Epidemiology of children with acquired immune deficiency syndrome (stage 3): A referral hospital-based study in Iran.


:Lack of recognition of human immunodeficiency virus (HIV) infection especially in children and delayed implementation of effective control programs makes HIV infection as a major cause for concern. Information on HIV epidemiology in Iran as well as other Islamic countries is limited. The aim of our study was to describe the clinical manifestation and laboratory finding of HIV infected children who were admitted to a referral Children Medical Center (CMC) in Tehran, Iran, during 11 years from January 2002 to January 2013. This was a retrospective study carried out over a period of 11 years. The records of all patients attending to the CMC with confirmed acquired immunodeficiency syndrome (AIDS) were screened. The patients were evaluated for social circumstance, family history, age, gender, clinical, and laboratory features. Clinical data including fever, respiratory distress, diarrhea, rash, etc. as well as laboratory tests including complete blood count, serum glucose level, electrolytes, liver function test, cultures, CD4 lymphocyte count were evaluated. During the study period, 32 HIV positive children were enrolled. The majority of patients were presented with weight loss, prolonged fever, respiratory infection and chronic diarrhea. In this study, salmonella infections as well as streptococcal pneumonia and candida infections followed by, tuberculosis and Pseudomonas aeruginosa infections were the predominant opportunistic infections. Since the number of HIV-positive children has been alarmingly increasing in recent years and perinatal transmission is the most common route of HIV infection in children, essential recommendations for prenatal HIV testing as well as appropriate antiretroviral therapy by HIV infected mothers are needed.


J Med Virol


Movahedi Z,Mahmoudi S,Pourakbari B,Keshavarz Valian N,Sabouni F,Ramezani A,Bahador A,Mamishi S




Has Abstract


2016-01-01 00:00:00












  • Phylogenetic analysis of human G9P[8] rotavirus strains circulating in Jiangsu, China between 2010 and 2016.

    abstract::Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children's H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Xu C,Fu J,Ai J,Zhang J,Liu C,Huo X,Bao C,Zhu Y

    更新日期:2018-09-01 00:00:00

  • Lower cellular immune responses to influenza A (H3N2) in the elderly.

    abstract::Influenza epidemic is an important cause of severe illness in the elderly. Age-dependent morbidity of influenza in the elderly is associated with weakened immunity. The baseline age-related memory T cell activity in Chinese persons who are exposed to influenza virus through natural infection, are associated with the p...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Jia N,Li C,Liu YX,Richardus JH,Feng D,Yang H,Dang RL,Ma YH,Xu XN,Cao WC

    更新日期:2009-08-01 00:00:00

  • Natural histories of hepatitis C virus infection in men and women simulated by the Markov model.

    abstract::The Markov model was introduced to simulate natural histories of hepatitis C virus (HCV) infection in men and women. The data set was constructed on 942 HCV carriers who were examined at least once a year without receiving antiviral therapies. Based on 2,251 patient-year data, the probabilities of transition between a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Tanaka J,Kumada H,Ikeda K,Chayama K,Mizui M,Hino K,Katayama K,Kumagai J,Komiya Y,Miyakawa Y,Yoshizawa H

    更新日期:2003-07-01 00:00:00

  • Naturally occurring hepatitis B surface gene variants in chronic hepatitis B virus infection: correlation with viral serotypes and clinical stages of liver disease.

    abstract::Virus variants escaping from host immunity may be implicated in the pathogenesis of hepatitis B virus (HBV) infection. In this cross-sectional study, the association was evaluated of the frequency of amino acid variation within the immunogenic epitopes of surface gene with different disease stages of chronic HBV infec...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Liu CJ,Kao JH,Shau WY,Chen PJ,Lai MY,Chen DS

    更新日期:2002-09-01 00:00:00

  • Clinical relevance and genotypes of circulating noroviruses in northern Taiwan, 2006-2011.

    abstract::The incidence of noroviral gastroenteritis has increased dramatically in recent years, and norovirus (NoV) genogroup II.4 (GII.4) is associated with outbreaks worldwide. The NoV genotypes and their clinical relevance in children hospitalized with acute gastroenteritis between 2006 and 2011 in northern Taiwan were eval...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Tsai CN,Lin CY,Lin CW,Shih KC,Chiu CH,Chen SY

    更新日期:2014-02-01 00:00:00

  • Temporal distribution of human rotavirus serotypes 1,2,3, and 4 in Venezuelan children with gastroenteritis during 1979-1989.

