Early inhibition of nitric oxide production increases HSV-1 intranasal infection.

Abstract:

:Here, we studied the role of nitric oxide (NO) production during the first steps of the respiratory infection of BALB/c mice with herpes simplex virus type 1 (HSV-1), strain F. Nitric oxide synthase II (NOS-II) mRNA and protein were detected by reverse transcription (RT)-PCR and dot blot, respectively in samples of lungs and turbinates early post-infection (p.i.). Immunohistochemical analysis revealed pulmonar macrophages and PMN expressing NOS-II in the lungs of infected animals. Animals intranasally treated with aminoguanidine (AG), a NOS inhibitor, during the first steps of infection, showed a dose-dependent increase in pneumonitis compared to controls. Viral titres in turbinates, lungs, and brains were higher in AG treated mice. Finally, histopathology studies revealed a stronger inflammation in eyes, and lungs of these animals. Taken together, these results suggest a role of NO in controlling primary HSV intranasal infection.

journal_name

J Med Virol

authors

Gamba G,Cavalieri H,Courreges MC,Massouh EJ,Benencia F

doi

10.1002/jmv.20093

keywords:

subject

Has Abstract

pub_date

2004-06-01 00:00:00

pages

313-22

issue

2

eissn

0146-6615

issn

1096-9071

journal_volume

73

pub_type

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