Low-level viremia is associated with non-B subtypes in patients infected with HIV with virological success following HAART introduction.

Abstract:

:This prospective study aimed to determine factors associated with detection of very low-level viremia in patients infected with HIV-1 with virological success following HAART introduction. Fifty-seven patients, mostly (n = 51, 89%) treated with a protease inhibitor-based regimen, were included and followed for 2 years. Viral loads were monitored by Abbott m2000 RealTime HIV-1. Patients were classified as (i) HIV-RNA-negative if viral loads remained strictly undetectable (0 copies/ml), or (ii) HIV-RNA-positive if at least one HIV-1 RNA could be detected in 1-49 copies/ml during follow-up. At month 24, 44 patients (77%) were in the HIV-RNA-positive group, whereas 13 (23%) remained without very low-level viremia. Univariate analysis, Kaplan-Meier curves and the Cox proportional hazard model revealed that B subtype was the only predictor of belonging to the HIV-RNA-negative group (HR 3.98; 95% CI 1.08-14.7). This association needs to be confirmed. Further study of the reservoir and the mechanisms of viral latency according to HIV-subtype will also be necessary to develop new therapeutic strategies and eradicate HIV infection.

journal_name

J Med Virol

authors

Saison J,Tardy JC,Scholtes C,Icard V,Trabaud MA,Perpoint T,Chidiac C,Ecochard R,André P,Ferry T,Lyon HIV Cohort Study.

doi

10.1002/jmv.23553

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

953-8

issue

6

eissn

0146-6615

issn

1096-9071

journal_volume

85

pub_type

杂志文章
  • The acyclovir legacy: its contribution to antiviral drug discovery.

    abstract::The discovery of acyclovir marked the beginning of an exciting era in antiviral research. Early studies on the novel mode of action explained the selectivity of the compound and the remarkably narrow spectrum of activity against a subset of the herpesviruses. Throughout the past decade many clinical trials have demons...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.1890410526

    authors: Darby G

    更新日期:1993-01-01 00:00:00

  • Homotypic immune response to primary infection with rotavirus serotype G1.

    abstract::Some aspects of rotavirus humoral immunity were assessed on the basis of distinguishing serotype-specific specificities (VP4/VP7) by using rotavirus reassortants, human and animal strains in neutralization assays in serum samples obtained during the acute phase, and 1, 6 and 12 months after primary natural infection. ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890470418

    authors: Rojas AM,Boher Y,Guntiñas MJ,Pérez-Schael I

    更新日期:1995-12-01 00:00:00

  • Treatment with cytotoxic immunosuppression agents increases urinary excretion of JCV in patients with autoimmune disease.

    abstract::Human JC virus is ubiquitous in human populations and is reactivated frequently in immunosuppressed patients. Fifty-one patients with autoimmune disease receiving immunomodulating therapy were evaluated to study the possible relationship between immunosuppression and JCV viruria. Patients were divided into cytotoxic a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/1096-9071(200012)62:4<505::aid-jmv16>3.0.c

    authors: Wang M,Tsai RT,Ou WC,Lin CK,Tsay GJ,Chang H,Chang D

    更新日期:2000-12-01 00:00:00

  • Receptor for pre-S1(21-47) component of hepatitis B virus on the liver cell: role in virus cell interaction.

    abstract::Attachment of hepatitis B virus to a hepatoblastoma cell line (HepG2) was examined using a synthetic peptide corresponding to the pre-S1 (21-47) region of the envelope protein. Scatchard analysis revealed a single class binding site of Kd 104 +/- 27 nM/l and 5.4 +/- 1.2 x 10(5) sites per cell. Competition of HBV with ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890370208

    authors: Dash S,Rao KV,Panda SK

    更新日期:1992-06-01 00:00:00

  • Altered expression of CXCR3 and CCR6 and their ligands in HTLV-1 carriers and HAM/TSP patients.

    abstract::Recruitment of leukocytes by chemokines and chemokine receptors to CNS plays a crucial role in the induction of inflammatory response in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). In the present study, chemokine and chemokine receptors involved in trafficking of lymphocytes to the CNS were me...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24779

    authors: Rafatpanah H,Felegari M,Azarpazhooh MR,Vakili R,Rajaei T,Hampson I,Hassanshahi G,Valizadeh N,Gerayli S,Hamid F,Zamanian S,MollaHosseini F,Rezaee SA

    更新日期:2017-08-01 00:00:00

  • Epidemiological analysis of COVID-19 and practical experience from China.

    abstract::The rapid spread of the epidemic has aroused widespread concern in the international community. Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) was first reported in China, with bats as the likely original hosts and pangolins as potential intermediate hosts. The current source of the disease is mainly pat...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审

    doi:10.1002/jmv.25813

    authors: Ye Q,Wang B,Mao J,Fu J,Shang S,Shu Q,Zhang T

    更新日期:2020-07-01 00:00:00

  • Seasonality and survival associated with three outbreak seasons of West Nile virus disease in Oklahoma--2003, 2007, and 2012.

