Abstract:
:No controlled trial in patients with chronic hepatitis B virus (HBV) infection on long-term entecavir (ETV) treatment, comparing switching to tenofovir disoproxil fumarate (TDF) with continuing the therapy, has been reported. Twenty-seven nucleos(t)ide-naïve patients with chronic HBV who underwent ETV therapy for ≥5 years and maintained virological response were included and randomized into two groups: one group continued ETV, and the other switched to TDF, in a 1:2 ratio. The primary endpoint was changed from baseline in serum hepatitis B surface antigen (HBsAg) level at week 48. The baseline characteristics were not different between nineteen patients in the TDF group and eight patients in the ETV group. Mean decreases in HBsAg level at week 48 were 0.023 and 0.042 log10 IU/mL in the TDF and ETV groups, respectively (P = 0.94). The mean drops in hepatitis B core-related antigens were also not different between the TDF and ETV groups at week 48 (P = 0.80). HBV DNA was sustainedly <2.1 log 10 copies/mL in all patients throughout the study period. In contrast, the mean aminotransferase levels were significantly higher in the TDF group than in the ETV group at weeks 12, 24, and 36, although being within the reference range. Estimated glomerular filtration rate was lower in the TDF group than in the ETV group at weeks 24 (P = 0.016) and 48 (P = 0.003). In conclusion, we could not find the effect on reducing HBsAg level by switching to TDF in chronic hepatitis B patients with maintained virological response to ETV for ≥5 years.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Iida-Ueno A,Enomoto M,Kozuka R,Tamori A,Kawada Ndoi
10.1002/jmv.25442subject
Has Abstractpub_date
2019-07-01 00:00:00pages
1295-1300issue
7eissn
0146-6615issn
1096-9071journal_volume
91pub_type
杂志文章,随机对照试验abstract::The various strains of human polyomavirus BK (BKV) show a marked heterogeneity in the non-coding control region (NCCR), which includes the origin of replication and the regulatory region for early and late transcription. A new BKV strain (DDP, U91605) was identified by direct detection and sequencing of PCR products o...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199908)58:4<413::aid-jmv15
更新日期:1999-08-01 00:00:00
abstract::Plenty of serologic tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been developed so far, thus documenting the importance of evaluating the relevant features of the immune response to this viral agent. The performance of these assays is currently under investigation. Amongst them, LIAISON®...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26605
更新日期:2020-10-16 00:00:00
abstract::Hepatitis B virus (HBV) infection is a dynamic process during which molecular variants are selected continuously to adapt to changes. In addition to drug resistant mutations, sequential antiviral therapy may also lead to the selection of deleted mutants. To investigate this process, the following samples were collecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21595
更新日期:2009-09-01 00:00:00
abstract::We investigated the molecular epidemiology and biological characteristics of wild measles viruses isolated since 1984 in Japan. The circulating measles virus was of genotype C1 before 1985, D3 from 1987 to 1990, and D5 from 1990 to 1997. It was replaced by the same cluster of Chicago-type D3 strain from 1997 to 1999. ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10443
更新日期:2003-08-01 00:00:00
abstract::The prevalence rate of IgG antibodies to cytomegalovirus (CMV) was determined in a sample of 567 women of childbearing age in the southern part of Israel by the immunoperoxidase assay to membrane antigen (IPAMA) technique. Urban Jewish women of Afro-Asian origin showed significantly higher rates of seropositivity than...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890240104
更新日期:1988-01-01 00:00:00
abstract::Epstein-Barr virus (EBV) serology continues to be the first diagnostic test when infectious mononucleosis is suspected. Due to possible mild immunosuppression in competitive athletes, EBV reactivation determined by increases in salivary viral load have been identified as one possible cause in recurrent respiratory inf...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23253
更新日期:2012-09-01 00:00:00
abstract::Limited data are available describing human papillomavirus (HPV) genotype distribution among females with cytological abnormalities in Switzerland. Cervical cell specimens obtained from 5,318 women were screened routinely by liquid-based Pap smear. All specimens with cellular abnormalities were analyzed subsequently f...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22126
