Abstract：
:Sera from 79 patients with acute self-limiting hepatitis, 17 patients with acute hepatitis B evolving into chronic HBsAg carriership, and 43 chronic HBsAg carriers without a history of acute hepatitis were analyzed for presence of hepatitis B virus (HBV)-DNA by a molecular hybridization technique. In acute self-limiting hepatitis, HBV-DNA was cleared within a few weeks after the onset of clinical symptoms. The longest period of DNA positivity observed in this group was 42 days. In 29 of 52 patients HBV-DNA was cleared before HBeAg disappeared. Among 17 patients who became chronic HBsAg carriers, HBV-DNA was present for more than 6 months in all but one. Most of the HBsAg carriers eventually cleared HBV-DNA. The DNA clearance frequently preceeded the conversion of HBeAg to anti-HBe. Thus, in many patients there was a transitional period with HBeAg but without HBV-DNA. HBV-DNA was found to be a better index of impending chronicity than HBeAg since persistence of HBeAg for more than 42 days was noted in 10% of the patients who nevertheless cleared HBsAg within 6 months. By that time all those patients had turned negative for HBV-DNA. On the other hand, in 16 of the 17 patients who became chronic carriers of HBsAg, HBV-DNA as well as HBeAg persisted for more than 6 months. The present results also suggest that infectivity in acute hepatitis B is a feature mainly of the presymptomatic and early symptomatic period.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Moestrup T,Hansson BG,Widell A,Blomberg J,Nordenfelt Edoi
10.1002/jmv.1890170406subject
Has Abstractpub_date
1985-12-01 00:00:00pages
337-44issue
4eissn
0146-6615issn
1096-9071journal_volume
17pub_type
杂志文章abstract：:Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9071(199612)50:4<325::AID-JMV8>
更新日期：1996-12-01 00:00:00
abstract：:Herpes simplex virus (HSV) DNA in the cerebrospinal fluid (CSF) of children with herpes simplex encephalitis (HSE) was quantified and typed using the polymerase chain reaction (PCR) assay. During the acute phase, HSV-DNA was detected in the CSF of 13 patients with HSE, including 5 neonates. A restriction profile of th...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890410214
更新日期：1993-10-01 00:00:00
abstract：:To design a safe and effective synthetic peptide vaccine against rubella virus (RV) infection, it is necessary to identify immunodominant T-cell epitopes of RV structural proteins. To define such epitopes, 49 overlapping synthetic peptides (17-34 residues in length) corresponding to more than 95% of the amino acid seq...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890400302
更新日期：1993-07-01 00:00:00
abstract：:The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21304
更新日期：2008-12-01 00:00:00
abstract：:Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic hepatitis. We report here an outbreak of HEV genotype 1f infection during April-May 2018 among people living at Halisohor, a low land in the southern part of Chottogram ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.26739
更新日期：2020-12-17 00:00:00
abstract：:Sera from 1,943 individuals from Auckland, New Zealand, were tested for the presence of serum antibodies to human T cell lymphotropic virus I (HTLV I), mainly with an enzyme-linked immunosorbent assay (ELISA) with cell extracts as target antigen. The individuals tested were blood donors and mostly Caucasian, but inclu...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890220410
更新日期：1987-08-01 00:00:00
abstract：:A study was carried out to determine whether hepatitis A virus (HAV) can be detected in the stools of patients hospitalized for HAV infection. Acute phase samples of whole blood and stool, as well as completed questionnaires, were obtained from 31 patients hospitalized at any of 13 hospitals in the Phoenix metropolita...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890090207
更新日期：1982-01-01 00:00:00
abstract：:Hemodialysis patients are at risk for hepatitis C and B virus infections. This study investigated the prevalences and risk factors of HCV and HBV infection and the distribution of HCV genotypes among hemodialysis patients and their spouses. From August to November 2011, a cross-sectional study was conducted on 20 hemo...