    abstract::West Nile virus (WNV) activity has fluctuated in the south-central United States since its introduction. Seasonal outbreaks are common, with three in Oklahoma during 2003, 2007, and 2012. Morbidity and mortality rates vary during each outbreak. Long-term neurologic sequelae in association with West Nile virus disease ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24235

    authors: Johnson MG,Adams J,McDonald-Hamm C,Wendelboe A,Bradley KK

    更新日期:2015-10-01 00:00:00

  • Genetic variation in clinical varicella-zoster virus isolates collected in Ireland between 2002 and 2003.

    abstract::Analysis of genetic variation in 16 varicella-zoster virus (VZV) isolates selected at random and circulating in the Irish population between March 2002 and February 2003 was carried out. A 919 bp fragment of the glycoprotein E gene (open reading frame 68) encompassing codon 150, at which a non-synonymous mutation defi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20048

    authors: Carr MJ,McCormack GP,Crowley B

    更新日期:2004-05-01 00:00:00

  • Altered patterns of norovirus GII.b recombinant forms in gastroenteritis outbreaks in Victoria, Australia, 2002-2005 compared to 2006-2011.

    abstract::GII.b norovirus is an obligatory recombinant with an open reading frame (ORF) 1 comprising the GII.b genotype and the ORF 2 region corresponding to one of a number of other norovirus genotypes. GII.b is the second most common genotype after GII.4 associated with gastroenteritis outbreaks in Victoria, Australia. The st...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23633

    authors: Bruggink LD,Marshall JA

    更新日期:2013-08-01 00:00:00

  • Prevalence of antibodies to enteroviruses and varicella-zoster virus among residents and overseas volunteers at agricultural settlements in Israel.

    abstract::Within the framework of a comprehensive study of the correlation between enteric diseases and wastewater utilization in agricultural settlements (kibbutzim) the prevalence of several viral antibodies was examined among kibbutz residents and overseas volunteers. The latter were assumed to be a group highly susceptible ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200211

    authors: Margalith M,Fattal B,Shuval HI,Morag A

    更新日期:1986-10-01 00:00:00

  • Expression quantitative trait loci for TNFRSF10 influence both HBV infection and hepatocellular carcinoma development.

    abstract::Tumor necrosis factor receptor superfamily member 10 (TNFRSF10) is a death domain-containing receptor for the apoptotic ligand TNFSF10, which involves multiple processes, including hepatocarcinogenesis and immune response against HBV infection. Several single nucleotide polymorphisms (SNPs) were identified as expressi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24363

    authors: Wen J,Song C,Liu J,Chen J,Zhai X,Hu Z

    更新日期:2016-03-01 00:00:00

  • Clinical characteristics of moderate COVID-19 patients aggravation in Wuhan Stadium Cabin Hospital: A 571 cases of retrospective cohort study.

    abstract::To report the clinical characteristics and potential risk factors of patients with coronavirus disease 2019 (COVID-19) in Wuhan Stadium Cabin Hospital in Hubei Province. A total of 571 patients of COVID-19 treated in the Wuhan Stadium Cabin Hospital were selected for analysis, univariable and multivariable logistic re...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26414

    authors: Shu L,Wang X,Li M,Chen X,Ji N,Shi L,Wu M,Deng K,Wei J,Wang X,Cao Y,Yan J,Feng G

    更新日期:2021-02-01 00:00:00

  • Crimean-Congo hemorrhagic fever virus-tick survey in endemic areas in Bulgaria.

    abstract::The Balkan Peninsula and Bulgaria in particular, is a well-known endemic region for Crimean-Congo hemorrhagic fever (CCHF). This study describes the prevalence of Crimean-Congo hemorrhagic fever virus (CCHFV) among tick populations from areas, previously recognized with emerging cases of CCHF disease in humans. These ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23214

    authors: Gergova I,Kunchev M,Kamarinchev B

    更新日期:2012-04-01 00:00:00

  • Association of mortality and recent Mycoplasma pneumoniae infection in COVID-19 patients.

    abstract::To compare characteristics and outcomes of patients who had COVID-19 with Mycoplasma pneumoniae immunoglobulin M (IgM) antibodies to those without M. pneumoniae antibodies. We retrospectively reviewed cases admitted over a 4-week period between 17 March 2020 and 14 April 2020 to the Hoboken University Medical Center, ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26467

    authors: Amin D,McKitish K,Shah PS

    更新日期:2021-02-01 00:00:00

  • Unexpected detection of simian SA11-human reassortant strains of rotavirus G3P[8] genotype from diarrhea epidemic among tribal children of Western India.

