Inhibition of hepatitis C virus NS3 function by antisense oligodeoxynucleotides and protease inhibitor.

abstract：:Hepatitis B virus (HBV) e antigen (HBeAg) seroconversion during chronic HBV infection is known to play an important role in disease progression and patient response to antiviral agents. The aim of the present study was to analyze gender disparity in distribution of major hydrophilic region (MHR) variants according to ...

journal_title：Journal of medical virology

authors： Lee SA,Cho YK,Lee KH,Hwang ES,Kook YH,Kim BJ

更新日期：2011-03-01 00:00:00

abstract：:An efficient method for cloning subgenomic fragments of the hepatitis B virus (HBV) was developed, utilizing its abundant single-stranded replicative intermediates. The total genomic DNA obtained from the liver tissue of patients with chronic HBV infection was treated by using the Klenow fragment of E. coli DNA polyme...

journal_title：Journal of medical virology

authors： Kajino K,Ohta Y,Miyamura T,Saito I

更新日期：1991-01-01 00:00:00

abstract：:The specificity and neutralizing activity of antibodies against the major herpes simplex virus type 1 (HSV-1) glycoproteins were tested in serum samples of patients with a history of HSV-1 infection. By preabsorption of sera to preparations of native and denatured HSV-1 proteins, followed by immunoblotting and microne...

journal_title：Journal of medical virology

authors： Eing BR,Kühn JE,Braun RW

更新日期：1989-01-01 00:00:00

abstract：:We report a male caucasian German pediatric patient of no Arab or Mediterranean ancestry with virus associated CNS lesions in Griscelli's syndrome (GS; McKusick No. 214450). The boy presented with recurrent infections, and meningitis with subsequent progressive signs of increased intracranial pressure leading to death...

journal_title：Journal of medical virology

authors： Wagner M,Müller-Berghaus J,Schroeder R,Sollberg S,Luka J,Leyssens N,Schneider B,Krueger GR

更新日期：1997-11-01 00:00:00

abstract：:Hepatitis C virus (HCV) is a single-stranded RNA virus related to the Flaviviridae family, and striking nucleotide sequence diversity has been reported among HCV isolates from different geographic areas. To study the distribution HCV genotypes among disease group in Korea, we subtyped HCV using the method of Okamoto e...

journal_title：Journal of medical virology

authors： Lee DS,Sung YC,Whang YS

更新日期：1996-05-01 00:00:00

abstract：:A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean+/-standard deviation age, 48.4+/-13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection ...

journal_title：Journal of medical virology

authors： Inoue J,Takahashi M,Nishizawa T,Narantuya L,Sakuma M,Kagawa Y,Shimosegawa T,Okamoto H

更新日期：2005-07-01 00:00:00

abstract：:The JC virus (JCV) is a common human virus persisting in renal tissue. In immunocompromised individuals it may reactivate and cause progressive multifocal leukoencephalopathy (PML). JCV has also been implicated in cancerogenesis, leading to various brain tumors and cancers of gastrointestinal tract. In this study the ...

journal_title：Journal of medical virology

authors： Kmieciak D,Debicki S,Trzeciak WH

更新日期：2008-06-01 00:00:00

abstract：:To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted either spontaneous...

journal_title：Journal of medical virology

authors： Karasawa T,Aizawa Y,Zeniya M,Kuramoto A,Shirasawa T,Toda G

更新日期：1995-04-01 00:00:00

abstract：:Respiratory tract infections are a principal cause of illness and mortality in children worldwide and mostly caused by viruses. In this study, the epidemiology of 11 respiratory RNA viruses was investigated in a cohort of hospitalized children at a tertiary referral center in Riyadh from February 2008 to March 2009 us...

journal_title：Journal of medical virology

authors： Amer HM,Alshaman MS,Farrag MA,Hamad ME,Alsaadi MM,Almajhdi FN

更新日期：2016-06-01 00:00:00

abstract：:Recently, several clusters of hepatitis A have been observed among hemophiliacs linked to factor VIII concentrates treated for virus inactivation solely with the solvent/detergent (S/D) method, a procedure that does not affect nonenveloped viruses such as the hepatitis A virus (HAV). A new outbreak of hepatitis A in s...

journal_title：Journal of medical virology

authors： Chudy M,Budek I,Keller-Stanislawski B,McCaustland KA,Neidhold S,Robertson BH,Nübling CM,Seitz R,Löwer J

更新日期：1999-02-01 00:00:00

abstract：:Currently, data examining nationally representative prevalence and trends of HBV or HCV among specific subgroups of pregnant women in the US are unavailable. We conducted a cross-sectional analysis of hospitalizations for liveborn singleton deliveries from 1998 to 2011 using data from the Nationwide Inpatient Sample. ...

