Abstract:
:Although it is understood that low-risk human papillomavirus (HPV) genotypes are associated with genital warts, there have been very few published studies reporting the genotype-specific prevalence of HPV among Chinese population. The aim of the study was to assess the prevalence of HPV genotypes in genital warts across China, and thus to evaluate the potential benefit of a quadrivalent HPV vaccine in this population. The tissue samples of a total of 1,005 genital warts cases were collected from seven geographical regions of China. HPV genotypes were analyzed using the general primer PCR and sequence-based typing method. Prevalence differences between sexes, geographical regions and age groups were assessed. The overall prevalence of HPV DNA in genital warts patients was 88.7% (891/1,005). Low-risk genotypes predominated, with a prevalence of 78.1% (785/1,005). The most prevalent genotypes were HPV-6 (41.3%), HPV-11 (37.6%) and HPV-16 (10.4%). Among HPV positive patients, single infections were more frequent (866/891, 97.2%) than co-infections (25/891, 2.8%). Both the overall prevalence of HPV DNA and that of HPV-6/-11/-16 (positive for any of the three types) decreased with age (P-trend = 0.010 and P-trend = 0.025, respectively). The prevalence of HPV-6/-11 (positive for either HPV type) and HPV-16 varied by geographic region (P = 0.003 and P ≤ 0.001, respectively). The prevalence of HPV-16 in female patients between urban and rural areas showed a marginally significant difference (P = 0.05). In sum, the results provide strong evidence that, in China, the most prevalent HPV genotypes in genital warts are HPV-6, HPV-11 and HPV-16. This indicates that a quadrivalent HPV vaccine may decrease the incidence of genital warts in the future.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Chang L,Ci P,Shi J,Zhai K,Feng X,Colombara D,Wang W,Qiao Y,Chen W,Wu Ydoi
10.1002/jmv.23646subject
Has Abstractpub_date
2013-10-01 00:00:00pages
1765-74issue
10eissn
0146-6615issn
1096-9071journal_volume
85pub_type
杂志文章,多中心研究abstract::Occult HBV infection is defined as the persistence of HBV DNA in individuals negative for HBV surface antigen (HBsAg), and many different mechanisms have been reported in different countries. However, in China, one of the endemic areas for HBV infection, no reports have been published on occult HBV infection. The pres...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21463
更新日期:2009-05-01 00:00:00
abstract::The polymerase chain reaction (RNA-PCR) was used for specific detection of respiratory syncytial virus (RSV) genomes in clinical specimens. A set of primers was selected from conserved regions of the 1B and N genes for detection of both subgroups. The primers were found to be RSV specific, all RSV strains generated a ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890440115
更新日期:1994-09-01 00:00:00
abstract::A total of 41 stool rotavirus specimens collected from children with acute diarrhea at four different locations in Akita Prefecture, Japan, during the peak of the winter diarrhea epidemic in 1988 were analyzed by polyacrylamide gel electrophoresis of viral RNA in conjunction with subgrouping assay. We found that a sin...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890280311
更新日期:1989-07-01 00:00:00
abstract::To investigate the intra-hepatic activation of the IFN system in patients affected by chronic HCV-infection in comparison with that observed in a non-infectious liver disease such as non-alcoholic steatohepatitis, we measured the liver steady state mRNA levels of interferon-alpha, interferon-beta and interferon-gamma ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10433
更新日期:2003-08-01 00:00:00
abstract::Faeces from 746 children less than 5 years old with acute gastroenteritis were screened for the presence of adenovirus particles or antigens by immunoelectron microscopy (IEM) and enzyme immunoassay (EIA). Thirty-five samples were positive by both IEM and EIA, two only by IEM, and two only by EIA, giving a total of 39...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890150213
更新日期:1985-02-01 00:00:00
abstract::Screening for high-risk human papillomavirus (HPV) types allows the detection of women at a high risk of cervical squamous carcinomas, thereby defining a subset of patients targeted for more intensive screening and follow-up. Thirty-four cervical biopsy specimens and isolated cells from cervical smears of normal women...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(SICI)1096-9071(199602)48:2<161::AID-JMV8>
更新日期:1996-02-01 00:00:00
