Human T-cell lymphotropic virus types I and II (HTLV-I and -II) infection among seroindeterminate cases in Argentina.

Abstract:

:Human T-cell lymphotropic virus (HTLV) seroindeterminate cases have been reported among blood donors (BD) and in at-risk populations worldwide, including Argentina. The objective of the present work was to study the presence of HTLV-I/II infection and its association to specific Western blot (WB) patterns among healthy BD and at-risk populations in Argentina. We analyzed 83 HTLV-I/II seroindeterminate WB cases diagnosed among BD (n = 49) and in different at-risk populations (n = 34) for human retroviruses infections. Multiple indeterminate WB patterns were observed. Out of the total, 13.2% (11/83) of the cases were found to be HTLV-I/II positive by nested-PCR (n-PCR), including 13.2% (11/83) HTLV-I and 2.4% (2/83) presenting HTLV-I and -II co-infection. Most of their serological profiles showed reactivity to gag or env codified proteins. Two samples amplified only one of the six analyzed genes (1 HTLV-I pol gene and 1 HTLV-II tax gene). There was no association between the presence of Trypanosoma cruzi infection and an HTLV-I/II indeterminate WB pattern (only 3 of the 83 samples were positive for T. cruzi antibodies). In conclusion, the majority of HTLV-seroindeterminate WB donors lacked HTLV provirus and was thus considered uninfected. However, when seroreactivity to Env and Gag proteins are observed on the WB and especially in at-risk populations, HTLV infection should be suspected; such individuals should be followed-up and retested.

journal_name

J Med Virol

authors

Berini CA,Eirin ME,Pando MA,Biglione MM

doi

10.1002/jmv.20731

subject

Has Abstract

pub_date

2007-01-01 00:00:00

pages

69-73

issue

1

eissn

0146-6615

issn

1096-9071

journal_volume

79

pub_type

杂志文章
  • In vitro neutralization of HSV-2: inhibition by binding of normal IgG and purified Fc to virion Fc receptor (FcR).

    abstract::We designed experiments to assess the effects of binding of the HSV-2 Fc receptor (FcR) to purified rabbit nonimmune IgG and purified Fc. Purified Fc (75 micrograms) or nonimmune IgG (100 micrograms) when bound to HSV-2 did not reduce infectivity but did protect the virions against thermal inactivation at 37 degrees C...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890130307

    authors: Dowler KW,Veltri RW

    更新日期:1984-01-01 00:00:00

  • Characterising variation in five genetic loci of cytomegalovirus during treatment for congenital infection.

    abstract::Cytomegalovirus (CMV) is the most common congenital infection in humans and a leading cause of sensorineural hearing loss. Ganciclovir (6 mg/kg twice daily for 42 days) has been shown to reduce hearing deterioration and is used in clinical practice. Vaccines and passive administration of antibody are being evaluated i...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24654

    authors: Kadambari S,Atkinson C,Luck S,Macartney M,Conibear T,Harrison I,Booth C,Sharland M,Griffiths PD

    更新日期:2017-03-01 00:00:00

  • Combined detection and genotyping of Chikungunya virus by a specific reverse transcription-polymerase chain reaction.

    abstract::A reverse transcription-polymerase chain reaction (RT-PCR) was developed for the detection of Chikungunya virus infection. Based on the nonstructural protein 1 (nsP1) and glycoprotein E1 (E1) genes of Chikungunya, two primer sets were designed. Total RNA were extracted from the cell culture fluid of Aedes albopictus C...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.10085

    authors: Hasebe F,Parquet MC,Pandey BD,Mathenge EG,Morita K,Balasubramaniam V,Saat Z,Yusop A,Sinniah M,Natkunam S,Igarashi A

    更新日期:2002-07-01 00:00:00

  • TT virus: preferential distribution in CD19(+) peripheral blood mononuclear cells and lack of viral integration.

