Abstract：
:Ideally, long-term lamivudine therapy should not induce tyrosine-methionine-aspartate-aspartate (YMDD) mutants (reverse transcription [rt]; rt M204I/V) in patients with chronic hepatitis B. There is little or no information on the clinical features of patients who do not develop such mutants. We analyzed 368 patients who received lamivudine therapy for more than 6 months between 1995 and 2003. Among them, 98 patients were negative for YMDD mutants during 5-year lamivudine therapy. Multivariate analysis identified hepatitis B e antigen (HBeAg) negativity, lack of cirrhosis, and high gamma glutamyltranspeptidase (GGTP) level as independent factors associated with lack of emergence of YMDD mutants during 5-year treatment. In these 98 patients, 21 patients developed YMDD mutants in the 5-year posttreatment follow-up. Old age was identified as the only factor associated with the emergence of YMDD mutants during that period. For all patients, 53 showed no elevation of alanine aminotransferase (ALT) or viral load after emergence of YMDD mutants during 5 years. Short latency to emergence of YMDD mutants, mixed (tyrosine-isoleucine-aspartate-aspartate (YIDD) [rtM204I] + tyrosine-valine-aspartate-aspartate (YVDD) [rtM204V]) type, and low ALT level were identified as independent factors associated with elevation ALT or viral load. HBeAg negativity, lack of cirrhosis, and high GGTP level were associated with lack of emergence of YMDD mutants during 5-year period. Young age protected against emergence of YMDD mutants over the 5-year period. Moreover, after the emergence of YMDD mutants, short latency to the emergence of YMDD mutant, mixed type mutants, and low baseline ALT level were associated with elevation of ALT or viral load.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Hashimoto Y,Suzuki F,Hirakawa M,Kawamura Y,Yatsuji H,Sezaki H,Hosaka T,Akuta N,Kobayashi M,Saito S,Suzuki Y,Kobayashi M,Arase Y,Ikeda K,Kumada Hdoi
10.1002/jmv.21681subject
Has Abstractpub_date
2010-04-01 00:00:00pages
684-91issue
4eissn
0146-6615issn
1096-9071journal_volume
82pub_type
杂志文章abstract：:Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24322
更新日期：2016-02-01 00:00:00
abstract：:A nationwide hepatitis B vaccination program was launched in Taiwan in 1984. To study the impact of this ongoing program on hepatitis B virus (HBV) infection, a follow-up seroepidemiologic study was carried out in 1989 in a Taipei district where pre-vaccination seroepidemiology had been studied. HBV markers were studi...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890340205
更新日期：1991-06-01 00:00:00
abstract：:Chitin in the form of microparticles (chitin microparticles, CMP) has been demonstrated to be a potent stimulator of macrophages, promoting T-helper-1 (Th1) activation and cytokine response. In order to examine the mucosal adjuvant effect of CMP co-administered with influenza hemagglutinin (HA) vaccine against influen...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20247
更新日期：2005-01-01 00:00:00
abstract：:Responses to influenza vaccination are poor in frail elderly subjects who suffer the greatest morbidity and mortality due to infection. Therefore, a randomized clinical trial was performed to determine the effect of a double dose and booster vaccination on antibody responses after influenza vaccination. A total of 815...
