LAP+ Treg is a better biomarker than total Treg in viral myocarditis.


:Latency associated peptide (LAP) is a protein expressed on the membrane of some regulatory T cells (Treg). LAP+ Treg have a greater immunomodulatory effect than that of their negative counterparts. In this study, we presented the data on the proportion of LAP+ Treg out of CD4+ cells in mice with viral myocarditis, which we believed was more sensitive and specific than that of the ratio of total Treg in CD4+ cells. Comparing with the previously recognized total Treg, LAP+ Treg was a better biomarker on myocardial inflammation.


J Med Virol


Wang X,Ge J,Chen R




Has Abstract


2019-05-01 00:00:00












  • Hepatitis E viral infection regulates estrogen signaling pathways: Inhibition of the cAMPK-PKA-CREB and PI3K-AKT-mTOR signaling pathways.

    abstract::Hepatitis E virus (HEV) infection has become a global concern with high mortality rates among pregnant women, especially those in their third trimester of pregnancy. Estrogen plays an important role in mediating the body, regulating physiological and pathological processes. Estrogen is activated by binding to estrogen...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Gong S,Hao X,Bi Y,Yang C,Wang W,Mickael HK,Zhang Y,Chen S,Qian Z,Huang F,Wei D,Yu W

    更新日期:2020-10-31 00:00:00

  • Distribution of BK polyomavirus genotypes in Tunisian renal transplant recipients.

    abstract::BK polyomavirus (BKV) is a ubiquitous virus in humans that remains latent in the urogenital tract after a primary infection during childhood. The virus, which is reactivated frequently and excreted in urine, can cause nephropathy in renal transplant recipients. BKV sequences are classified into four subtypes (I-IV). S...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Boukoum H,Nahdi I,Foulongne V,Zallema D,Aloui S,Achour A,Segondy M,Aouni M

    更新日期:2011-04-01 00:00:00

  • Detection of a nuclear antigen 2 (EBNA2)-variant Epstein-Barr virus strain in two siblings with fatal lymphoproliferative disease.

    abstract::An EBV type 1 variant strain was detected in two Turkish siblings (boy and girl), who both suffered and died from similar progressive Epstein-Barr virus (EBV)-associated lymphoproliferative disease. Molecular characterisation of this EBV isolate revealed a 51bp-deletion and six nucleotide changes within the Epstein-Ba...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Schuster V,Seidenspinner S,Kreth HW

    更新日期:1996-01-01 00:00:00

  • Efficacy of lamivudine in HBeAg-negative chronic hepatitis B.

    abstract::Hepatitis B e antigen (HBeAg)-negative chronic hepatitis B results from infection with hepatitis B virus mutants unable to produce HBeAg. It accounts for 7-30% of patients with chronic hepatitis B virus (HBV) worldwide, with the highest rates reported for Mediterranean Europe and Asia. Interferon (IFN) is currently th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章,评审


    authors: Rizzetto M

    更新日期:2002-04-01 00:00:00

  • Acute viral hepatitis types E, A, and B singly and in combination in acute liver failure in children in north India.

    abstract::The aetiological agents responsible for, and the outcome of, acute liver failure were investigated prospectively in 44 children (29 males, 15 females) attending a tertiary health care facility in India. The children were between the ages of 2 months and 13 years. Studies for viral infections and other etiologies could...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Arora NK,Nanda SK,Gulati S,Ansari IH,Chawla MK,Gupta SD,Panda SK

    更新日期:1996-03-01 00:00:00

  • Experimental studies of acute and recurrent herpes simplex virus infections in the murine heart and dorsal root ganglia.

    abstract::The multiplication of HSV-1 and HSV-2 strains in the heart and the corresponding dorsal root ganglia (DRG) was examined in experimentally infected mice. Infectious HSV-1 was recovered from the heart between the second and fourth day after inoculation and 3 days later from the DRG. Both the heart and DRG yielded infect...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Grodums EI,Kuling PJ,Zbitnew A

    更新日期:1981-01-01 00:00:00

  • Phylogenetic analysis of human G9P[8] rotavirus strains circulating in Jiangsu, China between 2010 and 2016.

    abstract::Rotavirus A (RVA) is the leading cause of acute viral gastroenteritis in children under 5 years of age worldwide. G9P[8] is a common RVA genotype that has been persistently prevalent in Jiangsu, China. To determine the genetic diversity of G9P[8] RVAs, 7 representative G9P[8] strains collected from Suzhou Children's H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Xu C,Fu J,Ai J,Zhang J,Liu C,Huo X,Bao C,Zhu Y

