Presence of Betapapillomavirus in Kaposi sarcoma lesions.

Abstract:

:Human herpes virus 8 (HHV 8) is recognized as the necessary cause of Kaposi sarcoma (KS) and in the recent past the human papillomavirus (HPV) has been linked to the development of cutaneous basal cell and squamous cell carcinomas. In a cross sectional study investigating Beta-HPV infections in skin lesions, an unexpected occurrence of HPV DNA was found in KS lesions of HIV infected individuals. Of the 18 KS cases included in the study 16 (89%) had HPV DNA detected. The most common Betapapillomavirus types were HPV14 [15 cases (83.3%)], HPV12 [8 cases (44.4%)], and HPV24 [7 cases (39%)]. Multiple Beta-HPV types were detected in 10 (62.5%) of the participants with HPV DNA positive lesions; of these 7 had a CD4+ count below 350 cells/µl and 3 had CD4+ counts above 350 cells/µl. The presence of Beta-HPV DNA in KS lesions is a newly described phenomenon. Further studies to elucidate the role of Beta-HPV in KS need to be conducted as it is possible that HHV 8 may not be the solitary viral carcinogen in KS tumorigenesis.

journal_name

J Med Virol

authors

Murahwa AT,Muchemwa FC,Duri K,Borok MZ,Kanyera RB,Manhanzva MT,Mapingure MP,Stray-Pedersen B

doi

10.1002/jmv.23944

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

1556-9

issue

9

eissn

0146-6615

issn

1096-9071

journal_volume

86

pub_type

杂志文章
  • Prevalence and genetic diversity of norovirus among patients with acute diarrhea in Guatemala.

    abstract::Noroviruses (NoVs) are a leading cause of acute gastroenteritis outbreaks and sporadic cases of diarrhea in industrialized countries. To study the prevalence and genetic diversity of NoVs in Guatemala, stool specimens were collected from hospitalized and ambulatory patients presenting with diarrhea (≥3 loose or liquid...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23578

    authors: Estévez A,Arvelo W,Hall AJ,López MR,López B,Reyes L,Moir JC,Gregoricus N,Vinjé J,Parashar UD,Lindblade KA

    更新日期:2013-07-01 00:00:00

  • Antigenic drift of hemagglutinin and neuraminidase in seasonal H1N1 influenza viruses from Saudi Arabia in 2014 to 2015.

    abstract::Antigenic drift of the hemagglutinin (HA) and neuraminidase (NA) proteins of the influenza virus cause a decrease in vaccine efficacy. Since the information about the evolution of these viruses in Saudi is deficient so we investigated the genetic diversity of circulating H1N1 viruses. Nasopharyngeal aspirates/swabs co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25759

    authors: Naeem A,Elbakkouri K,Alfaiz A,Hamed ME,Alsaran H,AlOtaiby S,Enani M,Alosaimi B

    更新日期:2020-03-11 00:00:00

  • Immunity against the GBV-B hepatitis virus in tamarins can prevent productive infection following rechallenge and is long-lived.

    abstract::GB virus-B (GBV-B) is the virus most closely related to hepatitis C virus (HCV). Thus, we have used GBV-B infection of tamarins, which develop acute hepatitis following experimental infection, as a surrogate model to study protective immunity. As challenge virus, we first produced a GBV-B pool from an infected tamarin...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21013

    authors: Bukh J,Engle RE,Govindarajan S,Purcell RH

    更新日期:2008-01-01 00:00:00

  • High human herpesvirus 8 seroprevalence in populations from Western Balkan countries.

    abstract::Patterns of endemicity of human herpesvirus 8 (HHV8) are still undefined in some European populations, such as those from Western Balkan countries. Serum samples from 605 human immunodeficiency virus-seronegative subjects (299 Albanians and 306 Kosovars) were tested for the presence of HHV8 antibodies to a capsid-rela...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20644

    authors: Chironna M,Tosatti MA,Di Gangi IM,Sallustio A,Germinario C,Coluzzi M,Quarto M,Chieco-Bianchi L,Calabrò ML

    更新日期:2006-07-01 00:00:00

  • Infection with GB virus C in patients with chronic liver disease.

    abstract::Infection with putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was surveyed in 286 patients with chronic liver disease in Japan. RNA of GBV-C was detected, by reverse-transcription polymerase chain reaction with nested primers from the 5'-noncoding region, in 19 patients (6.6%) at a frequency highe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Sugai Y,Nakayama H,Fukuda M,Sawada N,Tanaka T,Tsuda F,Okamoto H,Miyakawa Y,Mayumi M

    更新日期:1997-03-01 00:00:00

  • Will the emergent SARS-CoV2 B.1.1.7 lineage affect molecular diagnosis of COVID19?