更新日期:2011-08-01 00:00:00
abstract::Human bocavirus (HBoV) was first recognized in respiratory samples in 2005. The clinical importance of HBoV infection remains unclear. This report describes the clinical features and molecular phylogeny of HBoV isolates in children with acute respiratory infections. Nasopharyngeal aspirates were obtained from 1,528 ch...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23880
更新日期:2014-12-01 00:00:00
abstract::The prevention of mother to child transmission of HIV-1 by zidovudine monotherapy is well known, but increasingly combination anti-retroviral therapy is prescribed during pregnancy. In this prospective study, 19 pregnant women with human immunodeficiency virus-1 (HIV-1) infection who elected to take anti-retroviral th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199911)59:3<364::aid-jmv17
更新日期:1999-11-01 00:00:00
abstract::Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and -positive men who have sex with men (MSM)? MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24898
更新日期:2018-01-01 00:00:00
abstract::Until recently, human cytomegalovirus (hCMV) infection and anti-CMV treatment in transplanted patients have been monitored essentially by pp65 antigenemia, which is time-consuming and requires experienced operators. For the last two years, pp65 antigenemia levels have tended to be lower than previously in our laborato...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20326
更新日期:2005-05-01 00:00:00
abstract::Fifty-six renal allograft recipients were studied prospectively for 3 months or longer after transplant. The polymerase chain reaction (PCR) was used to screen peripheral blood leucocyte (PBL) specimens for CMV, human herpesvirus 6 (HHV6) and human herpesvirus 7 (HHV7) DNA (DNAemia) in 67 healthy controls and in seria...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199604)48:4<295::AID-JMV1>
更新日期:1996-04-01 00:00:00
abstract::The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL-6 (NF-IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx transactivated the inter...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199905)58:1<11::aid-jmv2>3
更新日期:1999-05-01 00:00:00
abstract::As a consequence of the high prevalence of TorqueTeno virus (TTV) in blood donors, thalassemia patients frequently acquire various genotypes of this virus through therapeutic blood transfusions. At present, the clinical consequences of TTV infection remain indeterminate for these patients. Here, several hundred thalas...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21070
更新日期:2008-02-01 00:00:00
abstract::Amphotropic murine leukemia virus (MLV) replicates in cells from various mammalian species including humans and is a potential contaminant in MLV vector preparations for human gene transfer studies. In general, MLV replication depends on the expression of viral genes under the control of 75 bp enhancer elements in the...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10202
更新日期:2002-10-01 00:00:00
abstract::Human herpesvirus 6 (HHV6) is a beta-herpesvirus capable of infecting several cell types from different origins. HHV6 is the etiological agent of exantem subitum and has been associated with several diseases, all characterized by an inflammatory response triggered by chemokines. We show that strain U1102 of HHV6 is ab...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10416
更新日期:2003-07-01 00:00:00
abstract::Incarcerated persons have high rates of infectious diseases. Few data on the prevalence of sexually transmitted diseases in prisoners are available. This multi-center cross-sectional study enrolled 973 inmates from eight Italian prisons. Demographic and behavioral data were collected using an anonymous standardized qu...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.20774
更新日期:2007-02-01 00:00:00
abstract::The quantification of human immunodeficiency virus type 1 (HIV-1) RNA or hepatitis C virus (HCV) RNA has been facilitated by adapting a spin column procedure for sample preparation and the use of chemiluminescent detection of polymerase chain reaction (PCR) products in microtiter plate format. All materials were comme...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-01-01 00:00:00