    abstract::In order to determine whether peripheral blood mononuclear cells (PBMC) contain proviral DNA or double-stranded replicative forms of TT virus (TTV) and to define which cell subset harbors TTV, we analyzed 126 PBMC DNA samples by PCR, using the NG059/NG061/NG063 and the T801/T935 primer sets. TTV sequences were detecte...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2142

    authors: Yu Q,Shiramizu B,Nerurkar VR,Hu N,Shikuma CM,Melish ME,Cascio K,Imrie A,Lu Y,Yanagihara R

    更新日期:2002-02-01 00:00:00

  • Rapid quantitative PCR assays for the simultaneous detection of herpes simplex virus, varicella zoster virus, cytomegalovirus, Epstein-Barr virus, and human herpesvirus 6 DNA in blood and other clinical specimens.

    abstract::Rapid diagnosis of human herpesvirus primary infections or reactivations is facilitated by quantitative PCRs. Quantitative PCR assays with a standard thermal cycling profile permitting simultaneous detection of herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr virus (EBV), a...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21095

    authors: Engelmann I,Petzold DR,Kosinska A,Hepkema BG,Schulz TF,Heim A

    更新日期:2008-03-01 00:00:00

  • Coronapp: A web application to annotate and monitor SARS-CoV-2 mutations.

    abstract::The avalanche of genomic data generated from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus requires the development of tools to detect and monitor its mutations across the world. Here, we present a webtool, coronapp, dedicated to easily processing user-provided SARS-CoV-2 genomic sequences and...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26678

    authors: Mercatelli D,Triboli L,Fornasari E,Ray F,Giorgi FM

    更新日期:2020-11-18 00:00:00

  • Effects of drug resistance on viral load in patients failing antiretroviral therapy.

    abstract::Previous studies on patients who develop drug resistant HIV-1 variants have shown that continued use of failing regimens might provide clinical benefit. However, the effect of long-term exposure to drug resistant variants may lead to emergence of compensatory mutations that may jeopardize this effect. In this study, w...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.20582

    authors: Machouf N,Thomas R,Nguyen VK,Trottier B,Boulassel MR,Wainberg MA,Routy JP

    更新日期:2006-05-01 00:00:00

  • Seroprevalence of West Nile and dengue virus in the human population of the Bolivian Chaco.

    abstract::To determine the seroprevalence of antibodies against dengue virus (DENV) and West Nile virus (WNV) in the human population of the Bolivian Chaco, we tested 256 inhabitants of two rural communities. The seroprevalence, confirmed by plaque reduction neutralization test, was 7.8% and 2.7% for DENV and WNV, respectively....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.25283

    authors: Bartoloni A,Remoli ME,Farchi F,Zammarchi L,Fortuna C,Benedetti E,Ciufolini MG,Macchioni F,Rojas P,Lara Y,Padilla C,Roselli M,Mantengoli E,Mantella A,Tolari F,Paredes GA,Monasterio J,Valdarchi C,Venturi G,Rezza G

    更新日期:2019-01-01 00:00:00

  • Prevalence and quantitation of adenovirus DNA from human tonsil and adenoid tissues.

    abstract::In this study, real-time PCR was used to quantify adenovirus DNA in cell suspensions prepared from 106 right and left tonsils and 10 adenoids obtained from 57 patients who underwent routine tonsillectomies and/or adenoidectomies. Eighty-four (72.4%) tonsils and adenoids samples were positive for HAdV by real-time PCR....