journal_title：Journal of medical virology

authors： Salemi JL,Spooner KK,Mejia de Grubb MC,Aggarwal A,Matas JL,Salihu HM

更新日期：2017-06-01 00:00:00

abstract：:The objective of the study was to assess the genotypic and phenotypic properties of 18 viral strains from human immunodeficiency virus-1 (HIV-1) positive patients and to identify subtype C isolates for vaccine design strategies. All the isolates were non-syncytium-inducing (NSI) in both the primary and MT-2 cell cultu...

journal_title：Journal of medical virology

authors： Treurnicht FK,Smith TL,Engelbrecht S,Claassen M,Robson BA,Zeier M,van Rensburg EJ

更新日期：2002-10-01 00:00:00

abstract：:Foscarnet (trisodium phosphonoformate) is a novel antiviral agent that inhibits viral-specific DNA polymerase. In the present study, eight males with chronic HBV carriage (HBeAg and HBV-DNA seropositivity greater than 12 months) showing chronic persistent hepatitis (CPH) or chronic active hepatitis (CAH) on liver biop...

journal_title：Journal of medical virology

authors： Bain VG,Daniels HM,Chanas A,Alexander GJ,Williams R

更新日期：1989-10-01 00:00:00

abstract：:During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isola...

journal_title：Journal of medical virology

authors： Lim CS,Chan KP,Goh KT,Chow VT

更新日期：2003-06-01 00:00:00

abstract：:The replication strategy of a human serotype 1 rotavirus, adapted to rapid growth in CV-1 cells, was investigated. A single cycle growth curve revealed eclipse and latent periods of 3 and 4 hours, respectively. Although the extent of reduction of host cell protein synthesis was directly related to the multiplicity of ...

journal_title：Journal of medical virology

authors： Heath RL,Birch CJ

更新日期：1988-05-01 00:00:00

abstract：:Passively administered antibodies to conserved epitopes on the attachment (G) glycoprotein of human respiratory syncytial virus (hRSV) have potential in the immunoprophylaxis of human infections. This study set out to generate monoclonal antibodies (MAbs) recognizing all prevalent lineages of HRSV and capable of immun...

journal_title：Journal of medical virology

authors： Robinson MJ,Tan CS,Fenwick F,Chambers CJ,Routledge EG,Toms GL

更新日期：2014-07-01 00:00:00

abstract：:The predictive value of two methods for measuring HIV RNA concentration in plasma was assessed in relation to CD4 lymphocyte counts during the asymptomatic period of infection. The design was a retrospective longitudinal case-control study for a mean period of 60 months involving 20 asymptomatic patients included in t...

journal_title：Journal of medical virology

authors： Delamare C,Burgard M,Deveau C,Chaix ML,Ivanoff S,Ramirez D,Tachet A,Bary M,Rouzioux C

更新日期：1998-01-01 00:00:00

abstract：:Exposure to Ljungan virus (LV) is implicated in the risk of autoimmune (type 1) diabetes but possible contribution by other parechoviruses is not ruled out. The aim was to compare children diagnosed with type 1 diabetes in 2005-2011 (n = 69) with healthy controls (n = 294), all from the Jämtland County in Sweden, usin...

journal_title：Journal of medical virology

authors： Nilsson AL,Vaziri-Sani F,Broberg P,Elfaitouri A,Pipkorn R,Blomberg J,Ivarsson SA,Elding Larsson H,Lernmark Å

更新日期：2015-07-01 00:00:00

abstract：:JC and BK polyomaviruses (JCV and BKV) infect humans and can cause severe illnesses in immunocompromised patients. Merkel cell polyomavirus (MCPyV) can be found in skin carcinomas. In this study, we assessed the occurrence of serum antibodies against MCPyV, BKV, and JCV polyomaviruses in a healthy population of the Cz...

journal_title：Journal of medical virology

authors： Sroller V,Hamšíková E,Ludvíková V,Vochozková P,Kojzarová M,Fraiberk M,Saláková M,Morávková A,Forstová J,Němečková S

更新日期：2014-09-01 00:00:00

abstract：:Human parechoviruses (HPeVs) infection is associated with a wide range of clinical syndromes such as respiratory, gastrointestinal, neurologic diseases, and neonatal sepsis-like illness. The main objective of this study was to investigate the epidemiology of HPeVs infection in hospitalized patients in a period of 2 ye...

journal_title：Journal of medical virology

authors： Piralla A,Furione M,Rovida F,Marchi A,Stronati M,Gerna G,Baldanti F

更新日期：2012-04-01 00:00:00

abstract：:Incarcerated persons have high rates of infectious diseases. Few data on the prevalence of sexually transmitted diseases in prisoners are available. This multi-center cross-sectional study enrolled 973 inmates from eight Italian prisons. Demographic and behavioral data were collected using an anonymous standardized qu...

journal_title：Journal of medical virology

authors： Sarmati L,Babudieri S,Longo B,Starnini G,Carbonara S,Monarca R,Buonomini AR,Dori L,Rezza G,Andreoni M,Gruppo di Lavoro Infettivologi Penitenziari (GLIP).

