Abstract:
:The discovery of acyclovir marked the beginning of an exciting era in antiviral research. Early studies on the novel mode of action explained the selectivity of the compound and the remarkably narrow spectrum of activity against a subset of the herpesviruses. Throughout the past decade many clinical trials have demonstrated the efficacy and safety of this drug. Furthermore, the development of resistance does not appear to be a significant issue in normal individuals. Acyclovir provided the stimulus for further work in the antiherpes area, and this has led to the recent discovery of an oral prodrug (256U87), which delivers higher levels of acyclovir by the oral route, and to the discovery of 882C87, a highly selective inhibitor of varicella zoster virus. The novel mode of action of acyclovir involves an extremely selective phosphorylation step carried out by the herpesvirus thymidine kinase. It has recently been shown with another nucleoside analogue, ganciclovir, active against human cytomegalovirus (HMCV), that activation can be carried out by other unrelated kinases (in this case the UL97 gene product). Studies of this type may lead to the development of further novel inhibitors.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Darby Gdoi
10.1002/jmv.1890410526subject
Has Abstractpub_date
1993-01-01 00:00:00pages
134-8eissn
0146-6615issn
1096-9071journal_volume
Suppl 1pub_type
杂志文章,评审abstract::Cervical specimens collected from 163 cytologically healthy women were screened for the presence of human papillomavirus (HPV) DNA and anti-HPV secretory IgA antibodies. HPV DNA was detected by a general primer mediated polymerase chain reaction (PCR), which amplifies a conserved region from the L1 ORF of genital HPVs...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890430219
更新日期:1994-06-01 00:00:00
abstract::The recent emergence of coronavirus disease 2019 (COVID-19) pandemic has reassessed the usefulness of historic convalescent plasma transfusion (CPT). This review was conducted to evaluate the effectiveness of CPT therapy in COVID-19 patients based on the publications reported till date. To our knowledge, this is the f...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25961
更新日期:2020-09-01 00:00:00
abstract::A total of 82 samples from patients with cervical cancer (Group 1) and 50 samples from patients with other genital diseases (Group 2) were collected in Gansu, China. All 132 samples were tested for HPV DNA with a typing kit that can detect 21 types of HPV, and also tested for neutralizing antibodies against HPV-16, -1...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21435
更新日期:2009-04-01 00:00:00
abstract::Human T-cell lymphotropic virus (HTLV) seroindeterminate cases have been reported among blood donors (BD) and in at-risk populations worldwide, including Argentina. The objective of the present work was to study the presence of HTLV-I/II infection and its association to specific Western blot (WB) patterns among health...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20731
更新日期:2007-01-01 00:00:00
abstract::Hepatitis A infections still represent a major global health concern. During the past years, a transition pattern of the hepatitis A epidemiology was noted in many parts of the world. In Tunisia, there is not a recent survey on age-specific hepatitis A virus seroprevalence. This study aimed to investigate the seroprev...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26563
更新日期:2020-09-28 00:00:00
abstract::The purpose of this study was to determine whether autophagy regulates the expression of human cytomegalovirus (HCMV) immediately early two viral protein (IE2). Rapamycin and 3-methyladenine (3-MA) were used to stimulate or suppress autophagy during HCMV infection. UL122 recombinant plasmid was transfected to overexpr...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26357
更新日期:2020-07-25 00:00:00
abstract::Following widespread outbreaks of oyster-associated gastroenteritis in Australia during 1978 in which Norwalk virus was implicated as the causative agent, collaborative studies were undertaken between laboratories in Australia and the United States to confirm the etiology. Immune electron microscopy (IEM) techniques w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890060103
更新日期:1980-01-01 00:00:00
abstract::Acute gastroenteritis (AGE) is a common illness in both adults and children worldwide and is caused by several microorganisms including viruses, bacteria, and parasites. Rotavirus (RV), which is the main cause of AGE, can occur as a mixed infection with other viruses. The aim of this study is to assess the molecular e...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.26013