    更新日期:2018-09-01 00:00:00

  • Detection and characterisation of bisegmented double-stranded RNA viruses (picobirnaviruses) in human faecal specimens.

    abstract::The prevalence of picobirnaviruses (PBVs) in human stools was investigated by polyacrylamide gel electrophoresis (PAGE) analysis of 832 faecal specimens collected between 1982 and 1993 from patients in various clinical groups. Similar prevalences (9-13%) were detected in patients with or without gastroenteritis and th...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Gallimore CI,Appleton H,Lewis D,Green J,Brown DW

    更新日期:1995-02-01 00:00:00

  • Detection of parvovirus B19 DNA, antigen, and particles in the human fetus.

    abstract::Human parvovirus B19 commonly infects children, causing erythema infectiosum (fifth disease). However, there is a significant adult population which has not been exposed to the virus and, consequently, does not have protective antibody. Recent reports have associated B19 infection during pregnancy with fetal death, al...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Clewley JP,Cohen BJ,Field AM

    更新日期:1987-12-01 00:00:00

  • The establishment of reference sequence for SARS-CoV-2 and variation analysis.

    abstract::Starting around December 2019, an epidemic of pneumonia, which was named COVID-19 by the World Health Organization, broke out in Wuhan, China, and is spreading throughout the world. A new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group of the International...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Wang C,Liu Z,Chen Z,Huang X,Xu M,He T,Zhang Z

    更新日期:2020-06-01 00:00:00

  • Anal HPV 16 and 18 viral load: A comparison between HIV-negative and -positive MSM and association with persistence.

    abstract::Does anal HPV viral load explain the difference in anal HPV persistence between HIV-negative and -positive men who have sex with men (MSM)? MSM ≥18 years were recruited in Amsterdam, the Netherlands, in 2010-2011. Anal self-swabs were collected every 6 months and genotyped (SPF10 -PCR-DEIA-LIPA25 -system). HPV16 and H...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Marra E,King A,van Logchem E,van der Weele P,Mooij SH,Heijman T,Meijer CJLM,Verhagen DWM,van der Sande MAB,Schim van der Loeff MF

    更新日期:2018-01-01 00:00:00

  • Ozone as adjuvant support in the treatment of COVID-19: A preliminary report of probiozovid trial.

    abstract::The evaluation of new therapeutic resources against coronavirus disease 2019 (COVID-19) represents a priority in clinical research considering the minimal options currently available. To evaluate the adjuvant use of systemic oxygen-ozone administration in the early control of disease progression in patients with COVID...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Araimo F,Imperiale C,Tordiglione P,Ceccarelli G,Borrazzo C,Alessandri F,Santinelli L,Innocenti GP,Pinacchio C,Mauro V,Recchia GE,Zancla S,Calò A,Poscia R,Ruberto F,d'Ettorre G,Bilotta F,Mastroianni C,Pugliese F

    更新日期:2020-10-28 00:00:00

  • Growth of human immunodeficiency virus I in cultured cells in the absence of the CD4 antigen.

    abstract::The ability of a variety of epithelial, embryonal, placental, and neuronal cells to express the CD4 antigen and to be infected by human immunodeficiency virus 1 (HIV-1) was examined. Only two (IMR-32 and HeLa-T4) expressed CD4 detectable by indirect immunofluorescence, and both were infectable by HIV-1. Two others, a ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Morrison NK,McCarthy K,Hart CA

    更新日期:1991-11-01 00:00:00

  • Serial changes in liver stiffness and controlled attenuation parameter following direct-acting antiviral therapy against hepatitis C virus genotype 1b.

    abstract::Little information is available on the impact of direct-acting antiviral (DAA) therapy on changes in liver fibrosis and steatosis. Liver stiffness (LS) and controlled attenuation parameter (CAP) values were evaluated using transient elastography. The study subjects were 214 elderly patients infected with HCV genotype ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Ogasawara N,Kobayashi M,Akuta N,Kominami Y,Fujiyama S,Kawamura Y,Sezaki H,Hosaka T,Suzuki F,Saitoh S,Suzuki Y,Arase Y,Ikeda K,Kobayashi M,Kumada H

    更新日期:2018-02-01 00:00:00

  • Hepatitis E virus genotype 1f outbreak in Bangladesh, 2018.

