Cytomegalovirus infection and atherosclerosis risk: A meta-analysis.

Abstract:

:Human cytomegalovirus (HCMV) infection is an important risk factor for atherosclerosis (AS). Numerous studies have been conducted to analyze the association between HCMV infection and risk of AS, but no clear consensus has been reached. So the objective of this paper was aimed to demonstrate the relationship between HCMV and AS by doing a meta-analysis. Relative literature was searched through the electronic databases PubMed, Embase, and CNKI. Data were accurately assessed and analyzed independently by two investigators. Ultimately, the 30 studies, involving 3328 cases and 2090 controls were included in our meta-analysis. The positive ratio of HCMV IgG, IgM, DNA and pp65 were, respectively, 63.26% (923/1459), 25.46% (69/271), 33.69% (381/1131), and 50.32% (158/314) in case patients. Meanwhile the positive ratio of HCMV IgG, IgM, DNA, and pp65 were, respectively, 52.12% (541/1038), 1.55% (3/194), 13.72% (79/576), and 12.26% (28/229) in control subjects. The positive ratio of HCMV infection was higher in atherosclerosis group than that in non-atherosclerosis group. Especially in Asian group, calculated odds ratios for the presence of HCMV infection in IgG-based HCMV tests, IgM-based tests, PCR-based tests, and pp65-based tests, expressed as OR (95% confidence intervals, 95%CI), were 3.07(95%CI 2.09-4.51), 8.92(95%CI 3.17-25.11), 6.75 (95%CI 3.50-13.02), and 5.72(95%CI 1.51-21.58), respectively. The meta-analysis results showed that HCMV infection is significant connected with an increased risk for AS.

journal_name

J Med Virol

authors

Jia YJ,Liu J,Han FF,Wan ZR,Gong LL,Liu H,Zhang W,Wardell T,Lv YL,Liu LH

doi

10.1002/jmv.24858

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

2196-2206

issue

12

eissn

0146-6615

issn

1096-9071

journal_volume

89

pub_type

杂志文章,meta分析
  • Persistence of high-risk human papillomavirus infection in a population-based cohort of Danish women.

    abstract::Persisting human papillomavirus (HPV) infection is a critical step in cervical carcinogenesis. This study was conducted to determine the type-specific HPV persistence and risk factors for persistence of high-risk HPV infections in a large cohort of Danish women. The study was based on a population-based prospective co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21750

    authors: Nielsen A,Kjaer SK,Munk C,Osler M,Iftner T

    更新日期:2010-04-01 00:00:00

  • Diagnosis and quantitative evaluation of parvovirus B19 infections by real-time PCR in the clinical laboratory.

    abstract::A real-time PCR assay was developed for quantitative detection of B19 DNA in clinical serum samples. The assay was carried out using a LightCycler instrument and product formation was monitored continuously with the fluorescent double-stranded DNA binding dye SYBR Green I. With an optimized PCR protocol, this system w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2218

    authors: Manaresi E,Gallinella G,Zuffi E,Bonvicini F,Zerbini M,Musiani M

    更新日期:2002-06-01 00:00:00

  • Interleukin-28B polymorphisms and interferon gamma inducible protein-10 serum levels in seronegative occult hepatitis C virus infection.

    abstract::Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24322

    authors: Bartolomé J,Castillo I,Quiroga JA,Carreño V

    更新日期:2016-02-01 00:00:00

  • Tumor necrosis factor-alpha and interferon-gamma inhibit synergistically viral replication in hepatitis B virus-replicating cells.

    abstract::The effects of tumor necrosis factor-alpha and/or interferon-gamma on the replication of hepatitis B virus were examined using HB611 cells. These cells were derived from human hepatoblastoma cells, Huh6, by integrating hepatitis B virus DNA, and produce hepatitis B virus continuously. Each of the cytokines inhibited h...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470314

    authors: Kawanishi Y,Hayashi N,Katayama K,Ueda K,Takehara T,Miyoshi E,Mita E,Kasahara A,Fusamoto H,Kamada T