    abstract::The temporal distribution and clinical severity of rotavirus VP7 serotypes 1, 2, 3, and 4 recovered from 427 Venezuelan children with acute gastroenteritis over a period of 11 years were studied. Rotavirus VP7 serotype was established by ELISA serotyping in 298 (69.78%) of the specimens while the serotype of the remai...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: White L,García D,Boher Y,Blanco M,Pérez M,Romer H,Flores J,Pérez-Schael I

    更新日期:1991-06-01 00:00:00

  • Congenital and perinatal infection with Junin virus in guinea pigs.

    abstract::Junin virus infection in guinea pigs is known to be similar to human Argentine hemorrhagic fever (AHF). The guinea pig was chosen as a model for transplacental transmission of Junin virus, as both guinea pig and man have a similar placental structure. Pregnant guinea pigs were infected with the pathogenic XJ strain of...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Sangiorgio P,Weissenbacher MC

    更新日期:1983-01-01 00:00:00

  • Accentuated antibody response to paramyxoviruses in individuals infected with human immunodeficiency virus.

    abstract::Sera from 31 human immunodeficiency virus (HIV)-infected patients, representing different clinical stages of HIV infection, were assayed for antibodies against measles and mumps viruses by various serological tests and compared to 23 healthy controls. Sera from four patients (two primary, one asymptomatic, and one acq...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Kövamees J,Sheshberadaran H,Chiodi F,Schwartz S,Orvell C,Fenyö EM,Norrby E

    更新日期:1988-09-01 00:00:00

  • Molecular characterization of astrovirus infection in children with diarrhea in Beijing, 2005-2007.

    abstract::Human astroviruses (HAstVs) have been recognized as one of the major causes of acute gastroenteritis in children. To provide more insight into the prevalence of HAstV gastroenteritis in China, 664 fecal samples were collected from children affected with acute gastroenteritis in Beijing from March 2005 to November 2007...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Guo L,Xu X,Song J,Wang W,Wang J,Hung T

    更新日期:2010-03-01 00:00:00

  • Floating density of hepatitis C virus particles and response to interferon treatment.

    abstract::Hepatitis C virus (HCV) particles can be classified into two major fractions according to their floating density in serum. However, the genomic heterogeneity of each fraction and the relationship between this viral characteristic and interferon (IFN) response in patients with chronic hepatitis are not known. In this s...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Sakai A,Kaneko S,Matsushita E,Kobayashi K

    更新日期:1998-05-01 00:00:00

  • Towards developing HIV-2 lentivirus-based retroviral vectors for gene therapy: dual gene expression in the context of HIV-2 LTR and Tat.

    abstract::Because of the distinct ability of retroviruses to integrate into the target cell genome and thus achieve long-term expression, retrovirus vectors hold great promise for stable gene transfer. Such vectors derived from human immunodeficiency retroviruses (HIVs) and other lentiviruses are envisioned to possess several a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Sadaie MR,Zamani M,Whang S,Sistron N,Arya SK

    更新日期:1998-02-01 00:00:00

  • Role of Calomys musculinus peritoneal macrophages in age-related resistance to Junin virus infection.

    abstract::In nature, the cricetid Calomys musculinus is the principal host of Junin virus, the etiological agent of Argentine hemorrhagic fever. In the experimental infection, adult C. musculinus survived whereas newborns died after intraperitoneal inoculation with the XJ.Cl3 strain of Junin virus. The role of peritoneal macrop...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Coulombié FC,Alché LE,Lampuri JS,Coto CE

    更新日期:1986-03-01 00:00:00

  • Molecular epidemiology of norovirus infection among children with acute gastroenteritis in Shanghai, China, 2001-2005.

    abstract::Norovirus is one of the major causes of outbreaks and sporadic cases of acute gastroenteritis in young children worldwide. Obtaining local baseline information regarding this virus is important for developing and evaluating prevention strategies of norovirus transmission in children. The age, seasonal distribution and...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Xu J,Yang Y,Sun J,Ding Y

    更新日期:2009-10-01 00:00:00

  • Epidemiology and clinical features of rotavirus, adenovirus, and astrovirus infections and coinfections in children with acute gastroenteritis prior to rotavirus vaccine introduction in Meerut, North India.

    abstract::There are limited reports on the etiology of multiple enteric viruses causing acute gastroenteritis (AGE) in North India. In the present study we have determined the prevalence of three enteric viruses, namely rotavirus, astrovirus (AstV) and adenovirus (AdV) in a total of 312 diarrheic children (<5 years) hospitalize...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Akdag AI,Gupta S,Khan N,Upadhayay A,Ray P

