Abstract:
:Concomitant infection with TT virus and hepatitis B virus (HBV) or hepatitis C virus (HCV) is common. However, the effect of TTV infection on chronic hepatitis B or C is unknown. The prevalence of TTV infection, the effect of TTV infection on the clinical, histological and virological features of patients with chronic hepatitis B or C, and the influence of TTV infection on the HCV response to interferon alfa therapy were studied. A total of 100 asymptomatic hepatitis B surface antigen carriers, 220 patients with HBV-related chronic liver diseases, and 110 patients with chronic hepatitis C treated with interferon alfa (3 million units subcutaneously three times a week for 24 weeks) were enrolled. Serum HCV RNA and serum TTV DNA were detected by the polymerase chain reaction (PCR). Serum HBV DNA and serum HCV RNA level were quantified by branched DNA assays. Infection with TTV was detected in 21.5% of HBV carriers and 37% of HCV carriers. TTV infection had little effect on the clinicopathological course of chronic HBV infection. In chronic hepatitis C, clinical features, histological severity, serum HCV RNA levels, and the response to interferon alfa therapy did not differ between those with and without TTV infection. The loss of serum TTV DNA did not correlate with the biochemical response as did in the loss of serum HCV RNA. In conclusion, TTV infection is found frequently in patients with chronic hepatitis B or C in Taiwan; however, coinfection with TTV does not affect the clinicopathological course of chronic hepatitis B or C and the response to interferon alfa therapy.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Kao JH,Chen W,Chen PJ,Lai MY,Chen DSdoi
10.1002/(sici)1096-9071(200004)60:4<387::aid-jmv4>keywords:
subject
Has Abstractpub_date
2000-04-01 00:00:00pages
387-92issue
4eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(200004)60:4<387::AID-JMV4>journal_volume
60pub_type
杂志文章abstract::Since outbreaks of severe acute hemorrhagic conjunctivitis occur worldwide [Hierholzer and Hatch, 1985] and the majority of the epidemics are caused by enterovirus 70 (EV-70), we developed an EV-70 IgM ELISA to simplify the diagnosis of these outbreaks. The test is based on the capture antibody technique and the use o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890210404
更新日期:1987-04-01 00:00:00
abstract::The increased incidence of a enterovirus infections observed in patients with type 1 diabetes preceding the development of the clinical disease could be partially explained by variation in the genes coding for enterovirus receptors. We carried out sequence analysis of the most common enterovirus receptor molecules in ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10352
更新日期:2003-05-01 00:00:00
abstract::Co-infection with hepatitis delta virus (HDV) and hepatitis B virus (HBV) has been shown to be associated with a more severe form of acute and chronic hepatitis. Cloning and expression of recombinant HDV antigen (rHDAg) in Escherichiacoli are described. Using purified rHDAg, a cost-effective indirect anti-HDV enzyme-l...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23212
更新日期:2012-03-01 00:00:00
abstract::Human parainfluenza virus 3 (HPIV-3) is a leading cause of respiratory disease in children worldwide. Previous sequence analyses of the entire virus genome, among different HPIV-3 strains, demonstrated that HN is the most variable gene. There is a dearth of data on HPIV-3 strains circulating in Saudi Arabia. In this r...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23326
更新日期:2012-08-01 00:00:00
abstract::GB virus C/hepatitis G virus (GBV-C/HGV) RNA was detected by reverse transcription-polymer- ase chain reaction with primers derived from the nonstructural region 3 (NS3) in 9 (4.1%) of 221 blood donors and 2 of 20 (10%) hemophilia patients in Martinique, French West Indies. Anti-E2 antibodies were found in sera from 3...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::Hepatitis C Virus (HCV) NS3 protease is an attractive target for antiviral agent development because it is required for viral replication. Because a stable cell culture system or small animal model to study HCV replication is not readily available, we constructed an in vitro model allowing the investigation of NS3 tra...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2089
更新日期:2001-12-01 00:00:00
abstract::Hepatitis E virus (HEV) infection is considered a neglected disease of major concern in developed countries. Clinically, HEV occurs as an acute and self-limited disease, though chronic cases mostly associated to HEV-3 are now being commonly reported in immunocompromised individuals and solid organ transplant recipient...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26231
更新日期:2020-06-27 00:00:00
abstract::human diploid fibroblasts and human primary liver cell carcinoma cells (PLC/PRF/5) were infected with hepatitis A virus (HAV) adapted to growth in cell culture or derived directly from human stool. Viral antigen was expressed in PLC/PRF/5 cells 28 days after infection with cell culture-adapted HAV, and 50 days after i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890070308
更新日期:1981-01-01 00:00:00
abstract::Human papillomavirus (HPV) is known to be the cause of almost all cervical cancers. The genotypes have been classified into high and low risk types according to their oncogenic potential. However, data for many of the genotypes are limited and some (HPV-26, 53, and 66) have no agreed status. A study was undertaken to ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20330
更新日期:2005-05-01 00:00:00
abstract::Immunological factors, such as cytokines, have been proposed as a cause of changes in the lipid profile of dengue patients. We studied whether serum lipid levels and serum TNF-α levels are associated in a group of dengue patients from an endemic region in the Northwest of Mexico. We found statistically important diffe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25056
更新日期:2018-06-01 00:00:00
abstract::The incidence of noroviral gastroenteritis has increased dramatically in recent years, and norovirus (NoV) genogroup II.4 (GII.4) is associated with outbreaks worldwide. The NoV genotypes and their clinical relevance in children hospitalized with acute gastroenteritis between 2006 and 2011 in northern Taiwan were eval...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23728
更新日期:2014-02-01 00:00:00
abstract::The genotypic inhibitory quotient (GIQ) is the ratio between drug concentration and the number of resistance mutations. However, as different resistance scores can be calculated for the same protease inhibitor, the ability of a GIQ to predict the virological outcome may vary depending on the resistance score used as t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20736