    abstract::This investigation is in continuation with the earlier studies on diarrhea epidemic due to rotavirus, that occurred at Jawhar western India, among tribal children during Dec 2000-Jan 2001 published by National Institute of Virology, Pune. Three rotavirus strains were isolated in cell culture from fecal specimens of af...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20425

    authors: Awachat PS,Kelkar SD

    更新日期:2005-09-01 00:00:00

  • Molecular characterization and phylogenetic analysis of human parainfluenza virus type 3 isolated from Saudi Arabia.

    abstract::Human parainfluenza virus 3 (HPIV-3) is a leading cause of respiratory disease in children worldwide. Previous sequence analyses of the entire virus genome, among different HPIV-3 strains, demonstrated that HN is the most variable gene. There is a dearth of data on HPIV-3 strains circulating in Saudi Arabia. In this r...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23326

    authors: Almajhdi FN,Alshaman MS,Amer HM

    更新日期:2012-08-01 00:00:00

  • Molecular Characterization of Non-Polio Enteroviruses Isolated from Acute Flaccid Paralysis Patients in Uganda.

    abstract::Enteroviruses (EVs) are RNA viruses that can cause many clinical syndromes including acute flaccid paralysis (AFP). Within the global polio laboratory network, EVs are categorized either as polioviruses or non-polio enteroviruses (NPEVs). Specific NPEVs have been described in polio-like residual paralytic events in AF...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26804

    authors: Tushabe P,Howard W,Bwogi J,Birungi M,Eliku JP,Kakooza P,Bukenya H,Namuwulya P,Gaizi J,Tibanagwa M,Kabaliisa T,Mulindwa J,Muhanguzi D,Suchard M,Gumede N,Bakamutumaho B

    更新日期:2021-01-17 00:00:00

  • Molecular and epidemiological study on nosocomial transmission of HCV in hemodialysis patients in Brazil.

    abstract::An epidemiological and molecular study of hepatitis C virus (HCV) infection was carried out in Brazilian hemodialysis centers. A total of 1,095 patients in all 15 hemodialysis centers in the State of Goiás, Brazil, were studied. All patients were interviewed for possible risk factors to HCV infection and serum samples...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20932

    authors: Carneiro MA,Teles SA,Lampe E,Espírito-Santo MP,Gouveia-Oliveira R,Reis NR,Yoshida CF,Martins RM

    更新日期:2007-09-01 00:00:00

  • Antibody-free virion titer greatly differs between hepatitis C virus genotypes.

    abstract::Hepatitis C virus (HCV) virions have been shown to be bound to antibodies in patients with chronic HCV infection. The sera from patients infected with genotype 1b HCV contained more antibody-free virions than those from patients with genotype 2a/2b HCV. When compared at the same levels of serum HCV RNA, free virion ti...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Kimura Y,Hayashida K,Ishibashi H,Niho Y,Yanagi Y

    更新日期:2000-05-01 00:00:00

  • Low incidence and high titers of antibodies to hepatitis B virus X-protein in sera of Chinese patients with hepatocellular carcinoma.

    abstract::Sera of patients from China with hepatocellular carcinoma (HCC) were tested for the presence of HBc/HBe- and HBx antibodies by immunoblotting using recombinant MS2 or beta gal fusion proteins as substrate. Antibodies against HBx were detected in four out of 68 HBsAg positive and in one out of three HBsAg negative sera...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890250310

    authors: Liang XH,Stemler M,Will H,Braun R,Tang ZY,Schröder CH

    更新日期:1988-07-01 00:00:00

  • Outbreaks of hepatitis A in England and Wales associated with two co-circulating hepatitis A virus strains.

    abstract::During 2002, an upsurge in frequency of hepatitis A outbreaks among injecting drug users was observed in England and Wales. As lack of risk factor information and the high mobility of the cases made linkage of outbreaks difficult, the relationship of nucleotide sequences in the VP1/2PA junction of the hepatitis A viru...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21207

    authors: Ngui SL,Granerod J,Jewes LA,Crowcroft NS,Teo CG,2002 Hepatitis A Outbreaks Investigation Network.

    更新日期:2008-07-01 00:00:00

  • Developing a sensitive HBV genotyping assay for HBV DNA suppressed patients using both DNA and RNA sequencing.

    abstract::Hepatitis B virus (HBV) genotypes impact treatment outcomes and disease progression. The current genotyping methods have limitations in patients with low HBV viral load. In this study, a more sensitive assay has been developed for determining the HBV genotype in HBV DNA suppressed patients. Fifty-five serum samples fr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26249

    authors: Liu Y,May L,Liu X,Martin R,Svarovskaia E,Gaggar A,Mo H,Feierbach B

    更新日期:2020-07-01 00:00:00

  • Respiratory disease caused by a species B2 adenovirus in a military camp in Turkey.

