Cervicovaginal synthesis of IgG antibodies to the immunodominant 175-199 domain of the surface glycoprotein gp46 of human T-cell leukemia virus type I.

Abstract:

:Paired sera, saliva and cervicovaginal secretions from 17 HTLV-I-infected women (19-75 yr) were tested for total IgA and IgG, for IgA and IgG to the immunodominant region gp46/175-Pro-199, for serum IgG to the neutralizing domains gp46/ 190-Pro-199 and gp46/190-Ser-199, or for tax-rex proviral HTLV-DNA. Serum antibodies to gp46/ 175-Pro-199 were detected more frequently in the IgG (13/17) than in the IgA (5/17) isotypes. The majority (8/12) of anti-gp46/175-Pro-199-positive sera reacted also to gp46/190-Pro-199 or to gp46/ 190-Ser-199, demonstrating their neutralizing properties. In saliva, antibodies to gp46/175-Pro-199 were not generally detected. In cervicovaginal secretions, IgG to gp46/175-Pro-199, but not IgA, were detected in 6/15 (40%) patients. The mean specific activity of IgG to gp46/175-Pro-199 showed a trend to be higher in cervicovaginal secretions (218 +/- 109) than in sera (14 +/- 4). Furthermore, in all patients with cervicovaginal IgG to gp46/175-Pro-199, the cervicogaginal/serum ratio (19 +/- 6) of anti-gp46 IgG specific activities were markedly above 1. HTLV-DNA was detected in 4/17 salivas, and in 3/15 cervicovaginal secretions, all from patients demonstrating cervicovaginal synthesis of IgG to gp46/175-Pro-199. In conclusion, IgG to gp46/175-Pro-199 in cervicovaginal secretions, when present, appear to be produced primarily locally because of local HTLV-I excretion. Since anti-gp46/175-Pro-199 antibodies usually support reactivities to neutralizing domains, their presence could be relevant for limiting HTLV-I transmission via cervicovaginal secretions.

journal_name

J Med Virol

authors

Bélec L,Georges-Courbot MC,Georges A,Mohamed AS,Londos-Gagliardi D,Hallouin MC,Hocini H,Guillemain B

doi

10.1002/(SICI)1096-9071(199609)50:1<42::AID-JMV9>3

subject

Has Abstract

pub_date

1996-09-01 00:00:00

pages

42-9

issue

1

eissn

0146-6615

issn

1096-9071

pii

10.1002/(SICI)1096-9071(199609)50:1<42::AID-JMV9>3

journal_volume

50

pub_type

杂志文章
  • Characterization of pandemic influenza A (H1N1) virus hemagglutinin specific polyclonal antibodies for biosensor applications.

    abstract::In this study, recombinant hemagglutinin protein (rH1N1HA) of Pandemic influenza virus and polyclonal antibodies against it for biosensor applications have been characterized. For rapid and high sensitive detection of H1N1 virus or its antibodies, PCR-free and label free detection method based on a surface plasmon res...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23753

    authors: Athmaram TN,Saraswat S,Sikarwar B,Verma SK,Singh AK,Boopathi M

    更新日期:2014-03-01 00:00:00

  • Influence of HCV genotype and co-infection with human immunodeficiency virus on CD4(+) and CD8(+) T-cell responses to hepatitis C virus.

    abstract::The role of T-cells in clearance of hepatitis C virus (HCV) during acute infection is critical. The relevance of the immunological response in the control of HCV replication is less clear in chronic HCV infection. HCV-specific T-cell responses were examined in 92 interferon-naive individuals with chronic hepatitis C. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20856

    authors: Capa L,Soriano V,García-Samaniego J,Nuñez M,Romero M,Cascajero A,Muñoz F,González-Lahoz J,Benito JM

    更新日期:2007-05-01 00:00:00

  • Epidemiology of enterovirus types causing neurological disease in Austria 1999-2007: detection of clusters of echovirus 30 and enterovirus 71 and analysis of prevalent genotypes.

