Severe metapneumovirus infections among immunocompetent and immunocompromised patients admitted to hospital with respiratory infection.

abstract：:To characterize cytotoxic T lymphocytes (CTLs) that appeared in circulation during lamivudine therapy, we analyzed HBV-specific CTLs using HLA-A24 tetramer and HBcAg-specific Th1 cells in patients receiving lamivudine therapy. Six patients (HLA-A24(+)) with chronic hepatitis B, six patients (HLA-A24(-)) with chronic h...

journal_title：Journal of medical virology

authors： Kondo Y,Asabe S,Kobayashi K,Shiina M,Niitsuma H,Ueno Y,Kobayashi T,Shimosegawa T

更新日期：2004-11-01 00:00:00

abstract：:Saliva and peripheral blood samples from 20 healthy adults were examined for the presence of human herpesvirus-6 (HHV-6) DNA sequences using the polymerase chain reaction. Eighteen out of 20 whole saliva samples contained detectable HHV-6 genomes. The majority of peripheral blood samples were also positive; however, t...

journal_title：Journal of medical virology

authors： Jarrett RF,Clark DA,Josephs SF,Onions DE

更新日期：1990-09-01 00:00:00

abstract：:The emergence of variants in the outer envelope proteins of hepatitis B virus (HBV) are found among individuals vaccinated against HBV and asymptomatic carriers of the infection. For example, children in The Gambia vaccinated against hepatitis B may show serological evidence of breakthrough infections, particularly if...

journal_title：Journal of medical virology

authors： Karthigesu VD,Allison LM,Ferguson M,Howard CR

更新日期：1999-08-01 00:00:00

abstract：:To determine the influence of ageing per se as well as of priming histories on the antibody response to influenza vaccination, haemagglutination inhibition (HI), ELISA IgG, IgA, IgM and neutralizing antibody titres were studied in 43 healthy young subjects (mean age 23 years) and 55 healthy elderly people (mean age 79...

journal_title：Journal of medical virology

authors： Remarque EJ,de Bruijn IA,Boersma WJ,Masurel N,Ligthart GJ

更新日期：1998-05-01 00:00:00

abstract：:The X gene product of human hepatitis B virus, HBx, transactivates the expression of viral and cellular genes through a wide variety of cis elements, including the nuclear factor for IL-6 (NF-IL6) binding sites, although HBx does not appear to bind DNA directly. We previously reported that HBx transactivated the inter...

journal_title：Journal of medical virology

authors： Ohno H,Kaneko S,Lin Y,Kobayashi K,Murakami S

更新日期：1999-05-01 00:00:00

abstract：:One hundred twelve peripheral blood specimens were tested for the presence of cytomegalovirus (CMV) by the tube culture indirect immunoperoxidase (TC-IPA) procedure, the shell vial assay [shell vials were pre- and postinoculation treated with medium containing 2 of 10% fetal bovine serum (FBS) or 100 micrograms% corti...

journal_title：Journal of medical virology

authors： Lipson SM,Kaplan MH,Simon JK,Ciamician Z,Tseng LF

更新日期：1992-09-01 00:00:00

abstract：:A solid-phase radioimmunoassay (RIA) for the detection of hepatitis B e antigen (HBeAg) and antibody (anti-HBe) was developed. The RIA was approximately 1,000-fold more sensitive than rheophoresis for HBeAg, and approximately 6,000-fold more sensitive than rheophoresis for anti-HBe. Generally, less than one-fifth of h...

journal_title：Journal of medical virology

authors： Mushahwar IK,Overby LR,Frosner G,Deinhardt F,Ling CM

更新日期：1978-01-01 00:00:00

abstract：:Genotype 1F was likely localized geographically to China as it has not been reported elsewhere. In this study, whole genome sequences of two rubella 1F virus isolates were completed. Both viruses contained 9,761 nt with a single nucleotide deletion in the intergenic region, compared to the NCBI rubella reference seque...

journal_title：Journal of medical virology

authors： Zhu Z,Chen MH,Abernathy E,Zhou S,Wang C,Icenogle J,Xu W

更新日期：2014-12-01 00:00:00

abstract：:Asymptomatic carriers have a major influence on the spreading of norovirus infections. The objective of this study was to examine the characteristics of patients and asymptomatic carriers affected by norovirus-related community gastroenteritis outbreaks. No significant difference between the two groups was observed in...

journal_title：Journal of medical virology

authors： Mori K,Konishi N,Suzuki Y,Harada S,Maeda M,Akase S,Obata H,Monma C,Nagano M,Kimoto K,Oda M,Somura Y,Hirai A,Shinkai T,Noda M,Sadamasu K

更新日期：2018-12-01 00:00:00

abstract：:Infection with the human cytomegalovirus (HCMV) accelerates disease progression in human immunodeficiency virus 1 (HIV-1)-infected individuals. This has been attributed to the transaction of HIV-1 gene expression by HCMV gene products. For transactivation to be effective in vivo both viruses must be present in the sam...