    更新日期:1995-11-01 00:00:00

  • Paper-based point-of-care testing for cost-effective diagnosis of acute flavivirus infections.

    abstract::Flavivirus infections are a serious healthcare concern in tropical and subtropical countries. Although well-established laboratory tests can provide early diagnosis of acute dengue or Zika infections, access to these tests is limited in developing countries, presenting an urgent need to develop simple, rapid, and robu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24806

    authors: Bedin F,Boulet L,Voilin E,Theillet G,Rubens A,Rozand C

    更新日期:2017-09-01 00:00:00

  • GBV-C viremia and clinical events in advanced HIV infection.

    abstract::GB Virus C (GBV-C) is a non-pathogenic flavivirus, commonly found in HIV infected patients. Studies suggest a survival benefit of GBV-C viremia in HIV infection. Impact of GBV-C viremia was evaluated on clinical outcome in multidrug-resistant HIV. The OPTIMA study enrolled advanced multidrug-resistant HIV patients wit...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/jmv.23845

    authors: Sahni H,Kirkwood K,Kyriakides TC,Stapleton J,Brown ST,Holodniy M,OPTIMA Study Team.

    更新日期:2014-03-01 00:00:00

  • Presence of hepatitis B and C viral genomes in US blood donors as detected by polymerase chain reaction amplification.

    abstract::Hepatitis C virus (HCV) represents a major cause of posttransfusion hepatitis worldwide. Posttransfusion hepatitis associated with hepatitis B virus (HBV) continues to occur. HBsAg-negative donor sera from the Rhode Island Blood Center between 1987 and 1988 were screened using more sensitive techniques to assess the p...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420210

    authors: Liang TJ,Bodenheimer HC Jr,Yankee R,Brown NV,Chang K,Huang J,Wands JR

    更新日期:1994-02-01 00:00:00

  • Seroepidemiological investigation of patients and family contacts in an epidemic of hepatitis A.

    abstract::Serial blood and faecal samples were collected from patients and family contacts during an outbreak of hepatitis A in a village and tested by a solid-phase competitive type radioimmunoassay for hepatitis A antigen and hepatitis A antibody. The amount and duration of excretion of hepatitis A antigen was correlated with...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890010303

    authors: Frösner GG,Overby LR,Flehmig B,Gerth HJ,Haas H,Decker RH,Ling CM,Zuckerman AJ,Frösner HR

    更新日期:1977-01-01 00:00:00

  • Saliva for diagnosis of SARS-CoV-2: First report from India.

    abstract::There are very few studies in search of an alternate and convenient diagnostic tool which can substitute nasopharyngeal swab (NPS) specimen for detection of SARS-CoV-2. In the study we analyzed, the comparison and agreement between the feasibility of using the saliva in comparison to NPS for diagnosis of SARS-CoV-2. A...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26719

    authors: Bhattacharya D,Parai D,Rout UK,Dash P,Nanda RR,Dash GC,Kanungo S,Palo SK,Giri S,Choudhary HR,Kshatri JS,Turuk J,Mishra BK,Lenka RK,Dash S,Pati S

    更新日期:2020-12-09 00:00:00

  • TT virus infection in patients with chronic hepatitis B or C: influence on clinical, histological and virological features.

    abstract::Concomitant infection with TT virus and hepatitis B virus (HBV) or hepatitis C virus (HCV) is common. However, the effect of TTV infection on chronic hepatitis B or C is unknown. The prevalence of TTV infection, the effect of TTV infection on the clinical, histological and virological features of patients with chronic...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200004)60:4<387::aid-jmv4>

    authors: Kao JH,Chen W,Chen PJ,Lai MY,Chen DS

    更新日期:2000-04-01 00:00:00

  • Prevalence of high risk genital papillomaviruses in the Belgian female population determined by fast multiplex polymerase chain reaction.

    abstract::Because in situ/filter hybridisation is not sensitive enough and because classical polymerase chain reaction (PCR) protocols are generally not sufficiently reproducible and specific, there is little accurate information on the prevalence of human papillomaviruses (HPV) 16, 18, and 33 infections in women without dyskar...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890360409

    authors: Vandenvelde C,Scheen R,Van Pachterbeke C,Loriaux C,Decelle J,Hubert T,Delhaye C,Cattoor JP,Duys M,Van Beers D