更新日期：2007-02-01 00:00:00

abstract：:A common causative agent for uterine cervical cancer is the human papillomavirus type 18 (HPV-18) which has three phylogenic variants: Asian-Amerindian, European, and African. Each variant shows significant molecular differences in the E6 gene. E6 oncoprotein is a negative regulator of tumor suppressor protein p53, he...

journal_title：Journal of medical virology

authors： Vazquez-Vega S,Sanchez-Suarez LP,Andrade-Cruz R,Castellanos-Juarez E,Contreras-Paredes A,Lizano-Soberon M,Garcia-Carranca A,Benitez Bribiesca L

更新日期：2013-07-01 00:00:00

abstract：:It has been reported that low-plasma cytomegalovirus (CMV) DNA loads are associated with an increased risk of overall mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Utilizing a conservative strategy for initiation of preemptive antiviral therapy (>1500 IU/mL), we characterized the virolog...

journal_title：Journal of medical virology

authors： Talaya A,Giménez E,Piñana JL,Albert E,Hernández-Boluda JC,Pérez A,Torres I,Solano C,Navarro D

更新日期：2019-06-01 00:00:00

abstract：:Influenza A/H3N2 viruses are associated with severe epidemics. Antiviral resistance and continued antigenic drift are the major concerns regarding prophylaxis and treatment of influenza. The objectives of this study were to investigate the prevalence and frequency of antiviral drug resistance in influenza A/H3N2 virus...

journal_title：Journal of medical virology

authors： Cai J,Wang X,Zhao B,Yao W,Wang X,Zhu Q,Zeng M

更新日期：2014-06-01 00:00:00

abstract：:Human herpes virus type 6 (HHV-6) DNA has been suggested to be a cofactor to human papillomavirus (HPV) in cervical cancer. In a cross-sectional study, we investigated the association between HHV-6 DNA detected in cervical brushings and high-grade squamous intraepithelial lesions (HSIL), while controlling for genital ...

journal_title：Journal of medical virology

authors： Tran-Thanh D,Koushik A,Provencher D,Drouin P,Dubuc-Lissoir J,Gauthier P,Allaire G,Kornegay J,Franco E,Coutlée F

更新日期：2002-12-01 00:00:00

abstract：:Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...

journal_title：Journal of medical virology

authors： Qian Y,Pu X,Yu Y,Yu X,Kong L,Liu L,Wang H,Shen H

更新日期：2020-03-01 00:00:00

abstract：:The current study aimed to investigate the diagnostic value of glycated albumin (GA), glycated hemoglobin (HbA1c), and a number of routine biomarkers as noninvasive indicators of liver fibrosis in patients with chronic hepatitis C (CHC). One hundred patients with CHC were subjected to full medical history and examinat...

journal_title：Journal of medical virology

authors： Abo El-Khair SM,El-Alfy HA,Elsamanoudy AZ,Elhammady D,Abd-Elfattah N,Eldeek B,Farid K

更新日期：2020-06-19 00:00:00

abstract：:Lamivudine therapy often causes breakthrough of hepatitis B virus (HBV) DNA and breakthrough hepatitis. The aim of this study was to determine the viral factors that relate to HBV-DNA breakthrough with and without breakthrough hepatitis. Among 82 patients with chronic hepatitis B (CHB) who received lamivudine at a dos...

journal_title：Journal of medical virology

authors： Horiike N,Duong TN,Michitaka K,Joko K,Hiasa Y,Konishi I,Yano M,Onji M

更新日期：2007-07-01 00:00:00

abstract：:Human immunodeficiency virus 2 (HIV-2) infection is characterized by a slower disease progression and lower transmission rates. The molecular features that could be assigned as directly involved in this in vivo phenotype remain essentially unknown, and the importance of HIV-2 as a model to understand pathogenicity of ...

journal_title：Journal of medical virology

authors： Santos-Costa Q,Parreira R,Moniz-Pereira J,Azevedo-Pereira JM

更新日期：2009-11-01 00:00:00

abstract：:Human T-lymphotropic virus type 1 (HTLV-1) infection causes adult T-cell leukemia and is characterized by long periods of clinical latency with low levels of viral production. Transcription of HTLV-1 is controlled through sequences in the promoter and enhancer regions of the long terminal repeat of the integrated prov...

journal_title：Journal of medical virology

authors： Newbound GC,O'Rourke JP,Collins ND,Andrews JM,DeWille J,Lairmore MD

更新日期：2000-10-01 00:00:00