Abstract:
:Knowledge of the nucleotide sequence in the region of the putative VP1/2A junction of the Hepatitis A virus (HAV) genome has enabled differentiation of HAV strains and their classification into seven genotypes, in some of which sub-genotypes A and B can be defined. A 168 base segment encompassing the putative VP1/2A junction of 27 clinical wild-type isolates of HAV from Cuba was amplified by reverse transcriptase-polymerase chain reaction and then sequenced. The Cuban isolates are clustered within sub-genotype IA. A single amino acid substitution, which does not correspond with any of the reported changes for other strains, was observed. A new sub-genotype variant is therefore postulated. This study provides new data on the genetic relatedness of HAVs from Cuba and on the distribution of sub-genotype IA in the Caribbean area.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Diaz BI,Sariol CA,Normann A,Rodríguez L,Flehmig Bdoi
10.1002/jmv.1023keywords:
subject
Has Abstractpub_date
2001-06-01 00:00:00pages
96-103issue
2eissn
0146-6615issn
1096-9071pii
10.1002/jmv.1023journal_volume
64pub_type
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