    更新日期:1992-04-01 00:00:00

  • Fulminant demyelinating encephalomyelitis associated with productive HHV-6 infection in an immunocompetent adult.

    abstract::Human herpesvirus 6 (HHV-6), the etiologic agent of roseola in young children, has been reported to be detectable in the brain of many neurologically normal adults, although regional localization to plaques of multiple sclerosis has also been demonstrated. Large amounts of this virus were present in multifocal demyeli...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199707)52:3<301::aid-jmv11

    authors: Novoa LJ,Nagra RM,Nakawatase T,Edwards-Lee T,Tourtellotte WW,Cornford ME

    更新日期:1997-07-01 00:00:00

  • Effect of antiviral therapy on the immunohistochemical expression of bcl-xL and bax protein in patients with HBeAg-negative chronic hepatitis B.

    abstract::The effect of antiviral treatment on apoptosis in chronic hepatitis B (CHB) has not been clarified. We evaluated the hepatic immunohistochemical expression of the pro-apoptotic bax and the antiapoptotic bcl-xL protein in HBeAg-negative CHB patients before and after treatment. In our study we included 72 paired biopsie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21780

    authors: Cholongitas E,Papatheodoridis GV,Manesis EK,Petraki K,Tiniakos D,Hadziyannis SJ

    更新日期:2011-07-01 00:00:00

  • Influenza A virus in Taiwan, 1980-2006: Phylogenetic and antigenic characteristics of the hemagglutinin gene.

    abstract::Limited amount of information is available in Taiwan on the genetic or antigenic characteristics of influenza A virus prior to the establishment of a Taiwan surveillance network in 2000. Isolates of H1N1 and H3N2 viruses in Taiwan between 1980 and 2006 were studied, and part of the hemagglutinin gene was analyzed due ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21531

    authors: Wang SF,Lee YM,Chan YJ,Liu HF,Yen YF,Liu WT,Huang JC,Chen YM

    更新日期:2009-08-01 00:00:00

  • Pet veterinarians have no increased risk of hepatitis E compared to the general population.

    abstract::The discovery of autochthonous hepatitis E in industrialized countries associated to genotype 3 has changed substantially the understanding about hepatitis E virus (HEV) circulation. In these countries transmission has been associated to the consumption and direct contact to swine, a well-known reservoir for HEV. More...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23927

    authors: Mesquita JR,Valente-Gomes G,Conceição-Neto N,Nascimento MS

    更新日期:2014-06-01 00:00:00

  • Significant impact of non-B HIV-1 variants genetic diversity in Gabon on plasma HIV-1 RNA quantitation.

    abstract::Evaluations of HIV-1 RNA viral load assays are lacking in Central Africa. The main objective of our study was to assess the reliability of HIV-1 RNA results obtained with three different assays for samples collected in Gabon. A total of 137 plasma specimens were assessed for HIV-1 RNA using the Abbott RealTime HIV-1® ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23770

    authors: Mouinga-Ondémé A,Mabika-Mabika A,Alalade P,Mongo AD,Sica J,Liégeois F,Rouet F

    更新日期:2014-01-01 00:00:00

  • A chemiluminescent, magnetic particle-based immunoassay for the detection of hepatitis C virus core antigen in human serum or plasma.

    abstract::Hepatitis C virus (HCV) exposure in blood donors is determined serologically by the detection of anti-HCV antibodies in serum or plasma. However, a "window" period of 30-70 days after exposure exists where specific antibodies to HCV antigens are not detected. The use of nucleic acid testing for the detection of HCV RN...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20716

    authors: Leary TP,Gutierrez RA,Muerhoff AS,Birkenmeyer LG,Desai SM,Dawson GJ

    更新日期:2006-11-01 00:00:00

  • Assessing risk of a short-term antiretroviral therapy discontinuation as a read-out of viral control in immune-based therapy.