journal_title：Journal of medical virology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1002/1096-9071(200104)63:4<293::aid-jmv1004>3.0
更新日期：2001-04-01 00:00:00
abstract：:Three hepatitis B surface antigen (HBsAg) preparations were compared: purified intact 22-nm HBsAg particles; HBsAg-derived, sodium dodecyl sulfate (SDS)-denatured P25 + GP30 polypeptide pool; and nondenatured P25 + GP30 micelles. The micelles had the same polypeptide composition as the P25 + GP30 pool. The immunogenic...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890110205
更新日期：1983-01-01 00:00:00
abstract：:Little information about immunity to respiratory syncytial virus (RSV) and disease pathogenesis in elderly persons exists. Humoral immunity to RSV was assessed in 41 young, 56 healthy elderly, and 49 frail elderly adults by measuring baseline RSV specific IgG by enzyme immunoassay (EIA) and microneutralization assay (...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9071(199910)59:2<221::aid-jmv16
更新日期：1999-10-01 00:00:00
abstract：:The emergence of drug-resistant variants during antiretroviral therapy is a serious obstacle to sustained suppression of the human immunodeficiency virus type 1 (HIV-1). For that reason, resistance assays are essential to guide clinicians in the selection of optimal treatment regimens. Genotypic assays are less expens...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20770
更新日期：2007-02-01 00:00:00
abstract：:Paired sera, saliva and cervicovaginal secretions from 17 HTLV-I-infected women (19-75 yr) were tested for total IgA and IgG, for IgA and IgG to the immunodominant region gp46/175-Pro-199, for serum IgG to the neutralizing domains gp46/ 190-Pro-199 and gp46/190-Ser-199, or for tax-rex proviral HTLV-DNA. Serum antibodi...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(SICI)1096-9071(199609)50:1<42::AID-JMV9>3
更新日期：1996-09-01 00:00:00
abstract：:Norovirus (NoV) is a causative agent of gastroenteritis in children and adults worldwide. Although reverse transcription-polymerase chain reaction (RT-PCR) has been accepted as the standard method for diagnosis of NoV infection, it requires well-trained personnel and sophisticated equipments. Performance of a commerci...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.21916
更新日期：2010-12-01 00:00:00
abstract：:Human Pegivirus (HPgV), formerly GB virus-C/Hepatitis G virus (GBV-C/HGV), collectively known as GBV-C, is widely spread and has been reported to be associated with non-A-E hepatitis. To our knowledge, no previous study was conducted about HPgV in Qatar. Thus, the objectives of this study were as follows: (i) to deter...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24289
更新日期：2015-12-01 00:00:00
abstract：:A novel real-time PCR assay system was developed to quantify the cytomegalovirus (CMV) genome load. The real-time PCR assay could detect from 6 to over 10(6) copies of CMV-DNA with a wide linear range. The virus load of immunocompromised patients with symptomatic CMV infections was quantified and compared to that of a...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/(sici)1096-9071(200004)60:4<455::aid-jmv14
更新日期：2000-04-01 00:00:00
abstract：:Hepatitis E virus (HEV) infection is considered a neglected disease of major concern in developed countries. Clinically, HEV occurs as an acute and self-limited disease, though chronic cases mostly associated to HEV-3 are now being commonly reported in immunocompromised individuals and solid organ transplant recipient...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.26231
更新日期：2020-06-27 00:00:00
abstract：:To characterize cytotoxic T lymphocytes (CTLs) that appeared in circulation during lamivudine therapy, we analyzed HBV-specific CTLs using HLA-A24 tetramer and HBcAg-specific Th1 cells in patients receiving lamivudine therapy. Six patients (HLA-A24(+)) with chronic hepatitis B, six patients (HLA-A24(-)) with chronic h...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.20194
更新日期：2004-11-01 00:00:00
abstract：:Mitochondrial DNA (mtDNA) of peripheral blood mononuclear cells (PBMCs) collected from Human immunodeficiency virus 1 (HIV-1)-infected patients and healthy controls were measured longitudinally using real-time polymerase chain reaction to evaluate the effects of antiretroviral agents on mtDNA synthesis in vivo and to ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.10423
更新日期：2003-08-01 00:00:00
abstract：:Human bocavirus (HBOV) has been reported as a worldwide distributed respiratory pathogen. It has also been associated with encephalitis recently by detection of the virus in cerebrospinal fluid (CSF) of patients presented with encephalitis. This retrospective study aimed to present clinical features of HBOV infections...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24263
更新日期：2015-11-01 00:00:00
abstract：:Human herpesvirus 6 (HHV-6) and human immunodeficiency virus type 1 (HIV-1) may interact during transplacental transmission of HIV-1. The placental syncytiotrophoblast layer serves as the first line of defense of the fetus against viruses. Patterns of replication of HHV-6 variant A (HHV-6A) and HIV-1 were analyzed in ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.2194
更新日期：2002-05-01 00:00:00