journal_title：Journal of medical virology

authors： Bertram S,Hufert FT,van Lunzen J,von Laer D

更新日期：1996-08-01 00:00:00

abstract：:Antisense protein (ASP) is the new actor of viral life of Human Immunodeficiency Virus type 1 (HIV-1) although proposed above 20 years ago. The asp ORF is into complementary strand of the gp120/gp41 junction of env gene. The ASP biological role remains little known. Knowing the Env markers of viral tropism, a dataset ...

journal_title：Journal of medical virology

authors： Dimonte S

更新日期：2017-01-01 00:00:00

abstract：:Rotavirus is a major cause of gastroenteritis in young children worldwide. There have been several recent reports concerning rotavirus isolation from adults, particularly in the elderly, presenting with gastroenteritis. In this study, the authors report on rotavirus outbreaks in five separate elderly care facilities b...

journal_title：Journal of medical virology

authors： Gunn L,Feeney SA,Cashman O,Collins PJ,Coyle PV,O'Shea H

更新日期：2012-12-01 00:00:00

abstract：:Strains of human coronavirus (HCV) isolated between 1974 and 1976 have been studied in vitro and in volunteers. All strains caused colds in volunteers, and those cultivable in tissue culture (TC) produced significantly more coryza and less sore throat than strains growing only in organ culture (OC). The TC strains wer...

journal_title：Journal of medical virology

authors： Reed SE

更新日期：1984-01-01 00:00:00

abstract：:Following widespread outbreaks of oyster-associated gastroenteritis in Australia during 1978 in which Norwalk virus was implicated as the causative agent, collaborative studies were undertaken between laboratories in Australia and the United States to confirm the etiology. Immune electron microscopy (IEM) techniques w...

journal_title：Journal of medical virology

authors： Grohmann GS,Greenberg HB,Welch BM,Murphy AM

更新日期：1980-01-01 00:00:00

abstract：:A previous study revealed a high prevalence of hepatitis B surface antigen (HBsAg) and hepatitis delta virus (HDV) RNA among 249 apparently healthy individuals (mean+/-standard deviation age, 48.4+/-13.9 years; 126 males and 123 females) in Ulaanbaatar, Mongolia. To investigate further the prevalence of HDV infection ...

journal_title：Journal of medical virology

authors： Inoue J,Takahashi M,Nishizawa T,Narantuya L,Sakuma M,Kagawa Y,Shimosegawa T,Okamoto H

更新日期：2005-07-01 00:00:00

abstract：:Thirty susceptible rhesus monkeys were inoculated with cell-free varicella-zoster virus strain OKA or strain KMcC. Both wild and attenuated strains were used. No clinical signs characteristic of human varicella were seen in any of the animals. Virus was not isolated from throat swabs, blood, or cerebrospinal fluid. An...

journal_title：Journal of medical virology

authors： Asano Y,Albrecht P,Behr DE,Neff BJ,Vickers JH,Rastogi SC

更新日期：1984-01-01 00:00:00

abstract：:The current study aimed to investigate the diagnostic value of glycated albumin (GA), glycated hemoglobin (HbA1c), and a number of routine biomarkers as noninvasive indicators of liver fibrosis in patients with chronic hepatitis C (CHC). One hundred patients with CHC were subjected to full medical history and examinat...

journal_title：Journal of medical virology

authors： Abo El-Khair SM,El-Alfy HA,Elsamanoudy AZ,Elhammady D,Abd-Elfattah N,Eldeek B,Farid K

更新日期：2020-06-19 00:00:00

abstract：:Epstein-Barr virus (EBV) reactivation and cell-mediated immune (CMI) responses were followed in 16 Antarctic expeditioners during winter-over isolation at 2 Australian National Antarctic Research Expedition stations. Delayed-type hypersensitivity (DTH) skin testing was used as an indicator of the CMI response, that wa...

journal_title：Journal of medical virology

authors： Mehta SK,Pierson DL,Cooley H,Dubow R,Lugg D

更新日期：2000-06-01 00:00:00

abstract：:The effect of different formulations of interferon on therapeutic response in patients coinfected with HIV and HCV is unclear. In this study, the safety, tolerability, viral kinetics (VK) modeling and host responses among HIV/HCV coinfected patients treated with pegylated-IFN or albinterferon alfa-2b (AlbIFN) with wei...

journal_title：Journal of medical virology

authors： Osinusi A,Bon D,Nelson A,Lee YJ,Poonia S,Shivakumar B,Cai SY,Wood B,Haagmans B,Lempicki R,Herrmann E,Sneller M,Polis M,Masur H,Kottilil S

