Abstract:
:The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence analysis of the E6 and the E7 regions has shown that all samples containing this duplication were related to E6-G350 variant of the HPV 16 (Chi square test, P = 0.0012). A comparison of cervical lesion severity of the examinees having regular or variant E1 genes has shown that the variant group had a significantly (Fischer's exact test, P = 0.0401) lower percentage of high grade disease cases, suggesting that this particular duplication might reduce the oncogenic potential of HPV 16, and also might clarify the differences of E6-G350 variant oncogenicity observed in European populations. Albeit, a decreased incidence of high grade cervical lesions can be linked to the prevalence of multiple HPV infection, the additional decrease of those cases with the variant E1 gene versus those without (10.5% and 18.6%, respectively) can only be ascribed to the effect of this particular HPV variant. Further research is needed to clarify the biology of these HPV 16 E1 variants.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Sabol I,Matovina M,Gasperov NM,Grce Mdoi
10.1002/jmv.21304subject
Has Abstractpub_date
2008-12-01 00:00:00pages
2134-40issue
12eissn
0146-6615issn
1096-9071journal_volume
80pub_type
杂志文章abstract::Resistance to adamantanes for treating influenza A(H3N2) has increased dramatically, worldwide, over the past 5 years. A comprehensive 10-year data set on the rise of adamantane-resistance in Hong Kong is reported. Nucleotide sequences encoding the M2-ion channel of influenza A(H3N2) were obtained from 281 H3N2 isolat...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21155
更新日期:2008-05-01 00:00:00
abstract::To assess whether the administration of a booster dose of influenza vaccine may enhance immune response in hemodialysis patients, 58 subjects were given two doses of the 2003/2004 season influenza vaccine, 1 month apart. "European Agency for the Evaluation of Medicinal Products" (EMEA) criteria were fully met in terms...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20936
更新日期:2007-08-01 00:00:00
abstract::Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children's H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25214
更新日期:2018-09-01 00:00:00
abstract::The aim of this study was to assess the seroprevalence, viremia, genotype distribution, and demographic history of hepatitis C virus (HCV) in the Republic of the Congo. Testing was carried out on sera samples collected in 2005 from 807 Bantus belonging to the Kongo, Teke, and Ngala subgroups and 80 Pygmies. Positive H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21724
更新日期:2010-04-01 00:00:00
abstract::The question of whether booster doses are required to maintain long-term protection against hepatitis B virus (HBV) after primary vaccination remains to be determined. Thus, the aim of this study was to evaluate the immune memory responses to hepatitis B surface antigen (HBsAg) challenge in vaccinated individuals thro...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24012
更新日期:2014-10-01 00:00:00
abstract::Genotype II.4 noroviruses (NoVs) are a leading cause of epidemic acute gastroenteritis in children and adults worldwide. The prevalence of different NoV genotypes causing outbreaks and sporadic cases of acute gastroenteritis in the region of Valencia, Spain, during a 4-year period (2008-11) was investigated. NoVs were...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24112
更新日期:2015-04-01 00:00:00
abstract::Crimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease caused by the Crimean-Congo hemorrhagic fever virus. Long non-coding RNAs (lncRNAs) are generally classified as transcripts longer than 200 nucleotides (nt). The various lncRNAs expressed in infected cells are responsible for regulating the expression of v...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25264
更新日期:2018-12-01 00:00:00
abstract::Many of the small round human fecal viruses implicated in outbreaks of nonbacterial gastroenteritis have been collected together and examined under the electron microscope. Negatively stained preparations without the addition of antibody were used so that the surface morphology of the virus particles remained clearly ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890090403
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. We aim to characterize the longitudinal test results of SARS-CoV-2 RNA in anal swabs and to explore the association with disease severity. METHODS:We...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26307
更新日期:2021-02-01 00:00:00
abstract::Nutrient starvation is a common phenomenon that occurs during T cell activation. Upon pathogen infection, large amounts of immune cells migrate to infection sites, and antigen-specific T cells are activated; this is followed by rapid proliferation through clonal expansion. The dramatic expansion of cells will commonly...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26423
更新日期:2020-08-13 00:00:00
abstract::Vaccine effectiveness may wane with increasing time since vaccination. This analysis used the Victorian sentinel general practitioner (GP) network to estimate vaccine effectiveness for trivalent inactivated vaccines in the 2012 season. A test-negative design was used where patients presenting to GPs with influenza-lik...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23847
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:Seasonal influenza is an annual occurrence that leads to large community outbreaks and increased hospitalisation. A number of studies have suggested that influenza A (FLUAV) is associated with increased rates of hospitalisation and mortality compared to influenza B (FLUBV). This study compared demographic an...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26600
更新日期:2020-10-15 00:00:00
abstract::The prevention of mother to child transmission of HIV-1 by zidovudine monotherapy is well known, but increasingly combination anti-retroviral therapy is prescribed during pregnancy. In this prospective study, 19 pregnant women with human immunodeficiency virus-1 (HIV-1) infection who elected to take anti-retroviral th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199911)59:3<364::aid-jmv17
更新日期:1999-11-01 00:00:00
abstract::The expression levels of many genes change after treatment of human immunodeficiency virus (HIV)-infected subjects by antiretroviral drugs. High-throughput analysis of tremendous datasets led to the discovery of genes that are implicated in the treatment pathways. In this study, we performed a gene-enrichment analysis...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25549
