Abstract:
:Glycoproteins of enveloped viruses replicating in nonprimate mammalian cells carry α-1,3-galactose (α-Gal) glycans, and can bind to anti-Gal antibodies which are abundant in humans. The antibodies have protected humans and their ancestors for millions of years, because they inhibit replication of many kinds of microbes carrying αGal glycans and aid complements and macrophages to destroy them. Therefore, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replicating in nonprimate mammalian cells (eg, PK-15 cells) carry αGal glycans and could be employed as a live vaccine for corona virus 2019 (COVID-19). The live vaccine safety could be further enhanced through intramuscular inoculation to bypass the fragile lungs, like the live unattenuated adenovirus vaccine safely used in US recruits for decades. Moreover, the immune complexes of SARS-CoV-2 and anti-Gal antibodies could enhance the efficacy of COVID-19 vaccines, live or inactivated, carrying α-Gal glycans. Experiments are imperatively desired to examine these novel vaccine strategies which probably have the critical advantages for defeating the pandemic of COVID-19 and preventing other viral infectious diseases.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Chen JMdoi
10.1002/jmv.26312subject
Has Abstractpub_date
2020-07-18 00:00:00eissn
0146-6615issn
1096-9071pub_type
杂志文章,评审abstract::To investigate the intra-hepatic activation of the IFN system in patients affected by chronic HCV-infection in comparison with that observed in a non-infectious liver disease such as non-alcoholic steatohepatitis, we measured the liver steady state mRNA levels of interferon-alpha, interferon-beta and interferon-gamma ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10433
更新日期:2003-08-01 00:00:00
abstract::The epidemiology of HTLV-I infection in female prostitutes was studied in a survey of 395 prostitutes from Callao, Peru (the port city of Lima), 72 prostitutes from Iquitos, Peru (another port city on the Amazon River), and 510 prenatal clinic patients from Lima. Prostitutes reported a mean of 8.8 years (range, 1-39 y...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380110
更新日期:1992-09-01 00:00:00
abstract::This is an audit of a new technique to improve the colposcopy service. Samples were tested for high risk HPV DNA using Digene Hybrid Capture II. Sixty-four percent of the sampled women under 30 had detectable high risk HPV DNA, decreasing to 44% in 30--39 year olds and to 27% in women over 40. High risk HPV prevalence...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20401
更新日期:2005-08-01 00:00:00
abstract::Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiti...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890170406
更新日期:1985-12-01 00:00:00
abstract::The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. To our knowledge, this is the f...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25961
更新日期:2020-09-01 00:00:00
abstract::The objective of this study was to determine the use of immune-complex dissociated (ICD) p24 antigen detection for the diagnosis and prognosis of HIV-1 infection in Ugandan children. Plasma collected prospectively from children born to HIV-1 infected Ugandan women was stored and later analyzed for the presence of neut...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200012)62:4<426::aid-jmv6>3.0.co
更新日期:2000-12-01 00:00:00
abstract::Although analytical treatment interruption is used as a strategy to test immunotherapeutic agents in HIV-infection, it may pose a risk for study participants. The potential risks of short-term interruption of antiretroviral therapy (ART) during treatment with an autologous dendritic cell immune-based therapy (AGS-004-...
journal_title:Journal of medical virology
pub_type: 杂志文章,随机对照试验
doi:10.1002/jmv.23297
更新日期:2012-06-01 00:00:00
abstract::In patients infected with the hepatitis C virus (HCV), a heterogeneous population of viruses, so-called quasispecies exists in vivo. The hypervariable regions (HVR) within the second envelope gene (HCV-E2) show particularly highly intratypic variability and are considered to be the target of neutralizing antibodies. T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199711)53:3<245::aid-jmv11
更新日期:1997-11-01 00:00:00
abstract::Interleukin 33 (IL-33) and soluble form of ST2 (sST2) are involved in inflammation. This study aimed to assess the role of serum IL-33 and sST2 in neonates with HCMV infection. The concentration of serum IL-33 and sST2 in 20 patients and 16 healthy controls were measure by enzyme-linked immune-sorbent assay (ELISA). T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25187
更新日期:2018-08-01 00:00:00
abstract::The putative interferon sensitivity determining region (ISDR) in the NS5a region of the hepatitis C virus (HCV) was analyzed in 13 interferon alpha (IFN-alpha) treated patients representing genotypes 1a, 1b, and 2b. These patients had previously been followed longitudinally during treatment with respect to viral load ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(199809)56:1<33::aid-jmv6>3
更新日期:1998-09-01 00:00:00
abstract::Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce hearing deterioration and is used in clinical practice. Vaccines and passive administration of antibody are being evaluated i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24654
更新日期:2017-03-01 00:00:00
abstract::Recent studies have demonstrated that several cellular factors are involved in entry of hepatitis C virus (HCV) into host cells. Detailed gene expression profiles of these factors in HCV-infected livers have not been reported for humans. Transcriptional levels of LDL receptor (LDLR), CD81, scavenger receptor class B t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22042
更新日期:2011-05-01 00:00:00
abstract::Saffold viruses (SAFV) have been discovered recently and they are classified into Theilovirus species in genus Cardiovirus in the Picornaviridae family. SAFV, especially those belonging to the genotype 2, have been difficult to propagate in laboratory cell lines. This study describes the successful isolation of an eff...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23352
更新日期:2012-09-01 00:00:00
abstract::Human polyomaviruses HPyV6, HPyV7, TSPyV, HPyV9, MWPyV, and KIPyV have been discovered between 2007 and 2012. TSPyV causes a rare skin disease trichodysplasia spinulosa in immunocompromised patients, the role of remaining polyomaviruses in human pathology is not clear. In this study, we assessed the occurrence of seru...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24440
更新日期:2016-07-01 00:00:00