更新日期：2014-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) load is one of the most important predictive factors of response to interferon treatment. However, little is known about the mode and determinants of viremia. The mode of viremia was investigated in 78 patients with chronic HCV genotype 1b infection during 1-2 years follow up. Virus load, deter...

journal_title：Journal of medical virology

authors： Hashimoto M,Chayama K,Kobayashi M,Tsubota A,Arase Y,Saitoh S,Suzuki Y,Ikeda K,Matsuda M,Koike H,Kobayashi M,Handa H,Kumada H

更新日期：1999-07-01 00:00:00

abstract：:Recently, human platelet antigens (HPAs) polymorphisms are found to play a role in susceptibility to hepatitis C virus (HCV) infection and fibrosis progression. The aim of the current study was to evaluate the possible association between the HPAs polymorphisms with liver fibrosis progression in HCV patients. HPAs pol...

journal_title：Journal of medical virology

authors： Ghasemi A,Zadsar M,Shaiegan M,Samiei S,Namvar A,Rasouli M,Moosanejad M

更新日期：2020-01-01 00:00:00

abstract：:The use of new Direct Acting Antivirals, specific of HCV, has greatly improved the HCV treatment. Most of the DAA are specific of HCV genotypes. Genotyping methods may target different regions of the HCV genome, though only the whole genome sequencing could confirm the correct genotype. The present study describes the...

journal_title：Journal of medical virology

authors： Mourez T,Decroos A,Goria O,Montialoux H,De Oliveira F,Larrat S,Plantier JC,Riachi G

更新日期：2018-05-01 00:00:00

abstract：:Cytomegalovirus (CMV) has been implicated in vascular pathologies and may warrant inclusion in cardiovascular predictive algorithms. We addressed this in healthy older adults and renal transplant recipients (RTR) as they retain a high burden of CMV. RTR (n  =  45) stable more than 2 years after transplantation and 58 ...

journal_title：Journal of medical virology

authors： Affandi JS,Lee S,Chih H,Brook E,Waters S,Howson P,Reid CM,Irish A,Price P

更新日期：2020-02-04 00:00:00

abstract：:The TT virus (TTV) was isolated recently from the serum of a patient with post-transfusion hepatitis. TTV infection is widespread in the general population, and its prevalence increases continuously with age. The pathogenic role of TTV in liver disease remains controversial, and the source of transmission is still unc...

journal_title：Journal of medical virology

authors： Komatsu H,Inui A,Sogo T,Kuroda K,Tanaka T,Fujisawa T

更新日期：2004-11-01 00:00:00

abstract：:Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, whi...

journal_title：Journal of medical virology

authors： Wang X,Ge J,Chen R

更新日期：2019-05-01 00:00:00

abstract：:Subgroup A respiratory syncytial viruses present in respiratory secretions and low passage level cell culture isolates were found to be markedly less susceptible to neutralization with monoclonal antibodies (MAbs) to the F glycoprotein than the cell culture adapted A2 virus strain. Low passage virus isolates collected...

journal_title：Journal of medical virology

authors： Marsh R,Connor A,Gias E,Toms GL

更新日期：2007-06-01 00:00:00

abstract：:In nature, the cricetid Calomys musculinus is the principal host of Junin virus, the etiological agent of Argentine hemorrhagic fever. In the experimental infection, adult C. musculinus survived whereas newborns died after intraperitoneal inoculation with the XJ.Cl3 strain of Junin virus. The role of peritoneal macrop...

journal_title：Journal of medical virology

authors： Coulombié FC,Alché LE,Lampuri JS,Coto CE

更新日期：1986-03-01 00:00:00

abstract：:The discovery of acyclovir marked the beginning of an exciting era in antiviral research. Early studies on the novel mode of action explained the selectivity of the compound and the remarkably narrow spectrum of activity against a subset of the herpesviruses. Throughout the past decade many clinical trials have demons...

journal_title：Journal of medical virology

authors： Darby G

更新日期：1993-01-01 00:00:00

abstract：:Present diagnostic criteria for occult hepatitis B virus (HBV) infection requires blood or liver samples to test positive for at least two HBV DNA targets in hepatitis B surface antigen (HBsAg) negative individuals. These criteria were derived from studies involving referred or selected patient populations. The object...

journal_title：Journal of medical virology

authors： Minuk GY,Huynh C,Uhanova J,Osiowy C

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND AND AIM:Genotype 3b hepatitis C virus (HCV) infection represents approximately 50% of patients with genotype 3 in China. We compared the efficacy of sofosbuvir (SOF) plus ribavirin (RBV) in Chinese patients with genotype 3a and 3b HCV. METHODS:The analyzed data are from a phase 3, open-label study of SOF pl...

journal_title：Journal of medical virology

authors： Huang R,Rao H,Xie Q,Gao Z,Li W,Jiang D,Mo H,Massetto B,Stamm LM,Brainard DM,Wei L

更新日期：2019-07-01 00:00:00