The possible role of CCR5Δ32 mutation in Crimean-Congo hemorrhagic fever infection.

Abstract:

:Crimean-Congo hemorrhagic fever infection (CCHF) is a viral zoonosis. The pathogenesis of this disease has not been established so far, however, cytokines account for its progression and outcome. The aim of the present study is to investigate the association between chemokine receptor 5 (CCR5) gene Δ32 mutation and pathogenity, severity, and mortality of CCHF. This case-control study included 133 CCHF patients diagnosed by detection of CCHV RNA positivity and 97 healthy control subjects. CCR5 gene Δ32 mutation analyzed by polymerase chain reaction (PCR) method. The results were compared by using SPSS 16.0 and WINPEPI software's. The genotype distribution and allele frequency of the CCR5Δ32 were statistically different between the patients and the control group (P = 0.017; OR: 4.98 95% CI = 1.65-14.99 and P = 0.019; OR:4.76 95%CI = 1.30-17.50, respectively). CCR5/CCR5 (W/W) genotype and W allele of CCR5 gene were more common in patient group than in controls. There was no significant difference in severe and mild cases with regard to genotype distribution and allele distribution of CCR5Δ32 mutation (P >0.05). These results suggest that the CCR5 gene and its product might play a role in the pathogenesis of CCHF disease. Future studies will help us to uncover the exact role of CCR5 in the pathogenesis and prognosis of CCHF and to treat the disease.

journal_name

J Med Virol

authors

Rustemoglu A,Ekinci D,Nursal AF,Barut S,Duygu F,Günal Ö

doi

10.1002/jmv.24865

subject

Has Abstract

pub_date

2017-10-01 00:00:00

pages

1714-1719

issue

10

eissn

0146-6615

issn

1096-9071

journal_volume

89

pub_type

杂志文章
  • Risk and clearance of GB virus C/hepatitis G virus infection in homosexual men: A longitudinal study.

    abstract::The risk and clearance of GB virus type C (GBV-C)/hepatitis G virus (HGV) infection was investigated in a cohort of homosexual men (n=180; median follow-up time, 7 years). The interaction between GBV-C/HGV RNA and antibodies against the E2 region of the virus, and the clinical impact of chronic GBV-C/HGV infection wer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199911)59:3<303::aid-jmv7>

    authors: Stark K,Doering CD,Bienzle U,Pauli G,Hamouda O,Engel AM,Schreier E

    更新日期:1999-11-01 00:00:00

  • Quantitative relationship between HBeAg and DNA polymerase activity in sera from patients with chronic active hepatitis during a three-month period.

    abstract::In eight patients with biopsy-confirmed chronic active hepatitis (CAH), hepatitis B e antigen (HBeAg) levels and DNA polymerase (DNA-P) activity were assayed three times a week for six weeks and once a week for another six weeks. HBeAg levels were rather constant, whereas DNA-P activity fluctuated. No correlation was ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(1980)5:4<295::aid-jmv1890050405>

    authors: Heijtink RA,van der Waart M,Weimar W,Schalm SW,Masurel N

    更新日期:1980-01-01 00:00:00

  • Incidence of hepatitis A virus (HAV) infection in rural Liberia.

    abstract::To provide background for future hepatitis A vaccine trials, sera were collected from 0- to 4-year-old Liberian infants and their mothers on two occasions an average of 14.75 months apart and tested for antibody to hepatitis A virus (anti-HAV). The prevalence of anti-HAV rose from 2.5% in infants 0-6 months of age to ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890150411

    authors: Prince AM,Brotman B,Richardson L,White T,Pollock N,Riddle J

    更新日期:1985-04-01 00:00:00

  • Hemagglutination inhibition, single radial hemolysis, and ELISA tests for the detection of IgG and IgM to rubella virus.

    abstract::Hemagglutination inhibition (HI), single radial hemolysis (SRH) and enzyme-linked immuno sorbent assay (ELISA), performed with commercial antigen and reagents are described and were compared in the three distinct situations that require rubella antibody detection. Determination of immunity status was carried out on 15...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(1980)5:4<273::aid-jmv1890050403>

    authors: Champsaur H,Dussaix E,Tournier P

    更新日期:1980-01-01 00:00:00

  • Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.

    abstract::To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted either spontaneous...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890450404

    authors: Karasawa T,Aizawa Y,Zeniya M,Kuramoto A,Shirasawa T,Toda G

    更新日期:1995-04-01 00:00:00

  • Sudden infant death syndrome associated with rotavirus infection.

