Genetic heterogeneity in the precore region of hepatitis B virus in hepatitis B e antigen-negative chronic hepatitis B patients: spontaneous seroconversion and interferon-induced seroconversion.


:To elucidate the relationship between the clinical severity of chronic liver disease and the precore mutations in hepatitis B e antigen (HBeAg)-negative hepatitis B virus (HBV) carriers, mutations were investigated in the precore region of HBV DNA in 20 chronic hepatitis B patients who seroconverted either spontaneously or after the administration of alpha-interferon (IFN), and 5 asymptomatic carriers. The precore mutation with a stop codon at nucleotide 1896 was found in all patients, irrespective of the histology and in all asymptomatic carriers. The second mutation at nucleotide 1899 was found in 40% of cases studied but always followed by the first mutation at nucleotide 1896. The mixed viral infection of precore mutant and wild-type HBV virus was found in 40% of seroconverted cases after IFN treatment and in sera of HBV carriers obtained within a year after the spontaneous seroconversion. These data suggest that the precore mutants prevail over wild-type HBV in all HBeAg-negative HBV carriers within several years after the seroconversion, but their prevalence could not confine the clinical severity of chronic liver disease.


J Med Virol


Karasawa T,Aizawa Y,Zeniya M,Kuramoto A,Shirasawa T,Toda G




Has Abstract


1995-04-01 00:00:00












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    journal_title:Journal of medical virology

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


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    pub_type: 杂志文章,多中心研究


    authors: Sagnelli E,Stroffolini T,Mele A,Almasio P,Coppola N,Ferrigno L,Scolastico C,Onofrio M,Imparato M,Filippini P

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    journal_title:Journal of medical virology

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    更新日期:2007-09-01 00:00:00

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


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    更新日期:2019-09-01 00:00:00

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    journal_title:Journal of medical virology

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Hashimoto Y,Ochi H,Abe H,Hayashida Y,Tsuge M,Mitsui F,Hiraga N,Imamura M,Takahashi S,Nelson Hayes C,Ohishi W,Kubo M,Tsunoda T,Kamatani N,Nakamura Y,Chayama K

    更新日期:2011-06-01 00:00:00

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    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Huang LY,Oystein Jonassen T,Hungnes O,Grinde B

    更新日期:2001-07-01 00:00:00