Abstract:
:Molecular investigation was undertaken of circulating hepatitis A virus (HAV) associated with cases of acute diarrhea among children under 5 years of age in Kumba-Cameroon. Reverse transcription PCR, sequencing, and phylogenetic analysis of a 371 bp segment of the VP1/P2A junction of six isolates obtained from stool samples showed the exclusive emergence of genetically related HAV subgenotype IA. All the isolates clustered within a unique lineage exhibiting a 99.5% nucleotide identity suggesting infection from a common source. The Cameroonian HAV isolates did not intermix or cluster with those from other regions of Africa and the rest of the world. Tajima's neutralization tests using the six sequences suggested HAV/IA population expansion (D = -1.37; P = 0.016). This is the first description of indigenous HAV genotypes circulating in Cameroon revealing a community-wide spread and predominance of HAV/1A infection in the Kumba area. These findings stress the need for routine molecular tracking of HAV infection as a contributory cause of acute diarrhea in Cameroonian children.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Forbi JC,Agwale SM,Ndip LM,Esona MDdoi
10.1002/jmv.23266subject
Has Abstractpub_date
2012-05-01 00:00:00pages
728-32issue
5eissn
0146-6615issn
1096-9071journal_volume
84pub_type
杂志文章abstract::Human papillomavirus (HPV) is a carcinogenic agent responsible for tumor development in many sexually involved tissues. We present a survey on the prevalence of HPV infection in a risk population for sexually transmitted infections (STIs). The studied population was formed by 125 STI clinic attendees, who took part in...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24746
更新日期:2017-06-01 00:00:00
abstract::The present study compared the efficacy of standard and extended durations of PEG-IFNα-2a monotherapy for treatment of HBeAg-negative Chinese patients with chronic hepatitis B. Patients were randomized to receive standard therapy (n = 38; 48 weeks treatment) or extended therapy (n = 42; 72 weeks treatment). Extended t...
journal_title:Journal of medical virology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jmv.24013
更新日期:2014-10-01 00:00:00
abstract::Hepatitis C Virus (HCV) genotype 4 predominates in Middle East and Central Africa countries. Recently, it has become also prevalent in Southern European countries where it is thought to have been introduced through immigration and the movement of intravenous drug users. In Italy, the prevalence of genotype 4 is partic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23384
更新日期:2012-10-01 00:00:00
abstract::Chronic HCV infection has emerged as a complex multifaceted disease with manifestations extending beyond the liver. HCV plays a direct role in glucose metabolism leading to both insulin resistance and type 2 diabetes. To evaluate the changes in the glycemic state following Sofosbuvir-based treatment regimens in diabet...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24897
更新日期:2017-12-01 00:00:00
abstract::HPV infection is a "necessary cause" of cervical cancer and it is sexually transmitted. Due to upcoming mass vaccination investigation on risk factors for infection is the basis to implement prophylactic strategy even in older women. The aim of the study was to evaluate predictors of high-risk (HR) HPV infection in ad...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21887
更新日期:2010-11-01 00:00:00
abstract::Parainfluenza virus type 3 (Para 3) is an important childhood pathogen causing a significant amount of bronchiolitis and pneumonia in infants. Virus data were analysed over a twelve-year period (1978-1989), and a peak incidence of infection was observed in spring as in Houston, USA, unlike in the United Kingdom where ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890350105
更新日期:1991-09-01 00:00:00
abstract::A total of 102,600 upper respiratory infections (URI) were recorded among young military conscripts in the Finnish Defence Forces during the study period from October 1991 to March 1994. This period covered three outbreaks caused by H3N2-subtype influenza A virus and one outbreak of influenza B. During the 1991/92 out...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10552
更新日期:2004-02-01 00:00:00
abstract::Little information is available on the impact of direct-acting antiviral (DAA) therapy on changes in liver fibrosis and steatosis. Liver stiffness (LS) and controlled attenuation parameter (CAP) values were evaluated using transient elastography. The study subjects were 214 elderly patients infected with HCV genotype ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24950
更新日期:2018-02-01 00:00:00
abstract::For assessing the role of circulating immune complexes (CIC) in chronic hepatitis C, the relative frequency of CIC was determined in 54 patients with chronic hepatitis C, 15 asymptomatic hepatitis C virus (HCV) carriers, and 54 healthy controls. IgM and IgG containing CIC were studied using both C1q and conglutinin (K...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460104
更新日期:1995-05-01 00:00:00
abstract::A total of 82 samples from patients with cervical cancer (Group 1) and 50 samples from patients with other genital diseases (Group 2) were collected in Gansu, China. All 132 samples were tested for HPV DNA with a typing kit that can detect 21 types of HPV, and also tested for neutralizing antibodies against HPV-16, -1...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21435
更新日期:2009-04-01 00:00:00
abstract::The seroprevalences of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers were evaluated in a random sample of 803 children attending school in Ashanti-Akim North district in Ghana in order to gain a better understanding of transmission patterns of these viruses, particularly horizontal transmission of HBV. T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199603)48:3<278::AID-JMV11
更新日期:1996-03-01 00:00:00
abstract::A multiplex polymerase chain reaction (PCR) assay that is capable of detecting and typing six serotypes of respiratory adenovirus (Ad) was developed, using multiple sets of type-specific primers. The detection of each different serotype depended on distinguishing different numbers and sizes of amplification products o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2174
更新日期:2002-04-01 00:00:00
abstract::Epstein-Barr virus (EBV) is an important DNA tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (NPC). DNA methylation and microRNAs (miRNAs) are the most studied epigenetic mechanisms that can prompt disease susceptibility. This study aimed to detect the effe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24863