更新日期:2020-05-15 00:00:00
abstract::In most developing countries, hepatitis B prevention is carried out early in life. In these countries, mobile immunization teams have a limited number of sessions to devote to each rural community; simultaneous administration of multiple antigens is thus normal practice. We compared the immune responses of Senegalese ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890190403
更新日期:1986-08-01 00:00:00
abstract::Although the haemagglutination inhibition assay is considered the "gold standard" for antigenic characterisation of influenza viruses, some limitations of this technique are well known. A new microneutralisation assay, as a tool for antigenic characterisation of influenza B viruses, has been standardised and its perfo...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20157
更新日期:2004-09-01 00:00:00
abstract::Elevated telomerase activity is observed in about 90% of human cancers. This activity correlates strictly with human telomerase reverse transcriptase (hTERT). Previously, it was shown that the Epstein-Barr virus-encoded latent membrane protein 1 (LMP1) induced telomerase activity in nasopharyngeal carcinoma cells. In ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20896
更新日期:2007-08-01 00:00:00
abstract::Oncogenic human papillomavirus (HPV), a causative agent of uterine cervical cancer, has also been detected in head and neck squamous cell cancers, especially in squamous cell carcinomas of the tonsils. However, the true HPV prevalence in normal and neoplasic oropharyngeal mucosa remains uncertain. To determine the pre...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20583
更新日期:2006-05-01 00:00:00
abstract::Noroviruses (NoV) and sapoviruses (SaV) are recognized as important causes of acute gastroenteritis in children worldwide. In this study, the prevalence and genetic variability of NoV and SaV were determined in hospitalized children <5 years of age with acute gastroenteritis in Hanoi, Vietnam. A total of 501 fecal spe...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23185
更新日期:2012-02-01 00:00:00
abstract::Shedding of herpes simplex virus type 1 (HSV-1) into saliva was studied in 83 patients with orofacial fractures. Infectious virus was isolated from 14 of 83 patients (16.8%) with no detectable herpetic lesion during hospitalization. Of the 83 patients, 44 (53%) had HSV-1 specific antibody. Virus shedding into saliva w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890280205
更新日期:1989-06-01 00:00:00
abstract::A possible new subgroup of human rotavirus was found by crossed immunoelectrophoresis and enzyme-linked immunosorbent assay. The epidemiology of the established subgroups 1 and 2 and this new variant was studied in two different communities. Of 398 rotavirus isolates from Malmö, Sweden, 26.8% were of type 1, 71.7% of ...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890120205
更新日期:1983-01-01 00:00:00
abstract::This retrospective study investigated and characterized the YMDD motif of the hepatitis B virus (HBV) reverse transcriptase (RT) gene, in sequential samples of 17 South African patients with chronic hepatitis B infection on lamivudine treatment. The profile of HBV genotypes as well as the genetic variability of pre-co...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.21479
更新日期:2009-06-01 00:00:00
abstract::Poliovirus (PV) is a member of the species Enterovirus C (EV-C), which may cause irreversible paralysis and death. So, for the purpose of analyzing the evolution of PV2 to help in eradicating PVs globally, a recombination analysis was performed to verify all viral genomes of EV-C, and we found 13 putative recombinatio...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25620
更新日期:2020-03-01 00:00:00
abstract::Fifty-three (96%) of 55 patients with coronary artery stenosis were positive for serum anti-HHV-6 IgG, and 50 (91%) of these patients had anti-HHV-7 IgG. The number of cases sero-positive for HHV-6 and -7 in the 54 age matched control volunteers was 52 (96%) and 53 (98%), respectively. No statistical difference in the...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10134
更新日期:2002-08-01 00:00:00
abstract::The purpose of this study was to evaluate the use of dried blood spots stored on filter paper as a means to provide specimens for virologic surveillance for measles virus (MV) in situations when the reverse cold chain is not available. Two single-step RT-PCR assays were evaluated for sensitivity of detection of MV nuc...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10144
