Probable implication of mutations of the X open reading frame in the onset of fulminant hepatitis B.

Abstract:

:A pathogenic role of precore-defective mutation in the onset of fulminant hepatitis B has been suggested. However, precore-defective mutants do not always cause fulminant hepatitis B and are not always isolated from affected patients. These findings strongly suggest the presence of some additional important mutations outside the precore region in fulminant hepatitis. In the present investigation an attempt was made to sequence the X open reading frame of hepatitis B virus DNA isolated from seven patients with fulminant hepatitis B and five patients with acute hepatitis B. The latter were used as controls. Since the X open reading frame encodes the X protein and contains the core promoter/enhancer II complex, some critical mutations may enhance or disrupt the replication and expression of hepatitis B virus DNA leading to fulminant hepatitis. A C-to-T substitution was found at nucleotide (nt) 1655, an A-to-T substitution at nt 1764 and a G-to-A substitution at nt 1766 in 4, 5 and 5 patients, respectively, out of the seven with fulminant hepatitis. These substitutions were not recognized in the patients with acute hepatitis. These mutations might change the function of the X protein and core promoter/enhancer II complex. It is suggested, therefore, that these mutations, as well as the precore-defective mutation, may play an important role in the pathogenesis of fulminant hepatitis.

journal_name

J Med Virol

authors

Kaneko M,Uchida T,Moriyama M,Arakawa Y,Shikata T,Gotoh K,Mima S

doi

10.1002/jmv.1890470304

subject

Has Abstract

pub_date

1995-11-01 00:00:00

pages

204-8

issue

3

eissn

0146-6615

issn

1096-9071

journal_volume

47

pub_type

杂志文章
  • Relative frequency of human rotavirus VP4 (P) genotypes recovered over a ten-year period from South African children with diarrhea.

    abstract::The relative frequency and distribution of the VP4 (P) genotypes of 227 human rotavirus field strains were investigated in South Africa. The stool samples were collected between 1984-1993 from infants and young children with diarrhea at Ga-Rankuwa Hospital, Pretoria, South Africa. The RNA was extracted from stools, he...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470102

    authors: Mphahlele MJ,Steele AD

    更新日期:1995-09-01 00:00:00

  • Genetic analysis of hepatitis A virus variants circulating among children presenting with acute diarrhea in Cameroon.

    abstract::Molecular investigation was undertaken of circulating hepatitis A virus (HAV) associated with cases of acute diarrhea among children under 5 years of age in Kumba-Cameroon. Reverse transcription PCR, sequencing, and phylogenetic analysis of a 371 bp segment of the VP1/P2A junction of six isolates obtained from stool s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23266

    authors: Forbi JC,Agwale SM,Ndip LM,Esona MD

    更新日期:2012-05-01 00:00:00

  • A novel real-time PCR system for simultaneous detection of human viruses in clinical samples from patients with uncertain diagnoses.

    abstract::A novel simultaneous detection system for human viruses was developed using a real-time polymerase chain reaction (PCR) system to identify causes of infection in clinical samples from patients with uncertain diagnoses. This system, designated as the "multivirus real-time PCR," has the potential to detect 163 human vir...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21962

    authors: Katano H,Kano M,Nakamura T,Kanno T,Asanuma H,Sata T

    更新日期:2011-02-01 00:00:00

  • Molecular epidemiology of human bocavirus infection in hospitalized children with acute gastroenteritis in South Africa, 2009-2015.

    abstract::Human bocavirus (HBoV) is known to be associated with a variety of clinical manifestation including acute gastroenteritis (AGE). Despite their global prevalence, no data is available on the epidemiology of HBoV associated with AGE in South Africa (SA). Between April 2009 and April 2015, 3765 stool specimens were colle...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25634

    authors: Netshikweta R,Chidamba L,Nadan S,Taylor MB,Page NA

    更新日期:2020-08-01 00:00:00

  • Human papillomavirus and mutated H-ras oncogene in cervical carcinomas and pathological negative pelvic lymph nodes: a retrospective follow-up.

    abstract::The metastasis status of pelvic lymph nodes (PLNs) seems to be a predictive factor of survival. It was suggested that the presence of HPV DNA and other biological markers in PLN may indicate a sub clinical early metastasis. The aim was to describe the prevalence and distribution patterns of HPV DNA and H-ras mutations...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21076

    authors: Landro ME,Dalbert D,Picconi MA,Cúneo N,González J,Vornetti S,Bazán G,Mural J,Basiletti J,Teyssié AR,Alonio LV

    更新日期:2008-04-01 00:00:00

  • Experimental infection of nonenveloped DNA virus (TTV) in rhesus monkey.