    abstract::In April 2004, two patients were admitted to hospital in Berlin, Germany, with clinical signs of acute respiratory infection after returning from a military exercise in their home country of Turkey. They were admitted to a high security infectious disease unit as epidemiological data pointed to an outbreak of unknown ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20441

    authors: Chmielewicz B,Benzler J,Pauli G,Krause G,Bergmann F,Schweiger B

    更新日期:2005-10-01 00:00:00

  • Interleukin-28B polymorphisms and interferon gamma inducible protein-10 serum levels in seronegative occult hepatitis C virus infection.

    abstract::Polymorphisms upstream interleukin (IL)-28B gene and serum levels of interferon gamma inducible protein-10 (IP-10) are associated with spontaneous and treatment-induced hepatitis C virus (HCV) clearance. Patients with seronegative occult HCV infection are anti-HCV and serum HCV-RNA negative but have viral RNA in liver...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24322

    authors: Bartolomé J,Castillo I,Quiroga JA,Carreño V

    更新日期:2016-02-01 00:00:00

  • Antibody assays for varicella-zoster virus: comparison of competitive enzyme-linked immunosorbent assay (ELISA), competitive radioimmunoassay (RIA), complement fixation, and indirect immunofluorescence assays.

    abstract::The competitive ELISA test was compared with competitive RIA, complement fixation, and indirect fluorescent antibody test for the detection of antibody to varicella-zoster virus (VZV). ELISA and RIA were the most sensitive tests, being tenfold as sensitive as indirect immunofluorescence and 20 times as sensitive as co...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890130407

    authors: Wreghitt TG,Tedder RS,Nagington J,Ferns RB

    更新日期:1984-01-01 00:00:00

  • Seroprevalence of hepatitis B virus infection in children in Taipei, 1989: five years after a mass hepatitis B vaccination program.

    abstract::A nationwide hepatitis B vaccination program was launched in Taiwan in 1984. To study the impact of this ongoing program on hepatitis B virus (HBV) infection, a follow-up seroepidemiologic study was carried out in 1989 in a Taipei district where pre-vaccination seroepidemiology had been studied. HBV markers were studi...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890340205

    authors: Tsen YJ,Chang MH,Hsu HY,Lee CY,Sung JL,Chen DS

    更新日期:1991-06-01 00:00:00

  • Upregulation of Epstein-Barr virus-encoded latent membrane protein by human herpesvirus 6 superinfection of EBV-carrying Burkitt lymphoma cells.

    abstract::The effect of HHV-6 strain A infection on the expression of Epstein-Barr virus- (EBV-) encoded growth transformation-associated genes in two EBV-positive Burkitt lymphoma cell lines, Akata and P3HR-3, was investigated. The results indicate that HHV-6A upregulates the expression of the latent membrane protein LMP-1 in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Cuomo L,Trivedi P,de Grazia U,Calogero A,D'Onofrio M,Yang W,Frati L,Faggioni A,Rymo L,Ragona G

    更新日期:1998-07-01 00:00:00

  • Interactions between beta-herpesviruses and human immunodeficiency virus in vivo: evidence for increased human immunodeficiency viral load in the presence of human herpesvirus 6.

    abstract::In vitro, beta-herpesviruses can stimulate or inhibit HIV replication under particular circumstances. In order to investigate the effects of beta-herpesvirus infection on HIV replication and vice versa at an organ level, we determined the quantitative relationships between cytomegalovirus (CMV), human herpesviruses (H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/(sici)1096-9071(199903)57:3<278::aid-jmv11

    authors: Emery VC,Atkins MC,Bowen EF,Clark DA,Johnson MA,Kidd IM,McLaughlin JE,Phillips AN,Strappe PM,Griffiths PD

    更新日期:1999-03-01 00:00:00

  • A two dose combined hepatitis A and B vaccine in Chinese youngsters.

    abstract::This open, randomized study was conducted in healthy Chinese youngsters, aged between 10 and 19 years to compare the reactogenicity and immunogenicity of two vaccines: the combined vaccine against hepatitis A and B was administered in a two-dose schedule with the profile of the corresponding monovalent vaccines, while...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Lee SD,Chan CY,Yu MI,Wang YJ,Chang FY,Lo KJ,Safary A

    更新日期:1999-09-01 00:00:00

  • Prevalence of human papillomaviruses in patients with head and neck squamous cell carcinoma in Lithuania and Belarus.

    abstract::Overall, head and neck sqamous cell carcinoma accounts for more than 550,000 cases annually worldwide. It is well known that human papillomavirus (HPV) is the main risk factor for cervical cancer development. As the incidence and the mortality of cervical cancer are closely related to the HPV prevalence, we hypothesiz...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23750

    authors: Gudleviciene Z,Didziapetriene J,Mackeviciene I,Cicenas S,Smolyakova R,Zhukavetc A

    更新日期:2014-03-01 00:00:00