journal_title：Journal of medical virology
pub_type： 杂志文章,多中心研究
doi：10.1002/jmv.23486
更新日期：2013-03-01 00:00:00
abstract：:Genotype II.4 noroviruses (NoVs) are a leading cause of epidemic acute gastroenteritis in children and adults worldwide. The prevalence of different NoV genotypes causing outbreaks and sporadic cases of acute gastroenteritis in the region of Valencia, Spain, during a 4-year period (2008-11) was investigated. NoVs were...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24112
更新日期：2015-04-01 00:00:00
abstract：:Human Pegivirus (HPgV), formerly GB virus-C/Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is widely spread and has been reported to be associated with non-A-E hepatitis. To our knowledge, no previous study was conducted about HPgV in Qatar. Thus, the objectives of this study were as follows: (i) to deter...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24289
更新日期：2015-12-01 00:00:00
abstract：:The hepatitis C virus (HCV) infects a substantial proportion of patients infected with human immunodeficiency virus (HIV). Patients infected with both HCV and HIV respond poorly to anti-HCV treatment with pegylated interferon alpha and ribavirin. But few data are available on the influence of ribavirin and interferon ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21227
更新日期：2008-09-01 00:00:00
abstract：:Puumala hantavirus (PUUV) glycoproteins G1 and G2 and nucleocapsid protein (N) were expressed in BHK-21 cells by transfection of a plasmid producing a recombinant alphavirus replicon. Coexpression of G1 and G2 from separate constructs seemed to be important for the optimal folding of the glycoproteins, as evaluated by...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：2001-11-01 00:00:00
abstract：:Currently, data examining nationally representative prevalence and trends of HBV or HCV among specific subgroups of pregnant women in the US are unavailable. We conducted a cross-sectional analysis of hospitalizations for liveborn singleton deliveries from 1998 to 2011 using data from the Nationwide Inpatient Sample. ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24725
更新日期：2017-06-01 00:00:00
abstract：:An outbreak of dengue type 2 occurred in North Queensland, Australia, between December 1996 and April 1997. Culture of serum in the Aedes albopictus C6/36 cell line with detection using immunofluorescent staining was compared with a culture-amplified detection system using an immunoperoxidase staining method in a micr...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：1999-02-01 00:00:00
abstract：:A patient presented with acute retinal necrosis of the left eye. Demonstration of herpes simplex virus (HSV) DNA in the aqueous humour confirmed the diagnosis. Negative results of HSV type-specific antibody tests based on gG antigens suggested a primary HSV infection. However, the patient had a past history of laborat...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20083
更新日期：2004-06-01 00:00:00
abstract：:Early estimates of the prevalence of TTV viremia in healthy adults of developed countries were in the order of 1--10 %, while similar estimates in Third World countries were considerably higher. Using three different PCRs, TTV-related DNA was detected in serum from 180 out of the 201 Norwegian blood donors tested, ind...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1062
更新日期：2001-07-01 00:00:00
abstract：:The live varicella vaccine has been recommended for use in immunocompromised subjects and in adults who are susceptible to chickenpox. However, we do not know how humoral and cell-mediated immune responses induced after vaccination differed from those obtained after natural infection. To answer this, 45 previously inf...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890250207
更新日期：1988-06-01 00:00:00
abstract：:The seroprevalence of hepatitis A antibodies in travellers attending London Travel Clinics increases with age and screening may eliminate the need for vaccination at present for approximately 40% of adults. The duration of protection by current hepatitis A vaccine(s) is still to be established. ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890440414
更新日期：1994-12-01 00:00:00
abstract：:Interleukin 6 (IL-6) is a pleiotropic cytokine with pivotal functions in the regulation of the biological responses of several target cells, including hepatocytes. Previous studies have shown that serum IL-6 levels are increased in hepatitis B patients. However, the role of IL-6 in modulating the anti-hepatitis B viru...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.25382
更新日期：2019-05-01 00:00:00