abstract::Rotavirus is the most common etiological cause of acute viral gastroenteritis in infants and young children worldwide, yet its role in the adult population is less well understood. We have recently identified rotavirus as the causative agent of severe diarrhea in adults, specifically in two gastroenteritis outbreaks i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20671
更新日期:2006-08-01 00:00:00
abstract::An efficient method for cloning subgenomic fragments of the hepatitis B virus (HBV) was developed, utilizing its abundant single-stranded replicative intermediates. The total genomic DNA obtained from the liver tissue of patients with chronic HBV infection was treated by using the Klenow fragment of E. coli DNA polyme...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890330107
更新日期:1991-01-01 00:00:00
abstract::Immunological factors, such as cytokines, have been proposed as a cause of changes in the lipid profile of dengue patients. We studied whether serum lipid levels and serum TNF-α levels are associated in a group of dengue patients from an endemic region in the Northwest of Mexico. We found statistically important diffe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25056
更新日期:2018-06-01 00:00:00
abstract::The quantitation of serum levels of hepatitis C virus (HCV) RNA in chronic hepatitis C has been regarded as one of the most important indicators for the outcome of interferon (IFN) therapy. The AMPLICOR HCV MONITOR version 1.0 (AMPLICOR v1.0) assay is widely used for the evaluation of the HCV level. A new generation a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10209
更新日期:2002-11-01 00:00:00
abstract::During 1999-2000, a sustained mumps outbreak in the highly vaccinated population in Singapore was attributed to vaccine failure associated with the Rubini vaccine strain. To explain this phenomenon, the complete nucleotide and amino acid sequences of the hemagglutinin-neuraminidase (HN) gene of eight mumps virus isola...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10393
更新日期:2003-06-01 00:00:00
abstract::Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children's H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25214
更新日期:2018-09-01 00:00:00
abstract::Analysis of 505 cases history of patients among men with viral hepatitis demonstrates that HBV infected patients represent 68.9% of the total and that a non-parenteral rate of transmission is the most likely means of hepatitis B infection. Saliva and serum testing for the presence of specific HBV markers (HBsAg, HBeAg...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/1096-9071(200008)61:4<433::aid-jmv4>3.0.co
更新日期:2000-08-01 00:00:00
abstract::A 6-month-old girl with active human cytomegalovirus (HCMV) infection developed Reye's syndrome after vaccination. She suffered from uncommon complications of HCMV infection, including Coombs-negative hemolytic anemia and cardiac injury, but recovered after the appropriate treatment with prompt ganciclovir and symptom...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23475
更新日期:2013-03-01 00:00:00
abstract::HPV infection is a "necessary cause" of cervical cancer and it is sexually transmitted. Due to upcoming mass vaccination investigation on risk factors for infection is the basis to implement prophylactic strategy even in older women. The aim of the study was to evaluate predictors of high-risk (HR) HPV infection in ad...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21887
更新日期:2010-11-01 00:00:00
abstract::Although hepatitis E virus (HEV) infection is a zoonosis, there is, currently, no standardized assay for quantitatively measuring anti-HEV antibody levels in HEV animal reservoirs. In this study, anti-HEV antibody positive serum from a rabbit (RS26) was calibrated by dose-response parallel line assay using the World H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24651
更新日期:2017-03-01 00:00:00
abstract::The aim of the study was to assess the prevalence of human papillomavirus (HPV) in the esophagus in the coastal region of Eastern Guangdong, Southern China, an area with a high incidence of esophageal carcinoma. Fresh surgical resection esophageal specimens were obtained from 176 esophageal carcinoma patients admitted...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10219
更新日期:2002-11-01 00:00:00
abstract::Although the haemagglutination inhibition assay is considered the "gold standard" for antigenic characterisation of influenza viruses, some limitations of this technique are well known. A new microneutralisation assay, as a tool for antigenic characterisation of influenza B viruses, has been standardised and its perfo...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20157
更新日期:2004-09-01 00:00:00
abstract::Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains wer...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890130208
