Transfusion-acquired cytomegalovirus infection in children in a hyperendemic area.

Abstract:

:Thirty-nine children without previous cytomegalovirus (CMV) infection received blood transfusion in the National Taiwan University Hospital. The overall transfusion-acquired CMV infection rate was 36% (14/39). Donor CMV seropositive rate was 70%. None of the nine children who had received seronegative blood became infected, in contrast to 14 of the 21 children (67%) who had received seropositive blood (P = 0.002). Another significant risk factor associated with CMV infection was the use of fresh blood: 13 of 15 (87%) with fresh seropositive blood were infected, in contrast to one of six (17%) with "old" seropositive blood (P = 0.01). Most of the fresh blood was used within 24 hours. This blood processing method was shown to account for the extremely high rate of CMV infection in those who had received fresh seropositive blood. The results indicated that the incidence of CMV infection can be reduced by avoiding the use of fresh blood, especially blood less than 24 hours old. For such a population in Taiwan with high prevalence of positive CMV antibody, this approach was more applicable than screening donor blood for CMV antibody.

journal_name

J Med Virol

authors

Lee PI,Chang MH,Hwu WL,Kao CL,Lee CY

doi

10.1002/jmv.1890360110

keywords:

subject

Has Abstract

pub_date

1992-01-01 00:00:00

pages

49-53

issue

1

eissn

0146-6615

issn

1096-9071

journal_volume

36

pub_type

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