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23678

    authors: Alkhalaf MA,Guiver M,Cooper RJ

    更新日期:2013-11-01 00:00:00

  • Long-term follow-up of patients with hepatitis C with a normal alanine aminotransferase.

    abstract::An attempt was made to identify factors influencing the cumulative probability of an increased alanine aminotransferase (ALT) level and hepatocarcinogenesis in hepatitis C patients with a normal ALT level initially. A total of 398 consecutive patients with a normal ALT level initially for 6 months or more and follow-u...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21342

    authors: Kumada T,Toyoda H,Kiriyama S,Sone Y,Tanikawa M,Hisanaga Y,Kanamori A,Atsumi H,Takagi M,Nakano S,Arakawa T,Fujimori M

    更新日期:2009-03-01 00:00:00

  • Inhibition of hepatitis C virus NS3 function by antisense oligodeoxynucleotides and protease inhibitor.

    abstract::Hepatitis C Virus (HCV) NS3 protease is an attractive target for antiviral agent development because it is required for viral replication. Because a stable cell culture system or small animal model to study HCV replication is not readily available, we constructed an in vitro model allowing the investigation of NS3 tra...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.2089

    authors: Heintges T,Encke J,zu Putlitz J,Wands JR

    更新日期:2001-12-01 00:00:00

  • Detection of human immunodeficiency virus (HIV) genome from the lymphocytes of homosexual men.

    abstract::Human immunodeficiency virus (HIV) is the primary etiological agent of acquired immunodeficiency syndrome (AIDS). This virus can be transmitted by blood or blood products. Homosexual males (HM) are regarded as one of the high-risk groups for AIDS. Lymphocytes obtained from HM were used for cocultivation with fresh HIV...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890230404

    authors: Lee YS,Baker L

    更新日期:1987-12-01 00:00:00

  • Isolation of rhinoviruses and coronaviruses from 38 colds in adults.

    abstract::Nasal washings were collected from 27 normal adults during 38 naturally acquired colds. The washings were exhaustively tested using tissue cultures, organ cultures and electron microscopy. Washings yielding no identifiable agent were inoculated into human volunteers, and further specimens obtained from the latter were...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890050306

    authors: Larson HE,Reed SE,Tyrrell DA

    更新日期:1980-01-01 00:00:00

  • Active replication of human immunodeficiency virus type 1 by peripheral blood mononuclear cells following coincubation with herpes viruses.

    abstract::Patients with acquired immunodeficiency syndrome (AIDS) commonly suffer from opportunistic infections associated with members of the herpes virus family. To investigate whether certain of these other viruses might have an effect on the ability of the human immunodeficiency virus type 1 (HIV-1) to replicate, we coincub...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890290207

    authors: Tremblay M,Gornitsky M,Wainberg MA

    更新日期:1989-10-01 00:00:00

  • Thermostabilization of Inoue-Melnick virus by salt.

    abstract::Inoue-Melnick virus (IMV) was stabilized to thermal inactivation at 50 degrees C by 1 M Na2SO4 but not by 1 M MgCl2, 1 M MgSO4, 2 M NaCl, and 2 M KCl. The latter salts enhanced the inactivation over that in distilled water. Na2SO4 stabilized IMV at 1 M concentration but enhanced inactivation at 0.1 M. Three types of I...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890200203

    authors: Nishibe Y,Inoue YK,Melnick JL

    更新日期:1986-10-01 00:00:00

  • Expression profiles of genes associated with viral entry in HCV-infected human liver.

    abstract::Recent studies have demonstrated that several cellular factors are involved in entry of hepatitis C virus (HCV) into host cells. Detailed gene expression profiles of these factors in HCV-infected livers have not been reported for humans. Transcriptional levels of LDL receptor (LDLR), CD81, scavenger receptor class B t...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.22042

    authors: Nakamuta M,Fujino T,Yada R,Aoyagi Y,Yasutake K,Kohjima M,Fukuizumi K,Yoshimoto T,Harada N,Yada M,Kato M,Kotoh K,Taketomi A,Maehara Y,Nakashima M,Enjoji M

    更新日期:2011-05-01 00:00:00

  • Identification of a novel human papillomavirus type 16 E1 gene variant with potentially reduced oncogenicity.