更新日期:1984-01-01 00:00:00
abstract::Complete coding regions were sequenced for two new enterovirus genomes: EV-B93 previously identified by VP1 sequencing, derived from a child with acute flaccid paralysis in the Democratic Republic of Congo; and EV-C95 from a French soldier with acute gastroenteritis in Djibouti. The EV-B93 P1 had more than 30% nucleot...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24062
更新日期:2015-03-01 00:00:00
abstract::A novel real-time PCR assay system was developed to quantify the cytomegalovirus (CMV) genome load. The real-time PCR assay could detect from 6 to over 10(6) copies of CMV-DNA with a wide linear range. The virus load of immunocompromised patients with symptomatic CMV infections was quantified and compared to that of a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/(sici)1096-9071(200004)60:4<455::aid-jmv14
更新日期:2000-04-01 00:00:00
abstract::In April 2004, two patients were admitted to hospital in Berlin, Germany, with clinical signs of acute respiratory infection after returning from a military exercise in their home country of Turkey. They were admitted to a high security infectious disease unit as epidemiological data pointed to an outbreak of unknown ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20441
更新日期:2005-10-01 00:00:00
abstract::Variation at the IL-28B locus was recently reported to be a significant predictive factor of viral response to pegylated-interferon plus ribavirin combination therapy against chronic hepatitis C. Predictive factors for the effect of therapy, including IL-28B polymorphism rs8099917 and viral and clinical factors were i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22028
更新日期:2011-06-01 00:00:00
abstract::Chikungunya fever a re-emerging infection with expanding geographical boundaries, can mimic symptoms of other infections like dengue, malaria which makes the definitive diagnosis of the infection important. The present study compares the utility of four laboratory diagnostic methods viz. IgM capture ELISA, an in house...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23406
更新日期:2012-11-01 00:00:00
abstract::BKPyV replication is a risk factor for the development of polyomavirus-associated nephropathy in kidney transplant recipients. Here, the case of a 42 years old Caucasian patient is described who developed a kidney allograft failure because of uncontrolled BKPyV replication 7 months after transplant despite a strong re...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25458
更新日期:2019-09-01 00:00:00
abstract::HIV-1 drug resistance mutations (DRMs) and substitutions were assessed after the failure of the first line non-nucleoside reverse transcriptase inhibitors (NNRTIs) + 2 nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) treatment regimens (efavirenz [EFV] + lamivudine[3TC] + zidovudine [ZDV] vs. EFV + 3TC +...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24361
更新日期:2016-03-01 00:00:00
abstract::Described for the first time in 1986, Parvovirus B19 (B19V) infection in kidney transplant recipients remains little-known and probably underestimated. The aims of this study were to establish B19V infection frequency during the first year after kidney transplant and to determine predisposing factors and manifestation...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23557
更新日期:2013-06-01 00:00:00
abstract::The genetic variability of hepatitis B virus (HBV) represents a challenge for the sensitivity of immunologic and molecular based assays. Genotyping studies show that the genetic diversity of HBV is very high even in industrialized countries. The analytical sensitivity of HBsAg and anti-HBs assays may be dependent on H...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20610
更新日期:2006-01-01 00:00:00
abstract::Lack of recognition of human immunodeficiency virus (HIV) infection especially in children and delayed implementation of effective control programs makes HIV infection as a major cause for concern. Information on HIV epidemiology in Iran as well as other Islamic countries is limited. The aim of our study was to descri...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24294
更新日期:2016-01-01 00:00:00
abstract::Recent evidence suggested that neurological manifestations occur in patients with a severe form of coronavirus disease (COVID-19). On the basis of this issue, neurologists are very concerned about patients with neurological disorders, especially multiple sclerosis (MS), as consumers of immunosuppressive or immune-modu...
journal_title:Journal of medical virology
pub_type: 杂志文章,评审
doi:10.1002/jmv.26593
更新日期:2020-10-12 00:00:00