abstract::Herpes zoster is a common infectious disease that can result in significant acute and chronic morbidity. The safety and efficacy of once-daily oral valomaciclovir (EPB-348) was evaluated for non-inferiority to 3-times daily valacyclovir, an approved therapy. In this study, 373 immunocompetent adults with onset of a he...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1002/jmv.23329
更新日期:2012-08-01 00:00:00
abstract::Considering the limitations of cytology for detection of residual cervical cancer after radiotherapy, the aim of this study was to evaluate the frequency and viral load of high-risk HPV in cervical and vaginal samples during the early follow-up of patients treated for invasive cervical cancer and correlate the results...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23303
更新日期:2012-07-01 00:00:00
abstract::The effects of tumor necrosis factor-alpha and/or interferon-gamma on the replication of hepatitis B virus were examined using HB611 cells. These cells were derived from human hepatoblastoma cells, Huh6, by integrating hepatitis B virus DNA, and produce hepatitis B virus continuously. Each of the cytokines inhibited h...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890470314
更新日期:1995-11-01 00:00:00
abstract::Human immunodeficiency virus (HIV) is the primary etiological agent of acquired immunodeficiency syndrome (AIDS). This virus can be transmitted by blood or blood products. Homosexual males (HM) are regarded as one of the high-risk groups for AIDS. Lymphocytes obtained from HM were used for cocultivation with fresh HIV...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230404
更新日期:1987-12-01 00:00:00
abstract::The presence of the E2 region of HPV 16 was determined by the polymerase chain reaction in biopsy samples with different histopathological diagnoses. The absence of the E2 gene was observed in 17 of 30 cases examined. The E2 deletions were not confined exclusively to invasive carcinomas or to integrated viral forms. I...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890410102
更新日期:1993-09-01 00:00:00
abstract::The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21227
更新日期:2008-09-01 00:00:00
abstract::For assessing the role of circulating immune complexes (CIC) in chronic hepatitis C, the relative frequency of CIC was determined in 54 patients with chronic hepatitis C, 15 asymptomatic hepatitis C virus (HCV) carriers, and 54 healthy controls. IgM and IgG containing CIC were studied using both C1q and conglutinin (K...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890460104
更新日期:1995-05-01 00:00:00
abstract::Immunoglobulin G (IgG) and M (IgM) antibodies against mumps virus were measured by an enzyme-linked immunosorbent assay (ELISA) in the serum and cerebrospinal fluid (CSF) specimens of patients with mumps meningitis. The CSF IgG antibodies correlated well with the respective antibody titers in serum. On the contrary, i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890080406
更新日期:1981-01-01 00:00:00
abstract::The objective of this study was to determine the use of immune-complex dissociated (ICD) p24 antigen detection for the diagnosis and prognosis of HIV-1 infection in Ugandan children. Plasma collected prospectively from children born to HIV-1 infected Ugandan women was stored and later analyzed for the presence of neut...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200012)62:4<426::aid-jmv6>3.0.co
更新日期:2000-12-01 00:00:00
abstract::In this study, we aimed to investigate the changes of lymphocyte subsets (CD3+ , CD4+ , CD8+ ) and inflammatory factors (interleukin-6 [IL-6], hypersensitive C-reactive protein [HS-CRP], and procalcitonin [PCT]) of alveolar lavage fluid in patients with severe corona virus-2019 (COVID-19) pneumonia and their clinical ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26827
更新日期:2021-01-28 00:00:00
abstract::Rotavirus was detected in the stools of five children stricken with sudden infant death syndrome (SIDS) over a three-week period. While none of the children had acute gastroenteritis, four of the five had acute upper respiratory infections. Rotavirus was also identified in tracheal aspirates from two of the infants. E...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890100409
更新日期:1982-01-01 00:00:00
abstract::In order to analyse the relationships between enteroviral replication and the myocardial damage at the onset of chronic cardiac infection, 2 mouse strains with different degrees of immunological competence (NMRI nu/nu, DBA/2) were infected by a myocarditic Coxsackie virus B3 (CVB3-M1) variant. At 31 days post-inoculat...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199706)52:2<206::aid-jmv15
更新日期:1997-06-01 00:00:00