Sarkar R,Banerjee I,Mohanty I,Jana AK,Kuruvilla KA,Kang G

    更新日期:2010-10-01 00:00:00

  • Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay.

    abstract::Several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-HSCT) are frequent, but viral reactivations after autologous HSCT (auto-HSCT) have not been investigated in detail. We performed multiplex polymerase chain reaction (PCR) assay to examine multiple...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24621

    authors: Inazawa N,Hori T,Nojima M,Saito M,Igarashi K,Yamamoto M,Shimizu N,Yoto Y,Tsutsumi H

    更新日期:2017-02-01 00:00:00

  • Comparative trial of acyclovir and vidarabine in disseminated varicella-zoster virus infections in immunocompromised patients.

    abstract::A comparative assessment of vidarabine and acyclovir in the treatment of varicella and disseminated zoster in immunosuppressed patients was undertaken. Thirty-eight immunosuppressed patients with varicella (N = 18) or disseminated zoster (N = 20) were treated intravenously with 10 mg/kg/day of vidarabine or 30 mg/kg/d...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章

    doi:10.1002/jmv.1890200205

    authors: Vildé JL,Bricaire F,Leport C,Renaudie M,Brun-Vézinet F

    更新日期:1986-10-01 00:00:00

  • The distribution of hepatitis B virus genotypes in Thailand.

    abstract::Phylogenetic analysis was performed on hepatitis B virus (HBV) strains obtained from 86 hepatitis B surface antigen (HBsAg) positive donors from Thailand originating throughout the country. Based on the S gene, 87.5% of strains were of genotype C while 10.5% were of genotype B, with all genotype B strains obtained fro...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23363

    authors: Louisirirotchanakul S,Olinger CM,Arunkaewchaemsri P,Poovorawan Y,Kanoksinsombat C,Thongme C,Sa-Nguanmoo P,Krasae S,Theamboonlert A,Oota S,Fongsatitkul L,Puapairoj C,Promwong C,Weber B

    更新日期:2012-10-01 00:00:00

  • Seroprevalence rates of HPyV6, HPyV7, TSPyV, HPyV9, MWPyV and KIPyV polyomaviruses among the healthy blood donors.

    abstract::Human polyomaviruses HPyV6, HPyV7, TSPyV, HPyV9, MWPyV, and KIPyV have been discovered between 2007 and 2012. TSPyV causes a rare skin disease trichodysplasia spinulosa in immunocompromised patients, the role of remaining polyomaviruses in human pathology is not clear. In this study, we assessed the occurrence of seru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24440

    authors: Šroller V,Hamšíková E,Ludvíková V,Musil J,Němečková Š,Saláková M

    更新日期:2016-07-01 00:00:00

  • The possible role of CCR5Δ32 mutation in Crimean-Congo hemorrhagic fever infection.

    abstract::Crimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. The aim of the present study is to investigate the association between chemokine receptor 5 (CCR5) gene Δ32 mutation and pa...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24865

    authors: Rustemoglu A,Ekinci D,Nursal AF,Barut S,Duygu F,Günal Ö

    更新日期:2017-10-01 00:00:00

  • Rhinovirus frequently detected in elderly adults attending an emergency department.

    abstract::The general aim was to investigate the burden of respiratory virus illness in a hospital emergency department, during two different epidemic seasons. Consecutive patients attending an emergency department during two study periods (February/March 2009 and 2010) were enrolled using broad inclusion criteria (fever/preced...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22205

    authors: Pierangeli A,Scagnolari C,Selvaggi C,Verzaro S,Spina MT,Bresciani E,Antonelli G,Bertazzoni G

    更新日期:2011-11-01 00:00:00

  • Mix-breeding with HEV-infected swine induced inapparent HEV infection in SPF rabbits.

    abstract::Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24374

    authors: Liu L,Wang L,Xia J,Zhang Y,Zeng H,Liu P,Zou Q,Wang L,Zhuang H

    更新日期:2016-04-01 00:00:00

  • Variation in human papillomavirus type-16 viral load within different histological grades of cervical neoplasia.

    abstract::The objective of this study was to investigate variation in human papillomavirus (HPV) type-16 load within histologically defined grades of cervical intraepithelial neoplasia. Two hundred and thirty-seven liquid based cytology samples were collected from women attending colposcopy clinics, DNA was extracted, and prese...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20875

    authors: Fiander AN,Hart KW,Hibbitts SJ,Rieck GC,Tristram AJ,Beukenholdt RW,Powell NG

    更新日期:2007-09-01 00:00:00

  • Human metapneumovirus-associated hospital admissions over five consecutive epidemic seasons: evidence for alternating circulation of different genotypes.

    abstract::Human metapneumovirus (hMPV) is a pathogen of the respiratory tract with a worldwide distribution. The purpose of this study was to identify hMPV as the cause of acute respiratory diseases in children admitted at Spedali Civili, a public hospital in Brescia, Italy. Eight hundred forty-six nasopharyngeal aspirate sampl...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23213

    authors: Apostoli P,Zicari S,Lo Presti A,Ciccozzi M,Ciotti M,Caruso A,Fiorentini S

    更新日期:2012-03-01 00:00:00

  • Experimental CVB3-induced chronic myocarditis in two murine strains: evidence of interrelationships between virus replication and myocardial damage in persistent cardiac infection.