    abstract::Hepatitis E virus (HEV) infection is a significant public health issue in many developing countries, causing waterborne outbreaks as well as sporadic hepatitis. We report here an outbreak of HEV genotype 1f infection during April-May 2018 among people living at Halisohor, a low land in the southern part of Chottogram ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Baki AA,Haque W,Giti S,Khan AA,Rahman MM,Jubaida N,Rahman M

    更新日期:2020-12-17 00:00:00

  • Rotavirus-specific subclass antibody and cytokine responses in Bangladeshi children with rotavirus diarrhoea.

    abstract::Rotavirus-specific subclass antibody responses and cytokines, tumour necrosis factor-alpha (TNF-alpha), interferon-gamma (IFN-gamma), interleukin-8 (IL-8), and IL-10, were measured in children 7-24 months of age with rotavirus diarrhoea (n = 29); the responses were compared with children with watery diarrhoea from who...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Azim T,Zaki MH,Podder G,Sultana N,Salam MA,Rahman SM,Sefat-e-Khuda,Sack DA

    更新日期:2003-02-01 00:00:00

  • Will the emergent SARS-CoV2 B.1.1.7 lineage affect molecular diagnosis of COVID19?

    abstract::As the coronavirus disease 2019 pandemic keep tackling global public health systems worldwide. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) genome keeps mutating. In that regard, the recent emergence of the B.1.1.7 lineage in the UK has called the attention of global authorities. One point of concer...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Ramírez JD,Muñoz M,Patiño LH,Ballesteros N,Paniz-Mondolfi A

    更新日期:2021-01-28 00:00:00

  • Infection with GB virus C/hepatitis G virus among blood donors and hemophiliacs in Martinique, a Caribbean island.

    abstract::GB virus C/hepatitis G virus (GBV-C/HGV) RNA was detected by reverse transcription-polymer- ase chain reaction with primers derived from the nonstructural region 3 (NS3) in 9 (4.1%) of 221 blood donors and 2 of 20 (10%) hemophilia patients in Martinique, French West Indies. Anti-E2 antibodies were found in sera from 3...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Césaire R,Martial J,Maier H,Kerob-Bauchet B,Bera O,Duchaud E,Brebion A,Pierre-Louis S

    更新日期:1999-10-01 00:00:00

  • Personal clothing as a potential vector of respiratory virus transmission in childcare settings.

    abstract::Previous investigations of fomite transmission have focused on the presence of pathogens on inanimate objects in clinical settings. There has been limited investigation of fomite transmission in non-clinical pediatric settings where there is a high prevalence of respiratory virus infections. Over a 5 week period, this...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Gralton J,McLaws ML,Rawlinson WD

    更新日期:2015-06-01 00:00:00

  • HIV-2 derived lentiviral vectors: gene transfer in Parkinson's and Fabry disease models in vitro.

    abstract::Lentiviral vectors are prime candidate vectors for gene transfer into dividing and non-dividing cells, including neuronal cells and stem cells. For safety, HIV-2 lentiviral vectors may be better suited for gene transfer in humans than HIV-1 lentiviral vectors. HIV-2 vectors cross-packaged in HIV-1 cores may be even sa...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: D'Costa J,Harvey-White J,Qasba P,Limaye A,Kaneski CR,Davis-Warren A,Brady RO,Bankiewicz KS,Major EO,Arya SK

    更新日期:2003-10-01 00:00:00

  • Epstein-Barr virus infection and its gene expression in gastric lymphoma of mucosa-associated lymphoid tissue.

    abstract::The role of Epstein-Barr virus (EBV) in the pathogenesis of gastric lymphoma of mucosa-associated lymphoid tissue (MALT) has not been well understood. The aim of the study was to investigate EBV infection and its gene expression in this tumor in order to understand its role in the pathogenesis. EBV infection was scree...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Xu WS,Chan AC,Lee JM,Liang RH,Ho FC,Srivastava G

    更新日期:1998-12-01 00:00:00

  • Amino acid substitutions in the hepatitis C virus core region of genotype 1b are the important predictor of severe insulin resistance in patients without cirrhosis and diabetes mellitus.

    abstract::Previous studies provided a direct experimental evidence for the contribution of HCV core protein in the development of insulin resistance (IR), but the clinical impact of HCV core region on IR is still not clear. The present study evaluated the impact of Amino acid (aa) substitutions of HCV-1b core region on IR in 12...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Akuta N,Suzuki F,Hirakawa M,Kawamura Y,Yatsuji H,Sezaki H,Suzuki Y,Hosaka T,Kobayashi M,Kobayashi M,Saitoh S,Arase Y,Ikeda K,Kumada H

