Abstract:
:Here, we studied the role of nitric oxide (NO) production during the first steps of the respiratory infection of BALB/c mice with herpes simplex virus type 1 (HSV-1), strain F. Nitric oxide synthase II (NOS-II) mRNA and protein were detected by reverse transcription (RT)-PCR and dot blot, respectively in samples of lungs and turbinates early post-infection (p.i.). Immunohistochemical analysis revealed pulmonar macrophages and PMN expressing NOS-II in the lungs of infected animals. Animals intranasally treated with aminoguanidine (AG), a NOS inhibitor, during the first steps of infection, showed a dose-dependent increase in pneumonitis compared to controls. Viral titres in turbinates, lungs, and brains were higher in AG treated mice. Finally, histopathology studies revealed a stronger inflammation in eyes, and lungs of these animals. Taken together, these results suggest a role of NO in controlling primary HSV intranasal infection.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Gamba G,Cavalieri H,Courreges MC,Massouh EJ,Benencia Fdoi
10.1002/jmv.20093keywords:
subject
Has Abstractpub_date
2004-06-01 00:00:00pages
313-22issue
2eissn
0146-6615issn
1096-9071journal_volume
73pub_type
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