更新日期:2019-12-01 00:00:00
abstract::In order to demonstrate the viral specificity of IgM-containing immune complexes (IgM-CIC) detected by a C1q assay in renal allograft recipients developing a CMV infection, a technique is described allowing: 1) the dissociation of IgM-CIC by action of an acid buffer, and 2) the characterization of the viral specificit...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890330312
更新日期:1991-03-01 00:00:00
abstract::The metastasis status of pelvic lymph nodes (PLNs) seems to be a predictive factor of survival. It was suggested that the presence of HPV DNA and other biological markers in PLN may indicate a sub clinical early metastasis. The aim was to describe the prevalence and distribution patterns of HPV DNA and H-ras mutations...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21076
更新日期:2008-04-01 00:00:00
abstract::During 2002, several epidemics of aseptic meningitis were attributed to echovirus 13 in Korea. The causative agents of these outbreaks were isolated and identified using rhabdosarcoma cells, HEp-2 and Buffalo green monkey kidney cells, and a neutralization test using monospecific antiserum. Fifty-four echovirus 13 iso...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10543
更新日期:2004-07-01 00:00:00
abstract::Critical cases of coronavirus disease 2019 (COVID-19) are associated with a high risk of mortality. It remains unclear why patients with the same critical condition have different outcomes. We aimed to explore relevant factors that may affect the prognosis of critical COVID-19 patients. Six critical COVID-19 inpatient...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26181
更新日期:2020-11-01 00:00:00
abstract::DNA plasmids are potent inducers of long-lasting antigen-specific CTL responses. Little is known about the distribution of antigen-specific CD8+ T cells in the lymphoid tissue and the non-lymphoid tissue after DNA immunization. HBsAg-specific CD8+ T cells in peripheral blood mononuclear cells, spleen, lymph nodes, and...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21039
更新日期:2008-02-01 00:00:00
abstract::Little information about immunity to respiratory syncytial virus (RSV) and disease pathogenesis in elderly persons exists. Humoral immunity to RSV was assessed in 41 young, 56 healthy elderly, and 49 frail elderly adults by measuring baseline RSV specific IgG by enzyme immunoassay (EIA) and microneutralization assay (...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199910)59:2<221::aid-jmv16
更新日期:1999-10-01 00:00:00
abstract::Human metapneumovirus (hMPV) is considered an important cause of acute respiratory infections. hMPV can cause morbidity in hematopoietic stem cell transplant recipients and recent research has demonstrated that it is an important virus in patients admitted to hospital with respiratory infections and suspected of havin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23477
更新日期:2013-03-01 00:00:00
abstract::An enzyme immunoassay utilizing a fluorogenic substrate (EIFA) was employed to compare humoral antibody responses to purified virion and dense body antigens in human cytomegalovirus (CMV) infections. Results of these antibody assays were also compared to those obtained by plaque reduction neutralization and complement...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890060204
更新日期:1980-01-01 00:00:00
abstract::In order to determine whether peripheral blood mononuclear cells (PBMC) contain proviral DNA or double-stranded replicative forms of TT virus (TTV) and to define which cell subset harbors TTV, we analyzed 126 PBMC DNA samples by PCR, using the NG059/NG061/NG063 and the T801/T935 primer sets. TTV sequences were detecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2142
更新日期:2002-02-01 00:00:00
abstract::A procedure is described for the detection of hepatitis C virus (HCV) RNA in blood by means of the polymerase chain reaction (PCR) in which the reverse transcription step and two rounds of amplification are carried out in a single tube. This results in fewer manipulations, reduced risk of contamination, and economy of...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380312
更新日期:1992-11-01 00:00:00
abstract::Several viruses are associated with gastroenteritis in infants. This pilot study, nested within a larger community-based project of early childhood infections, collected daily symptom data and 511 weekly stool samples from five healthy, fully vaccinated, term infants from birth until their second birthday. Real-time P...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24716
更新日期:2017-05-01 00:00:00
abstract::GB virus-B (GBV-B) is the virus most closely related to hepatitis C virus (HCV). Thus, we have used GBV-B infection of tamarins, which develop acute hepatitis following experimental infection, as a surrogate model to study protective immunity. As challenge virus, we first produced a GBV-B pool from an infected tamarin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21013
更新日期:2008-01-01 00:00:00
abstract::The ability of the anti-cancer drug, 9-Nitrocamptothecin (9NC), to inhibit replication of HIV-1 in clinically relevant primary lymphocytic cells was studied. Primary peripheral blood lymphocytes (PBLs) from a non-infected donor were freshly infected with HIV-1 and treated with 9NC by using three different treatment sc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1042
更新日期:2001-07-01 00:00:00
abstract::A serological survey for antibodies to hepatitis C virus (HCV), dengue viruses (DEN), West Nile virus (WN), and sindbis virus (SIN) was carried out in sera of selected groups of the population of the Islands of Mauritius (n = 449) and Rodrigues (n = 115), Indian Ocean. 8.3% of 564 sera were positive for anti-HCV. In M...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440411
更新日期:1994-12-01 00:00:00
abstract::Asymptomatic carriers have a major influence on the spreading of norovirus infections. The objective of this study was to examine the characteristics of patients and asymptomatic carriers affected by norovirus-related community gastroenteritis outbreaks. No significant difference between the two groups was observed in...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25079
更新日期:2018-12-01 00:00:00
abstract::The incidence of noroviral gastroenteritis has increased dramatically in recent years, and norovirus (NoV) genogroup II.4 (GII.4) is associated with outbreaks worldwide. The NoV genotypes and their clinical relevance in children hospitalized with acute gastroenteritis between 2006 and 2011 in northern Taiwan were eval...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23728
更新日期:2014-02-01 00:00:00