abstract：:Varicella zoster-virus (VZV) is a humanpathogenic alpha-Herpesvirus that causes chickenpox after primary infection. The virus spreads by aerosol or direct contact with infectious vesical fluids, it enters the body via the respiratory tract. In a first viremic stage it replicates in local lymph nodes, followed by a sec...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.10323
更新日期：2003-01-01 00:00:00
abstract：:The infectivity titer of a standard stock of the SAR-55 strain of hepatitis E virus (HEV) was determined in cynomolgus macaques (Macaca fascicularis) and the effect of dose on the course of the infection was examined by weekly monitoring of alanine aminotransferase (ALT) and anti-HEV levels. Antibody to HEV (anti-HEV)...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.1890430207
更新日期：1994-06-01 00:00:00
abstract：:G1P[8] rotaviruses are predominant in causing diarrheal infections in humans all over the world. This study reports the analysis of complete genomes of G1P[8] strains, two each recovered from Rotarix™ vaccine recipients and non-recipients hospitalized for acute gastroenteritis in Pune, western India. All four strains ...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.25007
更新日期：2018-04-01 00:00:00
abstract：:The prevalence of HCV genotypes in four republics of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan) was investigated. Overall, 197 HCV isolates from 66 blood donors and 131 patients with chronic hepatitis were typed. Viral sequences from sera of infected subjects were amplified by nested RT-PCR usi...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：
更新日期：1997-09-01 00:00:00
abstract：:Anal cancer is a rare disease. Nevertheless, it may be a reason for concern among groups in which its incidence is increasing: those who engage in anoreceptive intercourse, promiscuous persons, and those with sexually transmitted infections (HPV and HIV). The aim of this study was to evaluate the prevalence of abnorma...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.23346
更新日期：2012-09-01 00:00:00
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journal_title：Journal of medical virology
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doi：10.1002/jmv.25278
更新日期：2019-01-01 00:00:00
abstract：:The oncoprotein Tax was characterized genetically from a large cohort of human T-cell lymphotropic virus type 1 (HTLV-1) seropositive individuals from the most endemic region of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and HTLV-1 infection in Argentina, the province of San Salvador de Jujuy....
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doi：10.1002/jmv.21833
更新日期：2010-08-01 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. Here, we stratified COVID-19 patients based on their comorbidities to assess their risk of serious adverse outcomes. We collected 856 hospitalized cases diagnosed with COVID-19 from 17 January to 7 February 2020, in Zhejiang Prov...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.26183
更新日期：2020-11-01 00:00:00
abstract：:The rapid spread of the epidemic has aroused widespread concern in the international community. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) was first reported in China, with bats as the likely original hosts and pangolins as potential intermediate hosts. The current source of the disease is mainly pat...
journal_title：Journal of medical virology
pub_type： 杂志文章,评审
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更新日期：2020-07-01 00:00:00
abstract：:HIV-1 drug resistance mutations (DRMs) and substitutions were assessed after the failure of the first line non-nucleoside reverse transcriptase inhibitors (NNRTIs) + 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) treatment regimens (efavirenz [EFV] + lamivudine[3TC] + zidovudine [ZDV] vs. EFV + 3TC +...
journal_title：Journal of medical virology
pub_type： 杂志文章
doi：10.1002/jmv.24361
更新日期：2016-03-01 00:00:00
abstract：:During Epstein-Barr virus (EBV) latency, the EBV genome is largely silenced by methylation. This silencing is overturned during the switch to the lytic cycle. A key event is the production of the viral protein Zta which binds to three Zta-response elements (ZRE) from the Rta promoter (Rp), two of which (ZRE2 and ZRE3)...
journal_title：Journal of medical virology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
abstract：:Interleukin 33 (IL-33) and soluble form of ST2 (sST2) are involved in inflammation. This study aimed to assess the role of serum IL-33 and sST2 in neonates with HCMV infection. The concentration of serum IL-33 and sST2 in 20 patients and 16 healthy controls were measure by enzyme-linked immune-sorbent assay (ELISA). T...
journal_title：Journal of medical virology
pub_type： 杂志文章
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更新日期：2018-08-01 00:00:00
abstract：:Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatia...
journal_title：Journal of medical virology
pub_type： 杂志文章
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更新日期：2019-06-01 00:00:00
abstract：:Varicella in the immunocompetent adult is an infrequent but potentially serious infection. Previous studies in immunocompetent hosts and normal adults have demonstrated the value of intravenous acyclovir in the treatment of varicella-zoster virus infections. Oral acyclovir has also shown efficacy in both normal adults...
journal_title：Journal of medical virology
pub_type： 杂志文章,评审
doi：10.1002/jmv.1890410517
更新日期：1993-01-01 00:00:00