    abstract::Although analytical treatment interruption is used as a strategy to test immunotherapeutic agents in HIV-infection, it may pose a risk for study participants. The potential risks of short-term interruption of antiretroviral therapy (ART) during treatment with an autologous dendritic cell immune-based therapy (AGS-004-...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jmv.23297

    authors: Routy JP,Boulassel MR,Nicolette CA,Jacobson JM

    更新日期:2012-06-01 00:00:00

  • Norovirus infections and seroprevalence of genotype GII.4-specific antibodies in a Spanish population.

    abstract::Genotype II.4 noroviruses (NoVs) are a leading cause of epidemic acute gastroenteritis in children and adults worldwide. The prevalence of different NoV genotypes causing outbreaks and sporadic cases of acute gastroenteritis in the region of Valencia, Spain, during a 4-year period (2008-11) was investigated. NoVs were...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24112

    authors: Carmona-Vicente N,Fernández-Jiménez M,Ribes JM,Téllez-Castillo CJ,Khodayar-Pardo P,Rodríguez-Diaz J,Buesa J

    更新日期:2015-04-01 00:00:00

  • Evidence of intrafamilial transmission of rotavirus in a birth cohort in South India.

    abstract::Transmission of rotavirus infection was studied in a birth cohort of children based in an urban slum in Vellore and their familial contacts. Contemporaneous samples from index patients and their familial contacts were collected for analysis in three different settings. Firstly, samples were collected from familial con...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21263

    authors: Banerjee I,Primrose Gladstone B,Iturriza-Gomara M,Gray JJ,Brown DW,Kang G

    更新日期:2008-10-01 00:00:00

  • Prevalence of HBV genotypes in Central and Eastern Europe.

    abstract::The importance of hepatitis B virus (HBV) genotypes for disease progression and response to interferon-alpha-based treatment is well established. While almost all patients in the Mediterranean area are infected with HBV genotype D, HBV genotype A is dominant in Northern Europe. However, the distribution of HBV genotyp...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究

    doi:10.1002/jmv.21294

    authors: Deterding K,Constantinescu I,Nedelcu FD,Gervain J,Nemecek V,Srtunecky O,Vince A,Grgurevic I,Bielawski KP,Zalewska M,Bock T,Ambrozaitis A,Stanczak J,Takács M,Chulanov V,Slusarczyk J,Drazd'áková M,Wiegand J,Cornberg M,

    更新日期:2008-10-01 00:00:00

  • Nested polymerase chain reaction for detection of human immunodeficiency virus type 1 DNA in clinical specimens.

    abstract::A highly sensitive two-step polymerase chain reaction (PCR) method was evaluated for detection of human immunodeficiency virus type 1 (HIV-1) DNA in clinical specimens. The product resulting from the first amplification reaction is used as the template for the second PCR with an internal (nested) primer pair. Even whe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380304

    authors: Zazzi M,Romano L,Brasini A,Valensin PE

    更新日期:1992-11-01 00:00:00

  • Low-level plasma HIVs in patients on prolonged suppressive highly active antiretroviral therapy are produced mostly by cells other than CD4 T-cells.

    abstract::The cellular source(s) and the clinical significance of persistent low-level viremia, below 50 HIV RNA copies per ml of plasma, achieved in many patients with high adherence to highly active antiretroviral therapy (HAART) remain unclear. Also, it is not clear if residual plasma HIVs during HAART can become predominant...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21366

    authors: Sahu GK,Paar D,Frost SD,Smith MM,Weaver S,Cloyd MW

    更新日期:2009-01-01 00:00:00

  • Infection with human T lymphotropic virus type I in organ transplant donors and recipients in Spain.

    abstract::Human T-cell lymphotropic virus (HTLV) antibody screening is not recommended uniformly before transplantation in Western countries. In the year 2001, the first cases of HTLV-I infection acquired through organ transplantation from one asymptomatic carrier were reported in Europe. All three organ recipients developed a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20331

    authors: Toro C,Benito R,Aguilera A,Bassani S,Rodríguez C,Calderón E,Caballero E,Alvarez P,García J,Rodríguez-Iglesias M,Guelar A,del Romero J,Soriano V,HTLV Spanish Study Group.