    abstract::Between 1999 and 2007 1,388 stool specimens from patients with acute flaccid paralysis or aseptic meningitis were submitted to the Austrian reference laboratory for poliomyelitis. Samples (201) yielded non-poliovirus enterovirus in culture. One hundred eighty-one viruses were available for typing and 78 isolates which...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21374

    authors: Ortner B,Huang CW,Schmid D,Mutz I,Wewalka G,Allerberger F,Yang JY,Huemer HP

    更新日期:2009-02-01 00:00:00

  • Genetic analyses of Seoul hantavirus genome recovered from rats (Rattus norvegicus) in the Netherlands unveils diverse routes of spread into Europe.

    abstract::Seoul virus (SEOV) is the etiologic agent of hemorrhagic fever with renal syndrome. It is carried by brown rats (Rattus norvegicus), a commensal rodent that closely cohabitates with humans in urban environments. SEOV has a worldwide distribution, and in Europe, it has been found in rats in UK, France, Sweden, and Belg...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25390

    authors: Ling J,Verner-Carlsson J,Eriksson P,Plyusnina A,Löhmus M,Järhult JD,van de Goot F,Plyusnin A,Lundkvist Å,Sironen T

    更新日期:2019-05-01 00:00:00

  • HIV antibodies in whole saliva detected by ELISA and western blot assays.

    abstract::Paired serum and saliva samples were tested by enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) for the presence of human immunodeficiency virus (HIV) antibodies. The study group included 36 individuals known to be HIV seropositive and 14 healthy, seronegative controls. HIV antibodies were detected in a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890300403

    authors: Holmström P,Syrjänen S,Laine P,Valle SL,Suni J

    更新日期:1990-04-01 00:00:00

  • Colposcopy, punch biopsy, in situ DNA hybridization, and the polymerase chain reaction in searching for genital human papillomavirus (HPV) infections in women with normal PAP smears.

    abstract::To assess the prevalence of HPV infection in the genital tracts of women with normal PAP smears, a random series of 109 women was reexamined using colposcopy, a further PAP smear, and punch biopsies taken from the cervix (in 33 cases), vagina (212 cases), and anus (20 cases). The biopsy material was examined using rou...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890310404

    authors: Syrjänen S,Saastamoinen J,Chang FJ,Ji HX,Syrjänen K

    更新日期:1990-08-01 00:00:00

  • Misidentification of recombinant hepatitis C virus leading to treatment failure with direct acting antivirals.

    abstract::The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct genotype. The present study describes the...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25035

    authors: Mourez T,Decroos A,Goria O,Montialoux H,De Oliveira F,Larrat S,Plantier JC,Riachi G

    更新日期:2018-05-01 00:00:00

  • Phylogenetic analysis of human group C rotavirus in hospitalized children with gastroenteritis in Belém, Brazil.

    abstract::Group C rotavirus (RVC) is potentially an important pathogen associated with acute gastroenteritis (AG), especially in outbreaks. This study aims to detect and molecularly characterize RVC in hospitalized children with AG in Belém, Brazil. From May 2008 to April 2011, 279 stools were subjected to reverse-transcription...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24379

    authors: Lobo Pdos S,Guerra Sde F,Siqueira JA,Soares Lda S,Gabbay YB,Linhares AC,Mascarenhas JD

    更新日期:2016-04-01 00:00:00

  • Epidemiology of acute gastroenteritis outbreaks caused by Noroviruses in Okayama, Japan.

    abstract::Noroviruses (called formerly "Norwalk-like viruses") cause food-borne gastroenteritis outbreaks. These outbreaks were thought to be related to shellfish consumption, although non-shellfish related outbreaks also occurred frequently in Japan. To clarify the epidemiology of Norovirus outbreaks, 435 stool samples were co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20455

    authors: Hamano M,Kuzuya M,Fujii R,Ogura H,Yamada M

    更新日期:2005-10-01 00:00:00

  • Molecular detection and genetic variability of human metapneumovirus in Uruguay.

