Abstract:
:In the ongoing coronavirus disease 2019 (COVID-19) pandemic, one potential cause of concern is that some discharged COVID-19 patients are testing positive again for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA. To better understand what is happening and to provide public health policy planners and clinicians timely information, we have searched and reviewed published studies about discharged patients testing positive again for the SARS-CoV-2 RNA. Our search found 12 reports, all of which described patients in China. Our review of these reports indicates the presence of discharged patients who remain asymptomatic but test positive. However, it is unclear whether they are contagious because a positive reverse transcriptase - polymerase chain reaction (RT- PCR) test does not necessarily indicate the presence of replicating and transmissible virus. Our review suggests the need for timely, parallel testing of different samples, including, for example, fecal specimens, from COVID-19 patients before and after they are discharged from hospitals.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Han Z,Battaglia F,Terlecky SRdoi
10.1002/jmv.26250subject
Has Abstractpub_date
2020-07-01 00:00:00eissn
0146-6615issn
1096-9071pub_type
杂志文章,评审abstract::Recently developed monoclonal antibodies against the 42,000-dalton major inner capsid protein were used in an enzyme immunoassay to subgroup a total of 156 rotavirus specimens obtained from Japanese infants and young children with acute gastroenteritis during the period between December 1981 and April 1983. Only 2 spe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890170105
更新日期:1985-09-01 00:00:00
abstract::Potential risk factors for the development of hepatocellular carcinoma were analysed in 40 Caucasian patients with this malignancy. A higher proportion (14 of 40; 35%) had evidence of hepatitis C virus (HCV) infection than had evidence of either hepatitis B virus (HBV) carriage (17.5%) or alcohol abuse (30%). In all 1...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890380215
更新日期:1992-10-01 00:00:00
abstract::Knowledge of the precise timing of SARS-CoV-2 infection may be of clinical and epidemiological relevance. The presence of low-avidity IgGs has conventionally been considered an indicator of recent infection. Here, we carried out qualitative assessment of SARS-CoV-2-specific antibody avidity using an urea (6M) dissocia...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26344
更新日期:2021-02-01 00:00:00
abstract::The temporal distribution and clinical severity of rotavirus VP7 serotypes 1, 2, 3, and 4 recovered from 427 Venezuelan children with acute gastroenteritis over a period of 11 years were studied. Rotavirus VP7 serotype was established by ELISA serotyping in 298 (69.78%) of the specimens while the serotype of the remai...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890340202
更新日期:1991-06-01 00:00:00
abstract::It is well documented that perinatal transmission is the major cause of chronic HBV infection in China. However, the mechanisms of HBV perinatal transmission are not defined clearly. It is not known whether hepatitis B e antigen can cross the human placenta, and the rate of HBeAg decay in babies with and without HBV b...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10493
更新日期:2003-11-01 00:00:00
abstract::Hepatitis C virus (HCV) exposure in blood donors is determined serologically by the detection of anti-HCV antibodies in serum or plasma. However, a "window" period of 30-70 days after exposure exists where specific antibodies to HCV antigens are not detected. The use of nucleic acid testing for the detection of HCV RN...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20716
更新日期:2006-11-01 00:00:00
abstract::Rapid diagnosis of human herpesvirus primary infections or reactivations is facilitated by quantitative PCRs. Quantitative PCR assays with a standard thermal cycling profile permitting simultaneous detection of herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21095
更新日期:2008-03-01 00:00:00
abstract::GB virus-B (GBV-B) is the virus most closely related to hepatitis C virus (HCV). Thus, we have used GBV-B infection of tamarins, which develop acute hepatitis following experimental infection, as a surrogate model to study protective immunity. As challenge virus, we first produced a GBV-B pool from an infected tamarin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21013
更新日期:2008-01-01 00:00:00
abstract::Described for the first time in 1986, Parvovirus B19 (B19V) infection in kidney transplant recipients remains little-known and probably underestimated. The aims of this study were to establish B19V infection frequency during the first year after kidney transplant and to determine predisposing factors and manifestation...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23557
更新日期:2013-06-01 00:00:00
abstract::Isolated reactivity to hepatitis B virus (HBV) core antigen (anti-HBc) is observed relatively frequently in immunocompromised individuals, intravenous drug abusers (IVDA), and in the presence of HCV infection. The reason for the lack of HBsAg is not clear. The aim of the present study was to investigate which factors ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1052
更新日期:2001-07-01 00:00:00
abstract::Fluorescent in situ hybridization (FISH) was used to investigate the chromosomal integration sites of human herpesvirus 6 (HHV-6) in phytohemagglutinin-stimulated leukocytes and B lymphocytes from Epstein-Barr virus transformed lymphoblastoid cell lines (LCLs). Five different chromosomal integration sites were found i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21299
更新日期:2008-11-01 00:00:00
abstract::The replication strategy of a human serotype 1 rotavirus, adapted to rapid growth in CV-1 cells, was investigated. A single cycle growth curve revealed eclipse and latent periods of 3 and 4 hours, respectively. Although the extent of reduction of host cell protein synthesis was directly related to the multiplicity of ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890250113
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:Seasonal influenza is an annual occurrence that leads to large community outbreaks and increased hospitalisation. A number of studies have suggested that influenza A (FLUAV) is associated with increased rates of hospitalisation and mortality compared to influenza B (FLUBV). This study compared demographic an...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26600
更新日期:2020-10-15 00:00:00
