Abstract:
:Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in Korea, the VP3/VP1 and VP1/P2A junction regions were detected by RT-PCR from HAV IgM positives during 2005 and 2006. Among 160 HAV IgM positive sera, 30% (n = 48) were positive for HAV RNA. Additionally, the VP3/VP1 junction regions were detected all six stools, which collected from outbreak in Gyeonggi province. Phylogenetic analysis of the sequences obtained from 54 distinct HAV isolates revealed that most of the strains (n = 45) belonged to genotype IA and the others including nine strains belonged to genotype IIIA. Interestingly, a Q --> S amino acid change was dominantly observed at position 810 of the VP1/P2A junction region in 14 isolates. The molecular epidemiology of HAV infection in Korea has changed with the co-circulation of at least two genotypes and 810Q --> S amino acid substitutions were found to be prevalent. These results strongly suggest that various HAV strains, including genotype IIIA, might be imported from high-endemic countries into Korea.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Yun H,Kim S,Lee H,Byun KS,Kwon SY,Yim HJ,Lim YS,Jeong SH,Jee Ydoi
10.1002/jmv.21127subject
Has Abstractpub_date
2008-05-01 00:00:00pages
777-84issue
5eissn
0146-6615issn
1096-9071journal_volume
80pub_type
杂志文章abstract::Rotavirus is the most common etiological cause of acute viral gastroenteritis in infants and young children worldwide, yet its role in the adult population is less well understood. We have recently identified rotavirus as the causative agent of severe diarrhea in adults, specifically in two gastroenteritis outbreaks i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20671
更新日期:2006-08-01 00:00:00
abstract::Guinea pigs infected with Argentine hemorrhagic fever virus (Junin) were treated with pooled, homologous convalescent sera. Use of 15,000 or 5,000 therapeutic units of immune sera prevented all signs of illness when administered within 24 hr of infection. We could also prevent illness and death in infected guinea pigs...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890200303
更新日期:1986-11-01 00:00:00
abstract::To investigate whether vertical transmission of the human herpesvirus 8 (HHV-8) may occur during pregnancy or at delivery, we enrolled 295 women recruited attending the Division of Obstetrics and Gynecology of a University Teaching of Rome Tor Vergata, S. Eugenio Hospital. The study population was divided in two group...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20012
更新日期:2004-03-01 00:00:00
abstract::Monoclonal antibodies were raised against hepatitis B core antigen (HBcAg) synthesized in Escherichia coli. They identified a single immunodominant determinant on both liver-derived and E. coli-derived HBcAg. Cross-inhibition studies demonstrated that HBsAg-containing human sera which contained antibodies to HBcAg (an...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890190213
更新日期:1986-06-01 00:00:00
abstract::Human papillomavirus (HPV) RNA levels may be a more sensitive early indicator of predisposition to carcinogenesis than DNA levels. We evaluated whether levels of HPV-16 and HPV-18 DNA and messenger RNA (mRNA) in newly detected infections are associated with cervical lesion development. Female university students were ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21450
更新日期:2009-04-01 00:00:00
abstract::This study aimed to examine the baseline prevalence of genital human papillomavirus (HPV) infection among human immunodeficiency virus (HIV)-seropositive men who have sex with men in Taiwan and to determine the association of age and CD4+ T cell counts with HPV infection. In 2010, 305 men who have sex with men infecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23413
更新日期:2012-12-01 00:00:00
abstract::Hepatitis C virus (HCV) has infected approximately 170 million people worldwide. While the seroprevalence of anti-HCV antibody among Iranian blood donors is 0.13%, HCV infection is prevalent in 59-80% of Iranian injecting drug users. One hundred seventy-eight anti-HCV positive patients were referred to the Gastroenter...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23947
更新日期:2014-08-01 00:00:00
abstract::Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with genital warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in genital warts acro...
journal_title:Journal of medical virology
pub_type: 杂志文章,多中心研究
doi:10.1002/jmv.23646
更新日期:2013-10-01 00:00:00
abstract::Preemptive therapy in hematopoietic cell transplantation is initiated by a diagnostic technique at first detection of cytomegalovirus (CMV). The aim of this study was to use the viral dynamics of CMV DNA viral to start preemptive therapy, and to prospectively compare the CMV viral load kinetics to pp65 antigenemia. Tw...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21996
更新日期:2011-03-01 00:00:00
abstract::GB virus C/hepatitis G virus (GBV-C/HGV) RNA was detected by reverse transcription-polymer- ase chain reaction with primers derived from the nonstructural region 3 (NS3) in 9 (4.1%) of 221 blood donors and 2 of 20 (10%) hemophilia patients in Martinique, French West Indies. Anti-E2 antibodies were found in sera from 3...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1999-10-01 00:00:00
abstract::The purpose of this study was to determine whether autophagy regulates the expression of human cytomegalovirus (HCMV) immediately early two viral protein (IE2). Rapamycin and 3-methyladenine (3-MA) were used to stimulate or suppress autophagy during HCMV infection. UL122 recombinant plasmid was transfected to overexpr...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26357
更新日期:2020-07-25 00:00:00
abstract::Foscarnet (trisodium phosphonoformate) is a novel antiviral agent that inhibits viral-specific DNA polymerase. In the present study, eight males with chronic HBV carriage (HBeAg and HBV-DNA seropositivity greater than 12 months) showing chronic persistent hepatitis (CPH) or chronic active hepatitis (CAH) on liver biop...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890290214
更新日期:1989-10-01 00:00:00
abstract::Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7-30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia. Interferon (IFN) is currently th...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:
更新日期:2002-04-01 00:00:00
abstract::In early 2008, a sudden increase in oseltamivir (Tamiflu)-resistant influenza A H1N1 viruses was reported from several European countries. This resistant virus has spread globally and accounted for more than 95% of H1N1 viruses isolated in the following influenza season. A continuous close monitoring on the prevalence...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21783