    abstract::Human metapneumovirus (hMPV) has been described as circulating among the Uruguayan population at least since 1998 based on serologic evidence. However, no isolation attempts, molecular detection, or genetic studies have been carried out so far in the country. In the present study, molecular detection of circulating hM...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21752

    authors: Pizzorno A,Masner M,Médici C,Sarachaga MJ,Rubio I,Mirazo S,Frabasile S,Arbiza J

    更新日期:2010-05-01 00:00:00

  • Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study.

    abstract::Herpes simplex virus (HSV) establishes latency in neurons and recurrent infections in oral mucosa. This prospective study analyzes HSV prevalence in oral mucosal brush samples from men with known human papillomavirus (HPV) status. We hypothesized that HSV-1-infection could facilitate HPV persistence as a cofactor. Thi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24965

    authors: Mäki J,Paavilainen H,Kero K,Hukkanen V,Syrjänen S

    更新日期:2018-03-01 00:00:00

  • Oyster-associated gastroenteritis in Australia: the detection of Norwalk virus and its antibody by immune electron microscopy and radioimmunoassay.

    abstract::Following widespread outbreaks of oyster-associated gastroenteritis in Australia during 1978 in which Norwalk virus was implicated as the causative agent, collaborative studies were undertaken between laboratories in Australia and the United States to confirm the etiology. Immune electron microscopy (IEM) techniques w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890060103

    authors: Grohmann GS,Greenberg HB,Welch BM,Murphy AM

    更新日期:1980-01-01 00:00:00

  • Hepatitis C virus genotype 3 predominates in North and Central India and is associated with significant histopathologic liver disease.

    abstract::Hepatitis C virus (HCV) genotypes help to tailor the treatment response, but their influence on the disease severity and association with hepatic steatosis is not well understood. The prevalence of HCV genotypes and their correlation with the histopathological severity of liver disease and steatosis in Indian patients...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20561

    authors: Hissar SS,Goyal A,Kumar M,Pandey C,Suneetha PV,Sood A,Midha V,Sakhuja P,Malhotra V,Sarin SK

    更新日期:2006-04-01 00:00:00

  • Induction of apoptosis in HT-29 cells infected with SA-11 rotavirus.

    abstract::Rotavirus infection is associated both in vivo and in vitro with a series of subcellular pathological alterations leading to cell lysis. It has been suggested that these modifications can play a key role in the pathogenesis of rotavirus-associated diarrheal disease. We describe the effects of SA-11 rotavirus infection...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(SICI)1096-9071(199612)50:4<325::AID-JMV8>

    authors: Superti F,Ammendolia MG,Tinari A,Bucci B,Giammarioli AM,Rainaldi G,Rivabene R,Donelli G

    更新日期:1996-12-01 00:00:00

  • TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration.

    abstract::In order to determine whether peripheral blood mononuclear cells (PBMC) contain proviral DNA or double-stranded replicative forms of TT virus (TTV) and to define which cell subset harbors TTV, we analyzed 126 PBMC DNA samples by PCR, using the NG059/NG061/NG063 and the T801/T935 primer sets. TTV sequences were detecte...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2142

    authors: Yu Q,Shiramizu B,Nerurkar VR,Hu N,Shikuma CM,Melish ME,Cascio K,Imrie A,Lu Y,Yanagihara R

    更新日期:2002-02-01 00:00:00

  • Genetic analysis of hepatitis A virus variants circulating among children presenting with acute diarrhea in Cameroon.

    abstract::Molecular investigation was undertaken of circulating hepatitis A virus (HAV) associated with cases of acute diarrhea among children under 5 years of age in Kumba-Cameroon. Reverse transcription PCR, sequencing, and phylogenetic analysis of a 371 bp segment of the VP1/P2A junction of six isolates obtained from stool s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23266

    authors: Forbi JC,Agwale SM,Ndip LM,Esona MD

    更新日期:2012-05-01 00:00:00

  • Prevalence of human parechoviruses in central nervous system infections in children: a retrospective study in Shanghai, China.