    更新日期:2020-08-01 00:00:00

  • Efficient cloning of hepatitis B virus DNA from single-stranded replicative intermediates and its application to S1 mapping of viral RNA in human liver tissue.

    abstract::An efficient method for cloning subgenomic fragments of the hepatitis B virus (HBV) was developed, utilizing its abundant single-stranded replicative intermediates. The total genomic DNA obtained from the liver tissue of patients with chronic HBV infection was treated by using the Klenow fragment of E. coli DNA polyme...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Kajino K,Ohta Y,Miyamura T,Saito I

    更新日期:1991-01-01 00:00:00

  • Hepatitis C virus genotypes in different regions of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan).

    abstract::The prevalence of HCV genotypes in four republics of the former Soviet Union (Russia, Belarus, Moldova, and Uzbekistan) was investigated. Overall, 197 HCV isolates from 66 blood donors and 131 patients with chronic hepatitis were typed. Viral sequences from sera of infected subjects were amplified by nested RT-PCR usi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Viazov S,Kuzin S,Paladi N,Tchernovetsky M,Isaeva E,Mazhul L,Vasychova F,Widell A,Roggendorf M

    更新日期:1997-09-01 00:00:00

  • Algorithm based on CMV kinetics DNA viral load for preemptive therapy initiation after hematopoietic cell transplantation.

    abstract::Preemptive therapy in hematopoietic cell transplantation is initiated by a diagnostic technique at first detection of cytomegalovirus (CMV). The aim of this study was to use the viral dynamics of CMV DNA viral to start preemptive therapy, and to prospectively compare the CMV viral load kinetics to pp65 antigenemia. Tw...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Halfon P,Berger P,Khiri H,Martineau A,Pénaranda G,Merlin M,Faucher C

    更新日期:2011-03-01 00:00:00

  • Emergence of uncommon HIV-1 non-B subtypes and circulating recombinant forms and trends in transmission of antiretroviral drug resistance in patients with primary infection during the 2013-2015 period in Marseille, Southeastern France.

    abstract::Primary HIV-1 infections (PHI) with non-B subtypes are increasing in developed countries while transmission of HIV-1 harboring antiretroviral resistance-associated mutations (RAMs) remains a concern. This study assessed non-B HIV-1 subtypes and RAMs prevalence among patients with PHI in university hospitals of Marseil...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Tamalet C,Tissot-Dupont H,Motte A,Tourrès C,Dhiver C,Ravaux I,Poizot-Martin I,Dieng T,Tomei C,Bregigeon S,Zaegel-Faucher O,Laroche H,Aherfi S,Mokhtari S,Chaudet H,Ménard A,Brouqui P,Stein A,Colson P

    更新日期:2018-10-01 00:00:00

  • Detection of hepatitis C virus RNA genome in liver tissue by nonisotopic in situ hybridization.

    abstract::A rapid technique for the detection of hepatitis C virus (HCV) RNA in liver section using nonisotopic in situ hybridization was described. Only 3 of the 10 patients seropositive for antibody to HCV and HCV RNA had detectable HCV RNA in the hepatocytes (1%, 2%, and 15% of cells positive). No specific signal was detecte...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Lau JY,Davis GL

    更新日期:1994-03-01 00:00:00

  • Preliminary characterization of murine cytomegaloviruses with insertional and deletional mutations in the M34 open reading frame.

    abstract::A viable virus could not be recovered from a mutant murine cytomegalovirus (MCMV) BAC in which the M34 ORF had been deleted (BACDeltaM34). In contrast, an M34 mutant virus (RcM34), in which the M34 ORF was interrupted by transposon insertion at nt 44,827 of the Smith MCMV BAC, was attenuated in replication both in tis...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Baluchova K,Kirby M,Ahasan MM,Sweet C

    更新日期:2008-07-01 00:00:00

  • The correlation of TNF alpha levels with the lipid profile of dengue patients.

    abstract::Immunological factors, such as cytokines, have been proposed as a cause of changes in the lipid profile of dengue patients. We studied whether serum lipid levels and serum TNF-α levels are associated in a group of dengue patients from an endemic region in the Northwest of Mexico. We found statistically important diffe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Osuna-Ramos JF,Rendón-Aguilar H,Reyes-Ruiz JM,Del Ángel RM,Romero-Utrilla A,Ríos-Burgueño ER,Velarde-Rodriguez I,Velarde-Félix JS

    更新日期:2018-06-01 00:00:00

  • Human T-cell lymphotropic virus types I and II (HTLV-I and -II) infection among seroindeterminate cases in Argentina.