    abstract::In order to analyse the relationships between enteroviral replication and the myocardial damage at the onset of chronic cardiac infection, 2 mouse strains with different degrees of immunological competence (NMRI nu/nu, DBA/2) were infected by a myocarditic Coxsackie virus B3 (CVB3-M1) variant. At 31 days post-inoculat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199706)52:2<206::aid-jmv15

    authors: Andréoletti L,Hober D,Becquart P,Belaich S,Copin MC,Lambert V,Wattré P

    更新日期:1997-06-01 00:00:00

  • Cycling probe-based real-time PCR for the detection of Human herpesvirus 6A and B.

    abstract::Human herpesvirus 6 (HHV-6) is classified as two distinct species: HHV-6A and B. HHV-6B infection can cause several clinical manifestations in transplant recipients including encephalitis, bone marrow suppression, and pneumonitis. In contrast to HHV-6B, the clinical features of HHV-6A infection remain largely undefine...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24513

    authors: Ihira M,Yamaki A,Kato Y,Higashimoto Y,Kawamura Y,Yoshikawa T

    更新日期:2016-09-01 00:00:00

  • Human immune response to Puumala virus glycoproteins and nucleocapsid protein expressed in mammalian cells.

    abstract::Puumala hantavirus (PUUV) glycoproteins G1 and G2 and nucleocapsid protein (N) were expressed in BHK-21 cells by transfection of a plasmid producing a recombinant alphavirus replicon. Coexpression of G1 and G2 from separate constructs seemed to be important for the optimal folding of the glycoproteins, as evaluated by...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Kallio-Kokko H,Leveelahti R,Brummer-Korvenkontio M,Lundkvist A,Vaheri A,Vapalahti O

    更新日期:2001-11-01 00:00:00

  • Human and monoclonal antibodies to hepatitis B core antigen recognise a single immunodominant epitope.

    abstract::Monoclonal antibodies were raised against hepatitis B core antigen (HBcAg) synthesized in Escherichia coli. They identified a single immunodominant determinant on both liver-derived and E. coli-derived HBcAg. Cross-inhibition studies demonstrated that HBsAg-containing human sera which contained antibodies to HBcAg (an...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890190213

    authors: Ferns RB,Tedder RS

    更新日期:1986-06-01 00:00:00

  • Early inhibition of nitric oxide production increases HSV-1 intranasal infection.

    abstract::Here, we studied the role of nitric oxide (NO) production during the first steps of the respiratory infection of BALB/c mice with herpes simplex virus type 1 (HSV-1), strain F. Nitric oxide synthase II (NOS-II) mRNA and protein were detected by reverse transcription (RT)-PCR and dot blot, respectively in samples of lu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20093

    authors: Gamba G,Cavalieri H,Courreges MC,Massouh EJ,Benencia F

    更新日期:2004-06-01 00:00:00

  • Expression of matrix metalloproteinases and their inhibitors in the woodchuck model of hepatocellular carcinoma.

    abstract::Matrix metalloproteinases (MMPs) play a central role in tumor invasion and metastasis. Increased expression of MMPs occurs during development of hepatocellular carcinoma (HCC) in humans following infection with hepatitis B virus (HBV). Woodchucks are used as an animal model for hepadnavirus-induced HCC. All woodchucks...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23571

    authors: Ochoa-Callejero L,Toshkov I,Menne S,Martínez A

    更新日期:2013-07-01 00:00:00

  • Assessing risk of a short-term antiretroviral therapy discontinuation as a read-out of viral control in immune-based therapy.

    abstract::Although analytical treatment interruption is used as a strategy to test immunotherapeutic agents in HIV-infection, it may pose a risk for study participants. The potential risks of short-term interruption of antiretroviral therapy (ART) during treatment with an autologous dendritic cell immune-based therapy (AGS-004-...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jmv.23297

    authors: Routy JP,Boulassel MR,Nicolette CA,Jacobson JM

    更新日期:2012-06-01 00:00:00

  • The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.

    abstract::Epstein-Barr virus (EBV) is an important DNA tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (NPC). DNA methylation and microRNAs (miRNAs) are the most studied epigenetic mechanisms that can prompt disease susceptibility. This study aimed to detect the effe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24863

    authors: Zhao Z,Liu W,Liu J,Wang J,Luo B

    更新日期:2017-10-01 00:00:00

  • Polymorphism of the capsid L1 gene of human papillomavirus types 31, 33, and 35.

    abstract::The L1 gene encodes for the major capsid protein of human papillomaviruses (HPV). There is limited information on the polymorphism of L1 for types related to HPV-16. This report explores the polymorphism of L1 in phylogenetically related types 31, 33, and 35 compared to HPV-16. Genital specimens collected from 732 HIV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21777

    authors: Cornut G,Gagnon S,Hankins C,Money D,Pourreaux K,Franco EL,Coutlée F,Canadian Women's HIV Study Group.

    更新日期:2010-07-01 00:00:00

  • Detection of hepatitis C viraemia in Caucasian patients with hepatocellular carcinoma.

    abstract::Potential risk factors for the development of hepatocellular carcinoma were analysed in 40 Caucasian patients with this malignancy. A higher proportion (14 of 40; 35%) had evidence of hepatitis C virus (HCV) infection than had evidence of either hepatitis B virus (HBV) carriage (17.5%) or alcohol abuse (30%). In all 1...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380215

    authors: Garson JA,Wicki AN,Ring CJ,Joller H,Zala G,Schmid M,Buehler H

    更新日期:1992-10-01 00:00:00

  • Efficacy of lamivudine in HBeAg-negative chronic hepatitis B.

    abstract::Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7-30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia. Interferon (IFN) is currently th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:

    authors: Rizzetto M

    更新日期:2002-04-01 00:00:00