    abstract::Human parechoviruses (HPeV) are associated with central nervous system (CNS) infections and sepsis-like illnesses. However, data from China are not available. The aim of this study was to determine the prevalence, age, and seasonal distributions and genotypes of HPeV infections in children with CNS related disease in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23449

    authors: Zhong H,Lin Y,Su L,Cao L,Xu M,Xu J

    更新日期:2013-02-01 00:00:00

  • Four putative subtypes of human parvovirus B19 based on amino acid polymorphism in the C-terminal region of non-structural protein.

    abstract::The nucleotide sequence of 10 isolates of human parvovirus B19 (B19) were determined and compared throughout 96.3% of the open reading frames (4145 nucleotides from nt. 509-4653). In the 4145 nucleotides, 122 mutation sites were found, of which 24 were accompanied by amino acid displacement. Furthermore, the polymorph...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200009)62:1<60::aid-jmv10>3.0.co

    authors: Fukada K,Matumoto K,Takakura F,Yamaki M,Sato H,Okochi K,Maeda Y

    更新日期:2000-09-01 00:00:00

  • Genetic relatedness of Cuban HAV wild-type isolates.

    abstract::Knowledge of the nucleotide sequence in the region of the putative VP1/2A junction of the Hepatitis A virus (HAV) genome has enabled differentiation of HAV strains and their classification into seven genotypes, in some of which sub-genotypes A and B can be defined. A 168 base segment encompassing the putative VP1/2A j...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1023

    authors: Diaz BI,Sariol CA,Normann A,Rodríguez L,Flehmig B

    更新日期:2001-06-01 00:00:00

  • Quantification of infectious duck hepatitis B virus by radioimmunofocus assay.

    abstract::A simple method is described for the precise quantification of infectious duck hepatitis B virus (DHBV) in cell culture, using a radioimmunofocus assay (RIFA). Primary duck hepatocyte cell cultures were infected with serial dilutions of viral samples as for a plaque assay, but then maintained with liquid overlay mediu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Anderson DA,Grgacic EV,Luscombe CA,Gu X,Dixon R

    更新日期:1997-08-01 00:00:00

  • Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006.

    abstract::Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21127

    authors: Yun H,Kim S,Lee H,Byun KS,Kwon SY,Yim HJ,Lim YS,Jeong SH,Jee Y

    更新日期:2008-05-01 00:00:00

  • Possible role of cytotoxic T cells in acute liver injury in hepatitis C virus cDNA transgenic mice mediated by Cre/loxP system.

    abstract::A line of hepatitis C virus (HCV) transgenic mice was established previously that was mediated by Cre/loxP system using HCV cDNA, including core, E1, E2 and NS2 genes. Intravenous infection of a recombinant adenovirus that expresses Cre DNA recombinase (AxCANCre) induced HCV structural protein expression in the liver ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200011)62:3<308::aid-jmv2>3.0.co

    authors: Wakita T,Katsume A,Kato J,Taya C,Yonekawa H,Kanegae Y,Saito I,Hayashi Y,Koike M,Miyamoto M,Hiasa Y,Kohara M

    更新日期:2000-11-01 00:00:00

  • Immune-specific interferon production by peripheral blood mononuclear leukocytes from patients with primary and recurrent oro-labial herpes simplex virus infections.

    abstract::Immune-specific IFN (IFN) is produced by the peripheral blood mononuclear leukocytes (PBML) of greater than 95% of HSV-seropositive humans with infrequent recurrences of herpes labialis [Green, Yeh, and Overall, 1981]. However, herpes virus-induced immune-specific IFN was produced by PBML from only 33 of 48 (68.8%) pe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890160311

    authors: Green JA,Weiss PN,Yeh TJ,Spruance SL

    更新日期:1985-07-01 00:00:00

  • The aim of the measurement of Epstein-Barr virus DNA in hydroa vacciniforme and hypersensitivity to mosquito bites.