    abstract::Rotavirus was detected in the stools of five children stricken with sudden infant death syndrome (SIDS) over a three-week period. While none of the children had acute gastroenteritis, four of the five had acute upper respiratory infections. Rotavirus was also identified in tracheal aspirates from two of the infants. E...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890100409

    authors: Yolken R,Murphy M

    更新日期:1982-01-01 00:00:00

  • Efficacy of lamivudine in HBeAg-negative chronic hepatitis B.

    abstract::Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7-30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia. Interferon (IFN) is currently th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:

    authors: Rizzetto M

    更新日期:2002-04-01 00:00:00

  • Low prevalence of IgG antibodies against antigens of HEV genotypes 1 and 3 in women with a high-risk pregnancy.

    abstract::The aim of the study was to assess whether high-risk pregnant women have a higher prevalence of HEV during the perinatal period. This was a cross-sectional study of 428 patients: Group 1, 127 women with a high-risk pregnancy; Group 2, 97 asymptomatic people with reactivity to HCV or HBV; Group 3, 94 patients with clin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24878

    authors: Baptista-González H,Trueba-Gómez R,Rosenfeld-Mann F,Roque-Álvarez E,Méndez-Sánchez N

    更新日期:2017-11-01 00:00:00

  • Comparison of the efficacy of ribavirin plus peginterferon alfa-2b for chronic hepatitis C infection in patients with and without coagulation disorders.

    abstract::Many patients with coagulation disorders are infected with hepatitis C virus (HCV) that advances to end stage liver disease, resulting in an increased number of deaths. The efficacy of ribavirin and peginterferon combination therapy for chronic HCV infection in patients with coagulation disorders has not been clarifie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23444

    authors: Honda T,Katano Y,Kuzuya T,Hayashi K,Ishigami M,Itoh A,Hirooka Y,Nakano I,Ishikawa T,Toyoda H,Kumada T,Yamamoto K,Matsushita T,Kojima T,Takamatsu J,Goto H

    更新日期:2013-02-01 00:00:00

  • Performance of rapid tests for discrimination between HIV-1 and/or HIV-2 infections.

    abstract::Major differences exist between HIV-1 and HIV-2 in terms of epidemiology, pathogenicity, sensitivity to antiretrovirals. Determining the type of HIV infecting a patient is essential for management. The aim of this study was to evaluate the ability of simple/rapid tests to differentiate between HIV-1 and/or HIV-2 infec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24282

    authors: Gautheret-Dejean A,Bocobza J,Brunet S,Damond F,Plantier JC,Barin F

    更新日期:2015-12-01 00:00:00

  • Development and evaluation of a conventional RT-PCR for differentiating emerging influenza B/Victoria lineage viruses with hemagglutinin amino acid deletion from B/Yamagata lineage viruses.

    abstract:BACKGROUND:Recent influenza B/Victoria lineage viruses contain amino acid deletions at positions 162 to 164 of the haemagglutinin (HA) protein. These amino acid deletions have affected the detection of B/Victoria lineage viruses by the lineage-specific conventional reverse-transcription polymerase chain reaction (RT-PC...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25607

    authors: Chan WM,Wong LH,So CF,Chen LL,Wu WL,Ip JD,Lam AH,Yip CCY,Yuen KY,To KKW

    更新日期:2020-03-01 00:00:00

  • Laboratory confirmation of congenital rubella syndrome in infants: an eye hospital based investigation.

    abstract::A total of 190 specimens from South Indian children aged 0-59 months with ocular anomalies consistent with suspected congenital rubella syndrome (CRS) were investigated. Twenty-six of the 65 infants (40%) were confirmed as CRS by detection of rubella specific IgM. Rubella RNA was detected in 41 samples from 26 infants...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21097

    authors: Rajasundari TA,Sundaresan P,Vijayalakshmi P,Brown DW,Jin L

    更新日期:2008-03-01 00:00:00

  • Impact of disease-modifying drugs on the severity of  COVID-19 infection in multiple sclerosis patients.

    abstract::Recent evidence suggested that neurological manifestations occur in patients with a severe form of coronavirus disease (COVID-19). On the basis of this issue, neurologists are very concerned about patients with neurological disorders, especially multiple sclerosis (MS), as consumers of immunosuppressive or immune-modu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26593

    authors: Rostami Mansoor S,Ghasemi-Kasman M

    更新日期:2020-10-12 00:00:00

  • Molecular Characterization of Non-Polio Enteroviruses Isolated from Acute Flaccid Paralysis Patients in Uganda.

    abstract::Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AF...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26804

    authors: Tushabe P,Howard W,Bwogi J,Birungi M,Eliku JP,Kakooza P,Bukenya H,Namuwulya P,Gaizi J,Tibanagwa M,Kabaliisa T,Mulindwa J,Muhanguzi D,Suchard M,Gumede N,Bakamutumaho B