    更新日期:2005-06-01 00:00:00

  • DNA of mouse mammary tumor virus-like virus is present in human tumors influenced by hormones.

    abstract::Mouse mammary tumor virus (MMTV) is a hormonally regulated, oncogenic virus of mice. MMTV-like virus DNA has previously been detected in human breast cancers, liver disease, and liver cancers. It is hypothesized that local hormonal effects might be of primary importance in determining MMTV-like virus detection in huma...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21754

    authors: Johal H,Faedo M,Faltas J,Lau A,Mousina R,Cozzi P,Defazio A,Rawlinson WD

    更新日期:2010-05-01 00:00:00

  • Decompensated cirrhosis and liver transplantation negatively impact in DAA treatment response: Real-world experience from HCV-LALREAN cohort.

    abstract:INTRODUCTION:Although the effectiveness of direct-acting antivirals (DAAs) for the treatment of chronic hepatitis C virus (HCV) has been reported in real-world settings, predictive factors of treatment failure are lacking. Therefore, we sought to explore the baseline predictors of treatment response to DAAs. METHODS:T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26383

    authors: Ridruejo E,Piñero F,Mendizabal M,Cheinquer H,Wolff FH,Anders M,Reggiardo V,Ameigeiras B,Palazzo A,Alonso C,Schinoni MI,Zuain MGV,Tanno F,Figueroa S,Santos L,Peralta M,Soza A,Vistarini C,Adrover R,Fernández N,Perez

    更新日期:2020-08-04 00:00:00

  • Antibody-free virion titer greatly differs between hepatitis C virus genotypes.

    abstract::Hepatitis C virus (HCV) virions have been shown to be bound to antibodies in patients with chronic HCV infection. The sera from patients infected with genotype 1b HCV contained more antibody-free virions than those from patients with genotype 2a/2b HCV. When compared at the same levels of serum HCV RNA, free virion ti...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Kimura Y,Hayashida K,Ishibashi H,Niho Y,Yanagi Y

    更新日期:2000-05-01 00:00:00

  • Epidemiological and molecular investigation of norovirus and astrovirus infections in Rio Branco, Acre, Northern Brazil: A retrospective study.

    abstract::Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatia...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25395

    authors: Bitencurt ELR,Siqueira JAM,Medeiros TB,Bandeira RDS,de Souza Oliveira D,de Paula Souza E Guimarães RJ,da Silva Soares L,Macarenhas JDP,Teixeira DM,Silva RSU,Loureiro ECB,de Moraes Silva MC,da Silva LD,Gabbay YB

    更新日期:2019-06-01 00:00:00

  • The correlation of TNF alpha levels with the lipid profile of dengue patients.

    abstract::Immunological factors, such as cytokines, have been proposed as a cause of changes in the lipid profile of dengue patients. We studied whether serum lipid levels and serum TNF-α levels are associated in a group of dengue patients from an endemic region in the Northwest of Mexico. We found statistically important diffe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25056

    authors: Osuna-Ramos JF,Rendón-Aguilar H,Reyes-Ruiz JM,Del Ángel RM,Romero-Utrilla A,Ríos-Burgueño ER,Velarde-Rodriguez I,Velarde-Félix JS

    更新日期:2018-06-01 00:00:00

  • Diversity of viruses associated with acute gastroenteritis in children hospitalized with diarrhea in Ho Chi Minh City, Vietnam.

    abstract::A molecular epidemiological study on common diarrheal viruses was conducted in Ho Chi Minh City, Vietnam between October 2002 and September 2003. Fecal samples were collected from 1,010 hospitalized children with acute gastroenteritis. Those samples were screened for groups A, B, and C rotavirus, adenovirus, genogroup...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20857

    authors: Nguyen TA,Yagyu F,Okame M,Phan TG,Trinh QD,Yan H,Hoang KT,Cao AT,Le Hoang P,Okitsu S,Ushijima H

    更新日期:2007-05-01 00:00:00