Hepatitis C virus: buoyant density of the factor VIII-derived isolate in sucrose.

Abstract:

:Physicochemical and molecular characterization studies of hepatitis C virus (HCV), the major causative agent of parenterally transmitted non-A, non-B hepatitis (PT-NANBH), strongly suggest that it is a pesti-/flavivirus-like virus. Additional studies show that the buoyant density of plasma-derived HCV in sucrose is significantly lower than that of most tissue culture-derived flaviviruses (1.20 g/cm3). Our finding suggests, but does not prove, that at least one physicochemical property of HCV is more similar to that of the pestiviruses, bovine viral diarrhea virus (BVDV) and hog cholera virus (HogCV), than that of the flaviviruses.

journal_name

J Med Virol

authors

Bradley D,McCaustland K,Krawczynski K,Spelbring J,Humphrey C,Cook EH

doi

10.1002/jmv.1890340315

keywords:

subject

Has Abstract

pub_date

1991-07-01 00:00:00

pages

206-8

issue

3

eissn

0146-6615

issn

1096-9071

journal_volume

34

pub_type

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