Scoring system for risk stratification of viral reactivation during prophylactic antiviral treatment in Korean patients with hepatitis B undergoing anticancer chemotherapy: A multicenter study.

Abstract:

:Prophylactic antiviral therapy is recommended for hepatitis B virus (HBV)-infected patients with malignancies who are undergoing systemic chemotherapy. In the current study, we aimed to develop a risk scoring system to guide the selection of prophylactic antiviral agents. In this retrospective analysis, we included consecutive chronic hepatitis B patients who received antiviral prophylaxis for chemotherapy of solid or hematologic malignancies at three large-volume hospitals in Korea. The primary endpoint was HBV reactivation. The inverse probability treatment weighting method was used to minimize selection bias in terms of antiviral assignments. A total of 419 patients were enrolled: 129 patients received lamivudine (LAM), 216 received telbivudine (LdT), and 74 received entecavir (ETV), respectively. Of these, 36 patients developed on-treatment HBV reactivation (LAM, 17; LdT, 18; ETV, 1). Multivariate analysis identified three independent predictors for reactivation: hepatitis B e-antigen positivity, HBV DNA level, and type of malignancy. Accordingly, a risk scoring system was developed wherein one point was assigned for each of the risk factors. HBV reactivation occurred more frequently in the high-risk group (score ≥ 2) than in the low-risk group (hazards ratio, 14.17; P < 0.001). ETV exhibited superior prophylactic efficacy over LdT or LAM in the high-risk group, whereas no significant difference was noted in the low-risk group. The prognostic scoring system was useful for risk stratification of chemotherapy-related HBV reactivation. High genetic barrier agents appear to be vital for high-risk patients, whereas cost-effectiveness may be more relevant for low-risk patients.

journal_name

J Med Virol

authors

Kim HY,Yoo JJ,Oh S,Yu SJ,Kim YJ,Yoon JH,Kim W,Jung YJ,Kim BH,Kim CM,Park JW,Lee JH

doi

10.1002/jmv.25241

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

1593-1603

issue

10

eissn

0146-6615

issn

1096-9071

journal_volume

90

pub_type

杂志文章,多中心研究
  • Probable implication of mutations of the X open reading frame in the onset of fulminant hepatitis B.

    abstract::A pathogenic role of precore-defective mutation in the onset of fulminant hepatitis B has been suggested. However, precore-defective mutants do not always cause fulminant hepatitis B and are not always isolated from affected patients. These findings strongly suggest the presence of some additional important mutations ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470304

    authors: Kaneko M,Uchida T,Moriyama M,Arakawa Y,Shikata T,Gotoh K,Mima S

    更新日期:1995-11-01 00:00:00

  • Human papillomavirus type 11 neutralization in the athymic mouse xenograft system: correlation with virus-like particle IgG concentration.

    abstract::Neutralization of virus is likely to be necessary for development of an effective prophylactic vaccine against genital human papillomavirus (HPV) infection. Two New Zealand white rabbits were immunized with purified HPV type 11 (HPV 11) virions in Freund's adjuvant. An enzyme linked immunoassay (ELISA) was used to det...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199711)53:3<185::aid-jmv1>

    authors: Bryan JT,Jansen KU,Lowe RS,Fife KH,McClowry T,Glass D,Brown DR

    更新日期:1997-11-01 00:00:00

  • Human parainfluenza virus types 1-4 in hospitalized children with acute lower respiratory infections in China.

    abstract::Human parainfluenza viruses (HPIVs) are an important cause of acute lower respiratory tract infections (ALRTIs). HPIV-4, a newly identified virus, has been associated with severe ALRTIs recently. A total of 771 nasopharyngeal aspirate samples were collected from hospitalized children between March 2010 and February 20...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24580

    authors: Xiao NG,Duan ZJ,Xie ZP,Zhong LL,Zeng SZ,Huang H,Gao HC,Zhang B

    更新日期:2016-12-01 00:00:00

  • Antigenic relationships among human herpesvirus-6 isolates.

    abstract::Human herpesvirus 6 (HHV-6) prototype isolate GS is a newly identified lymphotropic herpesvirus and several subsequent herpes isolates were recognized as HHV-6 by their hybridization to a HHV-6(GS) DNA probe pZVH14. DNA restriction analysis and in vitro tropism studies show that HHV-6 isolates can be divided into two ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890370403

    authors: Chandran B,Tirawatnapong S,Pfeiffer B,Ablashi DV

    更新日期:1992-08-01 00:00:00

  • Impact of comorbidities on patients with COVID-19: A large retrospective study in Zhejiang, China.