    abstract::Human T-cell lymphotropic virus (HTLV) seroindeterminate cases have been reported among blood donors (BD) and in at-risk populations worldwide, including Argentina. The objective of the present work was to study the presence of HTLV-I/II infection and its association to specific Western blot (WB) patterns among health...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Berini CA,Eirin ME,Pando MA,Biglione MM

    更新日期:2007-01-01 00:00:00

  • Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir.

    abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofov...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Yoshizaki T,Wakisaka N,Kondo S,Murono S,Shimizu Y,Nakashima M,Tsuji A,Furukawa M

    更新日期:2008-05-01 00:00:00

  • Early inhibition of nitric oxide production increases HSV-1 intranasal infection.

    abstract::Here, we studied the role of nitric oxide (NO) production during the first steps of the respiratory infection of BALB/c mice with herpes simplex virus type 1 (HSV-1), strain F. Nitric oxide synthase II (NOS-II) mRNA and protein were detected by reverse transcription (RT)-PCR and dot blot, respectively in samples of lu...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Gamba G,Cavalieri H,Courreges MC,Massouh EJ,Benencia F

    更新日期:2004-06-01 00:00:00

  • Receptor for pre-S1(21-47) component of hepatitis B virus on the liver cell: role in virus cell interaction.

    abstract::Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Dash S,Rao KV,Panda SK

    更新日期:1992-06-01 00:00:00

  • Changing distribution of norovirus genotypes and genetic analysis of recombinant GIIb among infants and children with diarrhea in Japan.

    abstract::A total of 402 fecal specimens collected during July 2003-June 2004 from infants and children with acute gastroenteritis, encompassing five localities (Maizuru, Tokyo, Sapporo, Saga, and Osaka) of Japan, were tested for the presence of norovirus by RT-PCR. It was found that 58 (14.4%) fecal specimens were positive for...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Phan TG,Kuroiwa T,Kaneshi K,Ueda Y,Nakaya S,Nishimura S,Yamamoto A,Sugita K,Nishimura T,Yagyu F,Okitsu S,Müller WE,Maneekarn N,Ushijima H

    更新日期:2006-07-01 00:00:00

  • Tocilizumab challenge: A series of cytokine storm therapy experiences in hospitalized COVID-19 pneumonia patients.

    abstract::To recognize the period of exaggerated cytokine response in patients with coronavirus disease 2019 (COVID-19) pneumonia, and to describe the clinical outcomes of using tocilizumab as a treatment option. The data of 12 adult COVID-19 pneumonia patients who were followed in the inpatient clinics of Biruni University Med...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Borku Uysal B,Ikitimur H,Yavuzer S,Ikitimur B,Uysal H,Islamoglu MS,Ozcan E,Aktepe E,Yavuzer H,Cengiz M

    更新日期:2020-11-01 00:00:00

  • Infection with human T lymphotropic virus type I in organ transplant donors and recipients in Spain.

    abstract::Human T-cell lymphotropic virus (HTLV) antibody screening is not recommended uniformly before transplantation in Western countries. In the year 2001, the first cases of HTLV-I infection acquired through organ transplantation from one asymptomatic carrier were reported in Europe. All three organ recipients developed a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Toro C,Benito R,Aguilera A,Bassani S,Rodríguez C,Calderón E,Caballero E,Alvarez P,García J,Rodríguez-Iglesias M,Guelar A,del Romero J,Soriano V,HTLV Spanish Study Group.

    更新日期:2005-06-01 00:00:00

  • Cross-species hybridization: characterization of gene expression in woodchuck liver using human membrane arrays.

    abstract::Total RNA from normal adult woodchucks was analyzed using membrane arrays containing human cDNA clones, and the gene expression patterns were compared to human liver. Various hybridization and wash conditions were examined. In both the woodchuck and human livers, 352 genes were identified as highly expressed (Z-scores...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Rinaudo JA,Gerin JL

    更新日期:2004-10-01 00:00:00

  • Weathering the pandemic: How the Caribbean Basin can use viral and environmental patterns to predict, prepare, and respond to COVID-19.

    abstract::The 2020 coronavirus pandemic is developing at different paces throughout the world. Some areas, like the Caribbean Basin, have yet to see the virus strike at full force. When it does, there is reasonable evidence to suggest the consequent COVID-19 outbreaks will overwhelm healthcare systems and economies. This is par...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审


    authors: de Ángel Solá DE,Wang L,Vázquez M,Méndez-Lázaro PA

    更新日期:2020-09-01 00:00:00