    abstract::Epstein-Barr virus (EBV) DNA load in the blood increases in posttransplant lymphoproliferative disorders and chronic active EBV infection. In this report, we analyzed the EBV DNA load in the peripheral blood mononuclear cells (PBMCs) and plasma of patients with hydroa vacciniforme (HV) and/or hypersensitivity to mosqu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25811

    authors: Miyake T,Iwatsuki K,Hirai Y,Yamamoto T,Hamada T,Fujii K,Imamura H,Morizane S

    更新日期:2020-04-07 00:00:00

  • ITPA gene polymorphism (94C>A) effects on ribavirin-induced anemia during therapy in Egyptian patients with chronic hepatitis C.

    abstract::Inosine triphosphatase (ITPA) gene variants can protect against ribavirin (RBV)-induced anemia in patients treated for chronic hepatitis C. The aim of this study was to determine the relationship between genetic variants of ITPA polymorphism, anemia, RBV dose reduction, and treatment response in hepatitis C virus (HCV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24844

    authors: El Raziky M,Zayed NA,Abdel Baki A,Mansour SA,Shahin RMH

    更新日期:2017-10-01 00:00:00

  • Probable implication of mutations of the X open reading frame in the onset of fulminant hepatitis B.

    abstract::A pathogenic role of precore-defective mutation in the onset of fulminant hepatitis B has been suggested. However, precore-defective mutants do not always cause fulminant hepatitis B and are not always isolated from affected patients. These findings strongly suggest the presence of some additional important mutations ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470304

    authors: Kaneko M,Uchida T,Moriyama M,Arakawa Y,Shikata T,Gotoh K,Mima S

    更新日期:1995-11-01 00:00:00

  • Genomic analysis of the Chinese genotype 1F rubella virus that disappeared after 2002 in China.

    abstract::Genotype 1F was likely localized geographically to China as it has not been reported elsewhere. In this study, whole genome sequences of two rubella 1F virus isolates were completed. Both viruses contained 9,761 nt with a single nucleotide deletion in the intergenic region, compared to the NCBI rubella reference seque...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23936

    authors: Zhu Z,Chen MH,Abernathy E,Zhou S,Wang C,Icenogle J,Xu W

    更新日期:2014-12-01 00:00:00

  • Swine HEV infection in south India and phylogenetic analysis (1985-1999).

    abstract::Hepatitis E is endemic in India. It was recently noted that although all the Indian human hepatitis E virus (HEV) isolates (1976-2001) were placed in genotype I, the swine HEV recovered from western India (2000) belonged to genotype IV. This was in contrast to reports from the United States and Taiwan wherein both hum...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10301

    authors: Arankalle VA,Chobe LP,Walimbe AM,Yergolkar PN,Jacob GP

    更新日期:2003-03-01 00:00:00

  • Detection of a human rotavirus strain different from types 1 and 2--a new subgroup? Epidemiology of subgroups in a Swedish and an Ethiopian community.

    abstract::A possible new subgroup of human rotavirus was found by crossed immunoelectrophoresis and enzyme-linked immunosorbent assay. The epidemiology of the established subgroups 1 and 2 and this new variant was studied in two different communities. Of 398 rotavirus isolates from Malmö, Sweden, 26.8% were of type 1, 71.7% of ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890120205

    authors: Tufvesson B

    更新日期:1983-01-01 00:00:00

  • Switching to tenofovir disoproxil fumarate vs continuing treatment in patients with chronic hepatitis B who maintain long-term virological response to entecavir therapy: A randomized trial.

    abstract::No controlled trial in patients with chronic hepatitis B virus (HBV) infection on long-term entecavir (ETV) treatment, comparing switching to tenofovir disoproxil fumarate (TDF) with continuing the therapy, has been reported. Twenty-seven nucleos(t)ide-naïve patients with chronic HBV who underwent ETV therapy for ≥5 y...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/jmv.25442

    authors: Iida-Ueno A,Enomoto M,Kozuka R,Tamori A,Kawada N

    更新日期:2019-07-01 00:00:00