    abstract::Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. Here, we stratified COVID-19 patients based on their comorbidities to assess their risk of serious adverse outcomes. We collected 856 hospitalized cases diagnosed with COVID-19 from 17 January to 7 February 2020, in Zhejiang Prov...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26183

    authors: Ye C,Zhang S,Zhang X,Cai H,Gu J,Lian J,Lu Y,Jia H,Hu J,Jin C,Yu G,Zhang Y,Sheng J,Yang Y

    更新日期:2020-11-01 00:00:00

  • Impact of HIV infection and highly active antiretroviral therapy (HAART) on B cell subpopulations in children.

    abstract::B-cells play an important role in defending children against various infections. In view of scare data, we undertook this prospective cohort study to describe B cell compartment in HIV infected children (<5 years of age) and the effect of HAART on B cell subpopulations. HIV infected children (<5 years) from Pediatric ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25074

    authors: Singh R,Mukherjee A,Singla M,Vajpayee M,Negi N,Kabra SK,Lodha R,Das BK

    更新日期:2018-07-01 00:00:00

  • Human cytomegalovirus as a direct pathogen: correlation of multiorgan involvement and cell distribution with clinical and pathological findings in a case of congenital inclusion disease.

    abstract::The human cytomegalovirus (HCMV), a member of the Herpesviridae, is the most frequent cause of congenital virus infections and a major cause of morbidity and mortality in immunocompromised patients. Due to the lack of an appropriate animal model, insight into the pathogenesis of HCMV infections originates primarily fr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2208

    authors: Bissinger AL,Sinzger C,Kaiserling E,Jahn G

    更新日期:2002-06-01 00:00:00

  • Neutralization epitope diversity of coxsackievirus B4 isolates detected by monoclonal antibodies.

    abstract::Only recently have we begun to fully realize the diversity of virions within a single human isolate of the group B Coxsackieviruses. These intratypic (strain) differences may be one of the important factors influencing pathogenesis, e.g., myocarditis vs. pancreatitis. Yet, until the virion strains within a type can be...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200103

    authors: Webb SR,Kearse KP,Foulke CL,Hartig PC,Prabhakar BS

    更新日期:1986-09-01 00:00:00

  • Patterns of serum type 1 and type 2 immune markers in healthy carriers of HTLV-I.

    abstract::Type 1 immunity appears to be diminished in healthy Japanese carriers of human T-lymphotropic virus type I (HTLV-I), but type 2 status remains undetermined. To further examine the subclinical effect of HTLV-I on host immunity, we measured serum antibodies to the Epstein-Barr virus (EBV) in 415 healthy Japanese adults ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20633

    authors: Birmann BM,Mueller NE,Okayama A,Hsieh CC,Tsubouchi H,Harn D,Stuver SO

    更新日期:2006-06-01 00:00:00

  • Prevalence of genital, oral, and anal HPV infection among STI patients in Italy.

    abstract::Human papillomavirus (HPV) is a carcinogenic agent responsible for tumor development in many sexually involved tissues. We present a survey on the prevalence of HPV infection in a risk population for sexually transmitted infections (STIs). The studied population was formed by 125 STI clinic attendees, who took part in...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24746

    authors: Ciccarese G,Herzum A,Rebora A,Drago F

    更新日期:2017-06-01 00:00:00

  • Impact of disease-modifying drugs on the severity of  COVID-19 infection in multiple sclerosis patients.

    abstract::Recent evidence suggested that neurological manifestations occur in patients with a severe form of coronavirus disease (COVID-19). On the basis of this issue, neurologists are very concerned about patients with neurological disorders, especially multiple sclerosis (MS), as consumers of immunosuppressive or immune-modu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.26593

    authors: Rostami Mansoor S,Ghasemi-Kasman M

    更新日期:2020-10-12 00:00:00

  • Molecular characterization of serotype G9 rotaviruses circulating in South Korea between 2005 and 2010.

    abstract::A total of 18 rotavirus G9 strains in South Korea were collected during five rotavirus seasons between 2005 and 2010. The relationship between these strains was examined by analyzing the genetic variation of two major structural genes, VP7 and VP4. All the rotavirus isolates were of the G9P[8] genotype. The VP7 phylog...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23436

    authors: Than VT,Kang H,Lim I,Kim W

    更新日期:2013-01-01 00:00:00

  • Rapid development of genotypic resistance to lamivudine when combined with zidovudine in pregnancy.

    abstract::The prevention of mother to child transmission of HIV-1 by zidovudine monotherapy is well known, but increasingly combination anti-retroviral therapy is prescribed during pregnancy. In this prospective study, 19 pregnant women with human immunodeficiency virus-1 (HIV-1) infection who elected to take anti-retroviral th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199911)59:3<364::aid-jmv17

    authors: Clarke JR,Braganza R,Mirza A,Stainsby C,Ait-Khaled M,Wright A,Lyall H,Parker D,McClure MO,Weber JN,Taylor GP

