Abstract:
:HPV infection is a "necessary cause" of cervical cancer and it is sexually transmitted. Due to upcoming mass vaccination investigation on risk factors for infection is the basis to implement prophylactic strategy even in older women. The aim of the study was to evaluate predictors of high-risk (HR) HPV infection in adult women. Between 2006 and 2008, 100 women aged >18 years, with no previous treatment for cervical lesions, were screened for HR HPV infection in Rome, Italy. Risk factors for HPV infection were investigated through a questionnaire including: ethnicity, religion, education, marital status, sexual behavior, gynecological and obstetrical history, smoking and alcohol intake. Multivariate analysis identified the "never married-separated/divorced" status (OR: 3.38; 95% CI: 1.14-10.12) as predictor of HPV infection, while having a higher age at the first sexual intercourse (FSI) shows a protective effect (OR: 0.84; 95% CI: 0.71-1.00). A trend for the association between the infection and having more than three lifetime partners was also observed (OR: 2.57; 95% CI: 0.86-7.71). No significant association was found for other demographic characteristics investigated. These findings provide a contribution in the knowledge of an adult population defining a "high-risk" sexual behavioral profile and could be helpful to target prophylactic strategies in older woman.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Cercato MC,Mariani L,Vocaturo A,Carrone A,Terrenato I,Morano G,Benevolo M,Rollo F,Germelli C,Paolini F,Venuti Adoi
10.1002/jmv.21887subject
Has Abstractpub_date
2010-11-01 00:00:00pages
1921-7issue
11eissn
0146-6615issn
1096-9071journal_volume
82pub_type
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pub_type: 临床试验,杂志文章,多中心研究
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