Abstract:
:The tandem direct reiteration R1 in the varicella-zoster virus genome consists of two elements: units composed of 18 bp and those having 15 bp, both of whose numbers and types of combination patterns vary among strains. The variations of the R1 structure were examined in order to differentiate between the wild strains and a varicella vaccine (Oka) strain by the polymerase chain reaction using two primer sets. The results showed that the 31 wild strains were classified into nine patterns: the R1 structure consisted of a combination of 5 to 7 18-bp units and 8 to 12 15-bp units. The strain with a combination of 6 18-bp units and 10 15-bp units was found to be predominant in Japan, and the same pattern was found in the vaccine strain, so that differentiation between the vaccine strain and the wild strains in Japan merely by analysis of R1 in VZV genome is difficult.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Yoshida M,Tamura T,Hiruma Mkeywords:
subject
Has Abstractpub_date
1999-05-01 00:00:00pages
76-8issue
1eissn
0146-6615issn
1096-9071pii
10.1002/(SICI)1096-9071(199905)58:1<76::AID-JMV12>journal_volume
58pub_type
杂志文章abstract::Rapid diagnosis of human herpesvirus primary infections or reactivations is facilitated by quantitative PCRs. Quantitative PCR assays with a standard thermal cycling profile permitting simultaneous detection of herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), a...
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doi:
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