    更新日期:1999-11-01 00:00:00

  • Prevalence of delta agent among Chinese in Taiwan and Los Angeles.

    abstract::The prevalence of delta agent among 120 Chinese patients with HBsAg-positive chronic active and hepatocellular carcinoma from Taiwan and Los Angeles were studied by serological assay for antibody to delta antigen and immunoperoxidase staining for delta antigen in the liver biopsies. Of 120 patients, only four with chr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890140106

    authors: Govindarajan S,Lee SD,Tong MJ,Tsai YT,Lo KJ

    更新日期:1984-01-01 00:00:00

  • Herpesvirus detection and cytokine levels (IL-10, IL-6, and IFN-γ) in ocular fluid from Tunisian immunocompetent patients with uveitis.

    abstract::Human herpesviruses (HHVs) are involved in the pathogenesis of different types of uveitis. Cytokine response plays an important role in virus-induced immunopathology. This study aimed to investigate the incidence of HHVs in aqueous humor samples of immunocompetent patients with suspected viral uveitis and cytokine (IL...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23708

    authors: Nahdi I,Abdelwahed RB,Boukoum H,Bressollette-Bodin C,Attia S,Yahia SB,Fisson S,Khairallah M,Aouni M

    更新日期:2013-12-01 00:00:00

  • Mix-breeding with HEV-infected swine induced inapparent HEV infection in SPF rabbits.

    abstract::Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24374

    authors: Liu L,Wang L,Xia J,Zhang Y,Zeng H,Liu P,Zou Q,Wang L,Zhuang H

    更新日期:2016-04-01 00:00:00

  • Virus reactivations after autologous hematopoietic stem cell transplantation detected by multiplex PCR assay.

    abstract::Several studies have indicated that viral reactivations following allogeneic hematopoietic stem cell transplantation (allo-HSCT) are frequent, but viral reactivations after autologous HSCT (auto-HSCT) have not been investigated in detail. We performed multiplex polymerase chain reaction (PCR) assay to examine multiple...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24621

    authors: Inazawa N,Hori T,Nojima M,Saito M,Igarashi K,Yamamoto M,Shimizu N,Yoto Y,Tsutsumi H

    更新日期:2017-02-01 00:00:00

  • Risk factors associated with hepatitis C virus (HCV) infection among prostitutes and their clients in the city of Santos, São Paulo State, Brazil.

    abstract::We studied the role of sexual transmission in the epidemiology of HCV by a cross-sectional study comparing prostitutes and HCV seropositive and seronegative sexual clients recruited from the bordellos of the docks of Santos, São Paulo State. The average age in the prostitute group was 27.2 years. The median time spent...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Mesquita PE,Granato CF,Castelo A

    更新日期:1997-04-01 00:00:00

  • Clinical and economic burden of pre-emptive therapy of cytomegalovirus infection in hospitalized allogeneic hematopoietic cell transplant recipients.

    abstract::Cytomegalovirus (CMV) infection remains a major complication after allogeneic hematopoietic cell transplantation (allo-HCT). We conducted a retrospective study to determine the clinical and economic burden of pre-emptive therapy (PET) for CMV infection in 100 consecutive hospitalized adult CMV positive serostatus allo...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25574

    authors: El Haddad L,Ghantoji SS,Park AK,Batista MV,Schelfhout J,Hachem J,Lobo Y,Jiang Y,Rondon G,Champlin R,Chemaly RF

    更新日期:2020-01-01 00:00:00

  • Recombinant Newcastle Disease virus capsids displaying enterovirus 71 VP1 fragment induce a strong immune response in rabbits.

    abstract::The complete VP1 protein of EV71 was truncated into six segments and fused to the C-terminal ends of full-length nucleocapsid protein (NPfl) and truncated NP (NPt; lacks 20% amino acid residues from its C-terminal end) of newcastle disease virus (NDV). Western blot analysis using anti-VP1 rabbit serum showed that the ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20668

    authors: Sivasamugham LA,Cardosa MJ,Tan WS,Yusoff K

    更新日期:2006-08-01 00:00:00

  • Herpes viruses and duodenal ulcer disease.

    abstract::Antibodies to herpes simplex virus and Epstein-Barr virus were sought in the sera of 33 patients with endoscopically proved duodenal ulcer and 33 healthy controls. Neither the prevalence nor the antibody levels to both viruses were significantly different between the two groups. These results suggest that herpes virus...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890290314

    authors: Kottaridis SD,Mihas TA,Goula I,Mihas AA

    更新日期:1989-11-01 00:00:00

  • Hepatitis B surface antigen confirmatory testing for diagnosis of hepatitis B virus infection in Taiwan.