abstract：:A sensitive and reproducible real-time PCR assay based on TaqMan technology was developed for the detection and quantitation of hepatitis B virus (HBV) DNA in serum, and compared with an "in-house" qualitative PCR assay. HBV DNA was measured in 125 serum samples from 76 hepatitis B patients, consisting of 22 patients ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.2027
更新日期：2001-10-01 00:00:00
abstract：:The emergence of genotypic resistance in protease and reverse transcriptase (RT) gene regions was longitudinally evaluated in plasma samples from a group of 12 HIV-1-infected patients treated with different combination of antiretroviral therapies and selected on the basis of their clinical failure. Complex mutational ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9071(199912)59:4<480::aid-jmv10
更新日期：1999-12-01 00:00:00
abstract：:The presence of hepatitis GB virus C (GBV-C), also known as hepatitis G virus (HGV), and hepatitis C virus (HCV) were investigated in sera from 45 hemophiliacs from nine locations in Nicaragua using a nested polymerase chain reaction (PCR). Primers used to detect GBV-C and HCV derived from the helicase region and 5'UT...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：1997-06-01 00:00:00
abstract：:In early 2008, a sudden increase in oseltamivir (Tamiflu)-resistant influenza A H1N1 viruses was reported from several European countries. This resistant virus has spread globally and accounted for more than 95% of H1N1 viruses isolated in the following influenza season. A continuous close monitoring on the prevalence...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21783
更新日期：2010-08-01 00:00:00
abstract：:This study aimed at developing strategies for screening, predicting, and diagnosing intrauterine HBV infection in infants born to HBsAg positive mothers. A total of 1,360 infants born to 1,355 HBsAg positive mothers were followed for 1 year. All newborn infants received active and passive immunization within 24 hr aft...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.23667
更新日期：2013-10-01 00:00:00
abstract：:Chronic hepatitis B patients with low pre-treatment HBeAg (and HBV-DNA) levels are more likely to respond to interferon-alpha therapy. In retrospect, this low level of HBeAg may have been reached just before the start of therapy. Pre-treatment changes in HBeAg levels were studied in 121 patients undergoing interferon-...
journal_title：Journal of medical virology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2001-03-01 00:00:00
abstract：:Infection with putative non-A to E hepatitis virus, designated GB virus C (GBV-C), was surveyed in 286 patients with chronic liver disease in Japan. RNA of GBV-C was detected, by reverse-transcription polymerase chain reaction with nested primers from the 5'-noncoding region, in 19 patients (6.6%) at a frequency highe...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：1997-03-01 00:00:00
abstract：:Knowledge of the current epidemiology of chronic liver disease in Italy is mostly obsolete and fragmentary for the lack of up-to-date consistent data. In 2001, a 6-month prevalence study was undertaken in 79 hospitals to assess the characteristics of chronic liver disease in Italy. Both prevalent and incident cases we...
journal_title：Journal of medical virology
pub_type： 杂志文章,多中心研究
doi：10.1002/jmv.20313
更新日期：2005-04-01 00:00:00
abstract：:An enzyme-linked immunosorbent assay (ELISA) using recombinant nucleoprotein (rNP) was reported for the detection of immunoglobulin G (IgG) antibodies to Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV). The immunoglobulin M (IgM)-capture ELISA was developed for the diagnosis of CCHFV infections, using CCHFV rNP a...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20270
更新日期：2005-02-01 00:00:00
abstract：:To investigate whether the administration of IL-12 is effective against influenza virus infection, mice were intranasally administered IL-12 for three consecutive days and then infected with a non-lethal dose of the influenza virus. The IL-12-treated mice were more resistant to the virus than control mice with respect...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24494
更新日期：2016-09-01 00:00:00
abstract：:We compared characteristics of patients with GB virus C/hepatitis G virus (GBV-C/HGV) RNA to those of patients with GBV-C/HGV E2-antibody. GBV-C/HGV RNA and GBV-C/HGV antibody were assayed in 83 persons with hemophilia using a reverse transcription-polymerase chain reaction and an enzyme-linked immunosorbent assay, re...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9071(200001)60:1<34::aid-jmv6>3
更新日期：2000-01-01 00:00:00