    abstract::Virus fragments homologous to TTV were detected previously from an enterically transmitted outbreak of non-A-E hepatitis [Luo et al., 1999]. To test the susceptibility of the Rhesus monkey to this virus and to establish its transmission routes, 6 Rhesus monkeys were inoculated, 3 orally and another 3 intravenously. Th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200005)61:1<159::aid-jmv26

    authors: Luo K,Liang W,He H,Yang S,Wang Y,Xiao H,Liu D,Zhang L

    更新日期:2000-05-01 00:00:00

  • Rapid detection of varicella-zoster virus in clinical specimens using monoclonal antibodies on shell vials and smears.

    abstract::Monoclonal antibodies were used for detecting varicella-zoster virus (VZV) by immunofluorescence (IF) in clinical specimens inoculated on shell vial cultures. Vesicles of 74 patients with varicella or herpes zoster-like eruptions were tested by this method and by conventional cell culture. Further diagnostic tests wer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890280102

    authors: Schirm J,Meulenberg JJ,Pastoor GW,van Voorst Vader PC,Schröder FP

    更新日期:1989-05-01 00:00:00

  • Prevalence of HBV, HDV, HCV, and HIV infection during pregnancy in northern Benin.

    abstract::Pregnant women are not screened for HBsAg and anti-HCV antibodies in many African countries. As there are few data concerning the prevalence of HBV, HDV, and HCV serological markers in Benin, the aim of this study was to evaluate their 2011 prevalence in pregnant women undergoing HIV screening in a rural area of north...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23951

    authors: De Paschale M,Ceriani C,Cerulli T,Cagnin D,Cavallari S,Ndayaké J,Zaongo D,Priuli G,Viganò P,Clerici P

    更新日期:2014-08-01 00:00:00

  • Convalescent plasma transfusion for the treatment of COVID-19: Systematic review.

    abstract::The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. To our knowledge, this is the f...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25961

    authors: Rajendran K,Krishnasamy N,Rangarajan J,Rathinam J,Natarajan M,Ramachandran A

    更新日期:2020-09-01 00:00:00

  • Prevalence of the mutational pattern E44D/A and/or V118I in the reverse transcriptase (RT) gene of HIV-1 in relation to treatment with nucleoside analogue RT inhibitors.

    abstract::It has been reported that a new pattern of mutations, E44D/A and/or V118I, in the reverse transcriptase (RT) gene of HIV-1 confers a moderate level of resistance to lamivudine in the absence of the M184V mutation. The prevalence of this mutational pattern was studied in HIV-1 isolates obtained from 280 patients. These...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2145

    authors: Montes B,Segondy M

    更新日期:2002-03-01 00:00:00

  • Acute retinal necrosis six years after herpes simplex encephalitis: an elusive immune deficit suggested by insufficient test sensitivity.

    abstract::A patient presented with acute retinal necrosis of the left eye. Demonstration of herpes simplex virus (HSV) DNA in the aqueous humour confirmed the diagnosis. Negative results of HSV type-specific antibody tests based on gG antigens suggested a primary HSV infection. However, the patient had a past history of laborat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20083

    authors: Preiser W,Doerr HW,Buxbaum S,Rabenau HF,Baatz H

    更新日期:2004-06-01 00:00:00

  • Study of influenza C virus infection in France.

    abstract::From November 2004 to April 2007, specimens were obtained from 2,281 patients with acute respiratory tract illness in Normandy, France. Eighteen strains of influenza C virus were detected in these samples using a combined tissue culture/RT-PCR diagnostic method. Most patients with influenza C virus infection (13/18) w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21218

    authors: Gouarin S,Vabret A,Dina J,Petitjean J,Brouard J,Cuvillon-Nimal D,Freymuth F

    更新日期:2008-08-01 00:00:00

  • Virus-induced autoimmunity in hepatitis C virus infections: a rare event.

    abstract::Serial serum samples from 16 Italian patients presenting with acute hepatitis C virus (HCV) infections (which progressed to chronic hepatitis in six) were screened for the non-organ-specific autoantibodies most frequently associated with autoimmune hepatitis (AIH), as well as for antibodies against the hepatic asialog...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890420113

    authors: McFarlane BM,Bridger C,Tibbs CJ,Saleh MG,Fuzio A,Verucchi G,Attard L,Boschi A,Chiodo F,McFarlane IG

    更新日期:1994-01-01 00:00:00

  • Eastern region represents a worrying cluster of active hepatitis C in Algeria in 2012.

    abstract::Algeria is the largest country of Africa, peopled with populations living a range of traditional/rural and modern/urban lifestyles. The variations of prevalence of chronic active hepatitis care poorly known on the Algerian territory. We conducted a retrospective survey on all patients (n = 998) referred to our institu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24491

    authors: Bensalem A,Selmani K,Hihi N,Bencherifa N,Mostefaoui F,Kerioui C,Pineau P,Debzi N,Berkane S