    abstract::The human papillomavirus (HPV) 16 genome has been studied extensively, although no study has focused on the E1 gene that is implicated in viral DNA replication. After analyzing the E1 region of HPV 16 genomes in 429 cervical samples, 11.2% were found to contain a 63 nucleotides duplication in this region. Sequence ana...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21304

    authors: Sabol I,Matovina M,Gasperov NM,Grce M

    更新日期:2008-12-01 00:00:00

  • The effect of EBV on WIF1, NLK, and APC gene methylation and expression in gastric carcinoma and nasopharyngeal cancer.

    abstract::Epstein-Barr virus (EBV) is an important DNA tumor virus that is associated with approximately 10% of gastric carcinomas and 99% of nasopharyngeal cancers (NPC). DNA methylation and microRNAs (miRNAs) are the most studied epigenetic mechanisms that can prompt disease susceptibility. This study aimed to detect the effe...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24863

    authors: Zhao Z,Liu W,Liu J,Wang J,Luo B

    更新日期:2017-10-01 00:00:00

  • Nucleotide sequence of hepatitis B virus isolated from subjects without serum anti-hepatitis B core antibody.

    abstract::The nucleotide sequences of the precore/core and X open reading frames (ORFs) of hepatitis B virus (HBV) were studied in four subjects who were serologically negative for anti-hepatitis B core antibody. These subjects were positive for serum hepatitis B surface antigen and were considered to be asymptomatic HBV carrie...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890460306

    authors: Gotoh K,Mima S,Uchida T,Shikata T,Yoshizawa K,Irie M,Mizui M

    更新日期:1995-07-01 00:00:00

  • Detection of flavivirus antibodies in human serum by epitope-blocking immunoassay.

    abstract::Human flavivirus group-reactive, dengue complex-reactive, and encephalitis virus complex-reactive antibodies were detected using epitope-blocking immunoassays in which the binding of selected mouse monoclonal antibodies to flavivirus antigens was blocked by human serum. When late (greater than 6 months after illness) ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890230209

    authors: Burke DS,Nisalak A,Gentry MK

    更新日期:1987-10-01 00:00:00

  • Detection of integrated hepatitis B virus DNA in hepatocellular carcinoma cell lines by nonradioactive in situ hybridization.

    abstract::A sensitive and specific nonradioactive in situ hybridization method capable of detecting single-copy integrated hepatitis B virus (HBV) DNA sequences in hepatocellular carcinoma (HCC) cell lines was developed. In situ hybridization of biotinylated HBV (adr, adw) DNA probes with nine different human HCC cell lines wer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890300407

    authors: Tay N,Chan SH,Ren EC

    更新日期:1990-04-01 00:00:00

  • Phylogenetic analysis of the NS5 gene of Zika virus.

    abstract::ZIKV infection has become a global threat spreading across 31 countries in Central America, South America, and the Caribbean. However, little information is available about the molecular epidemiology of ZIKV. Shared mutation of a threonine residue to alanine at the same position in the C terminal of NS5 sequences was ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.24615

    authors: Adiga R

    更新日期:2016-10-01 00:00:00

  • Genetic analysis of HAV strains isolated from patients with acute hepatitis in Korea, 2005-2006.

    abstract::Hepatitis A virus (HAV) is a causative agent of acute viral hepatitis, which represents a significant public health problem. HAV is usually transmitted by oral-fecal route and prevalent not only in developing countries but also in developed countries worldwide. To characterize the HAV wild type strains circulating in ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21127

    authors: Yun H,Kim S,Lee H,Byun KS,Kwon SY,Yim HJ,Lim YS,Jeong SH,Jee Y

    更新日期:2008-05-01 00:00:00

  • Impact of COVID-19 preventative measures on dengue infections in Taiwan.

    abstract::We read with great interest the recent issue,1 which raised the concern about the co-circulation of dengue during the COVID-19 pandemic. This article is protected by copyright. All rights reserved. ...

    journal_title:Journal of medical virology

    pub_type: 信件

    doi:10.1002/jmv.26650

    authors: Lin SF,Lai CC,Chao CM,Tang HJ

    更新日期:2020-11-03 00:00:00

  • Two years outcome of women infected with high risk HPV having normal colposcopy following low-grade or equivocal cytological abnormalities: are HPV16 and 18 viral load clinically useful predictive markers?