    abstract::This study aimed to examine the application of hepatitis B surface antigen (HBsAg) confirmatory testing when diagnosing hepatitis B infection among young persons in Taiwan with a low prevalence rate of hepatitis B infection. HBsAg status, the presence of antibodies against HBsAg (anti-HBs), and the presence of antibod...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22127

    authors: Chu FY,Su FH,Cheng SH,Lin YS,Li CY,Chien CC,Lin YC,Chiang SY

    更新日期:2011-09-01 00:00:00

  • Immunogenicity of wild and attenuated varicella-zoster virus strains in rhesus monkeys.

    abstract::Thirty susceptible rhesus monkeys were inoculated with cell-free varicella-zoster virus strain OKA or strain KMcC. Both wild and attenuated strains were used. No clinical signs characteristic of human varicella were seen in any of the animals. Virus was not isolated from throat swabs, blood, or cerebrospinal fluid. An...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890140403

    authors: Asano Y,Albrecht P,Behr DE,Neff BJ,Vickers JH,Rastogi SC

    更新日期:1984-01-01 00:00:00

  • Acute viral hepatitis types E, A, and B singly and in combination in acute liver failure in children in north India.

    abstract::The aetiological agents responsible for, and the outcome of, acute liver failure were investigated prospectively in 44 children (29 males, 15 females) attending a tertiary health care facility in India. The children were between the ages of 2 months and 13 years. Studies for viral infections and other etiologies could...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199603)48:3<215::AID-JMV1>

    authors: Arora NK,Nanda SK,Gulati S,Ansari IH,Chawla MK,Gupta SD,Panda SK

    更新日期:1996-03-01 00:00:00

  • Recombinant nucleoprotein-based serological diagnosis of Crimean-Congo hemorrhagic fever virus infections.

    abstract::An enzyme-linked immunosorbent assay (ELISA) using recombinant nucleoprotein (rNP) was reported for the detection of immunoglobulin G (IgG) antibodies to Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV). The immunoglobulin M (IgM)-capture ELISA was developed for the diagnosis of CCHFV infections, using CCHFV rNP a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20270

    authors: Saijo M,Tang Q,Shimayi B,Han L,Zhang Y,Asiguma M,Tianshu D,Maeda A,Kurane I,Morikawa S

    更新日期:2005-02-01 00:00:00

  • Potential of large "first generation" human-to-human transmission of 2019-nCoV.

    abstract::To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok...

    journal_title:Journal of medical virology

    pub_type: 评论,杂志文章

    doi:10.1002/jmv.25693

    authors: Li X,Zai J,Wang X,Li Y

    更新日期:2020-04-01 00:00:00

  • Valomaciclovir versus valacyclovir for the treatment of acute herpes zoster in immunocompetent adults: a randomized, double-blind, active-controlled trial.

    abstract::Herpes zoster is a common infectious disease that can result in significant acute and chronic morbidity. The safety and efficacy of once-daily oral valomaciclovir (EPB-348) was evaluated for non-inferiority to 3-times daily valacyclovir, an approved therapy. In this study, 373 immunocompetent adults with onset of a he...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/jmv.23329

    authors: Tyring SK,Plunkett S,Scribner AR,Broker RE,Herrod JN,Handke LT,Wise JM,Martin PA,Valomaciclovir Zoster Study Group.

    更新日期:2012-08-01 00:00:00

  • Lack of effect of a booster dose of influenza vaccine in hemodialysis patients.

    abstract::To assess whether the administration of a booster dose of influenza vaccine may enhance immune response in hemodialysis patients, 58 subjects were given two doses of the 2003/2004 season influenza vaccine, 1 month apart. "European Agency for the Evaluation of Medicinal Products" (EMEA) criteria were fully met in terms...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20936

    authors: Tanzi E,Amendola A,Pariani E,Zappa A,Colzani D,Logias F,Perego A,Zanetti AR

    更新日期:2007-08-01 00:00:00

  • Qualitative assessment of SARS-CoV-2-specific antibody avidity by lateral flow immunochromatographic IgG/IgM antibody assay.

    abstract::Knowledge of the precise timing of SARS-CoV-2 infection may be of clinical and epidemiological relevance. The presence of low-avidity IgGs has conventionally been considered an indicator of recent infection. Here, we carried out qualitative assessment of SARS-CoV-2-specific antibody avidity using an urea (6M) dissocia...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26344

    authors: Valdivia A,Torres I,Huntley D,Alcaraz MJ,Albert E,Colomina J,Ferrer J,Carratalá A,Navarro D

    更新日期:2021-02-01 00:00:00

  • Human herpesvirus 6 integrates within telomeric regions as evidenced by five different chromosomal sites.

    abstract::Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs). Five different chromosomal integration sites were found i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21299

    authors: Nacheva EP,Ward KN,Brazma D,Virgili A,Howard J,Leong HN,Clark DA

    更新日期:2008-11-01 00:00:00