更新日期:2002-08-01 00:00:00
abstract::Multiple determinants are involved in the progression of human papillomavirus (HPV)-infected cervical lesion to invasive cancer. Human leukocyte antigen (HLA) polymorphism seems to play a role. This study examined the association between HLA-DRB1 polymorphism, high-risk HPV infection, and the development of cervical n...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20805
更新日期:2007-07-01 00:00:00
abstract::Rotaviruses are the major etiological agents of diarrhea in children less than 5 years of age. The commonest G types in humans are G1-4 and G9. G12 is a rare human rotavirus (HRV) strain first reported in the Philippines. In this study, 13 G12 strains obtained from a community-based cohort and a hospital-based surveil...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20872
更新日期:2007-09-01 00:00:00
abstract::This study aimed to examine the baseline prevalence of genital human papillomavirus (HPV) infection among human immunodeficiency virus (HIV)-seropositive men who have sex with men in Taiwan and to determine the association of age and CD4+ T cell counts with HPV infection. In 2010, 305 men who have sex with men infecte...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.23413
更新日期:2012-12-01 00:00:00
abstract::Norovirus (NoV) is a major cause of nonbacterial acute gastroenteritis (AGE) outbreaks worldwide, with infections reported in semiclosed environments, particularly in hospitals and nursing homes. Astrovirus (HAstV) is prevalent worldwide, especially in developing countries. We aimed to determine the prevalence, spatia...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.25395
更新日期:2019-06-01 00:00:00
abstract::In countries with a low prevalence of human T-lymphotropic virus (HTLV) infection, indeterminate HTLV serologies are a major problem in blood bank screening because of the uncertainties about infection in these cases. The recent discovery of two new types of simian T-lymphotropic viruses (STLV), which give an HTLV-ind...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:
更新日期:1997-05-01 00:00:00
abstract::Because Junin virus (JV) experimental encephalitis of mice and rats is characterized by mild histopathological changes that do not seem to justify per se lethality after intracerebral infection, such a murine model seems adequate to investigate the potential role of inducible nitric oxide synthase (iNOS) as a pathogen...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.10254
更新日期:2003-01-01 00:00:00
abstract::Variation at the IL-28B locus was recently reported to be a significant predictive factor of viral response to pegylated-interferon plus ribavirin combination therapy against chronic hepatitis C. Predictive factors for the effect of therapy, including IL-28B polymorphism rs8099917 and viral and clinical factors were i...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.22028
更新日期:2011-06-01 00:00:00
abstract::A real-time PCR assay was developed for quantitative detection of B19 DNA in clinical serum samples. The assay was carried out using a LightCycler instrument and product formation was monitored continuously with the fluorescent double-stranded DNA binding dye SYBR Green I. With an optimized PCR protocol, this system w...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.2218
更新日期:2002-06-01 00:00:00
abstract::Detection of respiratory viruses using polymerase chain reaction (PCR) is sensitive, specific and cost effective, having huge potential for patient management. In this study, the performance of an in-house developed conventional multiplex RT-PCR (mRT-PCR), real time RT-PCR (rtRT-PCR) and Luminex xTAG(®) RVP fast assay...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.24299
更新日期:2016-01-01 00:00:00
abstract::An enzyme-linked immunosorbent assay (ELISA) using recombinant nucleoprotein (rNP) was reported for the detection of immunoglobulin G (IgG) antibodies to Crimean-Congo hemorrhagic fever (CCHF) virus (CCHFV). The immunoglobulin M (IgM)-capture ELISA was developed for the diagnosis of CCHFV infections, using CCHFV rNP a...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.20270
更新日期:2005-02-01 00:00:00
abstract::Investigation of varicella-zoster virus (VZV) DNA in 20 healthy children with varicella vaccination was carried out by using the polymerase chain reaction (PCR) and nested double PCR. Samples of peripheral blood mononuclear cells (PBMC) and throat swabs were simultaneously collected 3 times (before, 1 week, and 4 week...
journal_title:Journal of medical virology
pub_type: 杂志文章
doi:10.1002/jmv.1890420110
更新日期:1994-01-01 00:00:00