更新日期:2017-10-01 00:00:00
abstract::Serial determinations of titers of binding antibodies to single stranded DNA were performed over a period of three years in 43 type B hepatitis patients with persisting HBsAg who had either developed chronic hepatitis or were asymptomatic carriers. Patients with histopathological diagnosis of chronic active or chronic...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890040204
更新日期:1979-01-01 00:00:00
abstract::Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 201...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25222
更新日期:2018-09-01 00:00:00
abstract::Prophylactic antiviral therapy is recommended for hepatitis B virus (HBV)-infected patients with malignancies who are undergoing systemic chemotherapy. In the current study, we aimed to develop a risk scoring system to guide the selection of prophylactic antiviral agents. In this retrospective analysis, we included co...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.25241
更新日期:2018-10-01 00:00:00
abstract::Rotaviruses were detected via electron microscopy in fecal specimens collected from school children during an outbreak of diarrhea and from a sporadic case in 1993 in Japan. All of the viruses were found to belong to human group C rotavirus by reverse passive hemagglutination assay (RPHA). These viruses replicated wel...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199601)48:1<48::AID-JMV8>3
更新日期:1996-01-01 00:00:00
abstract::The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21304
更新日期:2008-12-01 00:00:00
abstract::Although neutralizing antibodies against Hantaan virus (HTV) can protect hosts from viral infection, T-cell responses to HTV are also important in host defense against HTV. However, much less is known about cytotoxic T lymphocyte (CTL) responses to HTV. To identify CTL epitopes in the HTV nucleocapsid protein (NP), we...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract:BACKGROUND:Patients with thalassemia may also have cardiac abnormalities due to congenital problems, anemia, and increased burden of iron in their myocardium. This study was designed to evaluate the effects of direct acting antiviral (DAA) therapy on the cardiac function of hepatitis C virus (HCV)-infected patients wit...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25314
更新日期:2019-03-01 00:00:00
abstract::A metagenomic approach based on target independent next-generation sequencing has become a known method for the detection of both known and novel viruses in clinical samples. This study aimed to use the metagenomic sequencing approach to characterize the viral diversity in respiratory samples from patients with respir...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24984
更新日期:2018-03-01 00:00:00
abstract::Genital herpes is a common, distressing infection whose incidence has been underestimated. Recent serological surveys, employing type-specific antibody assays, show a rising prevalence of previous herpes simplex virus (HSV) type 2 infections in post-adolescent populations in developed countries; many of these infectio...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.1890410508
更新日期:1993-01-01 00:00:00
abstract::A thirteen-year-old boy with bilateral orchitis was diagnosed as being infected by Coxsackie A9 virus by isolation of the virus from a throat swab and a fecal specimen. Serologic investigations revealed the development of transitory specific neutralizing IgM antibodies against the isotate and of persistent antibodies ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890030207
更新日期:1978-01-01 00:00:00
abstract::The major risk factor for intrauterine transmission of human cytomegalovirus (HCMV) is a primary infection during pregnancy. The neutralizing antibody response appeared after an average of 13 weeks after seroconversion and therefore the absence of neutralizing titers in HCMV IgG positive pregnant women is a reliable m...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:2001-02-01 00:00:00
abstract::The human respiratory syncytial virus (HRSV) is the most important cause of admission to hospital for acute lower respiratory tract infections in infants and young children worldwide. Only few studies have investigated the molecular evolution of HRSV, and none has been conduct ed in Italy. The genetic diversity of the...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21012
更新日期:2007-12-01 00:00:00
abstract::Major differences exist between HIV-1 and HIV-2 in terms of epidemiology, pathogenicity, sensitivity to antiretrovirals. Determining the type of HIV infecting a patient is essential for management. The aim of this study was to evaluate the ability of simple/rapid tests to differentiate between HIV-1 and/or HIV-2 infec...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24282
更新日期:2015-12-01 00:00:00
abstract::Interferon (IFN) alfa has been used widely for the treatment of chronic hepatitis C virus (HCV) infections but only a small number of patients treated have shown a sustained biochemical and virological response. Anti-envelope E1 and E2 antibody titers were assessed retrospectively before, during, and after treatment w...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Epstein-Barr virus (EBV) reactivation and cell-mediated immune (CMI) responses were followed in 16 Antarctic expeditioners during winter-over isolation at 2 Australian National Antarctic Research Expedition stations. Delayed-type hypersensitivity (DTH) skin testing was used as an indicator of the CMI response, that wa...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200006)61:2<235::aid-jmv10
更新日期:2000-06-01 00:00:00
abstract::The TD97 strain vaccine virus was prepared from the Tanabe strain measles virus by low-temperature passages in primary cell cultures and ultraviolet (UV) mutagenesis. The TD97 strain exhibited the following characteristics: highly temperature sensitive, neither multiplying nor forming any plaques at 40 degrees C in Ve...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890320311
更新日期:1990-11-01 00:00:00
abstract::In nature, the cricetid Calomys musculinus is the principal host of Junin virus, the etiological agent of Argentine hemorrhagic fever. In the experimental infection, adult C. musculinus survived whereas newborns died after intraperitoneal inoculation with the XJ.Cl3 strain of Junin virus. The role of peritoneal macrop...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890180311
更新日期:1986-03-01 00:00:00