abstract::This investigation is in continuation with the earlier studies on diarrhea epidemic due to rotavirus, that occurred at Jawhar western India, among tribal children during Dec 2000-Jan 2001 published by National Institute of Virology, Pune. Three rotavirus strains were isolated in cell culture from fecal specimens of af...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20425
更新日期:2005-09-01 00:00:00
abstract::Enterovirus D68 (EV-D68) is an emergent viral pathogen associated with mild to severe respiratory infections. In this study, we describe respiratory infections associated with EV-D68 in Beijing over a 4 year period. Total nucleic acid was extracted from 7,945 clinical specimens collected between January 5, 2011 and Ju...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24505
更新日期:2016-09-01 00:00:00
abstract::Enteric adenoviruses are important etiological agents associated with sporadic infections and outbreaks of acute gastroenteritis in infants and children. Fecal samples were collected from 439 hospitalized patients in the years 2005-2007 from Pune, Aurangabad, and Nagpur cities of western India to identify the most pre...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21331
更新日期:2009-01-01 00:00:00
abstract::Responses to influenza vaccination are poor in frail elderly subjects who suffer the greatest morbidity and mortality due to infection. Therefore, a randomized clinical trial was performed to determine the effect of a double dose and booster vaccination on antibody responses after influenza vaccination. A total of 815...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1096-9071(200104)63:4<293::aid-jmv1004>3.0
更新日期:2001-04-01 00:00:00
abstract::Human rhinovirus (HRV), a single-stranded, positive-sense RNA virus, is associated with mild upper respiratory tract infections in children. The aim of this study was to carry out a molecular characterization and phylogeny-based classification of the circulating genotypes of HRV in hospitalized children with clinical ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23638
更新日期:2013-09-01 00:00:00
abstract::Subgroup A respiratory syncytial viruses present in respiratory secretions and low passage level cell culture isolates were found to be markedly less susceptible to neutralization with monoclonal antibodies (MAbs) to the F glycoprotein than the cell culture adapted A2 virus strain. Low passage virus isolates collected...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20892
更新日期:2007-06-01 00:00:00
abstract::Hepatitis B virus (HBV) DNA may persist in the liver in the absence of serum HBV-DNA after a self-limited acute hepatitis B. This may also occur in patients with chronic hepatitis C virus (HCV) infection but its prevalence and its impact on liver histology is unknown. HBV-DNA was tested by polymerase chain reaction (P...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20073
更新日期:2004-06-01 00:00:00
abstract::The ability of dengue virus-infected human monocyte-derived macrophages to induce permeability changes in primary human umbilical vein endothelial cells was investigated. Supernatants from dengue virus type 2-infected monocyte-derived macrophages increased permeability in human umbilical vein endothelial cell monolaye...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10340
更新日期:2003-04-01 00:00:00
abstract::A solid-phase radioimmunoassay (RIA) for the detection of hepatitis B e antigen (HBeAg) and antibody (anti-HBe) was developed. The RIA was approximately 1,000-fold more sensitive than rheophoresis for HBeAg, and approximately 6,000-fold more sensitive than rheophoresis for anti-HBe. Generally, less than one-fifth of h...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890020202
更新日期:1978-01-01 00:00:00
abstract::The evidence on genotype-specific risk in women infected with human papillomavirus (HPV) with normal cytology and the importance of the distinction of high-risk (HR)-HPV genotypes in the management of low-grade lesions suggest that the distinction of HR-HPV genotypes has the potential to improve the follow-up of patie...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21198
更新日期:2008-08-01 00:00:00
abstract::Comparison of RT-PCR assays established in house at various places revealed that laboratories could differ in sensitivity by as much as 1,000-fold in terms of the ability to detect measles virus sequences in clinical samples. The study indicates that PCR findings, positive or negative, are questionable if they are not...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10371
更新日期:2003-05-01 00:00:00
abstract::A viable virus could not be recovered from a mutant murine cytomegalovirus (MCMV) BAC in which the M34 ORF had been deleted (BACDeltaM34). In contrast, an M34 mutant virus (RcM34), in which the M34 ORF was interrupted by transposon insertion at nt 44,827 of the Smith MCMV BAC, was attenuated in replication both in tis...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21211
更新日期:2008-07-01 00:00:00
abstract::Human parvovirus B19 commonly infects children, causing erythema infectiosum (fifth disease). However, there is a significant adult population which has not been exposed to the virus and, consequently, does not have protective antibody. Recent reports have associated B19 infection during pregnancy with fetal death, al...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230409
更新日期:1987-12-01 00:00:00
abstract::In the ongoing coronavirus disease 2019 (COVID-19) pandemic, one potential cause of concern is that some discharged COVID-19 patients are testing positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. To better understand what is happening and to provide public health policy planners and ...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.26250
更新日期:2020-07-01 00:00:00
abstract::Self-limited involvement of the central nervous system (CNS) is a relatively common complication of primary infection with human herpesvirus six (HHV-6) in normal children. We describe an HIV-infected infant who developed fulminant encephalitis as a complication of HHV-6 infection. Immunohistochemical staining of CNS ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890450309
更新日期:1995-03-01 00:00:00
abstract::Junin virus infection in guinea pigs is known to be similar to human Argentine hemorrhagic fever (AHF). The guinea pig was chosen as a model for transplacental transmission of Junin virus, as both guinea pig and man have a similar placental structure. Pregnant guinea pigs were infected with the pathogenic XJ strain of...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890110210
更新日期:1983-01-01 00:00:00