Molecular Characterization of Non-Polio Enteroviruses Isolated from Acute Flaccid Paralysis Patients in Uganda.

Abstract:

:Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AFP patients. Retrospective analysis of 112 NPEV isolates from AFP patients was performed and thirty one NPEV types were identified of which 91% were Enterovirus B and 9% were Enterovirus A species. The NPEVs were distributed across the country with most patients in the eastern region (41/89; 46.1%). The highest proportion of patients were children less than 5 years (77/89; 86.5%) and male patients were more common (54/89; 60.7%). Echovirus 11 (11/89; 12.4%) was frequently observed and phylogenetic analysis of these sequences revealed high diversity. Coxsackievirus B5 (CV-B5), CV-B6, E21, and EV-B69 were only seen in patients with residual paralysis. Analyses of the EV-A71 sequence indicated a unique genogroup.

journal_name

J Med Virol

authors

Tushabe P,Howard W,Bwogi J,Birungi M,Eliku JP,Kakooza P,Bukenya H,Namuwulya P,Gaizi J,Tibanagwa M,Kabaliisa T,Mulindwa J,Muhanguzi D,Suchard M,Gumede N,Bakamutumaho B

doi

10.1002/jmv.26804

subject

Has Abstract

pub_date

2021-01-17 00:00:00

eissn

0146-6615

issn

1096-9071

pub_type

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