    abstract::Management of patients infected with high-risk HPV (hrHPV) despite normal colposcopy following abnormal cytology remains a clinical challenge. The aim of this study was to evaluate if, in that specific population, initial HPV 16 and HPV 18 viral loads are predictive of infection clearance over a 24-month follow-up. A ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.23276

    authors: Carcopino X,Henry M,Mancini J,Giusiano S,Boubli L,Olive D,Tamalet C

    更新日期:2012-06-01 00:00:00

  • Quantitative human papillomavirus 16 and 18 levels in incident infections and cervical lesion development.

    abstract::Human papillomavirus (HPV) RNA levels may be a more sensitive early indicator of predisposition to carcinogenesis than DNA levels. We evaluated whether levels of HPV-16 and HPV-18 DNA and messenger RNA (mRNA) in newly detected infections are associated with cervical lesion development. Female university students were ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.21450

    authors: Winer RL,Harris TG,Xi LF,Jansen KU,Hughes JP,Feng Q,Welebob C,Ho J,Lee SK,Carter JJ,Galloway DA,Kiviat NB,Koutsky LA

    更新日期:2009-04-01 00:00:00

  • Activation of a varicella-zoster virus-specific IgA response during acute Epstein-Barr virus infection.

    abstract::The influence of an acute Epstein-Barr virus (EBV) infection on the serological parameters of persistent varicella-zoster virus (VZV) and herpes simplex virus (HSV) was studied. Sera from 161 patients with infectious mononucleosis caused by EBV and 178 age-matched controls were tested for HSV- and VZV-specific IgA. 98...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.1890440308

    authors: Karner W,Bauer G

    更新日期:1994-11-01 00:00:00

  • Clinical and epidemiological characteristics of 320 deceased patients with COVID-19 in an Italian Province: A retrospective observational study.

    abstract::Studies have described clinical features of patients with coronavirus disease (COVID-19). However, limited data concerning the clinical characteristics of the Italian deaths are available. We aim to describe the clinical and epidemiological characteristics of 320 deceased from the Italian experience. We retrospectivel...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:10.1002/jmv.26147

    authors: Biagi A,Rossi L,Malagoli A,Zanni A,Sticozzi C,Comastri G,Gandolfi S,Villani GQ

    更新日期:2020-11-01 00:00:00

  • A randomised controlled trial of recombinant interferon-gamma in Chinese patients with chronic hepatitis B virus infection.

    abstract::Nineteen Chinese patients with chronic hepatitis B virus (HBV) infection, seropositive for HBV e antigen (HBeAg) and HBV DNA on at least three occasions in 6 months, were randomised to receive either recombinant human interferon-gamma (rIFN gamma) 0.1 mg/m2 intramuscularly thrice weekly for 16 weeks (n = 11) or no ant...

    journal_title:Journal of medical virology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/jmv.1890340310

    authors: Lau JY,Lai CL,Wu PC,Chung HT,Lok AS,Lin HJ

    更新日期:1991-07-01 00:00:00

  • Characterization of natural Epstein-Barr virus infection and replication in smooth muscle cells from a leiomyosarcoma.

    abstract::Cells from a leiomyosarcoma tumor (LMS-1) from a patient with the acquired immunodeficiency syndrome (AIDS) were explanted, cultured in vitro, and studied by phase-contrast microscopy for morphologic and growth characteristics, immunostaining for cell markers, EBER in situ hybridization and polymerase chain reaction f...

    journal_title:Journal of medical virology

    pub_type: 杂志文章

    doi:

    authors: Jenson HB,Montalvo EA,McClain KL,Ench Y,Heard P,Christy BA,Dewalt-Hagan PJ,Moyer MP

    更新日期:1999-01-01 00:00:00