    更新日期:2009-06-01 00:00:00

  • Epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of Echovirus 11.

    abstract::After an 8-day-old child had died with clinical signs of septicemia, 6 other newborns fell ill. Virus was isolated from various sites from all the 6 children (28 isolations). The agent was identified by cross neutralization tests as an antigenic variant of Echovirus 11. The agent could not be isolated from mothers or ...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Mertens T,Hager H,Eggers HJ

    更新日期:1982-01-01 00:00:00

  • Hepatitis C virus genotype 4 in Southern and Central Spain does not originate from recent foreign migration waves.

    abstract::Hepatitis C virus genotype 4 (HCV-4) is highly prevalent in Spain, but the information on the molecular characterization of HCV-4 in this region is scarce. Due to this, the molecular characteristics and the evolution of HCV-4 infection in Seville were analyzed (Southern Spain) and compared them with samples from Madri...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Di Lello FA,Neukam K,Parra-Sanchez M,Plaza Z,Soriano V,Cifuentes C,Mira JA,Poveda E,Pineda JA

    更新日期:2013-10-01 00:00:00

  • Potential of large "first generation" human-to-human transmission of 2019-nCoV.

    abstract::To investigate the genetic diversity, time origin, and evolutionary history of the 2019-nCoV outbreak in China and Thailand, a total of 12 genome sequences of the virus with known sampling date (24 December 2019 and 13 January 2020) and geographic location (primarily Wuhan city, Hubei Province, China, but also Bangkok...

    journal_title:Journal of medical virology

    pub_type: 评论,杂志文章


    authors: Li X,Zai J,Wang X,Li Y

    更新日期:2020-04-01 00:00:00

  • Detection of measles virus RNA in whole blood stored on filter paper.

    abstract::The purpose of this study was to evaluate the use of dried blood spots stored on filter paper as a means to provide specimens for virologic surveillance for measles virus (MV) in situations when the reverse cold chain is not available. Two single-step RT-PCR assays were evaluated for sensitivity of detection of MV nuc...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Katz RS,Premenko-Lanier M,McChesney MB,Rota PA,Bellini WJ

    更新日期:2002-08-01 00:00:00

  • Large scale study of HPV genotypes in cervical cancer and different cytological cervical specimens in Thailand.

    abstract::Identification of high-risk HPV genotypes in patients is essential for vaccination and prevention programs while the geographic distribution of cervical cancer varies widely. HPV 16 is the major cause of cervical cancer followed by HPV 18, HPV 31, HPV 52, or HPV 58 depending on geographic area. In this study, the dist...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Chansaenroj J,Junyangdikul P,Chinchai T,Swangvaree S,Karalak A,Gemma N,Poovorawan Y

    更新日期:2014-04-01 00:00:00

  • Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir.

    abstract::Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV) associated malignant tumor. Recently, cidofovir, an anti-viral drug which is an acyclic nucleoside analogue, has been reported to have an anti-tumor potential. Two patients with NPC, who had previously received multi-round therapy, were treated with cidofov...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Yoshizaki T,Wakisaka N,Kondo S,Murono S,Shimizu Y,Nakashima M,Tsuji A,Furukawa M

    更新日期:2008-05-01 00:00:00

  • Culture-amplified detection of dengue virus from serum in an outbreak of dengue fever.

    abstract::An outbreak of dengue type 2 occurred in North Queensland, Australia, between December 1996 and April 1997. Culture of serum in the Aedes albopictus C6/36 cell line with detection using immunofluorescent staining was compared with a culture-amplified detection system using an immunoperoxidase staining method in a micr...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Gleeson F,McBride J,Norton R

    更新日期:1999-02-01 00:00:00

  • Changes in circulation of B and non-B HIV strains: spotlight on a reference centre for infectious diseases in Northern Italy.

    abstract::Stored demographic data and HIV RT and protease sequences of 877 HIV patients attending for the first time the HIV/AIDS outpatient clinics of a reference Infectious Diseases centre in Northern Italy between 1999 and 2006 were stratified by 3-year spanning periods according to date of HIV infection. In the period 1980-...

    journal_title:Journal of medical virology

    pub_type: 杂志文章


    authors: Baldanti F,Paolucci S,Ravasi G,Maccabruni A,Moriggia A,Barbarini G,Maserati R

    更新日期:2008-06-01 00:00:00