    abstract::As the coronavirus disease 2019 pandemic keep tackling global public health systems worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) genome keeps mutating. In that regard, the recent emergence of the B.1.1.7 lineage in the UK has called the attention of global authorities. One point of concer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26823

    authors: Ramírez JD,Muñoz M,Patiño LH,Ballesteros N,Paniz-Mondolfi A

    更新日期:2021-01-28 00:00:00

  • Hepatitis C virus antibodies among risk groups in a South African area endemic for hepatitis B virus.

    abstract::The prevalence of anti-HCV was studied in a South African area endemic for hepatitis B virus. A total of 35,685 volunteer blood donors (22,034 whites, 9,218 Asians, 3,077 Africans, 1,356 coloureds), 71 haemophiliacs, 84 chronic dialysis patients, 100 antenatal attenders, 212 nurses, and 20 HIV-positive male homosexual...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890400113

    authors: Soni PN,Tait DR,Kenoyer DG,Fernandes-Costa F,Naicker S,Gopaul W,Simjee AE

    更新日期:1993-05-01 00:00:00

  • Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease.

    abstract::Hepatitis C virus (HCV) genotypes help to tailor the treatment response, but their influence on the disease severity and association with hepatic steatosis is not well understood. The prevalence of HCV genotypes and their correlation with the histopathological severity of liver disease and steatosis in Indian patients...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20561

    authors: Hissar SS,Goyal A,Kumar M,Pandey C,Suneetha PV,Sood A,Midha V,Sakhuja P,Malhotra V,Sarin SK

    更新日期:2006-04-01 00:00:00

  • Human papillomavirus DNA and anti-HPV secretory IgA antibodies in cytologically normal cervical specimens.

    abstract::Cervical specimens collected from 163 cytologically healthy women were screened for the presence of human papillomavirus (HPV) DNA and anti-HPV secretory IgA antibodies. HPV DNA was detected by a general primer mediated polymerase chain reaction (PCR), which amplifies a conserved region from the L1 ORF of genital HPVs...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890430219

    authors: Veress G,Kónya J,Csiky-Mészáros T,Czeglédy J,Gergely L

    更新日期:1994-06-01 00:00:00

  • Total HCV core antigen assay: a new marker of hepatitis C viremia for monitoring the progress of therapy.

    abstract::The ability of the total hepatitis C virus (HCV) core antigen assay was evaluated for monitoring the therapeutic responses of HCV-infected patients treated with interferon. The ability to detect and quantitate an independent structural protein component of HCV, in the presence of circulating antibodies, makes this ass...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10355

    authors: Zanetti AR,Romanò L,Brunetto M,Colombo M,Bellati G,Tackney C

    更新日期:2003-05-01 00:00:00

  • Predictors of human papilloma virus (HPV) infection in Italian women.

    abstract::HPV infection is a "necessary cause" of cervical cancer and it is sexually transmitted. Due to upcoming mass vaccination investigation on risk factors for infection is the basis to implement prophylactic strategy even in older women. The aim of the study was to evaluate predictors of high-risk (HR) HPV infection in ad...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21887

    authors: Cercato MC,Mariani L,Vocaturo A,Carrone A,Terrenato I,Morano G,Benevolo M,Rollo F,Germelli C,Paolini F,Venuti A

    更新日期:2010-11-01 00:00:00

  • Phylogenetic analysis of the NS5 gene of Zika virus.

    abstract::ZIKV infection has become a global threat spreading across 31 countries in Central America, South America, and the Caribbean. However, little information is available about the molecular epidemiology of ZIKV. Shared mutation of a threonine residue to alanine at the same position in the C terminal of NS5 sequences was ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24615

    authors: Adiga R

    更新日期:2016-10-01 00:00:00

  • The diagnosis of SARS-CoV2 pneumonia: A review of laboratory and radiological testing results.

    abstract::The rapid emergence of coronavirus disease 2019 (COVID-19) has necessitated the implementation of diverse pandemic control strategies throughout the world. To effectively control the spread of this disease, it is essential that it be diagnosed at an early stage so that patients can be reliably quarantined such that di...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26081

    authors: Zheng Z,Yao Z,Wu K,Zheng J

    更新日期:2020-11-01 00:00:00

  • A new strategy based on recombinant viruses as a tool for assessing drug susceptibility of human immunodeficiency virus type 1.

    abstract::The emergence of drug-resistant variants during antiretroviral therapy is a serious obstacle to sustained suppression of the human immunodeficiency virus type 1 (HIV-1). For that reason, resistance assays are essential to guide clinicians in the selection of optimal treatment regimens. Genotypic assays are less expens...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20770

    authors: Garcia-Perez J,Sanchez-Palomino S,Perez-Olmeda M,Fernandez B,Alcami J

    更新日期:2007-02-01 00:00:00

  • Comparison of characteristics between patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA and those with GBV-C/HGV E2-antibody in patients with hemophilia.