    更新日期:2021-01-17 00:00:00

  • Profile of pre-S deletions in the natural history of chronic hepatitis B infection.

    abstract::It have been suggested that hepatitis B virus (HBV) pre-S deletions may play a role in hepatocarcinogenesis. The aim of the study was to determine the prevalence of pre-S deletions in chronic hepatitis B patients in Hong Kong, the factors associated with the deletions and its relationship with hepatitis B e antigen (H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21901

    authors: Yeung P,Wong DK,Lai CL,Fung J,Seto WK,Yuen MF

    更新日期:2010-11-01 00:00:00

  • Depletion of mitochondrial DNA in HIV-1-infected patients and its amelioration by antiretroviral therapy.

    abstract::Mitochondrial DNA (mtDNA) of peripheral blood mononuclear cells (PBMCs) collected from Human immunodeficiency virus 1 (HIV-1)-infected patients and healthy controls were measured longitudinally using real-time polymerase chain reaction to evaluate the effects of antiretroviral agents on mtDNA synthesis in vivo and to ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10423

    authors: Miura T,Goto M,Hosoya N,Odawara T,Kitamura Y,Nakamura T,Iwamoto A

    更新日期:2003-08-01 00:00:00

  • Clinical manifestations of death with severe fever and thrombocytopenia syndrome: A meta-analysis and systematic review.

    abstract::Severe hemorrhagic fever disease is caused by severe fever with thrombocytopenia syndrome virus (SFTSV) infection, which belongs to the Phlebovirus genus in the Bunyaviridae family. A comprehensive literature search of PubMed, Web of Science, Embase, Cochrane Library, Chinese National Knowledge Infrastructure database...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26518

    authors: Wang X,Ren X,Ge Z,Cui S,Wang L,Chen Z,Tian D

    更新日期:2020-09-15 00:00:00

  • Frequent detection of hepatitis B virus variants associated with lamivudine resistance in treated South African patients infected chronically with different HBV genotypes.

    abstract::This retrospective study investigated and characterized the YMDD motif of the hepatitis B virus (HBV) reverse transcriptase (RT) gene, in sequential samples of 17 South African patients with chronic hepatitis B infection on lamivudine treatment. The profile of HBV genotypes as well as the genetic variability of pre-co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21479

    authors: Selabe SG,Song E,Burnett RJ,Mphahlele MJ

    更新日期:2009-06-01 00:00:00

  • Prediction of the efficacy of antiviral therapy for hepatitis C virus infection by an ultrasensitive RT-PCR assay.

    abstract::The efficacy of interferon therapy for hepatitis C virus (HCV) infection improved remarkably. However, virologic relapse occurs in a substantial proportion of patients with virologic response (defined as an HCV RNA level below 50 IU/ml at the end-of-treatment). A highly sensitive RT-nested PCR assay capable of detecti...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20908

    authors: Kinai E,Hanabusa H,Kato S

    更新日期:2007-08-01 00:00:00

  • Tumor necrosis factor-alpha and interferon-gamma inhibit synergistically viral replication in hepatitis B virus-replicating cells.

    abstract::The effects of tumor necrosis factor-alpha and/or interferon-gamma on the replication of hepatitis B virus were examined using HB611 cells. These cells were derived from human hepatoblastoma cells, Huh6, by integrating hepatitis B virus DNA, and produce hepatitis B virus continuously. Each of the cytokines inhibited h...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470314

    authors: Kawanishi Y,Hayashi N,Katayama K,Ueda K,Takehara T,Miyoshi E,Mita E,Kasahara A,Fusamoto H,Kamada T

    更新日期:1995-11-01 00:00:00

  • Isolation of saffold virus type 2 in green monkey kidney cells.

    abstract::Saffold viruses (SAFV) have been discovered recently and they are classified into Theilovirus species in genus Cardiovirus in the Picornaviridae family. SAFV, especially those belonging to the genotype 2, have been difficult to propagate in laboratory cell lines. This study describes the successful isolation of an eff...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23352

    authors: Blomqvist S,Lappalainen M,Paananen A,Ylipaasto P,Roivainen M

    更新日期:2012-09-01 00:00:00

  • HBeAg and anti-HBe detection by radioimmunoassay: correlation with vertical transmission of hepatitis B virus in Taiwan.

    abstract::A sensitive radioimmunoassay technique was used to detect hepatitis B e antigen (HBeAg). A strong correlation was found between HBeAg positivity of the serum of hepatitis B surface antigen (HBsAg) carrier women in Taiwan and the subsequent development of surface antigenemia in their babies. All babies who became chron...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890030310

    authors: Stevens CE,Neurath RA,Beasley RP,Szmuness W

    更新日期:1979-01-01 00:00:00

  • The impact of viral dynamics on the clinical severity of infants with respiratory syncytial virus bronchiolitis.

