Risk and clearance of GB virus C/hepatitis G virus infection in homosexual men: A longitudinal study.

Abstract:

:The risk and clearance of GB virus type C (GBV-C)/hepatitis G virus (HGV) infection was investigated in a cohort of homosexual men (n=180; median follow-up time, 7 years). The interaction between GBV-C/HGV RNA and antibodies against the E2 region of the virus, and the clinical impact of chronic GBV-C/HGV infection were studied. GBV-C/HGV RNA was detected by RT-PCR, and E2 antibodies were assessed by an immunoassay. At baseline, 63% of the participants had evidence of previous or current GBV-C/HGV infection. The GBV-C/HGV incidence rate was 2 per 100 person-years (95% confidence interval 0. 9-3.8) and was similar to the HIV incidence. The incidence of GBV-C/HGV infection was significantly higher in those reporting unprotected anal intercourse (3.6 per 100 person-years compared to 0 in the group without such sexual contacts). The occurrence of E2 antibodies was strongly associated with GBV-C/HGV RNA clearance. A loss of E2 antibodies was observed at a rate of 1.5 per 100 person-years. It was higher among HIV-infected individuals. Chronic GBV-C/HGV infection was not associated with clinical or biochemical evidence of liver disease.

journal_name

J Med Virol

authors

Stark K,Doering CD,Bienzle U,Pauli G,Hamouda O,Engel AM,Schreier E

doi

10.1002/(sici)1096-9071(199911)59:3<303::aid-jmv7>

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

303-6

issue

3

eissn

0146-6615

issn

1096-9071

pii

10.1002/(SICI)1096-9071(199911)59:3<303::AID-JMV7>

journal_volume

59

pub_type

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