    abstract::We compared characteristics of patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA to those of patients with GBV-C/HGV E2-antibody. GBV-C/HGV RNA and GBV-C/HGV antibody were assayed in 83 persons with hemophilia using a reverse transcription-polymerase chain reaction and an enzyme-linked immunosorbent assay, re...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(200001)60:1<34::aid-jmv6>3

    authors: Toyoda H,Takahashi I,Fukuda Y,Hayakawa T,Takamatsu J

    更新日期:2000-01-01 00:00:00

  • Detection of parvovirus B19 DNA, antigen, and particles in the human fetus.

    abstract::Human parvovirus B19 commonly infects children, causing erythema infectiosum (fifth disease). However, there is a significant adult population which has not been exposed to the virus and, consequently, does not have protective antibody. Recent reports have associated B19 infection during pregnancy with fetal death, al...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890230409

    authors: Clewley JP,Cohen BJ,Field AM

    更新日期:1987-12-01 00:00:00

  • Detection of a nuclear antigen 2 (EBNA2)-variant Epstein-Barr virus strain in two siblings with fatal lymphoproliferative disease.

    abstract::An EBV type 1 variant strain was detected in two Turkish siblings (boy and girl), who both suffered and died from similar progressive Epstein-Barr virus (EBV)-associated lymphoproliferative disease. Molecular characterisation of this EBV isolate revealed a 51bp-deletion and six nucleotide changes within the Epstein-Ba...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199601)48:1<114::AID-JMV18

    authors: Schuster V,Seidenspinner S,Kreth HW

    更新日期:1996-01-01 00:00:00

  • Rotavirus prevalence and relationships with climatological factors in Gabon, Africa.

    abstract::A one-year study of rotavirus prevalence was carried out using electron microscopy in Gabon, equatorial Africa. One hundred fifty-six nonhospitalized diarrheic children up to 10 years of age and 115 age-matched controls were investigated together with diarrheic adults and children over 10 years of age. Rotaviruses wer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890160210

    authors: Sitbon M,Lecerf A,Garin Y,Ivanoff B

    更新日期:1985-06-01 00:00:00

  • High frequency of lamivudine resistance mutations in Brazilian patients co-infected with HIV and hepatitis B.

    abstract::This study analyzed the genotype distribution and frequency of lamivudine (LAM) and tenofovir (TDF) resistance mutations in a group of patients co-infected with HIV and hepatitis B virus (HBV). A cross-sectional study of 847 patients with HIV was conducted. Patients provided blood samples for HBsAg detection. The load...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21845

    authors: Mendes-Correa MC,Pinho JR,Locarnini S,Yuen L,Sitnik R,Santana RA,Gomes-Gouvêa MS,Leite OM,Martins LG,Silva MH,Gianini RJ,Uip DE

    更新日期:2010-09-01 00:00:00

  • ORF61 protein of Varicella-zoster virus influences JNK/SAPK and p38/MAPK phosphorylation.

    abstract::Recently, it was demonstrated that the Varicella-zoster virus (VZV) infection led to an activation of MAP kinases. The viral protein encoded by ORF61 is a major effector of JNK/SAPK and p38/MAPK phosphorylation. ORF61 shows homology to HSV-1 ICP0, a multifunctional protein that influences the activity of c-Jun in infe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20373

    authors: Rahaus M,Desloges N,Wolff MH

    更新日期:2005-07-01 00:00:00

  • Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China.

    abstract::Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 201...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25222

    authors: Chen X,Shi T,Huang J,Xiao G,Huang J,Xiong Y,Li X,Chen H,Zheng X,Yu S,Chen Q

    更新日期:2018-09-01 00:00:00

  • Serologic and viral genome prevalence of HSV, EBV, and HCMV among healthy adults in Wuhan, China.

    abstract::The worldwide infection rate of herpesvirus is high, but the detailed prevalence in China, especially the central area, remains unclear. In the present study, the prevalence of herpes simplex virus (HSV), Epstein-Barr virus (EBV), and human cytomegalovirus (HCMV) was investigated in 303 healthy adults in Wuhan, a repr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24989

    authors: Wen L,Qiu Y,Cheng S,Jiang X,Ma YP,Fang W,Wang W,Cui J,Ruan Q,Zhao F,Hu F,Luo MH

    更新日期:2018-03-01 00:00:00

  • Sequence-specific detection method for reverse transcription, loop-mediated isothermal amplification of HIV-1.