    更新日期:2016-08-01 00:00:00

  • Genetic variants in IFIH1 and DDX58 influence hepatitis C virus clearance in Chinese Han population.

    abstract:AIMS:To investigate the association between two RIG-I-like receptor gene polymorphisms and hepatitis C virus (HCV) infection in Chinese Han population. METHODS:The current study genotyped two selected SNPs (IFIH1 rs3747517 and DDX58 rs9695310) using TaqMan allelic discrimination assay to assess their association with ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25398

    authors: Zhu XB,Zhuo LY,Yue M,Liu M,Zang F,Fan HZ,Wu JJ,Xia XS,Zhang AM,Yu RB,Huang P

    更新日期:2019-06-01 00:00:00

  • Treatment of junin virus-infected guinea pigs with immune serum: development of late neurological disease.

    abstract::Guinea pigs infected with Argentine hemorrhagic fever virus (Junin) were treated with pooled, homologous convalescent sera. Use of 15,000 or 5,000 therapeutic units of immune sera prevented all signs of illness when administered within 24 hr of infection. We could also prevent illness and death in infected guinea pigs...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200303

    authors: Kenyon RH,Green DE,Eddy GA,Peters CJ

    更新日期:1986-11-01 00:00:00

  • Serum thrombospondin-1 is altered in patients with hemorrhagic fever with renal syndrome.

    abstract::Hemorrhagic fever with renal syndrome (HFRS) is a severe acute viral disease with pathological changes of impaired capillary and small vessels and thrombocytopenia. In this study, serum thrombospondin (TSP)-1 concentration in patients with HFRS was determined to explore its possible role in the pathogenesis of HFRS. T...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21270

    authors: Liu Z,Zhao Q,Han Q,Gao M,Zhang N

    更新日期:2008-10-01 00:00:00

  • Molecular characterization of human respiratory syncytial virus subtype B: a novel genotype of subtype B circulating in China.

    abstract::Human respiratory syncytial virus (HRSV) is major pathogen of lower respiratory tract infections in infants and young children worldwide. There have been many studies regarding HRSV subgroup A (HRSV-A) G protein genetic variability but little information about HRSV subtype B (HRSV-B) G protein genetic diversity and mo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23960

    authors: Ren L,Xiao Q,Zhou L,Xia Q,Liu E

    更新日期:2015-01-01 00:00:00

  • Analysis of strain variation of R1 repeated structure in varicella-zoster virus DNA by polymerase chain reaction.

    abstract::The tandem direct reiteration R1 in the varicella-zoster virus genome consists of two elements: units composed of 18 bp and those having 15 bp, both of whose numbers and types of combination patterns vary among strains. The variations of the R1 structure were examined in order to differentiate between the wild strains...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Yoshida M,Tamura T,Hiruma M

    更新日期:1999-05-01 00:00:00

  • Fraction-specific populations of the hypervariable region of the hepatitis C virus in a patient with cryoglobulinemia.

    abstract::Nucleotide sequences of the hypervariable region (HVR) of the E2/NS1 gene of hepatitis C virus (HCV), which are now thought to contain epitopes for neutralizing antibodies, were compared between antibody-bound HCV and free HCV in a patient with type II cryoglobulinemia. Antibody-bound HCV was immunoprecipitated with a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460418

    authors: Kurosaki M,Enomoto N,Nouchi T,Sakuma I,Marumo F,Sato C

    更新日期:1995-08-01 00:00:00

  • The role of DCs in the immunopathogenesis of chronic HBV infection and the methods of inducing DCs maturation.

    abstract::Chronic hepatitis B virus (HBV) infection is the result of an inadequate immune response towards the virus. Dendritic cells (DCs), as the most efficient professional antigen-presenting cells (APCs), possess the strongest antigen presenting the effect in the body and can stimulate the initial T cell activation and prol...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.24306

    authors: Sun HH,Zhou DF,Zhou JY

    更新日期:2016-01-01 00:00:00

  • Efficacy of interferon-based antiviral therapy in patients with chronic hepatitis C infected with genotype 5: a meta-analysis of two large prospective clinical trials.

    abstract::The characteristics and response rate to pegylated interferon and ribavirin (PEG-INF + RBV) of patients with chronic hepatitis C infected with genotype 5 are poorly documented. A meta-analysis of two large phase III/IV prospective randomized clinical trials conducted in Belgium in patients with chronic hepatitis C (n ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,meta分析

    doi:10.1002/jmv.22049

    authors: D'Heygere F,George C,Van Vlierberghe H,Decaestecker J,Nakad A,Adler M,Delwaide J,Laureys A,Nevens F