    abstract::The impact of dynamic respiratory syncytial virus (RSV) load on the clinical severity of hospitalized infants with bronchiolitis has not been clarified. Nasopharyngeal aspirates were obtained from 60 infants who were diagnosed with bronchiolitis within 96 hr of wheezing onset upon admission and on days 3, 5, and 7 in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24111

    authors: Zhou L,Xiao Q,Zhao Y,Huang A,Ren L,Liu E

    更新日期:2015-08-01 00:00:00

  • Low-level viremia is associated with non-B subtypes in patients infected with HIV with virological success following HAART introduction.

    abstract::This prospective study aimed to determine factors associated with detection of very low-level viremia in patients infected with HIV-1 with virological success following HAART introduction. Fifty-seven patients, mostly (n = 51, 89%) treated with a protease inhibitor-based regimen, were included and followed for 2 years...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23553

    authors: Saison J,Tardy JC,Scholtes C,Icard V,Trabaud MA,Perpoint T,Chidiac C,Ecochard R,André P,Ferry T,Lyon HIV Cohort Study.

    更新日期:2013-06-01 00:00:00

  • Phylogenetic analysis of human group C rotavirus in hospitalized children with gastroenteritis in Belém, Brazil.

    abstract::Group C rotavirus (RVC) is potentially an important pathogen associated with acute gastroenteritis (AG), especially in outbreaks. This study aims to detect and molecularly characterize RVC in hospitalized children with AG in Belém, Brazil. From May 2008 to April 2011, 279 stools were subjected to reverse-transcription...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24379

    authors: Lobo Pdos S,Guerra Sde F,Siqueira JA,Soares Lda S,Gabbay YB,Linhares AC,Mascarenhas JD

    更新日期:2016-04-01 00:00:00

  • Latent membrane protein 1 encoded by Epstein-Barr virus induces telomerase activity via p16INK4A/Rb/E2F1 and JNK signaling pathways.

    abstract::Elevated telomerase activity is observed in about 90% of human cancers. This activity correlates strictly with human telomerase reverse transcriptase (hTERT). Previously, it was shown that the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induced telomerase activity in nasopharyngeal carcinoma cells. In ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20896

    authors: Ding L,Li L,Yang J,Zhou S,Li W,Tang M,Shi Y,Yi W,Cao Y

    更新日期:2007-08-01 00:00:00

  • The prevalence of human papillomavirus in the oropharynx in healthy individuals in a Brazilian population.

    abstract::Oncogenic human papillomavirus (HPV), a causative agent of uterine cervical cancer, has also been detected in head and neck squamous cell cancers, especially in squamous cell carcinomas of the tonsils. However, the true HPV prevalence in normal and neoplasic oropharyngeal mucosa remains uncertain. To determine the pre...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20583

    authors: do Sacramento PR,Babeto E,Colombo J,Cabral Ruback MJ,Bonilha JL,Fernandes AM,Pereira Sobrinho JS,de Souza FP,Villa LL,Rahal P

    更新日期:2006-05-01 00:00:00

  • Incidence of Alpha-Herpes virus induced ocular disease in Suriname.

    abstract::Herpes simplex virus (HSV) infection of the corneal stroma is the most prominent cause of scar formation impairing visual acuity and HSV keratitis is the leading cause of corneal opacity throughout the world. Suriname lacked test systems for microbial causes of ocular disease, therefore a polymerase chain reaction-bas...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23414

    authors: Adhin MR,Grunberg MG,Labadie-Bracho M,Pawiroredjo J

    更新日期:2012-12-01 00:00:00

  • Lack of effect of a booster dose of influenza vaccine in hemodialysis patients.

    abstract::To assess whether the administration of a booster dose of influenza vaccine may enhance immune response in hemodialysis patients, 58 subjects were given two doses of the 2003/2004 season influenza vaccine, 1 month apart. "European Agency for the Evaluation of Medicinal Products" (EMEA) criteria were fully met in terms...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20936

    authors: Tanzi E,Amendola A,Pariani E,Zappa A,Colzani D,Logias F,Perego A,Zanetti AR

    更新日期:2007-08-01 00:00:00

  • HDV infection in immigrant populations.

    abstract:AIMS:Little data have been published so far on the epidemiological aspects of hepatitis D virus (HDV) infection in immigrant populations and even poorer is the information on the virological, phylogenetic, and clinical aspects of this infection in these populations. This review article, aimed primarily at physicians ca...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.25570

    authors: Coppola N,Alessio L,Onorato L,Sagnelli C,Sagnelli E,Pisaturo M

    更新日期:2019-12-01 00:00:00