更新日期:2006-12-01 00:00:00
abstract::A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean+/-standard deviation age, 48.4+/-13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20363
更新日期:2005-07-01 00:00:00
abstract::BK virus (BKV) establishes a persistent, asymptomatic infection in more than 80% of the human population, and in immunocompromised individuals BKV causes acute urinary tract infections. Two forms of BKV, archetype and rearranged, have been recovered previously from urine samples. The rearranged form is believed to hav...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:2000-03-01 00:00:00
abstract::Human herpesvirus 6 (HHV6) is a beta-herpesvirus capable of infecting several cell types from different origins. HHV6 is the etiological agent of exantem subitum and has been associated with several diseases, all characterized by an inflammatory response triggered by chemokines. We show that strain U1102 of HHV6 is ab...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10416
更新日期:2003-07-01 00:00:00
abstract::There are limited reports on the etiology of multiple enteric viruses causing acute gastroenteritis (AGE) in North India. In the present study we have determined the prevalence of three enteric viruses, namely rotavirus, astrovirus (AstV) and adenovirus (AdV) in a total of 312 diarrheic children (<5 years) hospitalize...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25645
更新日期:2020-08-01 00:00:00
abstract::Infection with the human papillomavirus (HPV) is responsible for 99.7% of cervical cancers, the second most prevalent neoplasia in women worldwide and the fifth leading cause of death by cancer in this population. In Chile, the incidence rate is 14.4 cases per 100,000 women per year and it is considered a significant ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22057
更新日期:2011-05-01 00:00:00
abstract::The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) began in December 2019 and was basically under control in April 2020 in Wuhan. To explore the impact of intervention measures on the COVID-19 epidemic, we established susceptible-exposed-infectious-r...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26781
更新日期:2021-01-07 00:00:00
abstract::The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointestinal tract. In this study the ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21153
更新日期:2008-06-01 00:00:00
abstract::This is a case study of a child who developed roseola infantum first, then varicella, and was later affected by acute cerebellar syndrome, severe truncal ataxia, and myoclonic dystonia. Human herpesvirus 6 (HHV-6) A and B were detected in the cerebrospinal fluid (CSF) and peripheral blood, respectively, upon ataxia on...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20285
更新日期:2005-03-01 00:00:00
abstract::In vitro incubation of human cytomegalovirus (Towne strain) with 8 U/ml human recombinant myeloperoxidase plus sodium chloride and glucose nearly abolished viral infectivity. To assay the effect on intracellular infection, cell toxicity of the enzymes was first studied. Even the high dose of 16 U/ml of recombinant mye...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::A pathogenic role of precore-defective mutation in the onset of fulminant hepatitis B has been suggested. However, precore-defective mutants do not always cause fulminant hepatitis B and are not always isolated from affected patients. These findings strongly suggest the presence of some additional important mutations ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470304
更新日期:1995-11-01 00:00:00
abstract::DNA samples from recurrent condylomata acuminata biopsies of Greek males and females were examined for the presence of human papillomavirus (HPV) DNA using high-stringency Southern blot hybridization analysis. Of the twenty-six biopsies, 25 were positive for the HPV 6/11-related DNA sequences, and when further analyze...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420311
更新日期:1994-03-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. Here, we stratified COVID-19 patients based on their comorbidities to assess their risk of serious adverse outcomes. We collected 856 hospitalized cases diagnosed with COVID-19 from 17 January to 7 February 2020, in Zhejiang Prov...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26183
更新日期:2020-11-01 00:00:00
abstract:BACKGROUND AND AIM:A meta-analysis was performed to identify COVID-19 patients presenting with gastrointestinal (GI) symptoms during the first and second pandemic waves and investigate their association with the disease outcomes. METHODS:A systematic search in PubMed, Scopus, Web of Science, ScienceDirect, and EMBASE ...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.26836
更新日期:2021-02-02 00:00:00
abstract::We developed approaches using antisense RNA to inhibit hepatitis C virus (HCV) RNA translation and HCV core protein expression. An HCV genotype 1b cDNA comprising nt 1-1321 or a fusion construct consisting of HCV (nt 1-584) and luciferase cDNAs were inserted downstream of T7 and CMV promoter sequences and used to gene...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1999-03-01 00:00:00
abstract::Hepatitis B virus (HBV) e antigen (HBeAg) seroconversion during chronic HBV infection is known to play an important role in disease progression and patient response to antiviral agents. The aim of the present study was to analyze gender disparity in distribution of major hydrophilic region (MHR) variants according to ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21988
更新日期:2011-03-01 00:00:00
abstract::It is well documented that perinatal transmission is the major cause of chronic HBV infection in China. However, the mechanisms of HBV perinatal transmission are not defined clearly. It is not known whether hepatitis B e antigen can cross the human placenta, and the rate of HBeAg decay in babies with and without HBV b...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10493
更新日期:2003-11-01 00:00:00
abstract::Lymphocytic choriomeningitis virus (LCMV), which is one of several arenaviruses that are pathogenic for humans, causes encephalitis and meningitis in man. In this study, single-stage and nested reverse transcription-polymerase chain reaction (RT-PCR) assays were developed that targeted the GPC and N genes of LCMV. Bot...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-02-01 00:00:00
abstract::The current Agence Nationale de Recherche sur le SIDA (ANRS)/International AIDS Society (IAS) algorithm predicts resistance to etravirine for viruses harboring >/=3 mutations from a list of 13 reverse transcriptase (RT) mutations. Two weighted algorithms, best correlated with fold changes to etravirine, have been desc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21461
更新日期:2009-04-01 00:00:00