Abstract:
:A solid-phase radioimmunoassay (RIA) for the detection of hepatitis B e antigen (HBeAg) and antibody (anti-HBe) was developed. The RIA was approximately 1,000-fold more sensitive than rheophoresis for HBeAg, and approximately 6,000-fold more sensitive than rheophoresis for anti-HBe. Generally, less than one-fifth of hepatitis B antigen (HBsAg)-positive sera from blood donors were positive for either HBeAg or anti-HBe by rheophoresis; in contrast, more than 90% of the samples were positive by the RIA method. The ratio of HBeAg to anti-HBe among HBsAg carriers varied in different geographic localities. Also, the presence of HBeAg correlated directly with the titer of HBsAg and the presence of Dane core particles. Anti-HBe was associated with lower titers of serum HBsAg.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Mushahwar IK,Overby LR,Frosner G,Deinhardt F,Ling CMdoi
10.1002/jmv.1890020202subject
Has Abstractpub_date
1978-01-01 00:00:00pages
77-87issue
2eissn
0146-6615issn
1096-9071journal_volume
2pub_type
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