Abstract:
:Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpected occurrence of HPV DNA was found in KS lesions of HIV infected individuals. Of the 18 KS cases included in the study 16 (89%) had HPV DNA detected. The most common Betapapillomavirus types were HPV14 [15 cases (83.3%)], HPV12 [8 cases (44.4%)], and HPV24 [7 cases (39%)]. Multiple Beta-HPV types were detected in 10 (62.5%) of the participants with HPV DNA positive lesions; of these 7 had a CD4+ count below 350 cells/µl and 3 had CD4+ counts above 350 cells/µl. The presence of Beta-HPV DNA in KS lesions is a newly described phenomenon. Further studies to elucidate the role of Beta-HPV in KS need to be conducted as it is possible that HHV 8 may not be the solitary viral carcinogen in KS tumorigenesis.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Murahwa AT,Muchemwa FC,Duri K,Borok MZ,Kanyera RB,Manhanzva MT,Mapingure MP,Stray-Pedersen Bdoi
10.1002/jmv.23944subject
Has Abstractpub_date
2014-09-01 00:00:00pages
1556-9issue
9eissn
0146-6615issn
1096-9071journal_volume
86pub_type
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