Abstract:
:The nucleotide sequences of the precore/core and X open reading frames (ORFs) of hepatitis B virus (HBV) were studied in four subjects who were serologically negative for anti-hepatitis B core antibody. These subjects were positive for serum hepatitis B surface antigen and were considered to be asymptomatic HBV carriers. Sequencing of the precore/core ORF revealed precore wild type and 3 to 8 nucleotide substitutions (replacing 0 to 2 amino acids) in the core region compared with the sequence of subtype adr. These substitutions were not considered to have changed the epitope of the core antigen, resulting in the absence of anti-HBc as determined by a conventional diagnostic kit. The X ORF showed 1 to 5 nucleotide substitutions (replacing 1 to 3 amino acids) and the structure of the X protein and the core promoter/enhancer II complex appeared to be conserved. These findings strongly suggest that the absence of serum anti-HBc is not due to mutation of the HBV DNA but to an aberrant immune reaction of the host to HBV.
journal_name
J Med Viroljournal_title
Journal of medical virologyauthors
Gotoh K,Mima S,Uchida T,Shikata T,Yoshizawa K,Irie M,Mizui Mdoi
10.1002/jmv.1890460306subject
Has Abstractpub_date
1995-07-01 00:00:00pages
201-6issue
3eissn
0146-6615issn
1096-9071journal_volume
46pub_type
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