Abstract:
:The risk and clearance of GB virus type C (GBV-C)/hepatitis G virus (HGV) infection was investigated in a cohort of homosexual men (n=180; median follow-up time, 7 years). The interaction between GBV-C/HGV RNA and antibodies against the E2 region of the virus, and the clinical impact of chronic GBV-C/HGV infection were studied. GBV-C/HGV RNA was detected by RT-PCR, and E2 antibodies were assessed by an immunoassay. At baseline, 63% of the participants had evidence of previous or current GBV-C/HGV infection. The GBV-C/HGV incidence rate was 2 per 100 person-years (95% confidence interval 0. 9-3.8) and was similar to the HIV incidence. The incidence of GBV-C/HGV infection was significantly higher in those reporting unprotected anal intercourse (3.6 per 100 person-years compared to 0 in the group without such sexual contacts). The occurrence of E2 antibodies was strongly associated with GBV-C/HGV RNA clearance. A loss of E2 antibodies was observed at a rate of 1.5 per 100 person-years. It was higher among HIV-infected individuals. Chronic GBV-C/HGV infection was not associated with clinical or biochemical evidence of liver disease.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Stark K,Doering CD,Bienzle U,Pauli G,Hamouda O,Engel AM,Schreier Edoi
10.1002/(sici)1096-9071(199911)59:3<303::aid-jmv7>keywords:
subject
Has Abstractpub_date
1999-11-01 00:00:00pages
303-6issue
3eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(199911)59:3<303::AID-JMV7>journal_volume
59pub_type
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