    abstract::HIV diagnosis at the point-of-care or in resource-limited settings poses considerable challenges due to time and cost limitations. Currently, nucleic acid-based tests are the only reliable method for diagnosing recent infections during the window period post-infection and pre-seroconversion, but these tests are only s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21490

    authors: Curtis KA,Rudolph DL,Owen SM

    更新日期:2009-06-01 00:00:00

  • Monitoring of patients for cytomegalovirus after organ transplantation by centrifugation culture and PCR.

    abstract::A modified centrifugation culture technique and a polymerase chain reaction (PCR) is described for detection of early antigen and IE antigen DNA, respectively, for rapid and sensitive monitoring of active cytomegalovirus (HCMV) infection after organ transplantation. In a preliminary study, 541 clinical specimens (bloo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890380404

    authors: Prösch S,Kimel V,Dawydowa I,Krüger DH

    更新日期:1992-12-01 00:00:00

  • Clinical outcome of frequent exposure to Torque Teno virus (TTV) through blood transfusion in thalassemia patients with or without hepatitis C virus (HCV) infection.

    abstract::As a consequence of the high prevalence of TorqueTeno virus (TTV) in blood donors, thalassemia patients frequently acquire various genotypes of this virus through therapeutic blood transfusions. At present, the clinical consequences of TTV infection remain indeterminate for these patients. Here, several hundred thalas...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21070

    authors: Hu YW,Al-Moslih MI,Al Ali MT,Uzicanin S,Perkins H,Yi QL,Rahimi Khameneh S,Wu J,Brown EG

    更新日期:2008-02-01 00:00:00

  • Comparison of human herpesvirus 8 and Epstein-Barr virus seropositivity among children in areas endemic and non-endemic for Kaposi's sarcoma.

    abstract::Human herpesvirus 8 (HHV-8) is the etiologic agent of Kaposi's sarcoma (KS). Several studies indicate horizontal HHV-8 transmission among children in areas where KS is endemic, but few studies have assessed acquisition of HHV-8 by children in low seroprevalence areas. Antibody screening was carried out for HHV-8 and E...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10548

    authors: Martro E,Bulterys M,Stewart JA,Spira TJ,Cannon MJ,Thacher TD,Bruns R,Pellett PE,Dollard SC

    更新日期:2004-01-01 00:00:00

  • Mutants of the hepatitis B virus surface antigen that define some antigenically essential residues in the immunodominant a region.

    abstract::The nature of the immunodominant a region of hepatitis B virus surface antigen (HBsAg) has been examined by mutation of specific amino acid residues. Proline 142 was required for the exhibition of full antigenicity. Replacement of cysteines 124 and 147 by serines drastically reduced or eliminated reactivity with antib...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890290310

    authors: Ashton-Rickardt PG,Murray K

    更新日期:1989-11-01 00:00:00

  • Comparison between patients with norovirus-related gastroenteritis and asymptomatic carriers with respect to distribution of antibody-complexed viral particles and intestinal flora.

    abstract::Asymptomatic carriers have a major influence on the spreading of norovirus infections. The objective of this study was to examine the characteristics of patients and asymptomatic carriers affected by norovirus-related community gastroenteritis outbreaks. No significant difference between the two groups was observed in...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25079

    authors: Mori K,Konishi N,Suzuki Y,Harada S,Maeda M,Akase S,Obata H,Monma C,Nagano M,Kimoto K,Oda M,Somura Y,Hirai A,Shinkai T,Noda M,Sadamasu K

    更新日期:2018-12-01 00:00:00

  • Hepatitis C and arboviral antibodies in the island populations of Mauritius and Rodrigues.

    abstract::A serological survey for antibodies to hepatitis C virus (HCV), dengue viruses (DEN), West Nile virus (WN), and sindbis virus (SIN) was carried out in sera of selected groups of the population of the Islands of Mauritius (n = 449) and Rodrigues (n = 115), Indian Ocean. 8.3% of 564 sera were positive for anti-HCV. In M...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440411

    authors: Schwarz TF,Dobler G,Gilch S,Jäger G

    更新日期:1994-12-01 00:00:00

  • Comparison of respiratory syncytial virus humoral immunity and response to infection in young and elderly adults.

    abstract::Little information about immunity to respiratory syncytial virus (RSV) and disease pathogenesis in elderly persons exists. Humoral immunity to RSV was assessed in 41 young, 56 healthy elderly, and 49 frail elderly adults by measuring baseline RSV specific IgG by enzyme immunoassay (EIA) and microneutralization assay (...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199910)59:2<221::aid-jmv16

    authors: Falsey AR,Walsh EE,Looney RJ,Kolassa JE,Formica MA,Criddle MC,Hall WJ

    更新日期:1999-10-01 00:00:00