abstract:BACKGROUND:Recent influenza B/Victoria lineage viruses contain amino acid deletions at positions 162 to 164 of the haemagglutinin (HA) protein. These amino acid deletions have affected the detection of B/Victoria lineage viruses by the lineage-specific conventional reverse-transcription polymerase chain reaction (RT-PC...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25607
更新日期:2020-03-01 00:00:00
abstract::In end-stage renal disease patients treated by hemodialysis with HBeAg-negative chronic hepatitis B virus (HBV) infection, the evaluation of the presence of viral replication is essential in the assessment for renal transplantation. Data on HBV viral load, prevalence of precore mutations, as well as the influence of H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20691
更新日期:2006-10-01 00:00:00
abstract::Foscarnet (trisodium phosphonoformate) is a novel antiviral agent that inhibits viral-specific DNA polymerase. In the present study, eight males with chronic HBV carriage (HBeAg and HBV-DNA seropositivity greater than 12 months) showing chronic persistent hepatitis (CPH) or chronic active hepatitis (CAH) on liver biop...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890290214
更新日期:1989-10-01 00:00:00
abstract::To study the association between hepatitis B and schistosomiasis, 1,234 Egyptian males, ages 18 to 24, were interviewed, examined, and tested for Schistosoma mansoni infection and HBsAg. Sera from 91 (7.4%) of the study subjects were positive for HBsAg, and S. mansoni was found in the stools of 26.3%. There was no cor...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890230203
更新日期:1987-10-01 00:00:00
abstract::The polymerase chain reaction (RNA-PCR) was used for specific detection of respiratory syncytial virus (RSV) genomes in clinical specimens. A set of primers was selected from conserved regions of the 1B and N genes for detection of both subgroups. The primers were found to be RSV specific, all RSV strains generated a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440115
更新日期:1994-09-01 00:00:00
abstract::The use of quantitative assays for hepatitis C virus specific antibodies (anti-HCV) as a prognostic marker was evaluated in 31 patients with chronic hepatitis C treated with interferon (IFN). Changes in titers of serum HCV-RNA and anti-HCV antibodies; anti-C11 (anti-core), anti-C100 (anti-NS3), and anti-C7 (anti-NS3) ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420405
更新日期:1994-04-01 00:00:00
abstract::Complete coding regions were sequenced for two new enterovirus genomes: EV-B93 previously identified by VP1 sequencing, derived from a child with acute flaccid paralysis in the Democratic Republic of Congo; and EV-C95 from a French soldier with acute gastroenteritis in Djibouti. The EV-B93 P1 had more than 30% nucleot...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24062
更新日期:2015-03-01 00:00:00
abstract::Recent studies have demonstrated that several cellular factors are involved in entry of hepatitis C virus (HCV) into host cells. Detailed gene expression profiles of these factors in HCV-infected livers have not been reported for humans. Transcriptional levels of LDL receptor (LDLR), CD81, scavenger receptor class B t...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22042
更新日期:2011-05-01 00:00:00
abstract::Cells from a leiomyosarcoma tumor (LMS-1) from a patient with the acquired immunodeficiency syndrome (AIDS) were explanted, cultured in vitro, and studied by phase-contrast microscopy for morphologic and growth characteristics, immunostaining for cell markers, EBER in situ hybridization and polymerase chain reaction f...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::Antisense protein (ASP) is the new actor of viral life of Human Immunodeficiency Virus type 1 (HIV-1) although proposed above 20 years ago. The asp ORF is into complementary strand of the gp120/gp41 junction of env gene. The ASP biological role remains little known. Knowing the Env markers of viral tropism, a dataset ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24611
更新日期:2017-01-01 00:00:00
abstract::The detection of hepatitis B virus (HBV) DNA plays a critical role in determining the level of viral replication in HBV-infected patients. However, how to select appropriate HBV DNA detection method, low-sensitivity (ls) and hypersensitivity (hs) remains unclear. In this study, hepatitis B surface antigen (HBsAg), hep...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25271
更新日期:2019-02-01 00:00:00
abstract::Natural history of anal intraepithelial neoplasia and anal cancer is not fully understood. Factors associated with cytological abnormalities and predictors of progression to high-grade anal intraepithelial neoplasia still deserve investigation. The aim of this cross-sectional study was to assess the prevalence of HPV ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23831
更新日期:2014-03-01 00:00:00
abstract::Epstein-Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosqu...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25811
更新日期:2020-04-07 00:00:00
abstract::Heterogeneity of hepatitis C viral (HCV) genomes of several isolates from different countries has been reported, but there is little information on HCV isolates for the Federal Republic of Germany. Therefore, the nucleotide (nt) and deduced amino acid (aa) sequences of interesting parts of the viral genome derived fro...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890400407
更新日期:1993-08-01 00:00:00
abstract::Serum samples from 87 patients with hepatocellular carcinoma (HCC) in the United States were tested for evidence of hepatitis C viral (HCV) infection using an immunoblot assay for antibodies to the hepatitis C virus and the polymerase chain reaction to detect HCV RNA. The findings with these assays were compared to th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430205
更新日期:1994-06-01 00:00:00
abstract::The infectivity titer of a standard stock of the SAR-55 strain of hepatitis E virus (HEV) was determined in cynomolgus macaques (Macaca fascicularis) and the effect of dose on the course of the infection was examined by weekly monitoring of alanine aminotransferase (ALT) and anti-HEV levels. Antibody to HEV (anti-HEV)...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430207
更新日期:1994-06-01 00:00:00
abstract::Nineteen Chinese patients with chronic hepatitis B virus (HBV) infection, seropositive for HBV e antigen (HBeAg) and HBV DNA on at least three occasions in 6 months, were randomised to receive either recombinant human interferon-gamma (rIFN gamma) 0.1 mg/m2 intramuscularly thrice weekly for 16 weeks (n = 11) or no ant...
journal_title:Journal of medical virology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/jmv.1890340310
更新日期:1991-07-01 00:00:00