    更新日期:2011-05-01 00:00:00

  • Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy.

    abstract::The prevention of mother to child transmission of HIV-1 by zidovudine monotherapy is well known, but increasingly combination anti-retroviral therapy is prescribed during pregnancy. In this prospective study, 19 pregnant women with human immunodeficiency virus-1 (HIV-1) infection who elected to take anti-retroviral th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199911)59:3<364::aid-jmv17

    authors: Clarke JR,Braganza R,Mirza A,Stainsby C,Ait-Khaled M,Wright A,Lyall H,Parker D,McClure MO,Weber JN,Taylor GP

    更新日期:1999-11-01 00:00:00

  • Monoclonal antibody recognizing pre-S(2) epitope of hepatitis B virus: characterization of pre-S(2) epitope and anti-pre-S(2) antibody.

    abstract::A hybrid cell line producing monoclonal antibodies recognizing an epitope encoded by the pre-(S)2 region of hepatitis B virus (HBV) genome was obtained by fusion of mouse myeloma cells with lymphocytes from mice immunized with HBV. The monoclonal antibody Mo-F124 secreted from the hybrid line reacted with the pre-S(2)...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200204

    authors: Budkowska A,Riottot MM,Dubreuil P,Lazizi Y,Brechot C,Sobczak E,Petit MA,Pillot J

    更新日期:1986-10-01 00:00:00

  • Prevalence and quantitation of adenovirus DNA from human tonsil and adenoid tissues.

    abstract::In this study, real-time PCR was used to quantify adenovirus DNA in cell suspensions prepared from 106 right and left tonsils and 10 adenoids obtained from 57 patients who underwent routine tonsillectomies and/or adenoidectomies. Eighty-four (72.4%) tonsils and adenoids samples were positive for HAdV by real-time PCR....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23678

    authors: Alkhalaf MA,Guiver M,Cooper RJ

    更新日期:2013-11-01 00:00:00

  • Detection and characterisation of bisegmented double-stranded RNA viruses (picobirnaviruses) in human faecal specimens.

    abstract::The prevalence of picobirnaviruses (PBVs) in human stools was investigated by polyacrylamide gel electrophoresis (PAGE) analysis of 832 faecal specimens collected between 1982 and 1993 from patients in various clinical groups. Similar prevalences (9-13%) were detected in patients with or without gastroenteritis and th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890450204

    authors: Gallimore CI,Appleton H,Lewis D,Green J,Brown DW

    更新日期:1995-02-01 00:00:00

  • HIV-1 variability and progression to AIDS: a longitudinal study.

    abstract::HIV-1 replicative activity and its relation to the clinical and immunological evolution of infection was studied in a group of 150 HIV-1 seropositive Italian i.v. drug abusers over a 1 year period. HIV-1 was isolated from 90 (60%) subjects; two groups of isolates were distinguished, according to replicative activity "...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890320411

    authors: Fiore JR,Calabró ML,Angarano G,De Rossi A,Fico C,Pastore G,Bianchi LC

    更新日期:1990-12-01 00:00:00

  • Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study.

    abstract::Herpes simplex virus (HSV) establishes latency in neurons and recurrent infections in oral mucosa. This prospective study analyzes HSV prevalence in oral mucosal brush samples from men with known human papillomavirus (HPV) status. We hypothesized that HSV-1-infection could facilitate HPV persistence as a cofactor. Thi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24965

    authors: Mäki J,Paavilainen H,Kero K,Hukkanen V,Syrjänen S

    更新日期:2018-03-01 00:00:00

  • Variation in human papillomavirus type-16 viral load within different histological grades of cervical neoplasia.

    abstract::The objective of this study was to investigate variation in human papillomavirus (HPV) type-16 load within histologically defined grades of cervical intraepithelial neoplasia. Two hundred and thirty-seven liquid based cytology samples were collected from women attending colposcopy clinics, DNA was extracted, and prese...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20875

    authors: Fiander AN,Hart KW,Hibbitts SJ,Rieck GC,Tristram AJ,Beukenholdt RW,Powell NG

    更新日期:2007-09-01 00:00:00

  • Central nervous system involvement by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2).

    abstract::Neurologic sequelae can be devastating complications of respiratory viral infections. We report the presence of virus in neural and capillary endothelial cells in frontal lobe tissue obtained at postmortem examination from a patient infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Our observ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25915

    authors: Paniz-Mondolfi A,Bryce C,Grimes Z,Gordon RE,Reidy J,Lednicky J,Sordillo EM,Fowkes M

    更新日期:2020-07-01 00:00:00