更新日期:2010-08-01 00:00:00
abstract::Anal cancer is a rare disease. Nevertheless, it may be a reason for concern among groups in which its incidence is increasing: those who engage in anoreceptive intercourse, promiscuous persons, and those with sexually transmitted infections (HPV and HIV). The aim of this study was to evaluate the prevalence of abnorma...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23346
更新日期:2012-09-01 00:00:00
abstract::Hepatitis D virus (HDV) infection can cause severe acute and chronic liver disease in patients infected with hepatitis B virus (HBV). Despite the significant decline in the global HDV infection, it remains a major health concern in some countries. This study aimed to investigate the prevalence and clinical features of...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22095
更新日期:2011-07-01 00:00:00
abstract::Genetically different subpopulations were identified and purified from Japanese Encephalitis virus (JEV). Those with small plaques (SPs; <2 mm in diameter), derived from strains of T1P1, CJN, and CC27, were more competent than those with large plaques (LPs; >5 mm in diameter) when passaged in Neuro-2a cells. Differenc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20406
更新日期:2005-08-01 00:00:00
abstract::Persistent infection with high-risk human papillomavirus (HPV) causes cervical preneoplasic lesions and invasive cervical cancer. This study evaluated the prevalence and distribution of HPV genotypes in cervical exfoliated cells from Uruguayan women. Five hundred sixty-eight cervical specimens were examined by PCR usi...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23479
更新日期:2013-05-01 00:00:00
abstract::One hundred twenty strains of adenovirus types 1, 2, 5, and 6 (subgenus C), isolated at various times and places, were tested by neutralization and hemagglutination inhibition with two antisera of each type. Except for one type 5 strain they reacted largely type-specifically in both tests and neither qualitative nor q...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890180310
更新日期:1986-03-01 00:00:00
abstract::The seroprevalences of hepatitis B virus (HBV) and hepatitis C virus (HCV) markers were evaluated in a random sample of 803 children attending school in Ashanti-Akim North district in Ghana in order to gain a better understanding of transmission patterns of these viruses, particularly horizontal transmission of HBV. T...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199603)48:3<278::AID-JMV11
更新日期:1996-03-01 00:00:00
abstract::It has been suggested that some individuals may present genetic susceptibility to SARS-CoV-2 infection, with particular research interest in variants of the ACE2 and TMPRSS2 genes, involved in viral penetration into cells, in different populations and geographic regions, although insufficient information is currently ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26319
更新日期:2021-02-01 00:00:00
abstract::Studies have shown that swine HEV (sHEV) and rabbit HEV (rHEV) can experimentally infect rabbits and swine, respectively. However, no published data have documented isolating sHEV strains from rabbits in natural environment so far. To clarify the possibility of natural cross-species transmission of sHEV to rabbits, th...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24374
更新日期:2016-04-01 00:00:00
abstract::Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. Here, we stratified COVID-19 patients based on their comorbidities to assess their risk of serious adverse outcomes. We collected 856 hospitalized cases diagnosed with COVID-19 from 17 January to 7 February 2020, in Zhejiang Prov...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26183
更新日期:2020-11-01 00:00:00
abstract::It has been reported that low-plasma cytomegalovirus (CMV) DNA loads are associated with an increased risk of overall mortality in allogeneic hematopoietic stem cell transplantation (allo-HSCT). Utilizing a conservative strategy for initiation of preemptive antiviral therapy (>1500 IU/mL), we characterized the virolog...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25426
更新日期:2019-06-01 00:00:00
abstract::Human bocavirus (HBoV) was first recognized in respiratory samples in 2005. The clinical importance of HBoV infection remains unclear. This report describes the clinical features and molecular phylogeny of HBoV isolates in children with acute respiratory infections. Nasopharyngeal aspirates were obtained from 1,528 ch...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23880
更新日期:2014-12-01 00:00:00
abstract::Individuals infected with HIV have higher circulating Epstein-Barr virus (EBV) DNA load compared to healthy carriers. This study investigated whether level of spontaneous immunoglobulin secreting cells, one of the major hallmarks of HIV infection, is associated with an increase of EBV DNA load in PBMCs and the spontan...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23762
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA was found in the intestines and feces, but its clinical significance is not completely clear. We aim to characterize the longitudinal test results of SARS-CoV-2 RNA in anal swabs and to explore the association with disease severity. METHODS:We...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26307
更新日期:2021-02-01 00:00:00
abstract::Junin virus infection in guinea pigs is known to be similar to human Argentine hemorrhagic fever (AHF). The guinea pig was chosen as a model for transplacental transmission of Junin virus, as both guinea pig and man have a similar placental structure. Pregnant guinea pigs were infected with the pathogenic XJ strain of...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890110210
更新日期:1983-01-01 00:00:00
abstract::Alfa-fetoprotein (AFP) is used as a marker of early hepatocarcinogenesis. However, the impact of hepatitis B virus surface antigen (HBsAg) on this relationship in patients with HBV infection is not clear. The present study evaluated the relation between HBsAg and AFP levels at the initial visit in 1,610 untreated HBV ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23790
更新日期:2014-01-01 00:00:00
abstract::To characterize cytotoxic T lymphocytes (CTLs) that appeared in circulation during lamivudine therapy, we analyzed HBV-specific CTLs using HLA-A24 tetramer and HBcAg-specific Th1 cells in patients receiving lamivudine therapy. Six patients (HLA-A24(+)) with chronic hepatitis B, six patients (HLA-A24(-)) with chronic h...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20194
更新日期:2004-11-01 00:00:00